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Williams-Gray 2008 Brain Attentional control in PD

Sun, 24 Feb 2008 16:15:38 GMT

Brain Advance Access published January 4, 2008 doi:10.1093/brain/awm313 Brain (2007) Page 1 of 12 Attentional control in Parkinson’s disease is dependent on COMTval158met genotype Caroline H. Williams-Gray,1 Adam Hampshire,2 Roger A. Barker1,Ã and Adrian M. Owen2,Ã 1 Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge and 2MRC Cognition and Brain Sciences Unit, Cambridge, UK *These authors contributed equally to this work. Correspondence to: Caroline Williams-Gray, Cambridge Centre for Brain Repair, Department of Clinical Neurosciences, Univ

VanKampen 2006 JNeurosci D3 Agonists restore nigrostriatal pathway

Sun, 24 Feb 2008 16:15:29 GMT

7272 • The Journal of Neuroscience, July 5, 2006 • 26(27):7272–7280 Neurobiology of Disease Dopamine D3 Receptor Agonist Delivery to a Model of Parkinson’s Disease Restores the Nigrostriatal Pathway and Improves Locomotor Behavior Jackalina M. Van Kampen and Christopher B. Eckman Departments of Pharmacology and Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224 The presence of endogenous stem cell populations in the adult mammalian CNS suggests an innate potential for regeneration and represents a potential resource for neuroregenerative therapy aimed at the

Stanic 2004 BrainRes Glial responses to reinnervation of striatum

Sun, 24 Feb 2008 16:15:19 GMT

Brain Research 1023 (2004) 83 – 91 www.elsevier.com/locate/brainres Research report Glial responses associated with dopaminergic striatal reinnervation following lesions of the rat substantia nigra Davor Stanica,1, Wanida Tripanichkula,1, John Dragob, David I. Finkelsteinb, Malcolm K. Horneb,* b a Department of Medicine, Monash University, Monash Medical Centre, Block E, Level 5, 246 Clayton Rd, Clayton 3168, Australia Howard Florey Institute of Experimental Physiology and Medicine, Brain Injury and Repair, The University of Melbourne, Parkville, Victoria, 3010, Australia Accepted 14 July

Stanic 2003 EJNeurosci Timecourse of reinnervation after daergic lesion

Sun, 24 Feb 2008 16:15:09 GMT

European Journal of Neuroscience, Vol. 18, pp. 1175±1188, 2003 ß Federation of European Neuroscience Societies Timecourse of striatal re-innervation following lesions of dopaminergic SNpc neurons of the rat D. Stanic,1,Ã D. I. Finkelstein,1,2,Ã D. W. Bourke,1 J. Drago1,2 and M. K. Horne1,2 1 2 Department of Medicine, Monash University, Monash Medical Centre, Clayton, Australia Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, Victoria, 3010, Australia Keywords: 6-OHDA, dopamine, plasticity, sprouting, timecourse Abstract Previously we descri

Sherer 2006 MovDis GDNF Therapy for PD review

Sun, 24 Feb 2008 16:14:58 GMT

Movement Disorders Vol. 21, No. 2, 2006, pp. 136 –141 © 2006 Movement Disorder Society Viewpoint Crossroads in GDNF Therapy for Parkinson’s Disease Todd B. Sherer, PhD,1* Brian K. Fiske, PhD,1 Clive N. Svendsen, PhD,2 Anthony E. Lang, MD, FRCP,3 and J. William Langston, MD4 Michael J. Fox Foundation for Parkinson’s Research, New York, New York, USA 2 Waisman Center, University of Wisconsin, Madison, Wisconsin, USA 3 Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada 4 Parkinson’s Institute, Sunnyvale, California, USA 1 Abstract: The development of a neuro

Sagi 2007 NeurobiolDis Rasagiline regeneration DAergic

Sun, 24 Feb 2008 16:14:57 GMT

www.elsevier.com/locate/ynbdi Neurobiology of Disease 25 (2007) 35 – 44 Activation of tyrosine kinase receptor signaling pathway by rasagiline facilitates neurorescue and restoration of nigrostriatal dopamine neurons in post-MPTP-induced parkinsonism Yotam Sagi, Silvia Mandel, Tamar Amit, and Moussa B.H. Youdim⁎ Eve Topf and USA National Parkinson Foundation, Centers of Excellence for Neurodegenerative Diseases Research and Department of Pharmacology, Technion-Rappaport Faculty of Medicine, P.O.B. 9697, 31096 Haifa, Israel Received 20 March 2006; revised 4 July 2006; accepted 25 July 2006

McLeod 2006 EJN EPO and GDNF enhance MDN outgrowth in PD model

Sun, 24 Feb 2008 16:14:30 GMT

European Journal of Neuroscience, Vol. 24, pp. 361–370, 2006 doi:10.1111/j.1460-9568.2006.04919.x Erythropoietin and GDNF enhance ventral mesencephalic ﬁber outgrowth and capillary proliferation following neural transplantation in a rodent model of Parkinson’s disease M. McLeod, M. Hong, K. Mukhida, D. Sadi, R. Ulalia and I. Mendez Cell Restoration Laboratory, Brain Repair Centre, 12th ﬂoor, Department of Anatomy and Neurobiology and Surgery (Neurosurgery), Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5 Keywords: erythropoietin, fetal ventral mesencephalon, GDNF, neural t

Li 2007 JNeurosciRes Regeneration of DAergic axons CSPG glial scar

Sun, 24 Feb 2008 16:14:15 GMT

Journal of Neuroscience Research 85:536–547 (2007) Regeneration of Nigrostriatal Dopaminergic Axons by Degradation of Chondroitin Sulfate Is Accompanied by Elimination of the Fibrotic Scar and Glia Limitans in the Lesion Site Hong-Peng Li,1,2 Akiko Homma,1 Kazunori Sango,1 Koki Kawamura,1 Geoffrey Raisman,3 and Hitoshi Kawano1* Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Japan Department of Human Anatomy, College of Basic Medical Sciences, China Medical University, Shenyang, China 3 Division of Neurobiology, Norman and Sadie Lee Research Cou

Li 2007 JNeurosciRes Nigrostriatal Chondroitinase

Sun, 24 Feb 2008 16:13:45 GMT

Lang 2006 AnnNeurol GDNF intraputaminal

Sun, 24 Feb 2008 16:13:14 GMT

ORIGINAL ARTICLES Randomized Controlled Trial of Intraputamenal Glial Cell Line–Derived Neurotrophic Factor Infusion in Parkinson Disease Anthony E. Lang, MD,1 Steven Gill, MD,2 Nik K. Patel, MD,2 Andres Lozano, MD,3 John G. Nutt, MD,4 Richard Penn, MD,5 David J. Brooks, MD,6 Gary Hotton, MD,6 Elena Moro, MD,1 Peter Heywood, MD,1 Matthew A. Brodsky, MD,4 Kim Burchiel, MD,4 Patrick Kelly, MD,7 Arif Dalvi, MD,5 Burton Scott, MD,8 Mark Stacy, MD,9 Dennis Turner, MD,9 V. G. Frederich Wooten, MD,10 William J. Elias, MD,10 Edward R. Laws, MD,10 Vijay Dhawan, PhD,11 A. Jon Stoessl, MD12 James Matc

Kowsky 2007 PNAS RET signaling DAergic regeneration

Sun, 24 Feb 2008 16:13:10 GMT

RET signaling does not modulate MPTP toxicity but is required for regeneration of dopaminergic axon terminals ¨ ¨ ¨ Sebastian Kowsky*, Charlotte Poppelmeyer*, Edgar R. Kramer†, Bjorn H. Falkenburger*, Anja Kruse*, Rudiger Klein†, ¨ and Jorg B. Schulz*‡ *Department of Neurodegeneration and Restorative Research, Centers of Molecular Physiology of the Brain and Neurological Medicine, University of Goettingen, Waldweg 33, D-37073 Goettingen, Germany; and †Department of Molecular Neurobiology, Max–Planck Institute of Neurobiology, Am Klopferspitz 18, D-82152 Martinsried, Germany Edite

Kordower 2007 ArchNeurol AAV2-NTN in monkey MPTP

Sun, 24 Feb 2008 16:12:41 GMT

Delivery of Neurturin by AAV2 (CERE120)-Mediated Gene Transfer Provides Structural and Functional Neuroprotection and Neurorestoration in MPTP-Treated Monkeys Jeffrey H. Kordower, PhD,1,2 Christopher D. Herzog, PhD,3 Biplob Dass, PhD,1 Roy A. E. Bakay, MD,2 James Stansell III, BS,1 Mehdi Gasmi, PhD,3 and Raymond T. Bartus, PhD3 Objective: We tested the hypothesis that gene delivery of the trophic factor neurturin could preserve motor function and protect nigrostriatal circuitry in hemiparkinsonian monkeys. Methods: An adeno-associated virus–based vector encoding human neurturin (AAV2-NTN; al

Kondo 2005 JNeurol L-Dopa therapy neuroprotective

Sun, 24 Feb 2008 16:12:24 GMT

J Neurol (2005) 252 [Suppl 4]: IV/32–IV/36 DOI 10.1007/s00415-005-4007-6 Tomoyoshi Kondo Levodopa therapy from the neuroprotection viewpoint From a clinical outlook ■ Abstract There are many reports indicating the existence of free radical adducts in the Parkinson’s disease (PD) brain. However, levodopa may have two aspects in its characteristics, one is that levodopa is a source of free radicals in the pathogenesis of PD, and the other is that it is the precursor of the most efficient transmitter in dopaminergic neurons from the Prof. T. Kondo, MD, PhD ( ) Dept. of Neurology Wakayam

Klein 1999 BrainRes GAP43 overexpression in DAergic neurons

Sun, 24 Feb 2008 16:12:20 GMT

Brain Research 832 Ž1999. 136–144 Research report Generation of aberrant sprouting in the adult rat brain by GAP-43 somatic gene transfer Ronald L. Klein a a, ) , Robert K. McNamara b , Michael A. King Nicholas Muzyczka e,f , Edwin M. Meyer c,d a , Robert H. Lenox b , Department of Pharmacology and Therapeutics, UniÕersity of Florida, Campus Box 100267 JHMHC, GainesÕille, FL, 32610-0267, USA b Department of Psychiatry, UniÕersity of PennsylÕania, Philadelphia, PA 19104, USA c Department of Neuroscience, UniÕersity of Florida, GainesÕille, FL, 32610, USA d Veterans Administratio

Kirik 2000 JNeurosci rAAV GDNF DAergic regeneration

Sun, 24 Feb 2008 16:11:35 GMT

The Journal of Neuroscience, June 15, 2000, 20(12):4686–4700 Long-Term rAAV-Mediated Gene Transfer of GDNF in the Rat Parkinson’s Model: Intrastriatal But Not Intranigral Transduction Promotes Functional Regeneration in the Lesioned Nigrostriatal System Deniz Kirik, Carl Rosenblad, Anders Bjorklund, and Ronald J. Mandel ¨ Wallenberg Neuroscience Center, Department of Physiological Sciences, Division of Neurobiology, Lund University, 223 62 Lund, Sweden Previous studies have used recombinant adeno-associated viral (rAAV) vectors to deliver glial cell line-derived neurotrophic factor (GDN

Kawano 2005 JNeurosciRes Collagen Synthesis inhibition overrides regeneration failure of DAergic axons

Sun, 24 Feb 2008 16:11:13 GMT

Journal of Neuroscience Research 80:191^202 (2005) Inhibition of Collagen Synthesis Overrides the Age-Related Failure of Regeneration of Nigrostriatal Dopaminergic Axons Hitoshi Kawano,1* Hong-Peng Li,1 Kazunori Sango,1 Koki Kawamura,1 and Geo¡rey Raisman2 1 Department of Developmental Morphology,Tokyo Metropolitan Institute for Neuroscience, Fuchu,Tokyo, Japan 2 Division of Neurobiology, Norman and Sadie Lee Research Council, National Institute for Medical Research, London, United Kingdom To investigate the mechanism of the age-related failure of regeneration of transected axons, nigrostri

Guo 201 EJN Neuroimmunophilin ligands exert neuroregeneration and protection in MDN

Sun, 24 Feb 2008 16:10:54 GMT

European Journal of Neuroscience, Vol. 13, pp. 1683±1693, 2001 ã Federation of European Neuroscience Societies Neuroimmunophilin ligands exert neuroregeneration and neuroprotection in midbrain dopaminergic neurons Xin Guo,1 Valina L. Dawson,1,2,3 and Ted M. Dawson1,2 1 Department of Neurology, 2Department of Neuroscience and 3Department of Physiology, Johns Hopkins University School of Medicine, 600 N. Wolfe St., Carnegie 2±214, Baltimore, MD 21287, USA Keywords: 6-OHDA, FKBP, immunophilin, mouse, MPP+, rat, tyrosine hydroxylase Abstract Immunosuppressant drugs, like FK506, and nonimmun

Gill 2003 NatNeurosci GDNF infusion in human PD

Sun, 24 Feb 2008 16:10:46 GMT

ARTICLES Direct brain infusion of glial cell line–derived neurotrophic factor in Parkinson disease STEVEN S. GILL1, NIKUNJ K. PATEL1, GARY R. HOTTON2, KAREN O’SULLIVAN1, RENÉE MCCARTER1, MARTIN BUNNAGE1, DAVID J. BROOKS2, CLIVE N. SVENDSEN3 & PETER HEYWOOD1 © 2006 Nature Publishing Group http://www.nature.com/naturemedicine 1 Frenchay Hospital, Institute of Neurosciences, Bristol, UK MRC Clinical Sciences Center and Division of Neuroscience, Faculty of Medicine, Imperial College, Hammersmith Hospital, London, UK 3 The Waisman Center Stem Cell Research Program and Departments of Neurolog

Finkelstein 2000 Neurosci Axonal sprouting following SN lesions

Sun, 24 Feb 2008 16:10:09 GMT

Sprouting of substantia nigra neurons Pergamon PII: S0306-4522(00)00009-9 www.elsevier.com/locate/neuroscience Copyright Neuroscience Vol. 97, No. 1, pp. 99–112, 2000 99 2000 IBRO. Published by Elsevier Science Ltd Printed in Great Britain. All rights reserved 0306-4522/00 $20.00+0.00 AXONAL SPROUTING FOLLOWING LESIONS OF THE RAT SUBSTANTIA NIGRA D. I. FINKELSTEIN,*† D. STANIC,*† C. L. PARISH,* D. TOMAS,* K. DICKSON‡ and M. K. HORNE*§¶ *Department of Medicine, Monash University, Clayton 3168, Victoria, Australia ‡School of Life Sciences and Technology, Victoria University, St A

Brizard 2006 Reinnervation from remaining DAergic terminals by GDNF lenti in rat PD

Sun, 24 Feb 2008 16:09:58 GMT

www.elsevier.com/locate/ynbdi Neurobiology of Disease 21 (2006) 90 – 101 Functional reinnervation from remaining DA terminals induced by GDNF lentivirus in a rat model of early Parkinson’s disease Mara Brizard,a,1 Carole Carcenac,b,1 Alexis-Pierre Bemelmans,a Claude Feuerstein,b Jacques Mallet,a and Marc Savasta b,* a Laboratoire de Genetique Moleculaire des Processus Neurodegeneratifs et de la Neurotransmission-Unite Mixte de Recherche ´´ ´ ´´´ ´ 7091-Centre National de la Recherche Scientifique-Hopital de la Pitie-Salpetriere, batiment CERVI, 83 boulevard de l’Hopital, 75013 P

Borta 2007 JNeurochem Dopamine and adult neurogenesis

Sun, 24 Feb 2008 16:09:33 GMT

Journal of Neurochemistry, 2007, 100, 587–595 doi:10.1111/j.1471-4159.2006.04241.x REVIEW Dopamine and adult neurogenesis Andreas Borta and Gunter U. Hoglinger ¨ ¨ Experimental Neurology, Philipps University, Marburg, Germany Abstract Dopamine is an important neurotransmitter implicated in the regulation of mood, motivation and movement. We have reviewed here recent data suggesting that dopamine, in addition to being a neurotransmitter, also plays a role in the regulation of endogenous neurogenesis in the adult mammalian brain. In addition, we approach a highly controversial question:

Blanchard 1996 BrainRes DAergic sprouting after SN lesion

Sun, 24 Feb 2008 16:09:20 GMT

BRAIN RESEARCH ELSEVIER Brain Research709 (1996)319-325 Short communication Dopaminergic sprouting in the rat striatum after partial lesion of the substantia nigra V6ronique Blanchard a, Philippe Anglade a, Gustavo Dziewczapolski h, Marc Savasta c, Yves Agid a, Rita Raisman-Vozari a,, a INSERM U289, H~pital de la Salp~tri~re, 47 bd de l'H~pital, 75013 Paris, France b lnstituto de Investigaciones Farmacologicas, CONICET, Buenos Aires, Argentina c INSERM U318, Laboratoire de Physiologie, Section Neurophysiologie, CHU Grenoble, France Accepted 31 October1995 Abstract The capacity of the dopa

Bezard 1998 ProgNeurobiol Compensatory mechanisms in PD

Sun, 24 Feb 2008 16:08:52 GMT

Progress in Neurobiology Vol. 55, pp. 93 to 116, 1998 # 1998 Elsevier Science Ltd. All rights reserved Printed in Great Britain 0301-0082/98/$19.00 PII: S0301-0082(98)00006-9 COMPENSATORY MECHANISMS IN EXPERIMENTAL AND HUMAN PARKINSONISM: TOWARDS A DYNAMIC APPROACH ERWAN BEZARD* and CHRISTIAN E. GROSS Basal Gang, Laboratoire de Neurophysiologie, CNRS UMR 5543, UniversiteÂ de Bordeaux II, 146 rue Leo Saignat, 33076 Bordeaux, Cedex, France (Received 23 December 1997) AbstractÐThis paper provides an overview of the compensatory mechanisms which come into action during experimental and human p

Batchelor 2000 EJN Inhibition of GDNF and BDNF reduces DAergic sprouting in the striatum

Sun, 24 Feb 2008 16:08:40 GMT

European Journal of Neuroscience, Vol. 12, pp. 3462±3468, 2000 Ó Federation of European Neuroscience Societies Inhibition of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression reduces dopaminergic sprouting in the injured striatum P. E. Batchelor, G. T. Liberatore, M. J. Porritt, G. A. Donnan and D. W. Howells Departments of Medicine and Neurology, University of Melbourne, Austin and Repatriation Medical Centre, Heidelberg, Victoria 3084, Australia Keywords: antisense, BDNF, dopamine, GDNF, mice, sprouting, striatal injury Abstract After striatal

Winkler 1996 JNeurosci GDNF in SNpc protects against 6-OHDA

Sun, 24 Feb 2008 16:08:27 GMT

The Journal of Neuroscience, November 15, 1996, 16(22):7206 –7215 Short-Term GDNF Treatment Provides Long-Term Rescue of Lesioned Nigral Dopaminergic Neurons in a Rat Model of Parkinson’s Disease Christian Winkler,1,2 Hansjorg Sauer,1,3 Chong S. Lee,1,4 and Anders Bjorklund1 ¨ ¨ Lund University, Wallenberg Neuroscience Center, S-22362 Lund, Sweden, 2Neurosurgical Clinic, Nordstadt Hospital, D-30167 Hannover, Germany, 3Genentech Inc., South San Francisco, California 94080, 4Neurodegenerative Disorders Centre, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Can

Weishaupt 2006 JPinealRes

Sun, 24 Feb 2008 13:41:49 GMT

J. Pineal Res. 2006; 41:313–323 Doi:10.1111/j.1600-079X.2006.00377.x Ó 2006 The Authors Journal compilation Ó 2006 Blackwell Munksgaard Journal of Pineal Research Reduced oxidative damage in ALS by high-dose enteral melatonin treatment Abstract: Amyotrophic lateral sclerosis (ALS) is the collective term for a fatal motoneuron disease of diﬀerent etiologies, with oxidative stress as a common molecular denominator of disease progression. Melatonin is an amphiphilic molecule with a unique spectrum of antioxidative eﬀects not conveyed by classical antioxidants. In preparation of a possi

Wang 2005 EurJPharmacol Fasudil

Sun, 24 Feb 2008 13:41:42 GMT

European Journal of Pharmacology 512 (2005) 215 – 222 www.elsevier.com/locate/ejphar Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice Yi-Xin WangT, Valdeci da Cunha, Baby Martin-McNulty, Jon Vincelette, Weiwei Li, David F. Choy, Meredith Halks-Miller, Mithra Mahmoudi, Miriam Schroeder, Anthony Johns, David R. Light, William P. Dole Departments of Pharmacology and Cardiovascular Research, Berlex Biosciences, 2600 Hilltop Drive, Richmond, CA 94804, USA Received 8 November 2004; received in revised form 7 February 2005

Waibel 2004 JNeurol Rasagiline Riluzole G93A model

Sun, 24 Feb 2008 13:41:36 GMT

J Neurol (2004) 251 : 1080–1084 DOI 10.1007/s00415-004-0481-5 ORIGINAL COMMUNICATION Stefan Waibel Alexander Reuter Susanne Malessa Eran Blaugrund Albert C. Ludolph Rasagiline alone and in combination with riluzole prolongs survival in an ALS mouse model Received: 6 October 2003 Received in revised form: 17 February 2004 Accepted: 26 February 2004 St. Waibel · A. Reuter · S. Malessa · Prof. A. C. Ludolph ( ) Department of Neurology University of Ulm Oberer Eselsberg 45 89081 Ulm, Germany Tel.: +49-731/1771-200 Fax: +49-731/1771-202 E-Mail: albert.ludolph@rku.de E. Blaugrund Developmen

Van Damme 2005 NeurodegenDis Excitotoxicity in ALS

Sun, 24 Feb 2008 13:41:31 GMT

Toxicity Pathways in ALS Neurodegenerative Dis 2005;2:147–159 DOI: 10.1159/000089620 Diseases Excitotoxicity and Amyotrophic Lateral Sclerosis P. Van Damme M. Dewil W. Robberecht L. Van Den Bosch Neurobiology, Campus Gasthuisberg, Leuven, Belgium Key Words Excitotoxicity AMPA receptors Motor neuron Neurodegenerative disease Ca2+ metabolism Amyotrophic Lateral Sclerosis Abstract Since its description by Charcot more than 130 years ago, the pathogenesis of selective motor neuron degeneration in amyotrophic lateral sclerosis (ALS) remains unsolved. Over the years, many pathogenic mechanism

Rintoul 2003 J Neurosci GlutamateMitosTransport

Sun, 24 Feb 2008 13:41:06 GMT

The Journal of Neuroscience, August 27, 2003 • 23(21):7881–7888 • 7881 Cellular/Molecular Glutamate Decreases Mitochondrial Size and Movement in Primary Forebrain Neurons Gordon L. Rintoul, Anthony J. Filiano, Jacques B. Brocard, Geraldine J. Kress, and Ian J. Reynolds Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261 Mitochondria are essential to maintain neuronal viability. In addition to the generation of ATP and maintenance of calcium homeostasis, the effective delivery of mitochondria to the appropriate location within neurons is also likely to

Nagaoka 2006 JApplPhysiol

Sun, 24 Feb 2008 13:37:53 GMT

Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat Tetsutaro Nagaoka, Sarah A. Gebb, Vijaya Karoor, Noriyuki Homma, Kenneth G. Morris, Ivan F. McMurtry and Masahiko Oka J Appl Physiol 100:996-1002, 2006. First published Dec 1, 2005; doi:10.1152/japplphysiol.01028.2005 You might find this additional information useful... This article cites 33 articles, 23 of which you can access free at: http://jap.physiology.org/cgi/content/full/100/3/996#BIBL Updated information and services including high-resolution figures, can be found at: http://jap.physiology.org/c

Miana-Mena 2005 ALS motor testing for mice

Sun, 24 Feb 2008 13:37:47 GMT

Amyotrophic Lateral Sclerosis. 2005; 6: 55–62 ORIGINAL ARTICLE Optimal methods to characterize the G93A mouse model of ALS ˜ ¨ FRANCISCO J. MIANA-MENA1, MARIA J. MUNOZ2, GEMA YAGUE3, MARIO MENDEZ4, 1 ´ S CIRIZA1, PILAR ZARAGOZA1 & ROSARIO OSTA1 MARIA MORENO , JESU 1 Laboratorio de Genetica Bioquımica y Grupos Sanguıneos, 2Unidad de Farmacologıa, 3Unidad de Genetica Cuantitativa y ´ ´ ´ ´ ´ ´ ´ Mejora Animal, Facultad de Veterinaria de Zaragoza, Zaragoza, and 4Servicio de Neurofisiologıa Clınica, Hospital Universitario Miguel Server, Zaragoza, Spain Abstract In the present

Meininger 2005 NeurodegenDis Recent ALS trials

Sun, 24 Feb 2008 13:37:30 GMT

Clinical and Epidemiological Aspects of ALS Neurodegenerative Dis 2005;2:208–214 DOI: 10.1159/000089627 Diseases Clinical Trials in ALS: What Did We Learn from Recent Trials in Humans? Vincent Meininger ALS National Referral and Coordinating Centre, Hôpital Salpêtrière, Paris, France Key Words Clinical trials in ALS Prognostic factors in ALS Survival Abstract Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. No treatment is currently able to stop the disease process. In the absence of new active compounds there is an urgent need to develop new strategies

Klivenyi 1999 NatMed Creatine in ALS

Sun, 24 Feb 2008 13:37:27 GMT

© 1999 Nature America Inc. • http://medicine.nature.com ARTICLES Neuroprotective effects of creatine in a transgenic animal model of amyotrophic lateral sclerosis PETER KLIVENYI1, ROBERT J. FERRANTE2,3, RUSSELL T. MATTHEWS1, MIKHAIL B. BOGDANOV1, AUTUMN M. KLEIN2,3, OLE A. ANDREASSEN1, GERALD MUELLER1, MARIEKE WERMER1, RIMA KADDURAH-DAOUK4 & M. FLINT BEAL1,5 1 © 1999 Nature America Inc. • http://medicine.nature.com Neurochemistry Laboratory, Neurology Service,Massachusetts General Hospital and Harvard Medical School, 32 Fruit Street, Boston, Massachusetts 02118, USA 2 Departments of

Kawahara 2003 Nature ALSpatientsEditing

Sun, 24 Feb 2008 13:37:23 GMT

brief communications RNA editing and death of motor neurons There is a glutamate-receptor defect in patients with amyotrophic lateral sclerosis. he aetiology of sporadic amyotrophic lateral sclerosis (ALS), a fatal paralytic disease, is largely unknown. Here we show that there is a defect in the editing of the messenger RNA encoding the GluR2 subunit of glutamate AMPA receptors in the spinal motor neurons of individuals affected by ALS. This failure to swap an arginine for a glutamine residue at a crucial site in the subunit, which occurs normally in the affected brain areas of patients with

jakob et al 2002 j pineal res

Sun, 24 Feb 2008 13:37:21 GMT

J. Pineal Res. 2002; 33:186–187 LETTER TO THE EDITOR Copyright Ó Blackwell Munksgaard, 2002 Journal of Pineal Research ISSN 0742-3098 Melatonin as a candidate compound for neuroprotection in amyotrophic lateral sclerosis (ALS): high tolerability of daily oral melatonin administration in ALS patients tested in clinical trials for treatment of Alzheimer disease because of its capacity to reduce in vitro Ab formation as well as aggregation and neurotoxicity [2]. The doses applied range from 1 to 2000 mg (short term) per day in cancer studies. Application in man is predominantly oral [4]. In

Hattori 2004 CircRes Fasudil in vivo

Sun, 24 Feb 2008 13:37:20 GMT

Long-Term Treatment With a Specific Rho-Kinase Inhibitor Suppresses Cardiac Allograft Vasculopathy in Mice Tsuyoshi Hattori, Hiroaki Shimokawa, Midoriko Higashi, Junko Hiroki, Yasushi Mukai, Kozo Kaibuchi and Akira Takeshita Circ. Res. 2004;94;46-52; originally published online Nov 13, 2003; DOI: 10.1161/01.RES.0000107196.21335.2B Circulation Research is published by the American Heart Association. 7272 Greenville Avenue, Dallas, TX 72514 Copyright © 2004 American Heart Association. All rights reserved. Print ISSN: 0009-7330. Online ISSN: 1524-4571 The online version of this article, along w

Grunfeld 2006 ExpNeurol Epo for ALS

Sun, 24 Feb 2008 13:37:10 GMT

ARTICLE IN PRESS + model YEXNR-09383; No. of pages: 4; 4C: Experimental Neurology xx (2006) xxx – xxx www.elsevier.com/locate/yexnr Erythropoietin delays disease onset in an amyotrophic lateral sclerosis model Jonathan F. Grunfeld a,⁎, Yael Barhum b , Netta Blondheim b , Jose-Martin Rabey a , Eldad Melamed b , Daniel Offen b b a Department of Neurology, Asaf HaRofeh Medical Center, Tel Aviv University, Sackler School of Medicine, Israel Felsenstein Medical Research Center, Department of Neurology, Rabin Medical Center, Tel Aviv University, Sackler School of Medicine, Israel Received 2

Graf 2004 J Neural Transm VitE+Riluzole in ALS

Sun, 24 Feb 2008 13:37:06 GMT

DOI 10.1007/s00702-004-0220-1 J Neural Transm (2004) High dose vitamin E therapy in amyotrophic lateral sclerosis as add-on therapy to riluzole: results of a placebo-controlled double-blind study M. Graf, D. Ecker, R. Horowski, B. Kramer, P. Riederer, M. Gerlach, C. Hager, and A. C. Ludolph on behalf of the German vitamin E=ALS Study Group Investigators from the study group and Centres A. C. Ludolph1 , B. Kramer1, D. Ecker1, G. Becker2;y, J. Osterhage2 , W. H. Jost3 , B. Schrank3 , C. Stein3 , P. Kostopulos3 , S. Lubik3 , K. Wekwerth3 , R. Dengler4, M. Troeger4, A. Wuerz4 , A. Hoge4 , C. Sch

Goodall 2006 ExpRevMolMed ALS mechanisms

Sun, 24 Feb 2008 13:37:03 GMT

http://www.expertreviews.org/ expert reviews in molecular medicine Amyotrophic lateral sclerosis (motor neuron disease): proposed mechanisms and pathways to treatment Emily F. Goodall and Karen E. Morrison Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterised by loss of motor neurons. The cause of disease is unknown other than in the rare cases of familial disease arising from mutations in the superoxide dismutase 1 gene. Many theories for pathogenesis have been proposed – including oxidative stress, excitotoxicity, mitochondrial dysfunction and abnormal

Benatar 2007 NeurobiolDis ALS trials review

Sun, 24 Feb 2008 13:36:59 GMT

www.elsevier.com/locate/ynbdi Neurobiology of Disease 26 (2007) 1 – 13 Review Lost in translation: Treatment trials in the SOD1 mouse and in human ALS Michael Benatar⁎ Department of Neurology, Emory University School of Medicine, Woodruff Memorial Building, 1639 Pierce Drive, Atlanta, GA 30322, USA Received 20 October 2006; revised 12 December 2006; accepted 20 December 2006 Available online 3 January 2007 Therapeutic success in the superoxide dismutase (SOD1) mouse model of amyotrophic lateral sclerosis (ALS) has not translated into effective therapy for human ALS, calling into questio

Zou 2004 TINS Wnt singaling in axon guidance

Sun, 24 Feb 2008 12:23:46 GMT

Review TRENDS in Neurosciences Vol.27 No.9 September 2004 Wnt signaling in axon guidance Yimin Zou Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, Chicago, IL 60637, USA Recent studies have identiﬁed Wnt proteins as conserved axon guidance molecules in vertebrates and invertebrates. Wnt proteins are a large family of diffusible factors that play several important roles, both in embryonic development and in adult function. The signaling mechanisms of Wnt proteins are complex and, because Wnts are newly discovered as axon guidance cues, little is known ab

Zheng 2005 PNAS Nogo ko's don't regenerate

Sun, 24 Feb 2008 12:23:43 GMT

Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo Binhai Zheng*†‡, Jasvinder Atwal*†‡, Carole Ho*, Lauren Case§, Xiao-lin He¶, K. Christopher Garcia¶, Oswald Steward , and Marc Tessier-Lavigne*†**†† *Department of Biological Sciences, §Program in Neurosciences, **Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305; ¶Departments of Microbiology and Immunology and Structural Biology, Stanford University School of Medicine, Stanford, CA 94305; and Reeve–Irvine Research Cen

Zhao 2003 CurrentBiol UPS functions as inhibitory constraint on synaptic strengthening

Sun, 24 Feb 2008 12:23:32 GMT

Current Biology, Vol. 13, 887–898, May 27, 2003, 2003 Elsevier Science Ltd. All rights reserved. DOI 10.1016/S 09 60 - 98 22 ( 03 )0 0 33 2- 4 The Ubiquitin Proteasome System Functions as an Inhibitory Constraint on Synaptic Strengthening Yali Zhao,1,2 Ashok N. Hegde,6 and Kelsey C. Martin2,3,4,5,* 1 Department of Physiological Sciences 2 Brain Research Institute 3 Department of Psychiatry and Biobehavioral Sciences 4 Department of Biological Chemistry 5 Neuropsychiatric Institute University of California, Los Angeles Los Angeles, California 90095 6 Department of Neurobiology and Anatomy

Zhang 2007 Neuron NMDA receptor signaling - death and survival

Sun, 24 Feb 2008 12:23:22 GMT

Neuron Article Decoding NMDA Receptor Signaling: Identiﬁcation of Genomic Programs Specifying Neuronal Survival and Death Sheng-Jia Zhang,1 Marvin N. Steijaert,1,4 David Lau,1 Gunther Schutz,2 Celine Delucinge-Vivier,3 ¨ ¨ Patrick Descombes,3 and Hilmar Bading1,* 1 Department of Neurobiology, Interdisciplinary Center for Neurosciences (IZN), University of Heidelberg, 69120 Heidelberg, Germany 2 Deutsches Krebsforschungszentrum (DKFZ), 69120 Heidelberg, Germany 3 ´ ` Genomics Platform, Universite de Geneve, CH-1211 Geneva, Switzerland 4 Present address: Department of Biomedical Engineerin

Zhang 2005 Exp Eye Res STAT3 RGC

Sun, 24 Feb 2008 12:22:58 GMT

Experimental Eye Research 81 (2005) 103–115 www.elsevier.com/locate/yexer STAT3 activation in response to growth factors or cytokines participates in retina precursor proliferation Samuel Shao-Min Zhanga,b, Mu-Gen Liua,b, Arihiro Kanoa, Chun Zhanga,1, Xin-Yuan Fua, Colin J. Barnstableb,c,* b a Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06520, USA Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, Connecticut 06520, USA c Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut

Zhang 2004 Development Zic3 in retinal axon projection

Sun, 24 Feb 2008 12:22:46 GMT

Research article 1553 Disruption of gradient expression of Zic3 resulted in abnormal intraretinal axon projection Jinhua Zhang, Zhe Jin and Zheng-Zheng Bao* Department of Medicine and Cell Biology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA *Author for correspondence (e-mail: zheng.bao@umassmed.edu) Accepted 15 December 2003 Development 131, 1553-1562 Published by The Company of Biologists 2004 doi:10.1242/dev.01041 Summary The targeting of retinal ganglion axons toward the optic disc is the ﬁrst step in axon pathﬁnding in the visual sys

Yiu He 2006 CurrOpinNeurobiol Signaling mechanisms of myelin inhibitors

Sun, 24 Feb 2008 12:22:06 GMT

545 Signaling mechanisms of the myelin inhibitors of axon regeneration Glenn Yiu and Zhigang HeÃ One of the major obstacles to successful axon regeneration in the adult CNS is the presence of inhibitory molecules that are associated with myelin. Recent studies have identiﬁed several major myelin-associated inhibitors along with the relevant signaling molecules. Such advances have not only enhanced our understanding of the signaling mechanisms that are involved in the inhibition of axon regeneration in the adult CNS but also allowed us to assess the therapeutic potential of blocking these i

Yin 2003 JNeurosci Macrophage derived factors enhance optic nerve regeneration

Sun, 24 Feb 2008 12:21:54 GMT

2284 • The Journal of Neuroscience, March 15, 2003 • 23(6):2284 –2293 Macrophage-Derived Factors Stimulate Optic Nerve Regeneration Yuqin Yin,1,2* Qi Cui,4* Yiming Li,1,2 Nina Irwin,1,2 Dietmar Fischer,1,2 Alan R. Harvey,4 and Larry I. Benowitz1,2,3 1 Laboratories for Neuroscience Research in Neurosurgery, Children’s Hospital, Boston, Massachusetts 02115, 2Department of Surgery and 3Program in Neuroscience, Harvard Medical School, Boston, Massachusetts 02115, and 4School of Anatomy and Human Biology and Western Australian Institute for Medical Research, University of Western Australi

Yao 2006 NatNeurosci ß-actin mRNA localization for growth cone guidance

Sun, 24 Feb 2008 12:21:44 GMT

ARTICLES © 2006 Nature Publishing Group http://www.nature.com/natureneuroscience An essential role for b-actin mRNA localization and translation in Ca2+-dependent growth cone guidance Jiaqi Yao1, Yukio Sasaki2, Zhexing Wen1, Gary J Bassell2 & James Q Zheng1 Axon pathﬁnding requires directional responses of growth cones to extracellular cues, which have been shown to involve local synthesis of protein. The identity and functions of the locally produced proteins remain, however, unclear. Here we report that Ca21-dependent bidirectional turning of Xenopus laevis growth cones requires localiz

Yamashita J Cell Biol p75 in MAG signaling to Rho

Sun, 24 Feb 2008 12:21:35 GMT

JCB Report The p75 receptor transduces the signal from myelin-associated glycoprotein to Rho Toshihide Yamashita,1,2 Haruhisa Higuchi,1,2 and Masaya Tohyama1,2 1 2 Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan Core Research for Evolutional Science and Technology (CREST), Kawaguchi 332-0012, Japan yelin-associated glycoprotein (MAG) is a potent inhibitor of neurite outgrowth from a variety of neurons. The receptor for MAG or signals that elicit morphological changes in neurons remained to be established. Here we show that the neur

Wong 2003 JNeurosci Inactivation of MAG by chromophore-assisted laser inactivation promotes ON regeneration

Sun, 24 Feb 2008 12:21:16 GMT

3112 • The Journal of Neuroscience, April 15, 2003 • 23(8):3112–3117 Brief Communication Inactivation of Myelin-Associated Glycoprotein Enhances Optic Nerve Regeneration Eric V. Wong,1,3 Samuel David,2 Michele H. Jacob,1 and Daniel G. Jay1 Departments of Physiology and Neuroscience, Tufts University Medical School, Boston, Massachusetts 02111, 2Center for Research in Neuroscience, Montreal General Hospital Research Institute and McGill University, Montreal, Quebec, Canada, and 3Department of Biology, University of Louisville, Louisville Kentucky 40292 1 CNS regeneration in higher vert

Wettschurek 2002 JMolMed Rho Kinase review

Sun, 24 Feb 2008 12:20:49 GMT

J Mol Med (2002) 80:629–638 DOI 10.1007/s00109-002-0370-2 REVIEW Nina Wettschureck · Stefan Offermanns Rho/Rho-kinase mediated signaling in physiology and pathophysiology Received: 6 May 2002 / Accepted: 1 July 2002 / Published online: 7 September 2002 © Springer-Verlag 2002 Abstract The small GTPase Rho is implicated in many cellular functions such as cell adhesion, cell motility and migration, growth control, cell contraction, and cytokinesis. One of its main effectors, Rho-kinase, appears to play a key role in the regulation of force and velocity of actomyosin crossbridging in smoo

Weise 2000 MicroscResTech

Sun, 24 Feb 2008 12:20:43 GMT

MICROSCOPY RESEARCH AND TECHNIQUE 48:55–62 (2000) Degeneration and Regeneration of Ganglion Cell Axons ¨ JENS WEISE, RICHARD ANKERHOLD, AND MATHIAS BAHR* Neurologische Universitatsklinik, 72076 Tubingen, Germany ¨ ¨ KEY WORDS RGCs; axon growth; axon regrowth; axon guidance; axonal lesion; retino-tectal system ABSTRACT The retino-tectal system has been used to study developmental aspects of axon growth, synapse formation and the establishment of a precise topographic order as well as degeneration and regeneration of adult retinal ganglion cell (RGC) axons after axonal lesion. This pape

Weise 2000 Microsc Res Techn Stripe assay RGCs

Sun, 24 Feb 2008 12:20:35 GMT

Wang 2002 nature omg is a nogo receptor ligand inhibiting outgrowth

Sun, 24 Feb 2008 12:20:32 GMT

letters to nature completion of the three viscous load conditions (Supplementary Information). Monkey C was trained to perform movements with loads to eight directions uniformly distributed in hand-space. In order to save time during the viscous load conditions, neural activity was recorded only to targets at 908 and 2708, directions associated with large shoulder and elbow rotations, and thus large loads (Supplementary Information). Acknowledgements We thank K. Moore for technical assistance, and D.W. Cabel and S. Chan who assisted in some of the training and neuronal recording sessions. We

Wakita 2002 BrainRes APP for axonal damage

Sun, 24 Feb 2008 12:20:27 GMT

Brain Research 924 (2002) 63–70 www.elsevier.com / locate / bres Research report Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat a, a a a a Hideaki Wakita *, Hidekazu Tomimoto , Ichiro Akiguchi , Akinori Matsuo , Jin-Xi Lin , Masafumi Ihara a , Patrick-L. McGeer b a Department of Neurology, Faculty of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan b Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada Accepted 16 October 2001 Abstract Cerebral white matter (W

Vourc'h 2004 BrainResRev OMgp review

Sun, 24 Feb 2008 12:20:10 GMT

Brain Research Reviews 45 (2004) 115 – 124 www.elsevier.com/locate/brainresrev Review Oligodendrocyte myelin glycoprotein (OMgp): evolution, structure and function Patrick Vourc’h, Christian Andres * ´´ ´ ´ ´ Genetique et physiopathologie de l’autisme et des deficiences mentales, INSERM U619, CHRU Tours and Faculte de Medecine, ´ 2 bis Bd Tonnelle, 37032 Tours Cedex, France Accepted 7 January 2004 Abstract The oligodendrocyte myelin glycoprotein (OMgp) is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the central nervous system (CNS)

Verma 2005 JNeurosci Protein synthesis in axon needed for regeneration

Sun, 24 Feb 2008 12:20:02 GMT

The Journal of Neuroscience, January 12, 2005 • 25(2):331–342 • 331 Development/Plasticity/Repair Axonal Protein Synthesis and Degradation Are Necessary for Efficient Growth Cone Regeneration Poonam Verma,1 Sabrina Chierzi,1 Amanda M. Codd,2 Douglas S. Campbell,3 Ronald L. Meyer,4 Christine E. Holt,3 and James W. Fawcett1 1 Cambridge University Centre for Brain Repair, Cambridge CB2 2PY, United Kingdom, 2University of California, San Francisco, San Francisco, California 94143, 3Department of Anatomy, University of Cambridge, Cambridge CB2 3DY, United Kingdom, and 4Department of Develo

Vargas 2007 AnnRevNeurosci Wallerian degeneration

Sun, 24 Feb 2008 12:19:49 GMT

Annu. Rev. Neurosci. 2007.30:153-179. Downloaded from arjournals.annualreviews.org by Deutsche Forschungsgemeinschaft on 09/24/07. For personal use only. Why Is Wallerian Degeneration in the CNS So Slow? Mauricio E. Vargas and Ben A. Barres Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305; email: mevargas@stanford.edu, barres@stanford.edu Annu. Rev. Neurosci. 2007. 30:153–79 The Annual Review of Neuroscience is online at neuro.annualreviews.org This article’s doi: 10.1146/annurev.neuro.30.051606.094354 Copyright c 2007 by Annual Reviews. All

van Adel 2005 JNeurobiol CNTF acts through modulation of glia

Sun, 24 Feb 2008 12:19:44 GMT

Ciliary Neurotrophic Factor Protects Retinal Ganglion Cells from Axotomy-Induced Apoptosis via Modulation of Retinal Glia In Vivo B.A. van Adel,1 J.M. Arnold,2 J. Phipps,2 L.C. Doering,1 A.K. Ball1 1 Department of Pathology and Molecular Medicine, Faculty of Health Sciences, HSC-1R1, McMaster University, Hamilton, Canada PharmaGap, National Research Council, Ottawa, Canada 2 Received 10 May 2004; accepted 4 October 2004 Adenoviral-mediated transfer of ciliary neurotrophic factor (CNTF) to the retina rescued retinal ganglion cells (RGCs) from axotomy-induced apoptosis, presumably via activa

tsonis 2002 differentiation regenerative biology review

Sun, 24 Feb 2008 12:19:28 GMT

Differentiation (2002) 70:397–409 C Blackwell Verlag 2002 REVIEW Panagiotis A. Tsonis Regenerative biology: the emerging field of tissue repair and restoration Accepted in revised form: 17 May 2002 Abstract Regenerative biology has now been recognized as a new field with certain aims and goals. One direction of this new field is to understand the basic mechanisms by which tissues can be repaired and restored. The other direction examines the possibility of using this basic knowledge to apply it to medicine with the goal to clinically repair damaged tissues. Regeneration of tissues c

Trousse 2001 Development Shh for RGC growth

Sun, 24 Feb 2008 12:19:26 GMT

Development 128, 3927-3936 (2001) Printed in Great Britain © The Company of Biologists Limited 2001 DEV1694 3927 Control of retinal ganglion cell axon growth: a new role for Sonic hedgehog Françoise Trousse1,*, Elisa Martí1,*, Peter Gruss2, Miguel Torres3 and Paola Bovolenta1,‡ 1Instituto Cajal, CSIC, Av. Doctor Arce 37, 28002 Madrid, Spain 2Department of Molecular and Cell Biology, MPI, 3400 Göttingen,Germany 3Centro Nacional de Biotecnologia, CSIC, Canto Blanco, Madrid, Spain *These authors contributed equally to this work ‡Author for correspondence (e-mail: bovolenta@cajal.csic.e

Trapp 1998 NEJM axonal pathology in MS lesions

Sun, 24 Feb 2008 12:19:03 GMT

The New England Journal of Medicine AXONAL TRANSECTION IN THE LESIONS OF MULTIPLE SCLEROSIS BRUCE D. TRAPP, PH.D., JOHN PETERSON, B.S., RICHARD M. RANSOHOFF, M.D., RICHARD RUDICK, M.D., SVERRE MÖRK, M.D., PH.D., AND LARS BÖ, M.D. ABSTRACT Background Multiple sclerosis is an inflammatory demyelinating disease of the central nervous system and is the most common cause of neurologic disability in young adults. Despite antiinflammatory or immunosuppressive therapy, most patients have progressive neurologic deterioration that may reflect axonal loss. We conducted pathological studies of brain t

Thompson 2004 MCN HGF sympathetic neuron growth and survival through MAPK and PI3K

Sun, 24 Feb 2008 12:18:56 GMT

www.elsevier.com/locate/ymcne Mol. Cell. Neurosci. 27 (2004) 441 – 452 HGF promotes survival and growth of maturing sympathetic neurons by PI-3 kinase- and MAP kinase-dependent mechanisms Jane Thompson,a,b,* Xavier Dolcet,a,c Mark Hilton,a Mary Tolcos,a,d and Alun M. Daviesa,e a Department of Preclinical Veterinary Sciences, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH9 1QH, Scotland, United Kingdom b Fujisawa Institute of Neuroscience, Edinburgh EH8 9JE, Scotland, United Kingdom c Lab Anatomia Patologica-Genetica, Hospital Arnau de Vilanova, 25198 Lleid

thies and davenport 2002 j neurobiol rho-gtpases in growth cone behaviour

Sun, 24 Feb 2008 12:18:45 GMT

Independent Roles of Rho-GTPases in Growth Cone and Axonal Behavior Edda Thies,1 Roger W. Davenport2 1 Max-Planck Unit for Structural Molecular Biology, c/o Desy, Hamburg, Germany 2 Program in Neuroscience and Cognitive Science, Department of Biology, University of Maryland, College Park, Maryland 20742 Received 16 January 2002; accepted 20 June 2002 ABSTRACT: Many external signals influence growth cone motility, pathfinding, and the formation of synapses that lead to the final map formation of the retinotectal system. Chick temporal retinal ganglion cell axons (RGCs) collapse and ret

Thanos 1997 Exp Brain Res Regeneration retinofugal projections

Sun, 24 Feb 2008 12:18:39 GMT

Exp Brain Res (1997) 114:483–491 © Springer-Verlag 1997 R E S E A R C H A RT I C L E &roles:Solon Thanos · Rita Naskar · Peter Heiduschka Regenerating ganglion cell axons in the adult rat establish retinofugal topography and restore visual function &misc:Received: 19 July 1996 / Accepted: 26 November 1996 &p.1:Abstract The mechanisms of neuronal network response to axotomy are poorly understood. In one of the favoured models used to study the fate of injured neurons in the adult rat visual system, appreciable numbers of retinal neurons survive optic nerve injury under conditions of

Teusch 2006 Assay Drug Dev Technol Rho activation assay

Sun, 24 Feb 2008 12:18:20 GMT

ASSAY and Drug Development Technologies Volume 4, Number 2, 2006 © Mary Ann Liebert, Inc. A High-Content Screening Assay for the Nogo Receptor Based on Cellular Rho Activation Nicole Teusch and Claudia Kiefer Abstract: Rho family proteins can coordinate multiple signaling pathways through their ability to regulate both gene transcription and the actin cytoskeleton. With respect to the neuronal Nogo receptor (NgR), recent data assign a key role for the GTPase Rho in the control of cellular responses leading to actin cytoskeletal rearrangements and finally resulting in axonal outgrowth inhibi

Teng and Tang 2006 JNeurochem Axonal regeneration pathways - review

Sun, 24 Feb 2008 12:17:36 GMT

Journal of Neurochemistry, 2006, 96, 1501–1508 doi:10.1111/j.1471-4159.2006.03663.x MINI-REVIEW Axonal regeneration in adult CNS neurons – signaling molecules and pathways Felicia Yu Hsuan Teng and Bor Luen Tang Department of Biochemistry Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597 Abstract Failure of severed adult CNS axons to regenerate could be attributed to both a reduced intrinsic capacity to grow and an heightened susceptibility to inhibitory factors of the CNS extracellular environment. A particularly interesting and usefu

Ten Dijke 2004 TrensdBiochemSci TGF-beta signaling

Sun, 24 Feb 2008 12:17:32 GMT

Review TRENDS in Biochemical Sciences Vol.29 No.5 May 2004 New insights into TGF-b – Smad signalling Peter ten Dijke1 and Caroline S. Hill2 Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands Laboratory of Developmental Signalling, Cancer Research UK London Research Institute, Lincoln’s Inn Fields Laboratories, 44 Lincoln’s Inn Fields, London WC2A 3PX, UK 2 1 Transforming growth factor b (TGF-b) initiates its diverse cellular responses by binding to and activating speciﬁc cell surface receptors that have intrinsic

Temporin 2008 BBRC IL1ß regeneration RhoA p38 MAPK

Sun, 24 Feb 2008 12:17:19 GMT

Available online at www.sciencedirect.com Biochemical and Biophysical Research Communications 365 (2008) 375–380 www.elsevier.com/locate/ybbrc IL-1b promotes neurite outgrowth by deactivating RhoA via p38 MAPK pathway Ko Temporin a, Hiroyuki Tanaka a,b,*, Yusuke Kuroda a, Kiyoshi Okada a, Koji Yachi a, Hisao Moritomo a, Tsuyoshi Murase a, Hideki Yoshikawa a a Department of Orthopaedics, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan b Medical Center for Translational Research, Osaka University Hospital, Suita, Osaka 565-0871, Japan Received 15 October 2007 Avai

Tang 2003 Neurochem Int Inhibitors of neuronal regeneration

Sun, 24 Feb 2008 12:17:10 GMT

Neurochemistry International 42 (2003) 189–203 Review Inhibitors of neuronal regeneration: mediators and signaling mechanisms Bor Luen Tang a,b,∗ b a NCA Laboratory, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore Department of Biochemistry, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore Received 28 January 2002 Abstract Neuritogenesis and its inhibition are opposite and balancing processes during development as well as pathological states of adult neuron. In particular, the inability of adult central nervous

Tanabe 2000 JNeurosci TC10 for neuronal regeneration

Sun, 24 Feb 2008 12:17:04 GMT

The Journal of Neuroscience, June 1, 2000, 20(11):4138–4144 The Small GTP-Binding Protein TC10 Promotes Nerve Elongation in Neuronal Cells, and Its Expression Is induced during Nerve Regeneration in Rats Katsuhisa Tanabe,1,2,3,6 Taro Tachibana,4 Toshihide Yamashita,3 Yong Ho Che,2,3,6 Yoshihiro Yoneda,4 Takahiro Ochi,5 Masaya Tohyama,3,6 Hideki Yoshikawa,2 and Hiroshi Kiyama1,6 1 Department of Anatomy, Asahikawa Medical College, Asahikawa, 078-8510 Japan, Departments of 2Orthopaedic Surgery, 3Anatomy and Neuroscience, 4Anatomy and Cell Biology, and 5Applied Medical Engineering, Graduate Sc

Suzuki 2007 Neurosci SIRT in axonal degeneration and tubulin deacetylation

Sun, 24 Feb 2008 12:16:39 GMT

Neuroscience 147 (2007) 599 – 612 MAMMALIAN Sir2-RELATED PROTEIN (SIRT) 2–MEDIATED MODULATION OF RESISTANCE TO AXONAL DEGENERATION IN SLOW WALLERIAN DEGENERATION MICE: A CRUCIAL ROLE OF TUBULIN DEACETYLATION K. SUZUKI1 AND T. KOIKE* Molecular Neurobiology Laboratory, Division of Life Science, Graduate School of Life Science, Hokkaido University, North Ward N10 W8, Sapporo 060-0810, Japan Abstract—It has been shown that Wallerian degeneration, an anterograde degeneration of transected axons, is markedly delayed in a mutant mouse called slow Wallerian degeneration (WldS). These mice also

steiner 1997 PNAS immunophilin ligands sn regeneration

Sun, 24 Feb 2008 12:14:55 GMT

Proc. Natl. Acad. Sci. USA Vol. 94, pp. 2019–2024, March 1997 Neurobiology Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models (calcineurin cyclosporin A cyclophilin FK506 dopamine) JOSEPH P. STEINER*†, GREGORY S. HAMILTON‡, DOUGLAS T. ROSS*, HEATHER L. VALENTINE*, HONGZHI GUO*, MAUREEN A. CONNOLLY*, SHI LIANG*, CYNTHIA RAMSEY*, JIA-HE J. LI‡, WEI HUANG‡, PAMELA HOWORTH*, RAJAT SONI*, MICHAEL FULLER*, HANS SAUER*, ALISON C. NOWOTNIK*, AND PETER D. SUZDAK* Departments of *Neurobiological Research and ‡Medicinal Chemistr

stein 2003 rnajournal

Sun, 24 Feb 2008 12:14:48 GMT

REPORT RNAi: Mammalian oocytes do it without RNA-dependent RNA polymerase PAULA STEIN,1 PETR SVOBODA,1 MARTIN ANGER, and RICHARD M. SCHULTZ Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6018, USA ABSTRACT Studies in mutant organisms deficient in RNA interference (RNAi) and related post-transcriptional gene silencing implicated a role for a single class of RNA-dependent RNA polymerases (RdRp). Nevertheless, sequence homologs to these RdRps have not been found in coelomate organisms such as Drosophila or mammals. This lack of homologous sequences does not

stanic 2003 EJNeurosci striatal re-innervation after snpc lesions in rat

Sun, 24 Feb 2008 12:14:45 GMT

Stagi 2005 JNeurosci Axonal transport EGFP synaptophysin

Sun, 24 Feb 2008 12:14:35 GMT

352 • The Journal of Neuroscience, January 12, 2005 • 25(2):352–362 Cellular/Molecular Breakdown of Axonal Synaptic Vesicle Precursor Transport by Microglial Nitric Oxide Massimiliano Stagi,1,2 Petra S. Dittrich,3 Nadja Frank,1 Asparouh I. Iliev,1 Petra Schwille,3 and Harald Neumann1,2 1 Neuroimmunology Group, European Neuroscience Institute Gottingen, 37073 Gottingen, Germany, 2Institute of Multiple Sclerosis Research, University ¨ ¨ Gottingen and Hertie-Foundation, 37073 Gottingen, Germany, and 3Experimental Biophysics Group, Max-Planck Institute of Biophysical Chemistry, 37077 ¨

spittaels 1999 am j pathol

Sun, 24 Feb 2008 12:14:24 GMT

American Journal of Pathology, Vol. 155, No. 6, December 1999 Copyright © American Society for Investigative Pathology Animal Model Prominent Axonopathy in the Brain and Spinal Cord of Transgenic Mice Overexpressing Four-Repeat Human tau Protein Kurt Spittaels,* Chris Van den Haute,* Jo Van Dorpe,* Koen Bruynseels,* Kris Vandezande,* Isabelle Laenen,* Hugo Geerts,† Marc Mercken,† Raf Sciot,‡ Alfons Van Lommel,‡ Ruth Loos,§ and Fred Van Leuven* From the Experimental Genetics Group,* Center for Human Genetics, Flemish Institute for Biotechnology, Katholieke Universiteit Leuven, Leuve

Smith 1997 MCB Brn-3a

Sun, 24 Feb 2008 12:13:57 GMT

MOLECULAR AND CELLULAR BIOLOGY, Jan. 1997, p. 345–354 0270-7306/97/$04.00 0 Copyright 1997, American Society for Microbiology Vol. 17, No. 1 The Brn-3a Transcription Factor Induces Neuronal Process Outgrowth and the Coordinate Expression of Genes Encoding Synaptic Proteins MARTIN D. SMITH, SALLY J. DAWSON, AND DAVID S. LATCHMAN* Medical Molecular Biology Unit, Department of Molecular Pathology, University College London Medical School, London W1P 6DB, United Kingdom Received 19 June 1996/Returned for modiﬁcation 1 August 1996/Accepted 17 September 1996 The Brn-3a POU family transcript

shirvan 2002 J biol chem anti-sema3A in rgc protection

Sun, 24 Feb 2008 12:13:52 GMT

THE JOURNAL OF BIOLOGICAL CHEMISTRY © 2002 by The American Society for Biochemistry and Molecular Biology, Inc. Vol. 277, No. 51, Issue of December 20, pp. 49799 –49807, 2002 Printed in U.S.A. Anti-semaphorin 3A Antibodies Rescue Retinal Ganglion Cells from Cell Death following Optic Nerve Axotomy* Received for publication, May 16, 2002, and in revised form, September 18, 2002 Published, JBC Papers in Press, October 9, 2002, DOI 10.1074/jbc.M204793200 Anat Shirvan‡§, Michal Kimron¶, Vered Holdengreber , Ilan Ziv‡, Yehuda Ben-Shaul , Shlomo Melamed**, Eldad Melamed‡, Ari Barzilai

Shibuya 2005 JNeurolSci Fasudil in stroke patient trial

Sun, 24 Feb 2008 12:13:44 GMT

Journal of the Neurological Sciences 238 (2005) 31 – 39 www.elsevier.com/locate/jns Effects of fasudil in acute ischemic stroke: Results of a prospective placebo-controlled double-blind trial Masato Shibuya a, Shunsaku Hirai b, Minoru Seto c, Shin-ichi Satoh c,*, Eiichi Ohtomo d for the Fasudil Ischemic Stroke Study Group b a Chukyo Hospital, Nagoya, Japan Gunma University School of Medicine, Maebashi, Japan c Asahi Kasei Pharma Corporation, Shizuoka, Japan d Yokufukai Geriatric Hospital, Tokyo, Japan Received 16 December 2004; received in revised form 6 June 2005; accepted 6 June 2005 Ava

Shi 2007 ArchImmunolTherExp ROCK in apoptosis

Sun, 24 Feb 2008 12:13:40 GMT

REVIEW Arch. Immunol. Ther. Exp., 2007, 55, 61–75 PL ISSN 0004-069X DOI 10.1007/s00005-007-0009-7 Rho kinase in the regulation of cell death and survival Jianjian Shi and Lei Wei Division of Pediatric Cardiology, Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University, School of Medicine, Indianapolis, IN, USA Received: 2006.11.07, Accepted: 2006.12.21, Published online first: 2007.03.09 Abstract Rho kinase (ROCK) belongs to a family of serine/threonine kinases that are activated via interaction with Rho GTPases. ROCK is involved in a wide range of fun

Shevtsova 2006 GeneTher BclXl and GDNF in Axo and 6-OHDA

Sun, 24 Feb 2008 12:13:38 GMT

Gene Therapy (2006), 1–10 & 2006 Nature Publishing Group All rights reserved 0969-7128/06 $30.00 www.nature.com/gt ORIGINAL ARTICLE Potentiation of in vivo neuroprotection by BclXL and GDNF co-expression depends on post-lesion time in deafferentiated CNS neurons Z Shevtsova1,2, I Malik1,2,3, M Garrido1, U Scholl1, M Bahr1,2 and S Kugler1,2 ¨ ¨ ¨ ¨ ¨ Department of Neurology, Medical School, University of Gottingen, Gottingen, Germany and 2DFG Research Center for Molecular ¨ Physiology of the Brain (CMPB), Gottingen, Germany 1 To elucidate effective and long-lasting neuroprotective st

Shamah 2001 Cell Ephrin Ephexin RhoA signalling

Sun, 24 Feb 2008 12:13:30 GMT

Cell, Vol. 105, 233–244, April 20, 2001, Copyright ©2001 by Cell Press EphA Receptors Regulate Growth Cone Dynamics through the Novel Guanine Nucleotide Exchange Factor Ephexin Steven M. Shamah,1,6 Michael Z. Lin,1,6 Jeffrey L. Goldberg,2,7 Soline Estrach,3,7 Mustafa Sahin,1 Linda Hu,1 Mihaela Bazalakova,1 Rachel L. Neve,4 Gabriel Corfas,1 Anne Debant,3 and Michael E. Greenberg1,5 1 Division of Neuroscience Children’s Hospital and the Department of Neurobiology Harvard Medical School 300 Longwood Avenue Boston, Massachusetts 02115 2 Department of Neurobiology Stanford University Fairchil

Selzer 2003 Lancet Neurol

Sun, 24 Feb 2008 12:13:16 GMT

Axonal regeneration in the CNS Review Promotion of axonal regeneration in the injured CNS Michael E Selzer Molecules that are found in the extracellular environment at a CNS lesion site, or that are associated with myelin, inhibit axon growth. In addition, neuronal changes—such as an age-dependent reduction in concentrations of cyclic AMP— render the neuron less able to respond to axotomy by a rapid, forward, actin-dependent movement. An alternative mechanism, based on the protrusive forces generated by microtubule elongation or the anterograde transport of cytoskeletal elements, may und

Segal 2000 AnnurevNeuro Trk signaling

Sun, 24 Feb 2008 12:13:04 GMT

Annu. Rev. Neurosci. 2003. 26:299–330 doi: 10.1146/annurev.neuro.26.041002.131421 Copyright c 2003 by Annual Reviews. All rights reserved First published online as a Review in Advance on February 18, 2003 SELECTIVITY IN NEUROTROPHIN SIGNALING: Theme and Variations Rosalind A. Segal Annu. Rev. Neurosci. 2003.26:299-330. Downloaded from arjournals.annualreviews.org by Niedersaechsische Staats- und Universitaetsbibliothek on 03/15/06. For personal use only. Departments of Neurobiology and Pediatric Oncology, Harvard Medical School and Dana-Farber Cancer Institute, 44 Binney Street, Boston, Ma

Schröer 2007 EJN Trax controls axonal regeneration via GAP-43

Sun, 24 Feb 2008 12:12:56 GMT

European Journal of Neuroscience, Vol. 26, pp. 2169–2178, 2007 doi:10.1111/j.1460-9568.2007.05849.x Translin-associated factor-X (Trax) is a molecular switch of growth-associated protein (GAP)-43 that controls axonal regeneration ¨ Uwe Schroer,1,2 Gerd Fabian Volk,1 Tomas Liedtke1 and Solon Thanos1,2 1 ¨ Department of Experimental Ophthalmology, School of Medicine, University Eye Hospital Munster, Domagkstraße 15, 48149 ¨ Munster, Germany 2 ¨ Interdisciplinary Centre of Clinical R, Research (IZKF), 48149 Munster, Germany Keywords: axonal growth, GAP-43, maturation, retina, Trax Abst

Schratt 2006 Nature Brain specific miRNA dendridic development

Sun, 24 Feb 2008 12:12:43 GMT

Vol 439|19 January 2006|doi:10.1038/nature04367 ARTICLES A brain-speciﬁc microRNA regulates dendritic spine development Gerhard M. Schratt1,2,3, Fabian Tuebing4, Elizabeth A. Nigh1,2,3, Christina G. Kane1,2,3, Mary E. Sabatini3, Michael Kiebler4 & Michael E. Greenberg1,2,3 MicroRNAs are small, non-coding RNAs that control the translation of target messenger RNAs, thereby regulating critical aspects of plant and animal development. In the mammalian nervous system, the spatiotemporal control of mRNA translation has an important role in synaptic development and plasticity. Although a number of

Schnorrer 2004 CurrBiol Morphogens axon guidance

Sun, 24 Feb 2008 12:12:23 GMT

Current Biology, Vol. 14, R19–R21, January 6, 2004, ©2004 Elsevier Science Ltd. All rights reserved. DOI 10.1016/j.cub.2003.12.016 Axon Guidance: Morphogens Show the Way Frank Schnorrer and Barry J. Dickson Dispatch Hedgehog and Wnt family proteins can act as classic developmental morphogens to pattern a field of naïve cells. Surprising new studies show that members of these same protein families also act as guidance cues for growing axons in the developing nervous system. The idea that molecular gradients instruct tissue differentiation is an old one. Two distinct modes of action for

sapieha 2003 MCN FGF-2 by AAV axon growth after axotomy

Sun, 24 Feb 2008 12:12:18 GMT

Molecular and Cellular Neuroscience 24 (2003) 656 – 672 www.elsevier.com/locate/ymcne Fibroblast growth factor-2 gene delivery stimulates axon growth by adult retinal ganglion cells after acute optic nerve injury Przemyslaw S. Sapieha,a Martin Peltier,a Katherine G. Rendahl,b William C. Manning,b,1 and Adriana Di Poloa,* a Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec H3T 1J4, Canada ´ ´ b Department of Pharmacology, Chiron Corporation, Emeryville, CA 94608, USA Abstract Basic ﬁbroblast growth factor (or FGF-2) has been shown to be a potent stimul

Sandvig 2004 Glia Myelinderived axon growth inhibitors review

Sun, 24 Feb 2008 12:11:59 GMT

GLIA 46:225–251 (2004) Myelin-, Reactive Glia-, and ScarDerived CNS Axon Growth Inhibitors: Expression, Receptor Signaling, and Correlation with Axon Regeneration AXEL SANDVIG,3* MARTIN BERRY,1,2 LEE B. BARRETT,1 ARTHUR BUTT,2 1 AND ANN LOGAN 1 Molecular Neuroscience, Department of Medicine, University of Birmingham, Birmingham, United Kingdom 2 Neural Damage and Repair, Centre for Neuroscience, GKT School of Biological Sciences, King’s College, London, United Kingdom 3 Laboratory of Regenerative Neurobiology, Institute for Experimental Medical Research, Ullevål University Hospital, Oslo

Sanchez-Camacho 2005 BrainResRev Morphogens growth cone signaling

Sun, 24 Feb 2008 12:11:44 GMT

Brain Research Reviews 49 (2005) 242 – 252 www.elsevier.com/locate/brainresrev Review Morphogens as growth cone signalling molecules Cristina Sanchez-Camachoa, Josana Rodrıgueza, Jose Marıa Ruiza, Francoise Trousseb, ´ ´ ´ ´ ¸ a,* Paola Bovolenta b a Instituto Cajal, CSIC, Dr. Arce 37, Madrid 28002, Spain Centre de Biologie du Developpment, CNRS/UPS UMR 5547. Univ. P. Sabatier, Toulouse Cedex 4 31062, France Accepted 18 October 2004 Available online 24 December 2004 Abstract Morphogen signalling among cells is one of the most important mechanisms underlying the progressive pattern

Roux 2002 ProgNeurobiol p75 Trk signaling

Sun, 24 Feb 2008 12:11:23 GMT

Progress in Neurobiology 67 (2002) 203–233 Neurotrophin signaling through the p75 neurotrophin receptor Philippe P. Roux1 , Philip A. Barker∗ Centre for Neuronal Survival, Montreal Neurological Institute, McGill University, 3801 University Avenue, Montreal, Que., Canada H3A 2B4 Received 18 January 2002; accepted 31 May 2002 Abstract The neurotrophins are growth factors that play critical roles in the development, maintenance, survival, and death of the nervous system. The signal transducing systems that mediate the diverse biological functions of the neurotrophins are initiated by their

Rossi 2007 ProgNeurobiol Intrinsic axon growth properties

Sun, 24 Feb 2008 12:11:08 GMT

Progress in Neurobiology 81 (2007) 1–28 www.elsevier.com/locate/pneurobio Regulation of intrinsic neuronal properties for axon growth and regeneration Ferdinando Rossi *, Sara Gianola, Luigi Corvetti Rita Levi Montalcini Centre for Brain Repair, Department of Neuroscience, University of Turin, Corso Raffaello 30, I-10125 Turin, Italy Received 28 September 2006; received in revised form 4 November 2006; accepted 5 December 2006 Abstract Regulation of neuritic growth is crucial for neural development, adaptation and repair. The intrinsic growth potential of nerve cells is determined by the a

Rosenstiel 2003 JNeurotrauma FK504 and V10367 in ONC

Sun, 24 Feb 2008 12:10:34 GMT

JOURNAL OF NEUROTRAUMA Volume 20, Number 3, 2003 © Mary Ann Liebert, Inc. Differential Effects of Immunophilin-Ligands (FK506 and V-10,367) on Survival and Regeneration of Rat Retinal Ganglion Cells In Vitro and after Optic Nerve Crush In Vivo PHILIP ROSENSTIEL,1 PETER SCHRAMM,2 STEFAN ISENMANN,3 STEFAN BRECHT,2 CHRISTIAN EICKMEIER,4 ERICH BÜRGER,4 THOMAS HERDEGEN,2 JOBST SIEVERS,1 and RALPH LUCIUS1 ABSTRACT Immunophilins belong to the large family of peptidyl-prolyl-cis-trans-isomerases known to be involved in many cellular processes (e.g., protein trafficking and transcriptional regulati

Rosenblad 2003 EJN THdownreg after LV GDFN

Sun, 24 Feb 2008 12:10:22 GMT

European Journal of Neuroscience, Vol. 17, pp. 260±270, 2003 ß Federation of European Neuroscience Societies Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system Carl Rosenblad,1 Biljana Georgievska2 and Deniz Kirik2 1 2 NsGene A/S, Ballerup, Denmark Wallenberg Neuroscience Centre, Department Physiological Sciences, Lund University, Lund, Sweden Keywords: autoradiography, lentivirus, rat, striatum, substantia nigra Abstract Sustained neurotrophic factor treatment in neurodegenerative disorders such as Parkin

Rock-2 antibody sc-1851

Sun, 24 Feb 2008 12:10:11 GMT

Santa Cruz Biotechnology, Inc. SANTA CRUZ Rock-2 (C-20): sc-1851 BIOTECHNOLOGY BACKGROUND Rho, the Ras-related small GTPase, is responsible for the regulation of actin-based cytoskeletal structures including stress fibers, focal adhesions and the contractile ring apparatus (1,2). Rho proteins function as molecular switches that are able to turn cytokenesis on and off. Although little is known about signaling downstream of Rho, a host of putative Rho effector proteins have been described, including rhophilin, rhotekin, citron and the serine/threonine kinase, protein kinase N (3-6). Two addit

Rio-Tsonis 2003 Dev Dyn Eye Regeneration at the molecular age review

Sun, 24 Feb 2008 12:10:10 GMT

DEVELOPMENTAL DYNAMICS 226:211–224, 2003 REVIEWS A PEER REVIEWED FORUM Eye Regeneration at the Molecular Age Katia Del Rio-Tsonis1* and Panagiotis A. Tsonis2* Eye tissues such as the lens and the retina possess remarkable regenerative abilities. In amphibians, a complete lens can be regenerated after lentectomy. The process is a classic example of transdifferentiation of one cell type to another. Likewise, retina can be regenerated, but the strategy used to replace the damaged retina differs, depending on the animal system and the age of the animal. Retina can be regenerated by transdiffe

Rhee 2003 MolVis CNTF pathway

Sun, 24 Feb 2008 12:09:49 GMT

Molecular Vision 2003; 9:715-22 Received 9 June 2003 | Accepted 26 November 2003 | Published 16 December 2003 © 2003 Molecular Vision Expression of cytokine signal transduction components in the postnatal mouse retina Kun Do Rhee, Xian-Jie Yang Department of Ophthalmology, Jules Stein Eye Institute, David Geffen School of Medicine, Molecular Biology Institute, University of California, Los Angeles, CA Purpose: Members of the ciliary neurotrophic factor (CNTF) family of cytokines have been shown to influence neuronal differentiation during retinal develo