ECONOMICAL RECOVERY OF ETHYL

ACETATE AND TETRAHYDROFURAN
FROM THE PRODUCTION OF
CEFUROXIME ACID

V.RAGHUNATH
11707203026
N.SESHA GOPALAN 11707203038

INTERNAL GUIDE : S.JENISH

EXTERNAL GUIDE : SATISH

ABOUT ORCHID CHEMICALS &
PHARMACEUTICALS LTD.

Orchid Chemicals & Pharmaceuticals Ltd (Orchid) was established in
1992 as a 100% Export Oriented Unit (EOU). Commencing
operations in 1994, Orchid has achieved amazing and consistent
growth, quantitatively and qualitatively to emerge among the Top-15
companies in the Indian pharmaceutical industry in a short span of
fifteen years of operations.
Orchid has an established end-to-end connected infrastructure for
drug discovery and development. Orchid has two manufacturing sites
for APIs (at Alathur near Chennai and at Aurangabad, near Mumbai)
and three manufacturing sites for Dosage forms (at Irungattukottai
and Alathur in Chennai), besides a world-class R&D centre (at
Sholinganallur, Chennai).
In Alathur, Separation of complex solvent mixtures, residual from
production processes, are done in order to get single high purity
fractions to be reused or to be sold with economical benefit.

Mixture Pre-treatment plant

Multipurpose solvent recovery plant

The solvents are recycled & recovered in order to get single high purity fractions to be reused or to be sold with economical benefit. Several operations like distillation. are the by-products during the production of cefuroxime acid. This is due to the presence of TDS and solvents mixtures having the tendency to form azeotropes.ABSTRACT • • • • • • Recovery of complex solvent mixtures in the production of pharmaceutical components is very complicated. flashing. dehydration are involved here. . The percentage recovery & percentage loss for every operation involved is studied and estimated. Ethyl Acetate and TetraHydroFuran.

897 g/cm³.3 g/100 mL (20 °C) Refractive index (nD) : 1. 171 °F Solubility in water : 8. CAS No: 141-78-6 Properties Molecular formula : C4H8O2 Molar mass : 88.426 cP at 25 °C Vapour density: 3.105 g/mol Appearance : colorless liquid Density : 0. 190 K.6 °C. Melting point : −83. -118 °F Boiling point : 77.04 Vapour pressure: 100 mm Hg at 27 C Flash point: -4 C . it is manufactured on a large scale for use as a solvent.3720 Viscosity : 0.1 °C. 350 K.ETHYL ACETATE • • • • • • • • • • • • • • Ethyl acetate is the ester of ethanol and acetic acid.

Melting point : −108.5 Vapor Pressure (mm Hg): 129 @ 20C (68F) Evaporation Rate (BuAc=1): 8.4 °C (164.0 Flash point : −14 °C .48 cP at 25 °C Vapor Density (Air=1): 2.75 K) Boiling point : 66 °C (339.15 K) Solubility in water Miscible Viscosity : 0.11 g/mol Appearance : colorless liquid Density : 0.8892 g/cm3 (g/mL) @ 20 °C.: 109-99-9 Molecular formula : C4H8O Molar mass : 72.TETRAHYDROFURAN • • • • • • • • • • • • • IUPAC name : Oxolane CAS No.

RECOVERY PROCESS REMOVAL OF TDS  EA AND THF ENRICHMENT  RECOVERY OF EA  RECOVERY OF THF  .

PROCESS DESCRIPTION • • • • REMOVAL OF TDS FLASHING EA AND THF ENRICHMENT DISTILLATION RECOVERY OF EA DEHYDRATION USING CaCl2 DISTILLATION (THF REMOVAL) RECOVERY OF THF DISTILLATION (EA REMOVAL) DEHYDRATION USING NaOH DISTILLATION (ANHYDROUS THF RECOVERY) .

NOMENCLATURE EA = Ethyl Acetate  THF = Tetrahydrofuran  OI = Other Impurities  MC = Moisture Content  F = Feed  R = Residue  T = Top Product  B = Bottom Product  V = Vent  CaCl2 = Calcium Chloride  CAS = Chemical Abstract Service  .

MASS BALANCE .

The amount of EA.STUDY          Calculation of amount of Feed. Loss in distillation is mainly attributed to loss by vent owing to the fact that the column is closed & continuous. Loss in flashing/dehydration is mainly by residue. The peak value is noted. Top product. THF. in terms of Percentage. Top product. The percentage recovery of THF & EA for every process is calculated The percentage loss of THF & EA for every process is calculated . Bottom Product/Residue in every operation. OI & MC in Feed. The major components to be separated are Ethyl Acetete & TetraHydroFuran and other components are termed as Other Impurities. The composition is analysed through chromatography. Analysis of Composition of the above. Bottom Product/Residue in every operation is calculated.

=100 OC RESIDUE = 380 L .5 % MC = 4 % TOP TEMP.TDS REMOVAL FLASHING MOTHER LIQUOR = 7530 L EA = 51 % THF = 43 % OI = 6 % MC = 4 % TOP PRODUCT = 7150 L EA = 52 % THF = 43.=80 OC BOTTOM TEMP.5 % OI = 4.

22% .25 + 3.59% % of OI in residue : 7530*(6/100) = 7150*(4.80 = 321.8x x = 32.8x x = 34.3 = 3718 + 3.5/100) + 380*(x/100) 451.8x x = 33.18% % of THF in residue : 7530*(43/100) = 7150*(43.75 + 3.MASS BALANCE F=T+R Fxf = Txt + Rxr % of EA in Residue : 7530*(51/100) = 7150*(52/100) + 380*(x/100) 3840.5/100) + 380*(x/100) 3237.9 = 3110.

65/3237.2 Percentage of recovery of EA = ((3718/3840.3)*100) = 3.05% Percentage of loss of EA in residue = ((122.3/3840.8% Percentage of recovery of THF = ((3110.80 301.18% Percentage of loss of THF in residue = ((127.25 321.65 130.20 3718 3110.35 15.30 3237.9 451.25/3237.94% .3)*100) = 96.9)*100) = 3.3 127.9)*100) = 96.RESULT EA THF OI MC MOTHER LIQUOR ( FEED) TOP PRODUCT 3840.75 286 RESIDUE 122.

=64.2 % OI = 2.5% MC = 4 % CONTINOUS COLUMN TOP TEMP.91 L EA = 78 % THF = 19.65 % OI = 3.85 % MC = 4 % BOTTOM PRODUCT = 4372.EA AND THF ENRICHMENT FEED = 7150 L EA = 52 % THF = 43.5 % THF = 92.5 OC BOTTOM TEMP.25 L EA = 3.6 % .5 % OI = 4.=70OC TOP PRODUCT = 2281.8 % MC = 3.

5/100) = 2281.MASS BALANCE F=T+B+V Fxf = Txt + Bxb + Vxv % of EA lost by vent 7150*(52/100) = 2281.2/100) + 495.5/100)+4372.8/100) + 495.5*(3.5*(3.5*(92.889% % of THF lost by vent 7150*(43.91*(2.91*(78/100) + 495.85/100)+4372.484% .86*(x/100) x = 22.65/100)+4372.91*(19.622% % of OI lost by vent 7150*(4.86*(x/100) x = 31.86*(x/100) x = 45.5/100) = 2281.

61 839.12% Percentage of loss of THF by vent = ((157.44 157.85 122.25 BOTTOM PRODUCT 3410.49 37.83 111.75 286 TOP PRODUCT 79.42 VENT 227.84 2113.33 Percentage of recovery of EA = ((3490.16/3110.57 87.25)*100) = 5.82 91.94% Percentage of loss of EA by vent = ((227.05% .25)*100) = 94.45/3718)*100) = 93.25 321.RESULT EA THF OI MC FEED 3718 3110.09/3110.55 156.83% Percentage of recovery of THF = ((2953.55/3718)*100) = 6.

EA ENRICHMENT .

2 % OI = 4.RECOVERY OF ETHYL ACETATE DEHYDRATION USING CACL2 FEED = 9500 L + 532 L (MC) CACL2 = 390 L EA = 78.35 % DEHYDRATION USING CaCl2 RESIDUE = 549.8 % MC = 1.65 L (MC) .15 % OI = 6.5 % THF = 1.6 % PRODUCT = 8950 L EA = 80 % THF = 15.8% MC = 5.35 L + 415.

8/100) = 8950*(4.2/100) + 549.8/100) + 549.99% % of THF in residue : 9500*(1.MASS BALANCE F=T+R Fxf = Txt + Rxr % of EA in Residue : 9500*(78.2/100) = 8950*(80/100) + 549.6 + 5.4 + 5.35*(x/100) 1425 = 1360.35*(x/100) 646 = 429.35*(x/100) 7429 = 7160 + 5.49x x = 11.49x x = 48.49x x = 39.15/100) = 8950*(15.415% .76% % of OI in residue : 9500*(6.

62% .4 429.37% Percentage of loss of EA in residue = ((269/7429)*100) = 3.6 116.4 415.65 Percentage of recovery of EA = ((7160/7429)*100) = 96.35 RESIDUE 269 64.6 216.RESULT EA THF OI MC FEED 7429 1425 646 532 PRODUCT 7160 1360.

5 % OI = 14.11 % .5 OC BOTTOM TEMP.2 % OI = 4.4 % TOP TEMP.46 % THF = 0.35 % TOP PRODUCT = 1691 L + 40.35 (MC) L EA = 80 % THF = 15.4 OC BOTTOM PRODUCT = 6809 L + 7.20 % OI = 0.8% MC = 1.RECOVERY OF ETHYL ACETATE DISTILLATION (THF REMOVAL) DISTILLATION COLUMN FEED = 8950 L + 116.4 % MC = 2.=70.1 % THF = 78.33 % MC = 0.58 (MC) L EA = 7.=64.48 (MC) L EA = 99.

MASS BALANCE
F=T+B+V
Fxf = Txt + Bxb + Vxv
% of EA lost by vent
8950*(80/100) = 1691*(7.1/100)+6809*(99.46/100) + 450.71*(x/100)
x = 59.39%
% of THF lost by vent
8950*(15.2/100) = 1691*(78.5/100)+6809*(19.2/100) + 450.71 *(x/100)
x = 4.29%
% of OI lost by vent
8950*(4.8/100) = 1691*(14.4/100)+6809*(0.33/100) + 450.71*(x/100)
x = 36.30%

RESULT
EA

THF

OI

MC

FEED

7160

1360.4

429.6

116.35

TOP PRODUCT

120.06

1327.43

243.5

40.5

BOTTOM PRODUCT

6772.23

13.61

22.46

7.48

VENT

267.71

19.36

163.34

68.37

Percentage of recovery of EA = ((6892.29/7160)*100) = 96.26%
Percentage of loss of EA = ((267.71/7160)*100) = 3.73%

THF ENRICHMENT

(EA REMOVAL) FEED = 17593 L EA = 2.28 % OI = 0.RECOVERY OF TETRAHYDROFURAN DISTILLATION .02 % THF = 99.7 % MC = 5 % TOP TEMP.=64OC BOTTOM TEMP.=70OC BOTTOM PRODUCT = 4030 L EA = 8.11 % MC = 6.80 % OI = 2.76 % OI = 1.3 % DISTILLATION COLUMN TOP PRODUCT = 12660 L EA = 0.03 % MC = 3.13 % THF = 96.5 % .17 % THF = 89.

28/100)+4030*(89.13/100) = 12600*(0.03*(x/100) x = 59.39% % of THF lost by vent 17593*(96.75% .MASS BALANCE F=T+B+V Fxf = Txt + Bxb + Vxv % of EA lost by vent 17593*(2.03/100) + 902.80/100) + 902.7/100)+4030*(2.11/100) = 12600*(0.03*(x/100) x = 2.76/100) = 12600*(99.02/100)+4030*(8.48% % of OI lost by vent 17593*(1.03*(x/100) x = 92.17/100) + 902.

05 VENT 42.78/17022)*100) = 95.53 12568.22 24.359 TOP PRODUCT 2.09% Percentage of loss of THF = ((834.86 334.84 88.28 1108.95 834.73 17022 195.22/17022)*100) = 4.309 Percentage of recovery of THF= ((16187.62 633 BOTTOM PRODUCT 329.80 141.9% .RESULT EA THF OI MC FEED 374.25 3618.94 81.

035 % THF = 99.RECOVERY OF TETRAHYDROFURAN DEHYDRATION USING CAUSTICS FEED = 12660 L EA = 0.69 % MC = 4 % DEHYDRATION USING CAUSTICS FLAKES TOP PRODUCT = 12160 L EA = 0.61 L .02 % THF = 99.25 % RESIDUE = 500.45 % MC = 0.28 % OI = 0.33 % OI = 0.

035/100) = 12160*(0.43 + 5.4% % of THF in residue : 12660*(0.MASS BALANCE F=T+R Fxf = Txt + Rxr % of EA in Residue : 12660*(0.662% .5 + 5.61*(x/100) 87.02/100) + 500.35 = 79.04 + 5.8 = 12078.43 = 2.035/100) = 12160*(0.02/100) + 500.00x x = 98.06% % of OI in residue : 12660*(0.61*(x/100) 4.035/100) = 12160*(0.02/100) + 500.61*(x/100) 12568.00x x = 1.00x x = 0.

05 Percentage of recovery of THF= ((12078.62 633 BOTTOM PRODUCT 329.80 141.359 TOP PRODUCT 2.94 81.73 17022 195.09% Percentage of loss of THF = ((490.9% .RESULT EA THF OI MC FEED 374.28 1108.25 3618.53 12568.3/12660)*100) = 3.5/12660)*100) = 96.84 88.

5 % TOP PRODUCT = 575.04 % .02 % THF = 99.4% TOP TEMP.42 L EA = 0.74 % OI = 0.=68OC BOTTOM PRODUCT = 7200 L (ANHYDROUS THF) EA = 0.1 % THF = 96.65 % MC = 0.4 L EA = 0.017 % THF = 99.243 % MC = 0.2 % OI = 0.=63OC BOTTOM TEMP.7 % MC = 3.33 % OI = 0.RECOVERY OF TETRAHYDROFURAN DISTILLATION (THF RECOVERY) DISTILLATION COLUMN FEED = 8165.

42*(96.1*(0.MASS BALANCE F=T+B+V Fxf = Txt + Bxb + Vxv % of EA lost by vent 8165.73*(x/100) x = 0.18% % of OI lost by vent 8165.65/100) = 575.017/100) + 407.7/100)+7200*(0.74/100) + 407.42*(0.2/100)+7200*(99.7389% .73*(x/100) x = 92.1*(99.42*(0.243/100) + 407.73*(x/100) x = 7.1*(0.1/100)+7200*(0.076% % of THF lost by vent 8165.02/100) = 575.3/100) = 575.

69)*100) = 4.496 19.69 53.82 BOTTOM PRODUCT 1.69)*100) = 95.224 7181.55 4.56 TOP PRODUCT 0.88 Percentage of recovery of THF= ((7734.02 2.36% Percentage of loss of THF = ((375.83/8110.09 553.28 17.6% .63 8110.86/8110.RESULT EA THF OI MC FEED 1.07 40.

ENERGY BALANCE .

Natural condensation.  The energy supplied initially calculated.  The energy out with the product is also calculated. Insulation losses.  Energy loss is due to 3 reasons Barebody losses.STUDY Calculation of amount of Feed.  Analysis of Composition of the above.  The difference between the energy in and energy out is the energy lost. in terms of Percentage. Top product. Bottom Product/Residue in every operation.  .

51 MC .43% = 2881.50 .5% = 2499.4 THF .5 83.52% = 2987.86 THF .55 BOTTOM TEMP = 84.52% = 341.5 .38 6969.2 C 84.4% = 301.5% = 285.35 EA .20 83.4% = 38.1 MC .EA .3 THF .2 .4% = 239.76 Kg EA .51% = 3417.59 TDS REMOVAL TOP TEMP = 83.43.73 MC .2 .43.

81*0.5) + (3417.2) + (38.08*540) Qf = 895755.014 KCal ENERGY OUT: Qc1 = (5486.4*87.54*540) Qc2 = 90402.ENERGY BALANCE mλ+mCpΔT ENERGY IN: Qf = (6294.30*87.86*87.5*49.2) + (2987.6) + (2881.2) + (341.6) + (2499.59*0.73*98) + (268.38*28) + (239.6) + (285.5) + (268.406 KCal Qc2 = (626.1 KCal .5*0.64 KCal Qc1 +Qc2 = 810386.54*33.38*540) Qc1 = 719983.1*98) + (239.068*19.5*28.51*98) + (38.5*33.

91 Kcal .RESULT Qf – (Qc1 + Qc2) = 85368.91 Kcal The net loss in flashing stage is 85368.

55 64 .=70OC 55 35 78 55 .=64.35 79 77 BOTTOM TEMP.50 CONTINOUS COLUMN 77.5 OC 64 .8 .EA – THF ENRICHMENT TOP TEMP.

2) + (152.7*98) + (182.32*87.ENERGY BALANCE mλ+mCpΔT ENERGY IN: Qf = (1152*0.92*0.6) + (501.6 KCal Qr = (4369.32 Kcal Qi = Qf+ Qr = 679619.5*42.8) + (48*540) Qf = 154170.2) + (182.08*540) Qr = 525449.6) + (4048.08*7.04*87.12*98) + (48*1*42.5*7.38 KCal .8) + (599.

6) + (4002.072*23) Qphe = 11938.4*98) + (180*9) + (180*540) Qc1 = 523740.92*20) Qc3 = 8960 KCal Qphe = (966*0.3 KCal Qc2 = (480*0.08*0.6 KCal Qo = Qc1 +Qc2 +Qc3 +Qphe = 604133.5*23) + (36.5*14) + (16.5*87.8*87.24 KCal Qc3 = (430.ENERGY BALANCE ENERGY OUT: Qc1 = (4320*0.196 KCal .6) + (444.5*20) + (17.72*98) + (120*14) + (120*540) Qc2 = 59494.5*9) + (151.

184 Kcal .RESULT Qi – Qo = 75486.184 Kcal The net loss in EA & THF enrichment is 75486.

EA ENRICHMENT .

=80OC 55 35 80 55 .THF REMOVAL TOP TEMP.50 CONTINOUS COLUMN 78 35 80 72 BOTTOM TEMP.=68 OC 68 .55 68 .

ENERGY BALANCE mλ+mCpΔT ENERGY IN: Qf = (1183*0.2*540) Qf = 135521.56*0.876 Kcal Qi = Qf+ Qr = 607910.44*540) Qr = 472388.6) + (3685.2*43) + (116.566 KCal .6) + (179.68 KCal Qr = (4694.93*98) + (16.5*43) + (947.44*8) + (115.5*8) + (333.31*87.22*98) + (115.4*87.

6) + (351.92*98) + (1108*1*13) + (108*540) Qc1 = 453462.5*20) + (4.24 KCal Qc2 = (448*0.6 KCal Qphe = (2746.5*18) + (34.64*87.44*0.69 KCal .ENERGY BALANCE ENERGY OUT: Qc1 = (4392*0.5*25) + (3.98*0.68*98) + (12*18) + (12*540) Qc2 = 48227.75 KCal Qo = Qc1 +Qc2 +Qc3 +Qphe = 538047.56*20) Qc3 = 1945.10 KCal Qc3 = (185.02*25) Qphe = 34412.5*13) + (311.6) + (3447.8*87.

RESULT Qi – Qo = 69862.56 Kcal The net loss in THF removal is 69862.56 Kcal .

THF ENRICHMENT .

=69.5 OC 63.3 50 CONTINOUS COLUMN 71 35 71 63 BOTTOM TEMP.EA REMOVAL TOP TEMP.8 55 68.2 .2OC 55 35 69.55 .=63.

42 KCal Qr = (3800*0.96*98) + (75.6*540) Qf = 172426.716 KCal .64*98) + (200*8) + (200*540) Qr = 494585.6) + (3772.5*8) + (76*87.5*36) + (23.6) + (1087.94*87.2 Kcal Qi = Qf+ Qr = 667011.ENERGY BALANCE mλ+mCpΔT ENERGY IN: Qf = (1124.6*43) + (75.4*0.

5*13.5*20) + (50*20) Qc3 = 10500 KCal Qphe = (579*0.5*14.6) + (471.224 KCal Qc3 = (950*0.8) + (0.85*87.5*8.ENERGY BALANCE ENERGY OUT: Qc1 = (4275*0.2) Qphe = 4409.22*98) + (225*8.09*87.6) + (4244.02 KCal Qc2 = (475*0.2) + (21*14.8) + (25*540) Qc2 = 63345.58*98) + (25*13.8) + (225*540) Qc1 = 558078.34 KCal .1 KCal Qo = Qc1 +Qc2 +Qc3 +Qphe = 636332.8) + (0.

370Kcal .RESULT Qi – Qo = 30679.370 Kcal The net loss in THF removal is 30679.

33 55 65.=65.33 50 CONTINOUS COLUMN 66 35 78 63 BOTTOM TEMP.ANHYDROUS THF RECOVERY TOP TEMP.3 OC 65.=70OC 55 35 70 55 .

6) + (1186*98) + (6*31) + (6*540) Qf = 138181.23*87.1 KCal Qr = (3960*0.5*8) + (3.07*98) + (139.4*8) + (139.4*540) Qr = 466163.356 Kcal Qi = Qf+ Qr = 604344.5*31) + (0.6) + (3812.96*87.ENERGY BALANCE mλ+mCpΔT ENERGY IN: Qf = (1194*0.456 KCal .

72*15) Qphe = 9005.3) Qc2 = 58711.ENERGY BALANCE ENERGY OUT: Qc1 = (4347*0.5*10.8 KCal Qc3 = (72.3) + (4181.5*15.6) + (17*540) + (17*15.5*20) + (2.28*0.5*15) + (0.3) + (464.2 KCal .81*98) + (4.64*98) + (1.3) + (153*540) Qc1 = 516780.4 KCal Qo = Qc1 +Qc2 +Qc3 +Qphe = 585273.6) + (153*10.37*87.48*87.45*0.5 KCal Qc2 = (483*0.55*20) Qc3 = 775.5 KCal Qphe = (1199.

2 Kcal The net loss in THF removal is 19071.RESULT Qi – Qo = 19071.2 KCal .

POWER CONSUMPTION .

 . the power consumed for the specific batch is found out.  From the motor capacity.  The power consumed is determined by finding the capacity of the motor used for agitation.STUDY Power consumption in the recovery process is mainly due to the usage of agitator in the flashing and dehydration process.

75 Batch timing = 10 Hrs Cost per unit = 4.REMOVAL OF TDS     Motor capacity = 22 KW Motor error = 0.5*10 = 165 KW/Hr Cost = 165 * 4.8 Rs. . 22 KW * 0.12 Rs.5 KW Batch Timing = 10 Hr 16.12 Cost = 679.75 = 16.

12 Cost = 679.8 Rs.5*10 = 165 KW/Hr Cost = 165 * 4.75 Batch timing = 10 Hrs Cost per unit = 4.75 = 16.12 Rs.5 KW Batch Timing = 10 Hr 16.CACL2 DEHYDRATION     Motor capacity = 22 KW Motor error = 0. 22 KW * 0. .

12 Cost = 1019. .5 * 4.75 = 16.NAOH DEHYDRATION     Motor capacity = 22 KW Motor error = 0.12 Rs.5*15 = 247.5 KW/Hr Cost = 247.75 Batch timing = 15 Hrs Cost per unit = 4.5 KW Batch Timing = 15 Hr 16. 22 KW * 0.7 Rs.

COST ESTIMATION .

 .  The cost of all the process is evaluated to find the money spent for the entire recovery process per batch.STUDY The cost is estimated by evaluating the cost of steam.  The cost incurred by every process is studied. cooling water and power consumed by the agitator.

Cold water (condensor 2) = 29.8 * 1. Total cost = 4919.2032 Rs Cold water (condensor 1) = 238.160.89 * 0.TDS REMOVAL Mass of steam = 1658.08 * 9.8 Rs.3472 Rs.694 Rs.8 Kg  Cold water (condensor 1) = 238.6 = 2285.6 = 1925. Power consumed = 679.08 Kg  Cold water (condensor 2) = 29. .96 = 28.65 Rs.89 Kg  Cost of steam = 1658.

67 * 0.96 Rs. Total cost = 3244. .4 Rs Cold water (condensor 1) = 180.1606 = 1496.10 Kg  Cold water (condensor 2) = 19.8832 Rs.2432 Rs. Cold water (condensor 2) = 19.96 = 18.10 * 9.67 Kg  Cost of steam = 1260 * 1.6 = 1728.EA & THF ENRICHMENT Mass of steam = 1260 Kg  Cold water (condensor 1) = 180.

EA ENRICHMENT .

8 Rs.8 Rs. Total Cost = 679.CACL2 DEHYDRATION Power consumption cost= 679. .

1606 = 1305.6 = 1554. Cold water (condensor 2) = 15.9 * 9.94 * 0.96 = 15.22 Rs.3024 Rs.94 Kg  Cost of steam = 1125 * 1.24 Rs.675 Rs Cold water (condensor 1) = 161. . Total cost = 2875.9 Kg  Cold water (condensor 2) = 15.THF REMOVAL Mass of steam = 1125 Kg  Cold water (condensor 1) = 161.

THF ENRICHMENT .

76 Rs.94 * 0. Cold water (condensor 2) = 20.EA REMOVAL Mass of steam = 1250 Kg  Cold water (condensor 1) = 189.75 Rs Cold water (condensor 1) = 189.1024 Rs. .96 = 20. Total cost = 3289.912 Rs.6 = 1818.47 Kg  Cold water (condensor 2) = 20.1606 = 1450.47 * 9.94 Kg  Cost of steam = 1250 * 1.

Total Cost = 1019.7 Rs.7 Rs. .NAOH DEHYDRATION Power consumption Cost = 1019.

96 = 19.41 * 0.6 = 1672.1606 = 1299. Total cost = 2991.032 Rs.6336 Rs.87 Rs.536 Rs.17 Kg  Cold water (condensor 2) = 19.17 * 9. . Cold water (condensor 2) = 19. Cold water (condensor 1) = 174.41 Kg  Cost of steam = 1120 * 1.ANHYDROUS THF RECOVERY Mass of steam = 1120 Kg  Cold water (condensor 1) = 174.

6058 .76 NAOH DEHDYRATION 1019.2432 CACL2 DEHYDRATION 679.8 THF REMOVAL 2875.) FLASHING 4919. 2991.22 EA REMOVAL 3289.TOTAL COST PROCESS COST (Rs.536 TOTAL 19019.3472 EA & THF ENRICHMENT 3244.7 ANHYDROUS THF REC.

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