Unit 5: Glucose metabolism and glucose homeostasis Study Questions

1. Which statement (if any) about facilitated transporters and enzymes is FALSE? Both transporters and enzymes A. B. C. D. 2. are characterized by Km and Vmax values. catalyze chemical reactions. have an active site in which a substrate or ligand is bound. may be located in membranes.

In glycolysis the synthesis of ATP is catalyzed by A. B. C. D. E. glyceraldehyde 3-phosphate dehydrogenase. hexokinase. phosphofructokinase-1 (PFK-1). phosphoglycerate kinase. NONE of the above catalyze a reaction in which ATP is synthesized.

3.

The occurrence of the pentose phosphate pathway in hepatocytes is significant for all of the following EXCEPT synthesis of A. B. C. D. fatty acids from acetyl CoA glucose from pyruvate nucleotides triacylglycerides from glucose

4.

Which organ has the highest demand for glucose per gram of tissue? A. brain B. cardiac muscle C. liver D. pancreas E. skeletal muscle

5.

The human liver cannot produce glucose from A. pyruvate. B. even chain fatty acids. C. alanine. D. lactate. E. Glucose can be made from ALL the above precursors in human liver.

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6.

A common intermediate in the conversion of glycerol and lactate to glucose is A. glucose 6-phosphate. B. glycerol 3-phosphate. C. malate. D. oxaloacetate. E. phosphoenolpyruvate. F. pyruvate.

7.

When the ratio of plasma insulin:glucagon decreases, the activity of this hepatic enzyme decreases. A. adenylate cyclase B. fructose 1,6-bisphosphatase C. hexokinase D. the kinase activity of phosphofructokinase-2 E. protein kinase A

8.

Patients with McArdle’s disease, a glycogen storage disease, have a deficiency of muscle glycogen phosphorylase yet do not typically suffer hypoglycemia on fasting. From this information, you would predict that McArdle’s patients A. do not respond to glucagon in a normal fashion. B. show defect(s) in the synthesis of muscle glycogen. C. have defect(s) in one or more tricarboxylic acid cycle enzyme(s) in muscle. D. produce less lactic acid during exercise because lactate is more efficiently converted to pyruvate in muscle. E. show reduced flow of metabolites through the muscle glycolytic pathway during exercise.

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