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ERYTHROCYTES OR RED BLOOD CELLS (RBCS)
RBC is a circular, biconcave, non nucleated disc.Life span of RBCs is 120 days.Size of RBC -6.5 -8.8 micronThe central part of RBC is thinner then the circumferenceRBC Count:At birth: 6-8 million/cummAdults: 5-6 million/cummFemales 4.5- 6 million/cumm
FUNCTIONS
 
Transport of oxygen.
 
Helps in identifying the blood groups.RBC indices:1.
 
MCV volume of RBC in cubic microns.(Normal range 78 – 94 cubicmicrons)< 78cubic micron -microcytes, > 94 cubic micron macrocytes.2.
 
MCH: Amount of hemoglobin in a single RBC in pico gm.Normal range: 28 -32 pg.3.
 
MCHC: Concentration of hemoglobin in a single RBC(NORMAL -32-35%)MCHC < 33% HYPOCHROMIC RBC
 NOTE: MCHC is never greater than 38% as RBC can not carry Hb beyond their saturation point. Thus anemia can never be hyperchromic
 
 
 HAEMOPOIESIS
It is the development of the blood cells ie. RBC, WBC and platelets
 ERYTHROPOIESIS
Stages of erythropoiesisSTEM CELLSPROERYTHROBLASTEARLY NORMOBLASTINTERMEDIATE NORMOBLASTLATE NORMOBLASTRETICULOCYTESERYTHROCYTES
CHANGES IN RBC DURING ERYTHRPOISIES
1.
 
Reduction in cell size2.
 
Increased amount of cytoplasm3.
 
Basophilic cytoplasm changes to polychromatophilic and then acidophilicdue to decreased content of RNA4.
 
Disappearance of nucleusAPPLIED
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