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MATURATION OF GAMETES OOGENESIS MATURATION OF OOCYTE BEFOR BIRTH DR.IQ.

KHAN SCHOOL OF ANATOMY (IQSA) PRIMORDIAL GERM CELL FROM YOLK SAC REACH GONAD OF GENETIC FEMALE DIFFERNETIATE INTO MITOSIS 3RD MONTH PRE NATAL ARRANGED IN CLUSTER & PGC

OOGONIA

SURROUNDED BY FLAT EPITHELIAL CELLS FOLLICULAR CELLS DERIVED FROM SURFACE EPITHELLIUM OF OVARY PRIMARY OOCYTE

DERIVED FROM SINGLE CELL SOME ARREST THEMSELVES IN PROPHASE OF ME-1 GERM CELLS CELL DEATH BEGINS 7 TH MONTH MAJORITY OF OOGONIA PRE NATAL DIED EXCEPT FEW NEAR SURFACE PRIMARY OOCYTES IN ME1 PROPHASE PRIMARY OOCYTES + FLAT FOLLICULAR EPITHELIAL CELLS 5TH MONTH PRE NATAL 7 MILLION

ATRETIC

PRIMORDIAL FOLLICLE

JUST BEFORE BIRTH

MATURATION OF GAMETES OOGENESIS MATURATION OF OOCYTE AFTER BIRTH DR.IQ.KHAN SCHOOL OF ANATOMY (IQSA) PRIMARY OOCYTE IN PROPHASE ME-1 DONOT ENTER METAPHASE DIPLOTENE STAGE RESTING STAGE IN PROPHASE ARRESTED BY OOCYTE MATURATION INHIBITION OMI SECRETED BY FOLLICULAR CELLS

PRIMARY OOCYTE

P.OOCYTE AT BIRTH 6-8 LAC CHILD HOOD BECOMES ATRETIC PUBERTY 40,000 500 WILL BE OVULATED

BIRTH

ATRETIC OVULATION

FOR 40 YEARS MATERNAL REMAIN DORMANT IN AGE = DIPLOTENE STAGE OF ME-1 OF CHROMOSOMAL FOR 40 YEARS ABNORMALITIES

MATURATION OF GAMETES OOGENESIS MATURATION OF OOCYTE AFTER PUBERTY, TIME OF OVULATION DR.IQ.KHAN SCHOOL OF ANATOMY PRIMARY OOCYTE REMAIN DORMANT IN AT PUBERTY & DIPLOTENE STAGE OF MEOVULATION 1 15-20 PRIMORDIAL FOLLLICLE

SELECTED FROM POOL FOLLICULAR CELL CHANGE FROM FLAT CUBOIDAL STRATIFIED GRANULOSA CELLS GRANULOSA CELLS REST ON BASEMENT MEMBRANE SEPERATING THEM FROM OVARIAN C.TISSUE THECA FOLLICULI THECA EXTERNA FIBROUS CAPSULE GRADUALLY MERGES WITH OVARIAN C.TISSUE

PRIMARY / PRE ANTRAL FOLLICLE

GRANULOSA CELLS & OOCYTE SECRETE GLYCOPROTEIN ON SURFASE OF OOCYTE

FLUID FILLED SPACES APPEAR B/W GRANULOSA CELLS COALESCENCE OF SPACES ANTRUM FORMATION CRESCENT LARGE GRANULOSA CELLS SURROUNDING OOCYTE

ZONA PELLUCIDA

THECA INTERNA SECRETORY CELLS STERIOD SECRETION B.VESSELS

CUMULUS OOPHORUS

ONLY 1 REACHES FULL MATURITY LUTEINIZING HORMONE SURGE LH SURGE PRE OVULATORY GROWTH PHASE 2 DAUGHTER CELL OF UNEQUAL SIZE

OTHERS DEGENRATES ATRETIC

ME-1 COMPLTED

SECONDARY OOCYTE 23 DOUDLE STRUCTURED CHROMOSOME CYTOPLASM

FRIST POLAR BODY 23 DOUDLE STRUCTURED CHROMOSOME CYTOPLASM P.BODY LIES B/W Z.PELUCIDA & CELL MEMBRANE OF SEC.OOCYTE IN PERI VITELLINE SPACE 1ST POLAR BODY MAY UNDERGO SECOND DIVISION

CELLS ENTER ME-2 ARRESTED IN METAPHASE 3 HRS BEFORE OVULATION ME-2 IS COMPLETED ONLY IF OOCYTE IS FERTILIZED

OTHERWISE CELL DEGENERATE WITHIN 24 HOURS

PRIMARY OOCYTE PRIMORDIAL FOLLICLE

PRIMARY FOLLICLE

PRIMARY FOLLICLE

IMMATURESE CONDARY/ VESICULAR FOLLICLE

MATURE SECONDARY FOLLICLE

SECONDARY OOCYTE & POLAR BODIES