The Atlantic

With CRISPR, Scientists Engineered Nearly 4,000 Mutations of a Breast-Cancer Gene

The “tour de force” technique is supercharging the search for dangerous genetic variants.
Source: Stoyan Nenov / Reuters

BRCA1 is one of the best-studied cancer genes in the world. Still, on occasion, doctors will test a patient and find a BRCA1 mutation no one has ever seen before. This creates a dilemma. The newly discovered “variant of unknown significance,” or VUS, could be harmful, making a woman’s risk of developing breast cancer as high as 72 percent. Or it could be nothing to worry about at all.

“You hear these horror stories about people who have a VUS,” says, a breast-cancer

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