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CONTENTS

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.. 2551 (2008 Outstanding Scientist Awards)
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Curriculum Vitae: Professor Dr. Watchara Kasinrerk ........................................................................................13
List of Publications .................................................................................................................................................................15
The Achievements of Professor Dr. Watchara Kasinrerk ...............................................................................22

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. .................................................................28
. ............................................................................................30
Curriculum Vitae: Professor Dr. Apiwat Mutirangura ...........................................................................................32
List of Publications .................................................................................................................................................................33
The Achievements of Professor Dr. Apiwat Mutirangura..................................................................................43
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.. 2551 (2008 Young Scientist Awards)
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.. 2550 ...........................................................................................................88
2549/2550..........................................................................................................................................................94
- 2549/2550 .................................................................................................................................95
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(List of Outstanding Scientists) .............................................................................98
(List of Young Scientists) ....................................................................................101
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CD147
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and Conference on Human Leukocyte Differentiation Antigens (HLDA workshop)
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Dr. rer. nat. (Immunology) Universitat fur Bodenkultur Wein,

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2528-2536
2536-2539
2539-2549
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2546-2548
2546-2548
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Austrian Society of Allergology and


Immunology
. 1
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.
Winner of the Third awards of poster presentation ASEAN
Conference in Medical Laboratory Technology
Thailand Toray Science Foundation: Science and Technology Award
Thailand Toray Science Foundation

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.. 2549
.. 2550
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Member, Austrian Society of Allergology and Immunology


Scientific Committee, World Allergy Congress 2007, Bangkok, Thailand
Visiting Research Fellow, The University of New South Wales, Australia

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Curriculum
Vitae
Professor Dr. Watchara Kasinrerk
DATE OF BIRTH

PLACE OF BIRTH

MARITAL STATUS


OFFICE ADDRESS







PRESENT POSITION

6 November 1958
Phrae, Thailand
Married to Mrs. Juree Kasinrerk
Daughter: Miss Kasina Kasinrerk
Department of Medical Technology
Faculty of Associated Medical Sciences
Chiang Mai University
Chiang Mai 50200
Tel: +66(0) 53 945070
Fax: +66(0) 53 216424
E-mail: watchara@chiangmai.ac.th
Professor, Department of Medical Technology, Faculty of Associated
Medical Sciences, Chiang Mai University


EDUCATION

1981

1985
1992


HONORS AND
AWARDS

1993
1994

1996

1996

B.Sc. (Medical Technology) Chiang Mai University,


Thailand
M.Sc. (Microbiology) Chiang Mai University, Thailand
Dr. rer. nat. (Immunology) Universitat fur Bodenkultur
Wein, Austria
The Dissertation Prize, Austrian Society of Allergology
and Immunology, Austria
The TRF Research Scholar, The Thailand Research
Fund
Outstanding Research Award of The TRF Scholar, The
Thailand Research Fund
Career Development Award, The National Sciences
and Technology Development Agency

14

HONORS AND
AWARDS

1997
1998

1999

1999

2001

2003

2003

2003

2003

2004

2004

2005

2005

2006

2006

2006

2006

2007

2007

The TRF Research Scholar, The Thailand Research Fund


The Best Thesis Supervisor (Master degree), Graduate School,
Chiang Mai University
Alumni Award to the Distinguished Former Students, Faculty
of Associated Medical Sciences, Chiang Mai University
Taguchi Prize: Outstanding Research Achievements Award,
Thai Society of Biotechnology
The TRF Advanced Research Scholar, The Thailand Research
Fund
Outstanding Research Work, The National Research Council,
Thailand
The Best Poster Presentation Mahidol day, Faculty of
Medicine, Chiang Mai University
The Best Poster Presentation Mahidol day (the Second
level), Faculty of Medicine, Chiang Mai University
Research Team Strengthening Grant, National Center for
Genetic Engineering and Biotechnology, National Science
and Technology Development Agency
The Best Thesis Supervisor (Doctoral degree), Graduate
School, Chiang Mai University
The TRF Advanced Research Scholar, The Thailand Research
Fund
Science and Technology Award (Research Team), The
Thailand Toray Science Foundation
Poster presentation Award, ASEAN Conference in Medical
Laboratory Technology
Poster Presentation Award, the 6th National Graduate Student
Conference, Chulalongkorn University
Outstanding Research of the Year, The Thailand Research
Fund
The Best Thesis Supervisor (Master degree), Graduate School,
Chiang Mai University
The CMU Golden Elephant Award (The Best Teacher Award),
Chiang Mai University
The TRF Advanced Research Scholar, The Thailand Research
Fund
Mahidol B-Braun Award (Co-Research Investigator), Mahidol
University




MEMBERSHIPS,
COMMITTEE
ASSIGNMENTS,

THAILAND




INTERNATIONAL

2007
2007
2004-2008
1987-Present
1999-Present
2003-Present
2008-Present

National Innovation Award (the Second level), The


National Innovation Agency
Chiang Mai University Alumni Award, Chiang Mai
University
Scientific Committee, Allergy and Immunology
Society of Thailand
Member, The Association of Medical Technologist of
Thailand
Member, Thai Society for Biotechnology
Member, Thai Academic of Science and Technology
Foundation
Vice President, Allergy and Immunology Society of
Thailand

1989-Present Member, Austrian Society of Allergology and Immunology


2007
Scientific Committee, World Allergy Congress 2007,
Bangkok, Thailand

2008-Present Visiting Research Fellow, The University of New South
Wales, Australia
LIST OF PUBLICATIONS 1. Makonkawkeyoon S, Kasinrerk W, Vithayasai V. (1986) Regulation
of immuno-globulin secretion by T lymphocyte in human malaria.
Asian Pacific J Allergy Immunol 4: 13-17.

2. Makonkawkeyoon S, Hirunpetcharat C, Kasinrerk W, Vithayasai
V. (1987) Enumeration of interleukin 2-producing cells from rat
spleen. Asian Pacific J Allergy Immunol 5: 129-136.

3. Hirunpetcharat C, Kasinrerk W, Makonkawkeyoon S. (1988) Agar
plating technique for enumeration of IL-2 producing cells in human
peripheral blood mononuclear leukocytes. Asian Pacific J Allergy
Immunol 16: 81-87.

4. Kasinrerk W, Stockinger H., Knap W. (1989) Analysis of the myeloid
antibody panel with COS7 transfectants expressing the antigen
ICAM or CD43. Tissue antigens 33:233.

5. Makonkawkeyoon S, Kasinrerk W. (1989) Separation of human
suppressor and helper T cells by Concanavalin A-coated sheep
erythrocytes. Asian Pacific J Allergy Immunol 7: 125-131.

6. Makonkawkeyoon S, Kasinrerk W. (1989) In vitro suppression
of interleukin 2 production by Mycobacterium leprae antigen. Clin
Exp Immunol 76: 398-403.

15

16

LIST OF
PUBLICATIONS

7. Stockinger H, Ashmun RA, Dougherty G, Franklin WA, Goyert SM,


Hogarth M, Humphries K, Jose DG, Kasinrerk W, Lansdorp PM, Lock
AT, Pilkington G, Seed B, Tesio L, Williere G. (1989) Summary of the
myeloid workshop transfectoma studies. In: Leukocyte typing IV. Eds.
W. Knapp et.al. Oxford University Press, Oxford, 880-886.
8. Makonkawkeyoon S, Kasinrerk W, Dettrairat S, Vithayasai V. (1990)
Immunologic defects in leprosy patients I. Evidence of immune
aberration of suppressor-T lymphocyte in lepromatous leprosy. Int
J Lepr 58: 302-310.
9. Makonkawkeyoon S, Kasinrerk W, Supajatura V, Hirunpetcharat C,
Vithayasai V. (1990) Immunologic defects in leprosy patients II. Interleukin
1, interleukin 2, and interferon production in leprosy patients. Int J
Lepr 58: 311-318.
10. Gadd SJ, Majdic O, Kasinrerk W, Stockinger H, Maurer D, Eher R,
Knapp W. (1990) M5, a phosphoinositol linked myelomonocytic activation
associated antigen. Clin Exp Immunol 80: 252-256.
11. Stockinger H, Gadd SJ, Eher R, Majdic O, Schreiber W, Kasinrerk W,
Strass B, Schnabl E, Knapp W. (1990) Molecular characterization
and functional analysis of the leukocyte surface protein CD31. J
Immunol 145: 3889-3897.
12. Hirunpetcharat C, Maneekarn N, Kasinrerk W, Supajatura V, Praputpittaya
K, Makonkawkeyoon S. (1991) Enumeration of interleukin-1 producing
monocytes from human peripheral blood mononuclear leukocytes by
agar plating technique. J Immunol Methods 140: 173-180.
13. Kasinrerk W, Fiebinger E, Stefanova I, Baumruker T, Knapp W,
Stockinger H. (1992) Human leukocyte activation antigen M6, a member
of the immunoglobulin superfamily, is the species homoloque of rat
OX-47, mouse basigin and chicken HT7 molecule. J Immunol 149:
847-854.
14. Kasinrerk W, Baumruker T, Majdic O, Knapp W, Stockinger H. (1993)
CD1 molecule expression on human monocytes induced by granulocytemacrophage colony-stimulating factor. J Immunol 150: 579-584.
15. Kasinrerk W, Majdic O, Praputpittaya K, Sittisombut N. (1994)
Enhancement of lymphocyte proliferative response to PPD by an
anti-interleukin-2 receptor antibody (CD25). Immunology 83: 33-37.
16. Sittisombut N, Maneekarn N, Kanjanahaluethai A, Kasinrerk W,
Viputtikul K, Supawadee J. (1995) Lack of augmenting effect of
interferon-g on dengue virus multiplication in human peripheral
blood monocytes. J Med Virology 45: 43-49.

LIST
OF
PUBLICATIONS

17. Klausner JD., Makonkawkeyoon S, Akarasewi P, Nakata K, Kasinrerk


W, Corral L, Dewar RL, Lane C, Freedman VH, Kaplan G. (1996)
The effect of thalidomide on the pathogenesis of human
immunodeficiency virus type I and M. tuberculosis infection. J Acq
Imm Def Syn and Hum Retrovirology 11: 247-257.
18. Kasinrerk W, Tokrasinwit N, Piluk Y. (1996) Production of Mouse
anti-CD4 antibodies by DNA-Based Immunization. Asian Pacific J.
Allergy Immunol 14: 99-105.
19. Kasinrerk W, Tokrasinwit N, Changtumroung K. (1997) Production
of anti-CD4 antibodies in rabbits by DNA Immunization. Asia Pacific
J Mol Biol Biotech 5: 123-129.
20. Kasinrerk W, Tokrasinwit N, Intharasut S, Naveewongpanit P. (1997)
Manual rosetting method for enumerting CD4 positive cells. J Med
Lab Sci 11: 9-13.
21. Kasinrerk W, Tokrasinwit N, Naveewongpanit P. (1998) Production
of monoclonal antibody to CD4 antigen and development of reagent
for CD4+ lymphocyte enumeration. J Med Assoc Thailand 81:
879-892.
22. Kasinrerk W, Tokrasinwit N, Phunpae P. (1999) CD147 monoclonal
antibodies induce homotypic cell aggregation of monocytic cell
line U937 via LFA-1/ICAM-1 pathway. Immunology 96: 184-192.
23. Kasinrerk W, Tokrasinwit N. (1999) Inhibition of PHA-induced cell
proliferation by polyclonal CD4 antibodies generated by DNA
immunization. Immunol Letters 67: 237-242.
24. Kasinrerk W, Tokrasinwit N, Moonsom S, Stockinger H. (2000)
CD99 monoclonal antibody induces homotypic cell aggregation
of Jurkat cells through protein tyrosine kinase and protein kinase
C-dependent pathways. Immunol Letters 71: 33-41.
25. Moonsom S, Kasinrerk W. (2000) Production of anti-CD14
monoclonal antibodies by using CD14 expressing COS cells
as immunizing antigen. Asian Pac J Aller Immunol 18: 53-61.
26. Moonsom S, Khunkeawla P, Kasinrerk W. (2001) Production of
polyclonal and monoclonal antibodies against CD54 molecules by
intrasplenic immunization of plasmid DNA encoding CD54 protein.
Immunol Letters 76: 25-31.
27. Khunkeawla P, Moonsom S, Kongtawelert P, Kasinrerk W. (2001)
Engagement of CD147 molecule induced cell aggregation through
the activation of protein kinases and reorganization of the
cytoskelaton. Immunobiology 203: 659-669.

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18

LIST OF
PUBLICATIONS

28. Kasinrerk W, Moonsom S, Chawansuntati K. (2002) Production of


Antibodies by Single DNA immunization: Comparison of Various
Immunization Routes. Hybridoma and Hybridomics 21: 287-293.
29. Tayapiwatana C, Kasinrerk W. (2002) Construction and characterization
of phage-displayed leukocyte surface molecule, CD99. Apppl Mirobiol
Biotechnol 60: 336-341.
30. Chiampanichayakul S, Szekeres A, Khunkeawla P, Moonsom S, Leksa
V, Drbal K, Zlabinger GJ, Stockinger H, Kasinrerk W. (2002) Engagement
of Na, K-ATPase b 3 subunit by a specific monoclonal antibody
suppresses T and B lymphocyte activation. Int Immunol 14(12):14071414.
31. Puttikhunt C, Kasinrerk W, Srisa-ad S, Duangchinda T, Silakate W,
Moonsom S, Sittisombut N and Malasit P. (2003) Production of
anti-dengue NS1 monoclonal antibodies by DNA immunization. J Virol
Methods 109(1): 55-61.
32. Pongnikorn S, Fongmoon D, Kasinrerk W, Limtrakul PN. (2003) Effect
of bitter melon (Momordica charantia Linn.) on level and function of
natural killer cells in cervical cancer patients with radiotherapy. J Med
Assoc Thailand 86(1): 61-68.
33. Kasinrerk W. (2003) A flow cytometric method for enumeration of
lymphocyte sub-populations in sample containing lysis-resistant red
blood cells. Immunol Letters 86(3):259-264.
34. Tayapiwatana C, Arooncharus P and Kasinrerk W. (2003) Displaying
and epitope mapping of CD147 on VCSM13 phages: influence of
Escherichia coli strains. J Immunol Methods 281: 177-185.
35. Intasaia N, Arooncharus P, Kasinrerk W and Tayapiwatana C. (2003)
Construction of high density display of CD147 ectodomain on VCSM13
phage via gpVIII: effects of temperature, IPTG and helper phage
infection-period. Prot Express Purification Prot Express Purification 32:
323-331.
36. Vongchan P, Sajomsang W, Kasinrerk W, Subyen D, Kongtawelert P.
(2003) Anticoagulant activities of the chitosan polysulfate synthesized
from marine crab shell by semi-heterogeneous conditions. ScienceAsia
29: 115-120.
37. Keelapang P, Sriburi R, Supasa S, Panasa S, Panyadee N, Songjaeng
A, Jairangsri A, Puttikhunt C, Kasinrerk W, Malasit M, Sittisombut N.
(2004) Delayed virus export in Pr-M junction chimeric dengue virus
with enhanced PrM cleavage. J Virol 78: 2367-2381.

OF
LIST
PUBLICATIONS

38. Kritratanasak S, Chiampanichayakul S and Kasinrerk W. (2004)


Production of IgY anti-mouse IgG antibodies from chicken eggs.
Asian Pacific J Allergy Immunol 22: 61-68.
39. Boonmuen S, Tayapiwatana C, Kasinrerk W. (2005) Comparison
of Polyclonal Anti-CD147 Antibody Production Using DNA Based
and Phage-Displayed CD147 Immunizations. ScienceAsia 31:
83-86.
40. Punturee K, Wild CP, Kasinrerk W, Vinitketkumnuen U. (2005)
Immunomodulatory activities of Centella asiatica and Rhinacanthus
nasutus extracts. Asian Pac J Cancer Prev 6(3): 396-400.
41. Thammawonga P, Kasinrerk W, Turner RC and Tayapiwatana C.
(2006) Twin-arginine signal peptide attributes effective displaying
of CD147 on filamentous phage. Appl Microbiol Biotech 69(6):
697-703.
42. Chiampanichayakul S, Peng-in P, Khunkaewla P and Kasinrerk
W. (2006) CD147 contains different bioactive epitopes involving
the regulation of cell adhesion and lymphocyte activation. Immunobiol
211(3): 167-178.
43. Avirutnan P, Punyadee N, Noisakran S, Komoltri C S T,
Auethavornanan K, Jairungsri A, Kanlaya R, Tangthawornchaikul N,
Puttikhunt C, Pattanakitsakul S, Yenchitsomanus P,
Mongkolsapaya J, Kasinrerk W, Sittisombut N, Husmann M,
Blettner M, Vasanawathana S, Bhakdi S, and Malasit P. (2006)
Vascular leakage in severe Dengue virus infections: a potential
role for the non-structural viral protein NS1 and complement. J
Infect Dis 193(8): 1078-1088.
44. Jintaridtha P, Srisomsapb C, Vichittumarosc K, Kalpravidha R,
Winichagoonc P, Fucharoenc S, Svastib J, Kasinrerke W. (2006)
Chicken Egg Yolk Antibodies Specific for the Gamma ( g ) Chain
of Human Hemoglobin for Diagnosis of Thalassemia. Inter J
Hematol 83: 408-414.
45. Nouanthong P, Pata S, Sirisanthana T, Kasinrerk W. (2006) A
Simple Manual Rosetting Method for Absolute CD4+ Lymphocyte
Counting in Resource-Limited Countries. Clin Vaccine Immunol
13(5): 598-601.
46. Intasai N, Mai S, Kasinrerk W and Tayapiwatana C. (2006) Binding
of phage displaying multimeric CD147 on U937 cell conducts
apoptotic signal. Int J Immunol 18: 11591169.

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20

LIST OF
PUBLICATIONS

47. Tayapiwatana C, Chotpadiwetkul R, Kasinrerk W. (2006) A novel


approach of using streptavidin magnetic bead sorting in vivo biotinylated
survivin for monoclonal antibody production. J Immunol Methods
317: 1-11.
48. Chiampanichayakul S, Khunkaewla P and Kasinrerk W. (2006) Na, K
ATPase b 3 subunit (CD298): Association with a subunit and
expression on peripheral blood cells. Tissue Antigens 68(6): 509-17.
49. Noisakran S, Dechtawewat T, Rinkaewkanb P, Puttikhunt C,
Kanjanahaluethai A, Kasinrerk W, Sittisombut N, Malasit P. (2007)
Characterization of dengue virus NS1 stably expressed in 293T cell
lines. J Virol Methods 142: 67-80.
50. Khunkaewla P, Chiampanichayakul S, Yasamut A, Pata S, Kasinrerk
W. (2007) Production, characterization and functional analysis of newly
established CD99 monoclonal antibodies, MT99/1 and MT99/2.
Hybridoma 26(4): 241-250.
51. Limjindaporn T, Netsawang J, Noisakran S, Thiemmaca S, Wongwiwat
W, Sudsaward S, Avirutnan P, Puttikhunt C, Kasinrerk W, Sirburi R,
Sittisombut N, Yenchitsomanus P, Malasit P. (2007) Sensitization to
Fas-mediated apoptosis by dengue virus capsid protein. Biochem
Biochem Biophys Res Commun 362: 334-339.
52. Moonsom S, Chaisri U, Kasinrerk W, Angsuthanasombat C. (2007)
Binding characteristics to mosquito-larval midgut proteins of the cloned
domain II-III fragment from the Bacillus thuringiensis Cry4Ba toxin.
J Biochem Mol Biol 40(5): 783-90.
53. Avirutnan P, Zhang L, Punyadee N, Manuyakorn A, Puttikhunt C,
Kasinrerk W, Malasit P, Atkinson JP, Diamond MS. (2007) Secreted
Non-Structural Protein NS1 of Dengue Virus Attaches to the Surface
of Cells via Interactions with Heparan Sulfate and Chondroitin Sulfate
E. PLoS Pathog 3(11): 1798-1812.
54. Srithanaviboonchai K, Rungruengthanakit K, Nouanthong P, Pata S,
Sirisanthana T, Kasinrerk W. (2008) Novel low-cost assay for the
monitoring of CD4 counts in HIV-infected individuals. J Acquir Immune
Defic Syndr 47(2): 135-139.
55. Puttikhunt C, Keelapang P, Khemnu N, Sittisombut N, Kasinrerk W,
Malasit P. (2008) Novel anti-dengue monoclonal antibody recognizing
conformational structure of prM-E heterodimeric complex of dengue
virus. J Med Virol 80(1): 125-133.

LIST
OF
PUBLICATIONS

56. Tragoolpua K, Intasai N, Kasinrerk W, Mai S, Yuan Y, Tayapiwatana


C. (2008) Generation of functional scFv intrabody to abate the
expression of CD147 surface molecule of 293A cells. BMC
Biotechnol 8: 5.
57. Cressey R, Pimpa S, Chewaskulyong B,Tayapiwatana C and
Kasinrerk W. (2008) Simplified approaches for developing a tumour
antigen specific ELISA to detect circulating autoantibodies in cancer
patients. BMC Biotechnol 8:16.
58. Sangiambut S, Keelapang P, Aaskov J, Puttikhunt C, Kasinrerk
W, Malasit P, Sittisombut N. (2008) Multiple regions in dengue
virus capsid protein contribute to nuclear localization during virus
infection. J Gen Virol 89: 1254-1264.
59. Noisakran S, Sengsai S, Thongboonkerd V, Kanlaya R, Sinchaikul
S, Chen ST, Puttikhunt C, Kasinrerk W, Limjindaporn T, Wongwiwat
W, Malasit P, Yenchitsomanus PT. (2008) Identification of human
hnRNP C1/C2 as a dengue virus NS1-interacting protein. Biochem
Biophys Res Commun 372(1): 67-72.
60. Chitov T, Dispan R, Kasinrerk W. (2008) Incidence and diarrhegenic
potential of Bacillus cereus in pasteurized milk and cereal products
in Thailand. J Food Safety (in press).

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22

THE

ACHIEVEMENTS
OF

Professor Dr. Watchara Kasinrerk


Professor Dr. Watchara Kasinrerk was born on 6 November 1958
in Phrae province, Thailand. He received his B.Sc. in Medical Technology
and M.Sc. in Microbiology from Chiang Mai University. He later received
Ph.D. in Immunology from Universitat fur Bodenkultur Wien, Vienna, Austria,
in 1992. He began his academic career in the Department of Medical
Technology, Faculty of Associated Medical Sciences, Chiang Mai University
until today. In the Department, he teaches Immunology to both
undergraduate and graduate students, and also conducts both basic
and applied research in Immunology. He was appointed Professor of
Medical Technology in 2006.


Monoclonal antibody is a protein that
has 2 special properties. First, monoclonal
antibody can specifically react to its recognized
antigen. Second, monoclonal antibody can be
produced by hybridoma technique in any
laboratory. Currently, monoclonal antibodies
become an important tool for basic research in
many areas and also are employed for prevention
and treatment of various diseases. In addition,
monoclonal antibodies are utilized for development
of various immunodiagnostics. After Ph.D. study,
Professor Kasinrerk carries his research on the
establishment of efficient method for production
of monoclonal antibodies and using of monoclonal
antibodies for biochemical characterizations and
function studies of leukocyte surface molecules
and development of immunodiagnostic kits for
various diseases.

At the Biomedical Technology Research
Center, Department of Medical Technology, Faculty
of Associated Medical Sciences, Chiang Mai
University, Professor Kasinrerk conducts research
on the development of various technologies for

23

production of monoclonal antibodies. In his


laboratory, the antibodies are generated using
various platforms. These include the production of
antibody from chicken eggs by IgY technology,
production of monoclonal antibodies by DNA
immunization, antigen-bead immunization, and
immunization of recombinant protein produced
from prokaryotic and mammalian cells. In
addition, various home-made supplements for
hybridoma technology are also produced for
replacing of imported materials. From these
research works, various monoclonal antibodies
can be effectively produced in Professor
Kasinrerks research unit.

The immune system composes of many
types of leukocytes that work together. Leukocyte
surface molecules are demonstrated to be
involved in leukocyte communications and
immune-regulation. Biochemical characterizations
and functional studies of leukocyte surface
molecules, therefore, will lead to a better
understanding of the function of the immune
system. To study the function of leukocyte
surface molecules, in Professor Kasinrerks
laboratory, various monoclonal antibodies against
leukocyte surface molecules are produced. The

24

produced antibodies are further exploited in basic


researches on leukocyte surface molecules. He
has demonstrated that CD147 is a leukocyte
surface molecule which contains at least two
bioactive domains. Triggering of CD147 by
specific ligands induces signal transductions and
lead to the regulation of leukocyte functions.
This information may lead to the development
of new strategy or new drug for regulation of
immune responses. In addition, by using a
generated monoclonal antibody, he has also
uncovered a novel leukocyte surface molecule.
By the 8th Human Leukocyte Differentiation
Antigen (HLDA) Workshop held in Adelaide,
Australia, December 2004, this molecule was
defined as a new leukocyte surface molecule,
named CD298. This is the CD molecule discovered
by Thai researchers.

In addition, Professor Kasinrerk has
utilized and applied the produced monoclonal
antibodies for development of high performance

immunodiagnostic kits for several diseases.


Recently, he has developed a novel non-flow
cytometric method for enumeration of CD4+
lymphocytes. In stead of using a flow cytometer,
the method requires only an automatic
hematoanalyzer (Complete Blood Count or
CBC machine). This method is therefore an
alternative for enumerating CD4+ lymphocytes
for assessing HIV/AIDS patients, particularly in
limited-resource countries. In collaboration with
Associate Professor Dr. Chatchai Tayapiwatana
and Professor Suthat Fuchareon, he has
developed an immunochromatographic strip test
for rapid screening of a -thalassemia 1 carriers.
The developed method is simple and need no
sophiticated equipment and is suitable for
screening and ruling out of a -thalassemia 1
carrier in the mass populations. The developed
immunodiagnostics have now already transferred
to a private company for commercialization.

25


2






.

26



(IgY
Technology)
(DNA immunization)
(antigen
coated beads)



CD147
CD147

CD147

CD147



International Workshop and Conference on
Human Leukocyte Differentiation Antigens
(HLDA workshop) CD298

27

CD4+ lymphocytes



CD4+ lymphocytes

.



(Immunochromatographic strip test)
- 1

5
-




.. 2551







28

.

2551




68
1235






(Epstein Barr virus, EBV).





polymeric immunoglobulin receptor (PIGR)
(IgA) PIGR EBV
EBV




SHP-1


TTC12



(
)


1 1
1
1











10






2551

29

30

.. 2551


. 1 .. 2507 3
3
() 3 ..

2520-2523
2524-2530
2533-2536


..
Ph.D. Baylor College of Medicine, Houston, Texas, U.S.A.


2530-2539
2540-2541
2541-2547
2547-

2530-

2544-


2535
2537
2540
2544
2547
2550

(..)
(..)
(..)
(..)
(..)
(..)

2539

2542




(.) . impact
factor

.
Eminent Scientist & IRPC International Award Winner
(IRPC= International Research Promotion Council Asia-Pacific Chapter)
The Takeo Wada Outstanding Cancer Researcher
(Faculty of Medicine, Chiang Mai University and Takeo Wada fund)


.





2542
2543

2543

2548

2548
2549

2549

2549


2538-
2543-

31

32

Curriculum
Vitae
Professor Dr. Apiwat Mutirangura
DATE OF BIRTH

PLACE OF BIRTH

MARITAL STATUS




OFFICE ADDRESS

March 1st, 1964


Bangkok, Thailand
Married to Dr. Linda Mutirangura
Sons: Mr. Korn Mutirangura
Mr. Watanakitch Mutirangura
Master Dharm Mutirangura
Center for Excellence in Molecular Genetics of Cancer and Human
Diseases, Department of Anatomy, Faculty of Medicine, Chulalongkorn
University, Bangkok, Thailand
Phone & Fax: +662 256 4532; International Fax: +662 254 1931
E-mail: mapiwat@chula.ac.th




EDUCATION
1987

1993






PRESENT POSITIONS

M.D., Faculty of Medicine, Chiang Mai University, Thailand


Ph.D., Baylor College of Medicine, Houston, Texas, U.S.A.
(Mentor Professor David H. Ledbetter)
Ph.D. thesis
Segmental aneusomy in the Prader-Willi and Angelman
Syndromes: mechanisms and consequences
Baylor College of Medicine. Institute for Molecular Genetics,
1993.

- Professor in Genetics, Department of Anatomy, Faculty of Medicine,


Chulalongkorn University
- Director, Inter-Department Program of BioMedical Sciences, Faculty
of Graduate School, Chulalongkorn University

HONORS AND
1996 Young Scientist Award, Foundation for Promotion of Science
AWARDS
and Technology Under the Patronage of His Majesty the
King

1999 Best Research Award from The Thailand Research Fund
for publishing an article to highest impact factor journal
from all publications supported by The Thailand Research
Fund.

1999 Best Research Award from The Thailand Research Fund
for publishing an article with highest number of citations
from all publications supported by The Thailand Research
Fund.

2000 Eminent Scientist & IRPC International Award Winner
(IRPC= International Research Promotion Council AsiaPacific Chapter)

2000 The Takeo Wada Outstanding Cancer Researcher (Faculty
of Medicine, Chiang Mai University and Takeo Wada fund)

2005 Best Research Award, National Research Council of
Thailand (Molecular Genetics of Nasopharyngeal
Carcinoma)

2005 TRF Senior Research Scholar, The Thailand Research
Fund

2006 Most Citation Award, Chulalongkorn University 2006

2006 Outstanding Researcher, Chulalongkorn University

2006 Outstanding Researcher Award, National Research Council
of Thailand

MEMBERSHIPS AND
1995-present Member of the Genetic Society of Thailand
COMMITTEE
2000-present Member of the Scientific Advisory Committee,
ASSIGNMENT


The Anandamahidol Award Foundation.


LIST OF PUBLICATIONS 1. Mutirangura, A., Kuwano, A., Ledbetter, S. A., Chinault, A. C.,
and Ledbetter, D. H. Dinucleotide repeat polymorphism at the
D15S11 locus in the Angelman/Prader-Willi region (AS/PWS) of
chromosome 15. Hum Mol Genet, 1: 139, 1992.

2. Mutirangura, A., Ledbetter, S. A., Kuwano, A., Chinault, A. C.,
and Ledbetter, D. H. Dinucleotide repeat polymorphism at the
GABAA receptor beta 3 (GABRB3) locus in the Angelman/
Prader-Willi region (AS/PWS) of chromosome 15. Hum Mol
Genet, 1: 67, 1992.

33

34

OF
LIST
PUBLICATIONS

3. Kuwano, A., Mutirangura, A., Dittrich, B., Buiting, K., Horsthemke,


B., Saitoh, S., Niikawa, N., Ledbetter, S. A., Greenberg, F., Chinault,
A. C., and et al. Molecular dissection of the Prader-Willi/Angelman
syndrome region (15q11-13) by YAC cloning and FISH analysis.
Hum Mol Genet, 1: 417-425, 1992.
4. Mutirangura, A., Jayakumar, A., Sutcliffe, J. S., Nakao, M., McKinney,
M. J., Buiting, K., Horsthemke, B., Beaudet, A. L., Chinault, A. C., and
Ledbetter, D. H. A complete YAC contig of the Prader-Willi/Angelman
chromosome region (15q11-q13) and refined localization of the
SNRPN gene. Genomics, 18: 546-552, 1993.
5. Buiting, K., Dittrich, B., Gross, S., Greger, V., Lalande, M., Robinson,
W., Mutirangura, A., Ledbetter, D., and Horsthemke, B. Molecular
definition of the Prader-Willi syndrome chromosome region and
orientation of the SNRPN gene. Hum Mol Genet, 2: 1991-1994, 1993.
6. Mutirangura, A., Greenberg, F., Butler, M. G., Malcolm, S., Nicholls,
R. D., Chakravarti, A., and Ledbetter, D. H. Multiplex PCR of three
dinucleotide repeats in the Prader-Willi/Angelman critical region
(15q11-q13): molecular diagnosis and mechanism of uniparental
disomy. Hum Mol Genet, 2: 143-151, 1993.
7. Robinson, W. P., Bernasconi, F., Mutirangura, A., Ledbetter, D. H.,
Langlois, S., Malcolm, S., Morris, M. A., and Schinzel, A. A.
Nondisjunction of chromosome 15: origin and recombination. Am
J Hum Genet, 53: 740-751, 1993.
8. Coppes, M. J., Sohl, H., Teshima, I. E., Mutirangura, A., Ledbetter,
D. H., and Weksberg, R. Wilms tumor in a patient with Prader-Willi
syndrome. J Pediatr, 122: 730-733, 1993.
9. Nakao, M., Sutcliffe, J. S., Durtschi, B., Mutirangura, A., Ledbetter,
D. H., and Beaudet, A. L. Imprinting analysis of three genes in the
Prader-Willi/Angelman region: SNRPN, E6-associated protein, and
PAR-2 (D15S225E). Hum Mol Genet, 3: 309-315, 1994.
10. Saitoh, S., Mutirangura, A., Kuwano, A., Ledbetter, D. H., and
Niikawa, N. Isochromosome 15q of maternal origin in two PraderWilli syndrome patients previously diagnosed erroneously as
cytogenetic deletions. Am J Med Genet, 50: 64-67, 1994.
11. Saitoh, S., Harada, N., Jinno, Y., Hashimoto, K., Imaizumi, K., Kuroki,
Y., Fukushima, Y., Sugimoto, T., Renedo, M., Wagstaff, J., and et
al. Molecular and clinical study of 61 Angelman syndrome patients.
Am J Med Genet, 52: 158-163, 1994.

LIST OF
PUBLICATIONS

12. Christian, S. L., Robinson, W. P., Huang, B., Mutirangura, A., Line,
M. R., Nakao, M., Surti, U., Chakravarti, A., and Ledbetter, D. H.
Molecular characterization of two proximal deletion breakpoint
regions in both Prader-Willi and Angelman syndrome patients.
Am J Hum Genet, 57: 40-48, 1995.
13. Mutirangura, A., Jongpiputvanich, S., Norapucsunton, T.,
Theamboonlers, A., Srivuthana, S., Promchainant, C., Tumwasorn,
S., and Sueblinvong, T. Multiplex PCR to detect the dystrophin
gene deletion in Thai patients. J Med Assoc Thai, 78: 460-465,
1995.
14. Jongpiputvanich, S., Norapucsunton, T., and Mutirangura, A.
Diagnosis and carrier detection in a Duchenne muscular dystrophy
family by multiplex polymerase chain reaction and microsatellite
analysis. J Med Assoc Thai, 79 Suppl 1: S15-21, 1996.
15. Mutirangura, A., Norapucsunton, T., Tannirandorn, Y., and
Jongpiputvanich, S. DNA diagnosis for clinical and prenatal
diagnosis of spinal muscular atrophy in Thai patients. J Med
Assoc Thai, 79 Suppl 1: S11-14, 1996.
16. Poovorawan, Y., Chongsrisawat, V., Tanunytthawongse, C.,
Norapaksunthorn, T., Mutirangura, A., and Chandrakamol, B.
Extrahepatic biliary atresia in twins: zygosity determination by
short tandem repeat loci. J Med Assoc Thai, 79 Suppl 1:
S119-124, 1996.
17. Mutirangura, A., Tanunyutthawongese, C., Kerekhanjanarong, V.,
Sriuranpong, V., Pornthanakasem, W., Yenrudi, S., Supiyaphun,
P., and Voravud, N. Loss of heterozygosity for chromosome 11
in Epstein-Barr-virus associated nasopharyngeal carcinoma. J
Med Assoc Thai, 79 Suppl 1: S65-70, 1996.
18. Tanunyutthawongese, C., Sriuranpong, V., Kerekhanjanarong, V.,
Changchup, B., Yenrudi, S., Supiyaphun, P., Voravud, N., and
Mutirangura, A. Microsatellite instability in Epstein-Barr virus
associated with nasopharyngeal carcinoma. J Med Assoc Thai,
79 Suppl 1: S71-77, 1996.
19. Mutirangura, A., Supiyaphun, P., Trirekapan, S., Sriuranpong, V.,
Sakuntabhai, A., Yenrudi, S., and Voravud, N. Telomerase activity
in oral leukoplakia and head and neck squamous cell carcinoma.
Cancer Res, 56: 3530-3533, 1996.

35

36

OF
LIST
PUBLICATIONS

20. Mutirangura, A., Tanunyutthawongese, C., Pornthanakasem, W.,


Kerekhanjanarong, V., Sriuranpong, V., Yenrudi, S., Supiyaphun, P.,
and Voravud, N. Genomic alterations in nasopharyngeal carcinoma:
loss of heterozygosity and Epstein-Barr virus infection. Br J Cancer,
76: 770-776, 1997.
21. Voravud, N., Charuruks, N., and Mutirangura, A. Squamous cell
carcinoma of head and neck. J Med Assoc Thai, 80: 207-218, 1997.
22. Mutirangura, A., Pornthanakasem, W., Theamboonlers, A., Sriuranpong,
V., Lertsanguansinchi, P., Yenrudi, S., Voravud, N., Supiyaphun, P.,
and Poovorawan, Y. Epstein-Barr viral DNA in serum of patients
with nasopharyngeal carcinoma. Clin Cancer Res, 4: 665-669, 1998.
23. Christian, S. L., Bhatt, N. K., Martin, S. A., Sutcliffe, J. S., Kubota,
T., Huang, B., Mutirangura, A., Chinault, A. C., Beaudet, A. L., and
Ledbetter, D. H. Integrated YAC contig map of the Prader-Willi/
Angelman region on chromosome 15q11-q13 with average STS
spacing of 35 kb. Genome Res, 8: 146-157, 1998.
24. Mutirangura, A., Pornthanakasem, W., Sriuranpong, V., Supiyaphun,
P., and Voravud, N. Loss of heterozygosity on chromosome 14 in
nasopharyngeal carcinoma. Int J Cancer, 78: 153-156, 1998.
25. Mutirangura, A., Sriuranpong, V., Termrunggraunglert, W., Tresukosol,
D., Lertsaguansinchai, P., Voravud, N., and Niruthisard, S. Telomerase
activity and human papillomavirus in malignant, premalignant and
benign cervical lesions. Br J Cancer, 78: 933-939, 1998.
26. Thongprasom, K., Mutirangura, A., and Cheerat, S. Telomerase activity
in oral lichen planus. J Oral Pathol Med, 27: 395-398, 1998.
27. Mutirangura, A., Charuruks, N., Shuangshoti, S., Sakdikul, S.,
Chatsantikul, R., Pornthanakasem, W., Sriuranpong, V., Supiyaphun,
P., and Voravud, N. Identification of distinct regions of allelic loss
on chromosome 13q in nasopharyngeal cancer from paraffin
embedded tissues. Int J Cancer, 83: 210-214, 1999.
28. Dhamcharee, V., Mutirangura, A., Tannirandom, Y., Jongpiputvanich,
S., and Romyanan, O. Prenatal prediction of spinal muscular atrophy
by SMN deletion analysis. Southeast Asian J Trop Med Public
Health, 30 Suppl 2: 186-187, 1999.
29. Sukcharoen, N., Mutirangura, A., and Limpongsanurak, S. Telomerase
activity in complete hydatidiform mole. J Reprod Med, 44: 465-470,
1999.

OF
LIST
PUBLICATIONS

30. Tangkijvanich, P., Tresukosol, D., Sampatanukul, P., Sakdikul, S.,


Voravud, N., Mahachai, V., and Mutirangura, A. Telomerase assay
for differentiating between malignancy-related and nonmalignant
ascites. Clin Cancer Res, 5: 2470-2475, 1999.
31. Shuangshoti, S., Mitphraphan, W., Kanvisetsri, S., Griffiths, L.,
Navalitloha, Y., Pornthanakasem, W., and Mutirangura, A.
Astroblastoma: report of a case with microsatellite analysis.
Neuropathology, 20: 228-232, 2000.
32. Shotelersuk, K., Khorprasert, C., Sakdikul, S., Pornthanakasem,
W., Voravud, N., and Mutirangura, A. Epstein-Barr virus DNA in
serum/plasma as a tumor marker for nasopharyngeal cancer.
Clin Cancer Res, 6: 1046-1051, 2000.
33. Shuangshoti, S., Navalitloha, Y., Kasantikul, V., Shuangshoti, S.,
and Mutirangura, A. Genetic heterogeneity and progression in
different areas within high-grade diffuse astrocytoma. Oncol
Rep, 7: 113-117, 2000.
34. Kerekhanjanarong, V., Sitawarin, S., Sakdikul, S., Saengpanich,
S., Chindavijak, S., Supiyaphun, P., Voravud, N., and Mutirangura,
A. Telomerase assay and nested polymerase chain reaction
from nasopharyngeal swabs for early noninvasive detection of
nasopharyngeal carcinoma. Otolaryngol Head Neck Surg, 123:
624-629, 2000.
35. Shotelersuk, V., Ittiwut, C., Srivuthana, S., Wacharasindhu, S.,
Aroonparkmongkol, S., Mutirangura, A., and Poovorawan, Y.
Clinical and molecular characteristics of Thai patients with
achondroplasia. Southeast Asian J Trop Med Public Health, 32:
429-433, 2001.
36. Kongruttanachok, N., Sukdikul, S., Setavarin, S., Kerekhjanarong,
V., Supiyaphun, P., Voravud, N., Poovorawan, Y., and Mutirangura,
A. Cytochrome P450 2E1 polymorphism and nasopharyngeal
carcinoma development in Thailand: a correlative study. BMC
Cancer, 1: 4, 2001.
37. Shotelersuk, V., Ittiwut, C., Shotelersuk, K., Triratanachat, S.,
Poovorawan, Y., and Mutirangura, A. Fibroblast growth factor
receptor 3 S249C mutation in virus associated squamous cell
carcinomas. Oncol Rep, 8: 1301-1304, 2001.

37

38

OF
LIST
PUBLICATIONS

38. Pornthanakasem, W., Shotelersuk, K., Termrungruanglert, W., Voravud,


N., Niruthisard, S., and Mutirangura, A. Human papillomavirus DNA
in plasma of patients with cervical cancer. BMC Cancer, 1: 2, 2001.
39. Ungaro, P., Christian, S. L., Fantes, J. A., Mutirangura, A., Black, S.,
Reynolds, J., Malcolm, S., Dobyns, W. B., and Ledbetter, D. H.
Molecular characterisation of four cases of intrachromosomal
triplication of chromosome 15q11-q14. J Med Genet, 38: 26-34,
2001.
40. Mutirangura, A. Serum/plasma viral DNA: mechanisms and diagnostic
applications to nasopharyngeal and cervical carcinoma. Ann N Y
Acad Sci, 945: 59-67, 2001.
41. Pimtanothai, N., Charoenwongse, P., Mutirangura, A., and Hurley, C.
K. Distribution of HLA-B alleles in nasopharyngeal carcinoma
patients and normal controls in Thailand. Tissue Antigens, 59: 223225, 2002.
42. Sriwilaijareon, N., Petmitr, S., Mutirangura, A., Ponglikitmongkol, M.,
and Wilairat, P. Stage specificity of Plasmodium falciparum
telomerase and its inhibition by berberine. Parasitol Int, 51: 99-103,
2002.
43. Kimkong, I., Mutirangura, A., and Pimtanothai, N. Distribution of
human leukocyte antigens-E alleles in Thailand. J Med Assoc Thai,
86 Suppl 2: S230-236, 2003.
44. Hirunsatit, R., Kongruttanachok, N., Shotelersuk, K., Supiyaphun, P.,
Voravud, N., Sakuntabhai, A., and Mutirangura, A. Polymeric
immunoglobulin receptor polymorphisms and risk of nasopharyngeal
cancer. BMC Genet, 4: 3, 2003.
45. Chalitchagorn, K., Shuangshoti, S., Hourpai, N., Kongruttanachok,
N., Tangkijvanich, P., Thong-ngam, D., Voravud, N., Sriuranpong, V.,
and Mutirangura, A. Distinctive pattern of LINE-1 methylation level
in normal tissues and the association with carcinogenesis. Oncogene,
23: 8841-8846, 2004.
46. Sriuranpong, V., Mutirangura, A., Gillespie, J. W., Patel, V.,
Amornphimoltham, P., Molinolo, A. A., Kerekhanjanarong, V.,
Supanakorn, S., Supiyaphun, P., Rangdaeng, S., Voravud, N., and
Gutkind, J. S. Global gene expression profile of nasopharyngeal
carcinoma by laser capture microdissection and complementary
DNA microarrays. Clin Cancer Res, 10: 4944-4958, 2004.

OF
LIST
PUBLICATIONS

47. Hirankarn, N., Kimkong, I., and Mutirangura, A. HLA-E


polymorphism in patients with nasopharyngeal carcinoma. Tissue
Antigens, 64: 588-592, 2004.
48. Pornthanakasem, W. and Mutirangura, A. LINE-1 insertion
dimorphisms identification by PCR. Biotechniques, 37: 750, 752,
2004.
49. Suankratay, C., Shuangshoti, S., Mutirangura, A., Prasanthai, V.,
Lerdlum, S., Shuangshoti, S., Pintong, J., and Wilde, H. EpsteinBarr virus infection-associated smooth-muscle tumors in patients
with AIDS. Clin Infect Dis, 40: 1521-1528, 2005.
50. Chantranuwat, C., Sriuranpong, V., Huapai, N., Chalermchai, T.,
Leungtaweeboon, K., Voravud, N., and Mutirangura, A.
Histopathologic characteristics of pulmonary adenocarcinomas
with and without EGFR mutation. J Med Assoc Thai, 88 Suppl
4: S322-329, 2005.
51. Kantaputra, P. N., Limwongse, C., Tochareontanaphol, C.,
Mutirangura, A., Mevatee, U., and Praphanphoj, V. Contiguous
gene syndrome of holoprosencephaly and hypotrichosis simplex:
Association with an 18p11.3 deletion. Am J Med Genet A, 2006.
52. Kitkumthorn, N., Yanatassaneejit, P., Kiatpongsan, S., Phokaew,
C., Trivijitsilp, P., Termrungruanglert, W., Tresukosol, D., Triratanachat,
S., Niruthisard, S., and Mutirangura, A. Cyclin A1 promoter
hypermethylation in human papillomavirus-associated cervical
cancer. BMC Cancer, 6: 55, 2006.
53. Kiatpongsan, S., Mutirangura, A., and Tannirandorn, Y. Future
cancer management with stem cell knowledge and technology.
J Med Assoc Thai, 89: 1322-1332, 2006.
54. Sriuranpong, V., Chantranuwat, C., Huapai, N., Chalermchai, T.,
Leungtaweeboon, K., Lertsanguansinchai, P., Voravud, N., and
Mutirangura, A. High frequency of mutation of epidermal growth
factor receptor in lung adenocarcinoma in Thailand. Cancer
Lett, 239: 292-297, 2006.
55. Kiatpongsan, S., Niruthisard, S., Mutirangura, A., Trivijitsilp, P.,
Vasuratna, A., Chaithongwongwatthana, S., and Lertkhachonsuk,
R. Role of human papillomavirus DNA testing in management
of women with atypical squamous cells of undetermined
significance. Int J Gynecol Cancer, 16: 262-265, 2006.

39

40

OF
LIST
PUBLICATIONS

56. Ruchusatsawat, K., Wongpiyabovorn, J., Shuangshoti, S., Hirankarn,


N., and Mutirangura, A. SHP-1 promoter 2 methylation in normal
epithelial tissues and demethylation in psoriasis. J Mol Med, 84:
175-182, 2006.
57. Listman, J. B., Malison, R. T., Sughondhabirom, A., Yang, B. Z.,
Raaum, R. L., Thavichachart, N., Sanichwankul, K., Kranzler, H. R.,
Tangwonchai, S., Mutirangura, A., Disotell, T. R., and Gelernter, J.
Demographic changes and marker properties affect detection of
human population differentiation. BMC Genet, 8: 21, 2007.
58. Wattanawaraporn, R., Singhsilarak, T., Nuchprayoon, I., and
Mutirangura, A. Hypermethylation of TTC12 gene in acute
lymphoblastic leukemia. Leukemia, 21: 2370-2373, 2007.
59. Ittiwut, C., Listman, J., Mutirangura, A., Malison, R., Covault, J.,
Kranzler, H. R., Sughondhabirom, A., Thavichachart, N., and Gelernter,
J. Interpopulation linkage disequilibrium patterns of GABRA2 and
GABRG1 genes at the GABA cluster locus on human chromosome
4. Genomics, 91: 61-69, 2008.
60. Shuangshoti, S., Hourpai, N., Pumsuk, U., and Mutirangura, A. Line-1
hypomethylation in multistage carcinogenesis of the uterine cervix.
Asian Pac J Cancer Prev, 8: 307-309, 2007.
61. Pattamadilok, J., Huapai, N., Rattanatanyong, P., Vasurattana, A.,
Triratanachat, S., Tresukosol, D., and Mutirangura, A. LINE-1
hypomethylation level as a potential prognostic factor for epithelial
ovarian cancer. Int J Gynecol Cancer, 2007.
62. Yanatatsaneejit, P., Chalermchai, T., Kerekhanjanarong, V.,
Shotelersuk, K., Supiyaphun, P., Mutirangura, A., and Sriuranpong,
V. Promoter hypermethylation of CCNA1, RARRES1, and HRASLS3
in nasopharyngeal carcinoma. Oral Oncol, 44: 400-406, 2008.
63. Mutirangura, A. Quantitative PCR analysis for methylation level of
genome: clinical implications in cancer. Asian Biomedicine, 1: 121128, 2007.
64. Hirunsatit, R., Ilomaki, R., Malison, R., Rasanen, P., Ilomaki, E.,
Kranzler, H. R., Kosten, T., Sughondhabirom, A., Thavichachart, N.,
Tangwongchai, S., Listman, J., Mutirangura, A., Gelernter, J., and
Lappalainen, J. Sequence variation and linkage disequilibrium in
the GABA transporter-1 gene (SLC6A1) in five populations:
implications for pharmacogenetic research. BMC Genet, 8: 71, 2007.

OF
LIST
PUBLICATIONS


PATENTS


REVIEW ARTICLES
AND TEXTBOOKS:

65. Tangkijvanich, P., Hourpai, N., Rattanatanyong, P., Wisedopas,


N., Mahachai, V., and Mutirangura, A. Serum LINE-1 hypomethylation
as a potential prognostic marker for hepatocellular carcinoma.
Clin Chim Acta, 379: 127-133, 2007.
66. Subbalekha, K., Pimkhaokham, A., Pavasant, P., Chindavijak, S.,
Phokaew, C., Shuangshoti, S., Matangkasombut, O., and Mutirangura,
A. Detection of LINE-1s Hypomethylation in Oral Rinses of Oral
Squamous Cell Carcinoma Patients. Oral Oncol, In Press.
67. Wattanasirichaigoon, D., Murangura, A., Promsonthi, P., Punburana,
P., Suwannarat, P., and Leupairat, U. Maternal uniparental disomy
of chromosome 16 resulting in hemoglobin Barts hydrops fetalis.
Clinical Genetics, In Press.
69. Phokaew, C., Subbalekha, K., Kowudtitham, S., Shuangshoti, S.,
and Mutirangura, A. LINE-1 methylation patterns of different loci
in normal and cancerous cells. Nucleic Acids Res, In Revision.
70. Pornthanakasem, W., Kongruttanachok, N., Phuangphairoj, C.,
Suyarnsestakorn, C., Sanghangthum, T., Oonsiri, S., Ponyeam,
W., Thanasupawat, T., Matangkasombut, O., and Mutirangura, A.
LINE-1 methylation status of endogenous DNA double-strand
breaks. Nucleic Acids Res, 36: 3667-3675, 2008.
1. Airhart, S. D., Mutirangura, A., and Ledbetter, D. H. Method for
the diagnosis of genetic disorders associated with chromosomal
abnormalities and uniparental disomy. 1994-03-31, WO9406936.
2.
.
LINE-1 . 25 .. 2551,
0801002098.
1. Advance genetics in prenatal diagnosis
, ,
2537 :
2537.
2. microsatellite
: , ,
:
2539.

41

42

REVIEW ARTICLES
AND TEXTBOOKS:

3. Mutirangura, A. Genomic imprinting. In textbook: Proceedings of


the Medical Congress in Commemorations of the 50th Anniversary
of the Faculty of Medicine Chulalongkorn University, June 3-6,
1997 (in Thai).
4.
Human gene & genome: structure, mutation &
analysis Human and molecular genetics


: , 2541.
5. (Prenatal genetic
diagnosis) :
(Prenatal diagnosis) : .. , 2542.
6. Mutirangura, A. Molecular mechanisms of nasopharyngeal carcinoma
development In: Thomas Sebastian, S. Jayamony. Editors Recent
Advances & Research Update in Medicine Kerala, INDIA: The
Researchman, 2543.
7. Mutirangura, A. Circulating DNA and cancer diagnosis in the future.
Chula Med J, 45: 199-206, 2001.
8. Mutirangura, A. Serum/plasma viral DNA: mechanisms and diagnostic
applications to nasopharyngeal and cervical carcinoma Ann N Y
Acad Sci, 945: 59-67, 2001.
9.
:
, 2546.
10. .
: .
:
, :
, 2548.
11.
http://www.md.chula.ac.th/biomed/news%20file/.pdf

43

THE

ACHIEVEMENTS
OF

Professor Dr. Apiwat Mutirangura

New Discoveries in the Molecular Genetics


of Cancer


In 1994, Professor Dr. Apiwat Mutirangura and his colleagues
started molecular genetics research at Chulalongkorn University to
explore cancer biology. Since then, his group has reported 68 original
scientific articles, and to date these articles have received more
than 1235 citations. More importantly, his group discovered several
unique molecular genetic events related to human diseases, and
these discoveries have contributed to the advancement of

44

research, public health and medical service.


His research experience may be unique.
Molecular and cellular biology research usually
requires advanced technologies and large
budgets. Research in Thailand usually received
relatively limited resources. Nonetheless, his
experiments were performed almost exclusively
in Thailand by Thai scientists applying basic
technologies. This article reports his work and
reveals how he could succeed.

First Approach


Professor Mutiranguras first grant from
The Thailand Research Fund was to describe
frequencies of loss of heterozygosity (LOH) in
nasopharyngeal carcinoma (NPC) chromosomes.
This research provided information for locating
important tumor suppressor genes preventing
NPC development. His group was the first to
report genome wide mutations in this cancer.
They subsequently reported a total of four
follow-up original articles using the same
approach. One of the factors that contributed
to the success of this study with a minimum
of technical obstacles was that Professor
Mutirangura used the same molecular genetic
techniques as those used in his Ph.D. thesis,
but for a different research objective. While
he was a Ph.D. student at Baylor College of
Medicine, USA, in addition to participating in
the human genome project, he discovered
the mechanism of uniparental disomy (UPD)
of chromosome 15. Both LOH and UPD studies
were based on microsatellite analysis, which
is the same DNA fingerprinting method that is
currently used for personal identification in
forensics. Under normal circumstances, getting
started is difficult for a young scientist. His

experience suggested that one should start


his or her own research by applying the
technology that they know best. Moreover, in
science, applying a technology from one field
to another usually results in a productive
outcome.

Discovery by Hypothesis


Professor Mutiranguras first publication
was to report the frequency of telomerase
activity in oral leukoplakia, a type of oral lesion
with the potential to develop into oral cancer.
When cells express telomerase, the cells
possess limitless proliferation potential.
Telomerase activity was also commonly found
in cancer cells, but not in normal tissue.
Moreover, cancer develops from normal cells
via a multistep carcinogenesis process. This
means that gradual histological changes from
normal tissue to premalignant and then
malignant tissues can be observed. Because
oral leukoplakia is premalignant tissue of oral
cancer, it was reasonable to hypothesize that
these lesions possessed telomerase activity.
This is an example that demonstrates how to
have a new discovery by prediction. When
there are connections between parameters, a
correlation between the shared parameters can
be hypothesized. For the telomerase study,

not only telomerase and cancer are connected


but premalignant lesions and cancer also are.
Therefore, an association between telomerase
activity and premalignant lesions was
hypothesized.

They have used this approach to
discover several new molecular genetic
characteristics in human diseases. The most
important example is the discovery of Epstein
Bar virus (EBV) DNA in serum of NPC patients.
EBV infection of the nasopharyngeal epithelium
is one of the prerequisites of NPC. Therefore,
most NPC cells possess EBV DNA. Interestingly,
there were several reports that demonstrated
a significant amount of cancer DNA in patients
sera or plasma, known as circulating free cell
DNA. Their discovery led to several subsequent
evaluations between the quantity of plasma
EBV DNA and patients clinical conditions.
Interestingly, plasma EBV DNA disappeared
after irradiation, particularly among NPC patients
with complete remission. The EBV DNA
reappears if the cancer relapses, or persists

because of incomplete response to treatment.


Therefore, the quantity of plasma EBV DNA
has been a useful tool for monitoring NPC
patient treatment outcomes.

Discovery from Unexpected


Observations


Many scientific discoveries were
serendipitous. Professor Mutirangura believes
that many such discoveries have been
ignored. Moreover, it may be possible to
increase the likelihood of such discoveries.

Recently, Professor Mutiranguras group
reported the methylation status of endogenous
DNA double strand breaks (EDSBs). They found
that EDSBs contain higher levels of
methylation than the cellular genome.
The differences in methylation levels between
EDSBs and the rest of the genome suggest
that EDSBs are differentially processed by
breakage, end-modification, or repair,
depending on the DNA methylation status.

45

46

If these pathways have different precisions,


methylated and unmethylated DNAs should
have unequal rates of spontaneous mutation.
This study may help explain how cancer
genomes, which have genome-wide decreases
in DNA methylation levels, mutate faster than
normal cells. The mechanism will be
important information for further research
in cancer prevention. Professor Mutirangura
hypothesized that methylated EDSB
processing, such as repair, may be slower
and more precise than unmethylated EDSB.
Consequently, hypomethylated genomes are
more unstable. Their study is the first report
of EDSBs, and there is no current technique
capable of identifying such rare
sequences. Interestingly, at first, his group did
not aim to identify generalized EDSBs, but they
were exploring the existence of lymphoidderived, locus-specific EDSBs, particularly from
V(D)J recombination, in NPC. Nonetheless,
their first experiment detected EDSBs from all

of their negative controls, DNA from normal


non-lymphocytic cells. Under normal
circumstances, this experimental result would
have been thrown away. However, at the
time, the potential correlation between EDSBDNA methylation and global hypomethylationgenomic instability occurred to Professor
Mutirangura.
In conclusion, Professor Mutirangura believes
serendipitous discoveries can happen when
scientists observe new events or when use new
methods of observation. For example, previous
studies observed methylation of LINE-1
interspersed repetitive sequences by Southern
blotting and hybridization and found complete
methylation of the sequence in normal cells.
When Professor Mutiranguras group used novel
PCR methods, COBRALINE-1 or CU-L1, they
found that methylation patterns of the sequences
can be varied. Moreover, scientists should learn
to observe the unexpected and must not ignore
such results. Finally, scientists must be able

47

to connect their findings with potential causes


of the unexpected results and understand
the importance of the observations. These
connections provide the starting hypotheses
for subsequent studies.

Conclusion


Among his 68 publications, Professor
Mutirangura reported several unprecedented
molecular genetic events including the
mechanism of UPD 15, telomerase activity in
premalignant lesions, EBV DNA in NPC patients
sera, human papilloma viral DNA in cervical
cancer patients plasma, new NPC susceptibility genes, polymeric immunoglobulin receptor
(PIGR) and HLA-E, SHP-1 methylation in normal
epithelium and demethylation in psoriasis,
promoter methylation of several genes in
NPC, cervical cancer and TTC12 methylation
in leukemia, genome wide methylation patterns

and EDSB methylation status. Some discoveries


occurred through standard hypothesis testing
techniques. UPD, SHP-1 and TTC12 methylation,
genome wide methylation patterns and EDSB
methylation status were serendipitous discoveries.

Human and molecular genetic research
begins with basic research to understand the
biology of DNA. This understanding is important
to develop novel and better applications in
medicine and public health. Therefore, basic
research (in this case, molecular genetics) is
important, not only for mankind; it will also build
the foundation for improving the socioeconomic
status of each nation, both directly and
indirectly. Basic research is competitive and
usually requires large budgets and excellent
resources or dependable international collaborations. Nonetheless, Professor Mutirangura
believes the most important tools for success
in science are intellect and wisdom.

48


.. 2537


68 1235


15
(uniparental
disomy, UPD)



(telomerase)
(oral leukoplakia)





EBV (Epstein Bar virus, EBV)

EBV

EBV

EBV


(CH3)
(endogenous DNA
double strand breaks, EDSBs)
EDSBs

49

50




EDSBs

(V(D)J recombination)




, EDSBs
( )



1 (LINE-1)


68

UPD15,
EBV


PIGR
HLA-E, SHP-1


TTC12

EDSBs,
UPD15,
SHP-1, TTC12,
EDSBs


Prof. David H
Ledbetter, Prof. Arthur L. Beaudet ..


.. ..
.. ..
..
.. ..
.. ..
.. ..
.. ..
..
.. ..
.. .. ..
...
.. ..
..
.. Ms Petra Hirsch, Dr. J. Silvio
Gutkind, .. ..
..
..
. ...
.. ...


. ..
.
EDSBs. .. .
.. . .
..
1 .
.. .
. ...
.
.
...
.
. .

..

51

52

.. 2551

Narattaphol Charoenphandhu, M.D., Ph.D.


.
26 .. 2521
.

()
.. 2538





(epithelium)
( ) .. 2542

.. 2544
( Deans List)

.
.. 2545-2547 .


( )
.


(Consortium for Calcium and
Bone Research COCAB)



.. 2550

.


. . ( .)

.
.

17 4
American Journal of Physiology
(impact factor)
.
.
(reviewer)

Bone Biochimica et
Biophysica Acta .

20
14 1
3 2

.







.
(multidisciplinary
research) (vertical approach)
(horizontal approach)
(in vivo)

organ transplantation,
electrophysiology, radionuclide tracer, bone histomorphometry, dual-energy X-ray absorptiometry,
confocal fluorescent microscopy, molecular cloning
microarray


(
20
)

53

54

.

(DC circuit impedance analysis)



atomic force microscopy nanoindentation

( )

(bone
membrane)
.
(osteoblast)



Histochemistry and Cell Biology
Microscopy ( Journal
Citation Reports 2006)


Assistant Professor Dr. Narattaphol
Charoenphandhu was born on the 26th of April
1978 to Dr. Rongphol Charoenphandhu, former
Permanent Secretary of the Prime Ministers
Office and the Secretary General of the Cabinet,
and Mrs. Nitra Charoenphandhu (Naigowit). He
received his secondary education from the
Assumption College, and in 1995 enrolled in
the Faculty of Medicine Siriraj Hospital. After
joining the Mahidol Universitys Medical Scholars
Program, he graduated with a B.Sc. in Medical
Science (Hons.) from the Faculty of Science in
1999 with a senior project on the bioelectrical
characteristics of epithelium under the supervision
of Professor Emeritus Liangchai Limlomwongse.
In 2001, he was awarded a Ph.D. in Physiology
with Deans List prize from the same institution
under the supervision of Professor Nateetip

55

Krishnamra, a TRF Senior Research Scholar.


In 2002, he resumed clinical study at the Faculty
of Medicine Siriraj Hospital and graduated M.D.
(Hons.) in 2004.

Dr. Narattaphol joined the Department
of Physiology, Faculty of Science, Mahidol
University as a lecturer in 2005, and has been
an Assistant Professor in Physiology since 2007.
His main mission is to produce advanced
research works on calcium metabolism concurrently with teaching medical students of the
Faculty of Medicine Ramathibodi Hospital. Dr.
Narattaphol has contributed significantly to
publications from the Consortium for Calcium
and Bone Research (COCAB), of which Professor
Nateetip Krishnamra is the founder and present
director. He receives supports from the TRFCHE Research Grant for New Scholar and the
Research Career Development Grant (TRF

Research Scholar), and is also supported by


grants from COCAB and Professor Nateetips
TRF Senior Research Scholar grant. He has
published 17 articles in international journals,
including 4 publications in the prestigious highimpact American Journal of Physiology. All publications represent research performed entirely in
Thailand, and have Dr. Narattaphol as the first
or corresponding author. In addition, he is a
reviewer for several international journals, such
as Bone and Biochimica et Biophysica Acta. At
present, Dr. Narattaphol together with Professor
Nateetip supervise 20 laboratory members, i.e.,
14 graduate students, 1 post-doctoral fellow, 3
post-master fellows, and 2 technicians.

The ultimate goal of Dr. Narattaphols
work is to answer the question of how to
help Thai people have strong and healthy bone?
This question should bring awareness to the

56

future risk that comes with aging population


and should be included in the public health
policy. Aging is accompanied by degenerative
diseases, especially metabolic bone diseases
which are expensive to treat and eventually lead
to morbidity and mortality. To optimize efficiency
of the prevention and treatment, one needs full
understanding of the mechanism of the overall
calcium-regulating system. To achieve his goal,
Dr. Narattaphol has adopted both vertical and
horizontal approaches to multidisciplinary
research. For the vertical approach, he uses
various available techniques, e.g., organ transplantation, electrophysiology, radionuclide tracer, bone
histomorphometry, dual-energy X-ray absorptiometry, confocal fluorescent microscopy,
molecular cloning and microarray, to elucidate
in depth the calcium-regulating machinery. He
has proposed a novel theory pertaining to
the transepithelial calcium transport in the

intestine, as well as the optimal calcium


concentration for effective calcium absorption.
His findings can be applied to improve forms
of calcium-fortified tablets and calciumenriched diet, and to mitigate osteopenia or
osteoporosis in patients with chronic
metabolic acidosis or in lactating women.

For the horizontal approach,
Dr. Narattaphol has applied knowledge in
physics, chemistry, material science and
computer science to develop working
models, e.g., bio-physical modeling, direct
current (DC) circuit and impedance analyses
and computational programming, to explain
how calcium is tran-sferred from diet to bone.
In addition, he works with other young
scientists to use atomic force microscopy and
nanoindentation to evaluate bone strength at
the nano scale. He also starts new fields of
research in bone and calcium metabolism

57

in Thailand, such as the neural control of


bone function, improvement of the trabecular
bone strength at the micro and nano levels by
non-impact exercise (e.g., swimming), and the
theoretical concept of bone membrane.
Dr. Narattaphol postulates that bone cells can
form bone membrane which regulates calcium
exchange between blood and bone, and may
be a novel therapeutic target for reducing bone
loss. Because of its scientific merit, this work
has recently been published in the Histochemistry and Cell Biology, a journal with the
highest impact factor in the microscopy area.

58

.. 2551
Naratip Vittayakorn, Ph.D.
. 10
2520
. 1

. ()
.



4

.
.

.





.
( (.)
)
()
Materials Science (Electroceramics)

.


Iowa State University

2 Professor Dr. David P.
Cann Professor Dr. Xiaoli Tan
.. 2548

59

.


(.)


.
2


(combustion technique)





.

(.)
(TGIST) .


(.-.)
2549-2551
.
.. 2549
.
The 5th Asian Meeting of

60

Ferroelectrics (AMF-5) Noda


Young Scientist Award
35

.. 2550
.. 2550
- (. .) .
( .) 2551-2553
Morphotropic phase boundary in ferroelectric
based on perovskite structure

.

.
.
.

.

(NRC KMITL)
.
.
(MTEC) .


(TMEC)

30
(corresponding author) 24
Journal of
Applied Physics, Journal of Materials Research,
Journal of American Ceramic Society, Journal
of Physics D: Applied Physics, Applied Physics
A: Materials Science & Processing Smart
Materials and Structures
(reviewer)
Journal of European Ceramic
Society, Current Applied Physics, Solid State
Science, Applied Physics A: Materials Science &
Processing, Physica Scripta, Journal of Materials
Science, Phase transition Journal of Alloys
and Compounds .

The Smart/Intelligent Materials and


Nano Technology 2008 (Smartmat-08) The
International conference on Engineering and
Applied Sciences, and Technology (ICEAST 2007)



Dr. Naratip Vittayakorn was born in
Chiang Mai on 10th March 1977. He is the
oldest child of Mr. Nipon Vittayakorn and
Associate Professor Soisuda Vittayakorn. He
has one younger sister whose name is Miss
Sirion Vittayakorn. He married to Dr. Wanwilai
(Chaisan) Vittayakorn.

61


Dr. Naratip finished his high school
from Montfort College and then studied in
Materials Science Program, Department of
Physics, Faculty of Science at Chiang Mai
University. During his senior year, he has an
opportunity to conduct a research project at
electroceramic laboratory which Professor
Emeritus Tawee Tunkasiri was the head of the
laboratory. He was supervised by Associate
Professor Gobwute Rujijanagul. After his graduation, he realized that he wanted to gain an
insight into Materials Science so he became a
graduate student. While studying, he began his
research work seriously and found out he liked
research work and felt exciting to see the results
of an experiment. He was later granted a Ph.D.
scholarship in Materials Science from The
Commission on Higher Education (CHE). He
was again supervised by Associate Professor
Gobwute Rujijanagul. During 2003-2004, he went
to do his research at Iowa State University,
Iowa, U.S.A. under Professor David P. Cann

and Xiaoli Tans supervision. He graduated in


2005 and published 4 articles in the international
journals. He is now an instructor in the Chemistry
Department, Faculty of Science, King Mongkuts
Institute of Technology Ladkrabang which sponsored his Ph.D. education.

Dr. Naratips main research interests
focus on piezoelectric ceramics used in electronic
devices. He is interested in both lead-based
piezoelectrics and lead-free piezoelectric ceramics.
For lead-based piezoelectrics, his aim is to
develop synthesis process by using a combustion
technique, which is the new technique to synthesize nano-sized powders of piezoelectric materials,
reduce calcination temperature and fabricate
high density ceramic without calcination process
to save time and avoid complex processing. For
lead-free piezoelectric ceramics, his objective
is to find suitable compositions with excellent
electrical properties equivalent to lead-based
piezoelectrics in order to reduce electronic
waste pollution caused by lead-based piezoelec-

62

trics. Furthermore, he attempts to develop


piezoelectrics which can be used in high
temperature applications. He also has strong
interest in studying of morphotropic phase
boundary (MPB) of different ferroelectric solid
solutions.

His research is jointly funded by many
organizations, including KMITLs Research Fund,
National Research Council of Thailand (NRCT),
Thailand Graduate Institute of Science and
Technology (TGIST), NSTDA. In 2006-2008,
he was granted a TRF-CHE Research Grant
for New Scholar from The Thailand Research
Fund (TRF) and The Commission on Higher
Education (CHE) with Professor Emeritus
Tawee Tunkasiri as his mentor. In the year
2006, he received Young Scientist Award,
the award for researchers who are under
35 years of age and have a good quality
research and presentation, in the 5th Asian
Meeting of Ferroelectric (AMF-5) in Noda,

Japan. In addition, in 2007 he won


Outstanding Young Researcher Award from
TRF-CHE. Now, he is working on the project
Morphotropic Phase Boundary in Ferroelectric
Based on Perovskite Structure, funded by
Research Career Development Grant from TRFCHE.

Dr. Naratip has strong research collaborative efforts with researchers in Thailand and
abroad including Professor Emeritus Tawee
Tunkasiri, Associate Professor Gobwute Rujijanagul and Assistant Professor Rattikorn Yimnirun
from Department of Physics, Faculty of Science,
Chiang Mai University, Associate Professor Jiti
Nukeaw from Nanotechnology Research Center
King Mongkuts Institute of Technology Ladkrabang (NRC-KMITL), Mr. Rangson Muanghlua,
researcher from Electronic Research Center
(ERC), Dr. Pitak Laoratanakul from National
Metal and Materials Technology Center (MTEC).
Assistant Professor Teerachai Bongkarn, from

Department of Physics, Naresuan University


and Mr. Anucha Ruangphanit from The Thai
Microelectronics Center (TMEC).

From the strong research collaborative
effects, Dr. Naratip has published over thirty
articles in peer-reviewed international journals.
He is the corresponding author of twenty-four
articles published in international journals such
as Journal of Applied Physics, Journal of
Materials Research, Journal of American Ceramic
Society, Journal of Physics D: Applied Physics,
Applied Physics A: Materials Science & Processing and Smart Materials and Structures.

Dr. Naratip is a regular reviewer for
both Thai and international journals for instance
Journal of European Ceramic Society, Current
Applied Physics, Solid State Science, Applied
Physics A: Materials Science & Processing,
Physica Scripta, Journal of Materials Science,
Phase Transition and Journal of Alloys and
Compounds. Furthermore, Dr. Naratip served

63

as the organizing committee of the Smart/


Intelligent Materials and Nano Technology 2008
(Smartmat-08), The International Conference on
Engineering, Applied Sciences, and Technology
(ICEAST 2007), and has served as the organizing
committee of many other national conferences.

64

.. 2551
Burin Gumjudpai, Ph.D., F.R.A.S.
.
28 .. 2516

( )

.

4
.. 2533

Niels Bohr

.. 2534
A
Brief History of Time
3 ,

Niels Bohr Institute

SOTUS 5

.. 2539

(TPTP)
.. 2541 .
.. British Council
British-Thai Scholarship Scheme (
14 400
)
University of Sussex

.. 2542
Dr. Mark Hindmarsh

University of Southampton
Institute of Cosmology and Gravitation,
University of Ports-mouth
.. 2546
Professor Roy Maartens
Part-time lecturer University of
Portsmouth Fellow
of the Royal Astronomical Society

65

.
.

TPTP
.. 2549 TPTP



.
Thai Schools on Cosmology
Symposiums

CRNPhysics . ICTP
.
.
.
. .


.

5

Randall Sundrum II (dark radiation)


5

(dark energy)

(branes)

(dark matter)


supernovae


(low energy effective theories)
( Quantum Gravity)
.

Review
Dark Energy-Current Advances and Ideas
preprints 12
. SPIRES

66

163 ( 18 2551) .

Tokyo University of Science, Jamia Millia
(India), IUCAA (India), CERN, Queen Mary
University of London, Victoria University (Canada)
.-. (
.. 2547-2549 ..
2549-2552)
.

Southeast Asian Astronomy Network
Chair of Theoretical Astrophysics and
Cosmology Working Group .. 2550

.
.-. .. 2548

(
) .. 2550

2

.. 2549 2550

6 .. 2549,
2550 2551 .
7 . Headmaster
Visiting Scholar
Department of Applied Mathematics and
Theoretical Physics, University of Cambridge

1
Centre for Theoretical Cosmology, University of Cambridge


Dr. Burin Gumjudpai was born on
Sunday 28th October 1973 in Phetchabun
Province. He is the oldest son of Mrs.
Voraphan and Mr. Prateep Khamchadpai. In his
early years, he went to local schools in a
small town of Lomsak in Phetchabun
Province. The subject in high school he liked
most was not physics at the beginning, but
English grammar. Later, realizing that
structures of grammatical rules could be
flexible, Burin turned his eyes into physics
and mathematics which he found constructive
and inductive. In 1991, he then went to the
Faculty of Science, Chiang Mai University
(CMU) for a Physics degree. Inspired by
books on Niels Bohrs life and A Brief
History of Time, Burin and his friends formed
a student group dubbed The Students Forum
for Theoretical Physics at CMU when they were
in the 3rd year with a future hope to set up a
real institute for theoretical physics in the spirits
of the Niels Bohr Institute. Being an average
student and much involving in students right
movement, he spent 5 years for the degree
which was completed in May 1996. Few months

later, he took a teaching post at Naresuan


University and set up the Tah Poe Group of
Theoretical Physics (TPTP) at Naresuan in the
same year. In 1998 he was supported by the
British Council and the Royal Thai Government
Scholarship to go to the U.K. for his Masters
and Doctoral degrees. His M.Sc. in Physics
under Dr. Mark Hindmarsh was completed in
1999 at the University of Sussex, followed by
a Ph.D. in Cosmology under Professor Roy
Maartens at the Institute of Cosmology and
Gravitation in Portsmouth in 2003. In the same
year, he was elected a Fellow of the Royal
Astronomical Society, U.K. He came back to
Naresuan, and started all TPTP activities according to plans designed years ago. With aim of
putting a seed of cosmology in Thailand, during
his Ph.D. years at Portsmouth, he initiated the
Thai Schools on Cosmology and the ThaiPhysUniverse Symposiums which were schools were
held in 2002, 2003, 2004 and 2005. Later, in
2006, the TPTP then declared itself to the Tah
Poe Academia Institute for Theoretical Physics
and Cosmology.


Dr. Burins research targets are mainly
to understand what makes the universe expands
with acceleration and how it works. The area
involves and overlaps much between very High
Energy Physics at Planck scale, e.g., quantum
gravities, Einsteins general relativity and very
large-scale astrophysical knowledge. Two main
beliefs for the culprits of acceleration are either
dark energy and/or effects of modification of
Einsteins gravities to extra-dimensional theory
or modification of background geometry affected
by matter in Einsteins equation.

Dr. Burin is a recipient of the TRF-CHE
Outstanding New Researcher Award in 2005
from The Thailand Research Fund, Honorary
Mention for Thesis Prize in Physical Sciences
and Mathematics from the National Research
Council of Thailand in 2007 and Naresuan
University Research Honour Badges from
H.R.H. Princess Maha Chakkri Sirindhorn for
twice in 2006 and 2007. He also won 6
Naresuan Universitys Outstanding Researcher
Prizes in various prize categories in 2006, 2007
and 2008. At present, Dr. Burin is a Lecturer in
Physics at Naresuan University, TRF Research
Scholar, and Headmaster of the TPTP. He is
currently conducting dark energy research at
DAMTP, University of Cambridge as a Visiting
Scholar.

67

68

.. 2551
Satit Saejung, Ph.D.
.
5 .. 2519

()
.

.. 2534

(.)





.. 2543

(.)

.

.. 2546 Some geometric

properties in Musielak-Orlicz sequence spaces


equipped with the Luxemburg norm
.



.. 2549 .


(.) (.)
.
7

(Convergences of fixed point iteration schemes in Banach spaces)


.
(sufficient condition)
(fixed point property)


Professor Antonio Jimenez-Melado, Professor

Enrique Llorens-Fuster () Professor Ji Gao


() Professor Emanuele Casini
Professor Pier Luigi Papini ()
.
(direct sum
of Banach spaces) Professor
Patrick N. Dowling ()



(best
possible result) .

20

.. 2551 .

.

. .

2 .
(reviewer) Mathematical Reviews (The American Mathematical Society) Zentralblatt
MATH (The European Mathematical Society)
(referee)
Abstract and Applied Analysis, American
Mathematics Monthly, Asian-European Journal
of Mathematics, Georgian Mathematical Journal,
Journal of Mathematical Analysis and Applications, Mathematical Inequalities and Applications
Thai Journal of Mathematics


Assistant Professor Dr. Satit Saejung
was born on January 5, 1976 in Khon Kaen
Province. He is the elder son of Mr. Yiyang
Saejung and Mrs. Eng Saejung and he is married to Mrs. Chewapat Saejung (Uttaponpisarn).
He graduated at the high school level from
Kaennakhon Witthayalai under the Development

69

70

and Promotion of Science and Technology


Talent Project (DPST), funded by the Institute
for the Promotion of Teaching Science and
Technology (IPST), and went on to study at
Khon Kaen University and Chiang Mai University
leading to B.Sc. and M.Sc. degrees in Mathematics, respectively. In 2000, he received a
scholarship (the Royal Golden Jubilee Ph.D.
Program) from The Thailand Research Fund
to study Ph.D. in Mathematics at Chiang Mai
University under the supervision of Professor
Dr. Sompong Dhompongsa. His thesis title was
Some geometric properties in Musielak-Orlicz
sequence spaces equipped with the Luxemburg
norm.

Dr. Satit received his Ph.D. degree in
2003 from Chiang Mai University and became
a lecturer at the Department of Mathematics
at this University. He then moved to Khon Kaen
University where he is now Assistant Professor
of the Department of Mathematics. In 2006, he

received a research grant from the Commission


on Higher Education and The Thailand Research Fund and his mentor for this project
was Professor Dr. Suthep Suantai. He published
7 papers concerning convergences of fixed
point iteration schemes in Banach spaces. He
is also interested in investigating sufficient conditions for the fixed point property in Banach
spaces. In this direction, he has published
several papers and he has collaborated closely
with famous mathematicians in this area, e.g.,
Professor Antonio Jimenez-Melado, Professor
Enrique Llorens-Fuster (Spain), Professor Ji
Gao (U.S.A.), Professor Emanuele Casini, and
Professor Pier Luigi Papini (Italy). Besides such
research, he and Professor Patrick N. Dowling
(U.S.A.) studied the stability of certain geometric properties under taking the direct sums and
published papers concerning this. All mentioned papers provide new results in fixed point
theory and they are significant improvements

71

of many known results in the literature. Furthermore, some results are best possible and widely
studied by many authors. He has published
over 20 papers in international journals.

In 2008, Dr. Satit received a research
grant from the Faculty of Science, Khon Kaen
University to establish a research group on
Fixed Point Theory. The members of the
group are Assistant Professor Dr. Satit Saejung
(Principal Investigator), Associate Professor Dr.
Somchit Chotchaisthit, Dr. Kittikorn Nakprasit,

Lecturer Kanokwan Wongchan, and some


graduate students. Dr. Satit has served as a
reviewer for Mathematical Reviews (The American Mathematical Society) and Zentralblatt
MATH (The European Mathematical Society),
and as a referee for Abstract and Applied
Analysis, American Mathematics Monthly, AsianEuropean Journal of Mathematics, Georgian
Mathematical Journal, Journal of Mathematical
Analysis and Applications, Mathematical Inequalities and Applications and Thai Journal of
Mathematics.

72

.. 2551
Artiwan Shotipruk, Ph.D.

19 .. 2516
3
1
1

1
.

4 5

(
)

The Johns Hopkins University,


Maryland .. 2538

The University of Michigan, Ann Arbor

Professor Henry Y. Wang Professor


Perter B. Kaufman

(photobioreactor)

ultrasound

.

Magaret Sokol
Susan Lipschutz
Women Graduate Student

.
.. 2544 ..
2545

.
. .

.
.

-


seed
money

. .

H.
pluvailis

(Subcritical and supercritical fluid technology)


. Professor
Motonobu Goto
- (TJTTP)
Kumamoto
3 .. 2546
.. 4547 .

(.)

. Professor
Motonobu Goto

sub and super-critical fluid




.


Hydrolysis




. (
)
. (
) .
( ) . .
( ) .

73

74

.. 2551 .
.
sub and
supercritical fluids

.
()
sub and supercritical fluids .

1, 3-propanediol
glycerine
glycerine

. ()
.

.

19 ( 15 )
6

.. 2550
. 1
Science Direct Top
25 Hottest Articles ( 11)
. reviewer

visiting professor Kumamoto
.. 2551


Assistant Professor Dr. Artiwan Shotipruk
was born on the 19th of August 1973. She is
the third child of Mr. Sant and Mrs. Suthirak
Shotipruk. Dr. Artiwan has one sister, Mrs. Sawinee Ratchanont, two brothers, Mr. Piyasak and
Mr. Krisakorn Shotipruk.

Dr. Artiwan finished primary and secondary school from Santa Cruz Convent School
and entered high school at Triam Udom Suksa
School. After that, she received the Thai Government Scholarship to continue the higher study
in The United States of America. She enrolled
undergraduate study in chemical engineering at
The Johns Hopkins University, Maryland. After
graduation in 1995, she continued the graduate
studies in chemical engineering at The University
of Michigan, Ann Arbor, under the Ph.D. thesis
supervision of Professor Henry Y. Wang and
Professor Peter B. Kaufman. Her thesis work
was related to the design of photobioreactor
system and ultrasound assisted extraction of
plant metabolites. During the time of her
graduate studies, she received The Magaret
Sokol Spring/Summer Research Grant and was
the department award nominee for The Susan
Lipschutz Women Graduate Student, The University of Michigan.

After finishing the Ph.D. program in 2003,
Dr. Artiwan started working as a lecturer at the
Department of Chemical Engineering, Faculty of

75

Engineering, Chulalongkorn University, a prestigious institute where she had a chance to


meet and work in the same environment with
several inspiring researchers such as Professor
Piyasan Prasertham, Professor Suttichai Assabumrungrat, Assistant Professor Bunjerd
Jongsomjit, and Assistant Professor Joongjai
Panpranot, the previous best scientist award
recipients. Dr. Artiwan joined the Biochemical
Engineering Research Group during which
time; Associate Professor Chirakarn Muangnapoh was the group leader, who tirelessly
assisted her by giving advices on teaching
and research. Initially, Dr. Artiwan received
the research grant from the University, the

Faculty, and the Department of Chemical


Engineering, which allowed her to readily
start off the research work which involved
the cultivation of single cell algae, H. pluvialis.
This work was under the collaboration of
Associate Professor Prasert Pavasant and Dr.
Sorawit Powtongsuk.

With the special interest in the clean
technology of subcritical and supercritical fluids,
Dr. Artiwan then formed the collaboration with
Professor Motonobu Goto under Thailand Japan
Technology Transfer Program (TJTTP) and visited
Kumamoto University, Japan, in 2003 to obtain
her first exposure to the technology. After her
visit, she then received research grant from

76

The Thailand Research Fund (TRF) in 2003,


having Associate Professor Prasert Pavasant
and Professor Motonobu Goto as research
mentors. This is the most important step that
allowed her to set up the experimental
station and started research in the area of sub
and supercritical fluids at Chulalongkorn
University. Initially, Dr. Artiwan applied this
technology to extraction of single cell algae
and Thai herbal plants. The research was
then extended to cover hydrolysis reaction in
subcritical fluid for the production of highvalued protein product from available
bioresources in Thailand such as spent brewers
yeast, deoiled rice bran, soybean meal, and silk
waste. The research works have been conducted
under the collaboration of various researchers,
including Associate Professor Wanchai DeEknamkul, Associate Professor Weena Jiratchariyakul, Associate Professor Manop Suphantharika, Associate Professor Jutamaad Satayavivad,
and Dr. Nuchanart Rangkadilok. Presently, Dr.

Artiwan plans to extend her research to apply


sub and supercritical fluids to catalytic reactions
for the production of biofuel. This work will be
under the collaboration with Assistant Professor
Navadol Laosiripojana. In addition to the research
work in sub and supercritical fluid technology,
Dr. Artiwan is currently conducting research on
the biological production of 1,3-propanediol from
glycerine, the by-product of biodiesel production.
This project is led by Associate Professor
Chirakarn Meungnapoh and sponsored by PTT
Chemical Public Co. Ltd.

77


Until now, Dr. Artiwan has published
19 international papers and 15 of which she
is the corresponding author. Six of these
(supported by TRF) were granted the 2007
Chulalongkorn University Ratchadapiseksompoj
Award. Moreover, one of the six was ranked
11th on the Science Direct Top 25 Hottest
Articles. In addition to these, Dr. Artiwan has

frequently been invited to review manuscripts


submitted to several international journals.
Recently, she has also been invited as a Kumamoto University visiting professor in 2008.

78

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