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Annu. Rev. Genomics Hum. Genet. 2004. 5:479–510 doi: 10.1146/annurev.genom.5.061903.180014 Copyright c 2004 by Annual Reviews. All rights reserved First published online as a Review in Advance on June 1, 2004 EPIGENETICS AND HUMAN DISEASE Yong-hui Jiang, Jan Bressler, and Arthur L. Beaudet Annu. Rev. Genom. Human Genet. 2004.5:479-510. Downloaded from arjournals.annualreviews.org by UNIVERSITY...

Opinion TRENDS in Genetics Vol.21 No.11 November 2005 An evolutionary framework for common diseases: the ancestral-susceptibility model Anna Di Rienzo1 and Richard R. Hudson2 1 2 Department of Human Genetics, University of Chicago, Chicago, IL 60637, USA Department of Ecology and Evolution, University of Chicago, Chicago, IL 60637, USA Unlike rare mendelian diseases, which are due to new mu...

Update TRENDS in Genetics Vol.21 No.7 July 2005 377 Genetical genomics in humans and model organisms Dirk-Jan de Koning and Chris S. Haley The Roslin Institute, Roslin, Midlothian, UK, EH25 9PS Genetical genomics has been proposed to map loci controlling gene-expression differences (eQTLs) that might underlie functional trait variation. We briefly review the studies in model species and conc...

Published by Oxford University Press 2005 Advance Access publication 25 July 2005 International Journal of Epidemiology 2005;34:1129–1137 doi:10.1093/ije/dyi130 How many genes underlie the occurrence of common complex diseases in the population? Quanhe Yang,1* Muin J Khoury,2 JM Friedman,3 Julian Little4 and W Dana Flanders5 Accepted 31 May 2005 Background Most common human diseases are due ...

European Journal of Human Genetics (2007) 15, 228–236 & 2007 Nature Publishing Group All rights reserved 1018-4813/07 $30.00 www.nature.com/ejhg ARTICLE Methods for the selection of tagging SNPs: a comparison of tagging efficiency and performance Keyue Ding1 and Iftikhar J Kullo*,1 1 Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN, USA There is great interest...

European Journal of Human Genetics (2005) 13, 677–686 & 2005 Nature Publishing Group All rights reserved 1018-4813/05 $30.00 www.nature.com/ejhg ARTICLE Linkage disequilibrium patterns vary substantially among populations Sarah L Sawyer1,3, Namita Mukherjee2,4, Andrew J Pakstis2, Lars Feuk1, Judith R Kidd2, Anthony J Brookes1,5,6 and Kenneth K Kidd*,2,6 1 2 Center for Genomics and Bioinforma...

REPORTS A Regulatory SNP Causes a Human Genetic Disease by Creating a New Transcriptional Promoter Marco De Gobbi,1* Vip Viprakasit,2* Jim R. Hughes,1 Chris Fisher,1 Veronica J. Buckle,1 Helena Ayyub,1 Richard J. Gibbons,1 Douglas Vernimmen,1 Yuko Yoshinaga,3 Pieter de Jong,3 Jan-Fang Cheng,4 Edward M. Rubin,4 William G. Wood,1 Don Bowden,5 Douglas R. Higgs1‡ We describe a pathogenetic mechani...

Applying Genomics to the Study of Complex Disease Brian D. Juran, B.S.,1 and Konstantinos N. Lazaridis, M.D.1 ABSTRACT The interest in dissecting the genetic and environmental components of complex human disease is growing, fueled by the emerging advances in the field of genomics and related disciplines. Improved understanding of the pathogenesis of complex liver diseases such as gallbladder s...

Copyright Ó 2006 by the Genetics Society of America DOI: 10.1534/genetics.106.057281 Design of Microarray Experiments for Genetical Genomics Studies ´ Julio S. S. Bueno Filho,* Steven G. Gilmour† and Guilherme J. M. Rosa‡,1 *Departamento de Ciencias Exatas, Universidade Federal de Lavras, Lavras, Minas Gerais 37200-000, Brazil, †School of Mathematical ˆ Sciences, Queen Mary, University of Lond...

This article was downloaded by:[University of P ennsylvania] [University of P ennsylvania] O n: 3 March 2007 Access D etails: [subscription number 768516620] Publisher: Informa H e althcare Informa Ltd R egistered in E ngland and W ales R egistered Number: 1072954 R egistered office: Mortimer House, 37-41 Mortimer Stre et, London W1T 3JH, U K Publication details, including instructions for aut...