Fortune

THE RIDDLE OF THE WALL IN THE BRAIN

THE BLOOD-BRAIN BARRIER HAS LONG STYMIED DRUG DEVELOPMENT FOR BRAIN DISORDERS. RESEARCHERS HAVE FINALLY BEGUN TO BREAK THROUGH IT.

FOR YEARS the darndest thing kept happening to drugs in clinical trials to treat brain disorders: They never made it to the brain. For pharmaceutical companies this problem was as costly—developing treatments for the central nervous system takes an average of 15 years and $1.5 billion—as it was, in hindsight, kind

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