Documents tagged with scientific posters

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SAFC Biosciences Scientific Posters - Homogeneity Analysis and Cell Culture Performance of Powder Ce

consisting of a pin mill combined with three-dimensional conical mixer technology. The purpose of this study was twofold: first, to demonstrate the homogeneity of key components in powder cell cul...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Optimizing Medium Components for Polyethylenimine Mediated Tra

At bioreactor scale polyethylenimine (PEI) mediated transient transfection is a well established method for recombinant protein expression in the biopharmaceutical industry. However, transient tra...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Virus Production in Vero Cells Using a Serum-Free Medium

The manufacture of viral vaccines has historically been accomplished using animal products such as chicken eggs, or cell cultures using fetal bovine serum. To reduce regulatory concerns in vaccine...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Using Microarray Technology to Select Housekeeping Genes in CH

SAFC Biosciences (SAFCB) Cell Xpress technology combines in situ imaging with laser manipulation to identify, select, and monitor expansion of high recombinant protein secreting clones. Cell Xpre...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Ex Vivo Expansion of Hematopoietic Stem Cells Using a Defined

Autologous or allogeneic hematopoietic stem cell (HSC) transplantation is a commonly used therapy for cancer patients following chemotherapy to reconstitute the ablated hematopoietic system. Ex vi...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Understanding Metabolic Needs of EB14 Cells in Culture

EB14 is a genetically stable diploid cell line derived from chicken embryonic stem cells. EB14 cells demonstrate great potential in virus and recombinant protein production for prophylactic and th...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Cell Xpress™ Cell Line Optimization Service Using Laser-Enable

SAFC Biosciences (SAFCB) Cell Xpress technology combines in situ imaging with laser manipulation to identify, select, and monitor expansion of high recombinant protein secreting clones. Cell Xpre...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Using Microarray Technology to Select Housekeeping Genes in CH

In the present study, we have identifi ed species-specifi c housekeeping genes for Chinese Hamster Ovary (CHO) cells using data from gene expression profi ling. Genes that are suitable for normal...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - An Evaluation of the Intrinsic IgG Production Capabilities of

Cell Xpress™-Assisted Analysis of Clone Stability in Recombinant Chinese Hamster Ovary Cells
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - An Evaluation of the Intrinsic IgG Production Capabilities of

Multiple strains of Chinese Hamster Ovary (CHO) parental cell lines are currently used for biotherapeutic protein production. While it has been established that each of these parental lines posses...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Streamlined Strategy for Rapid Development and Optimization of

The robustness of Chinese Hamster Ovary (CHO) cells in large-scale recombinant protein production and their ability to sustain active biological function of expressed proteins prompts their wide u...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Rapid Selection of Optimal Formulations for Divergent Clones T

The successful culture of Chinese Hamster Ovary (CHO) cells can be a challenging endeavor. Historical data shows that CHO clones have diverse nutritive requirements. Selecting a medium designed s...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Simplifi cation of Fed-Batch Process for PER.C6® Cells in Bior

To attain the quantity of product required to meet the needs of their customers, manufacturers of monoclonal antibodies often use a fed batch bioreactor system for production. Each additional fe...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Development and Optimization of EX-CELL™ EBx™ Serum-Free Mediu

Although egg-based and primary chicken embryonic fi broblast (CEF) systems are commonly used for human and veterinary vaccine production, many limitations exist for these systems, including cumb...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - The Effects of Media Formulations on the Biochemical Profile o

Cell Xpress™ Technology Facilitates High - Producing Recombinant Cell Line Generation Using Glutamine Synthetase Gene Expression System
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - The Effects of Media Formulations on the Biochemical Profile o

One of the major concerns for the biopharmaceutical industry is maintaining the product quality parameters of recombinant proteins such as humanized monoclonal antibodies (MAb’s) when process cha...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Soy Hydrolysate Optimization for Cell Culture Applications

Soy hydrolysates often provide signifi cant performance enhancements to the serum-free cultivation of mammalian cells and are frequently used in the biomanufacturing industry. However, historical...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Optimization of Serum-Free Media for EB14 Cell Growth and Vira

Many human and animal vaccines are currently being developed and produced in eggs or primary chicken embryonic fibroblasts (CEF). However, there are known limitations to these platforms, includin...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Proteomic Analysis of CHO Cells during Recombinant Protein Pro

A proteomics approach was used to study protein expression changes in a recombinant IgGproducing CHO cell line throughout a fed-batch culture. Protein expression profi les were analyzed by 2-dime...
  • SAFC-Global published this 02 / 20 / 2009
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SAFC Biosciences Scientific Posters - Development of Animal Component-Free Medium for Virus Producti

The use of wild-type reovirus has been developed as a cancer treatment by Oncolytics Biotech (Reolysin™). We developed an animal component-free cell culture medium to facilitate the production of...
  • SAFC-Global published this 02 / 20 / 2009
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