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Vpt421 Veterinary Toxicology Tanuvas Lecture Notes

Vpt421 Veterinary Toxicology Tanuvas Lecture Notes

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VPT 421 TOXICOLOGY TANUVAS LECTURE NOTES
VPT 421 TOXICOLOGY TANUVAS LECTURE NOTES

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Published by: Sunil on Sep 11, 2012
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10/28/2015

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Toxic metals may be cumulative and stored in definite tissue locations.

Although metals may be cumulative in nature, toxicosis is not necessarily due to

storage.

This is because some storage sites are toxicologically inert.

Route of exposure may be important in modifying toxicosis.

Metallic compounds can bind to enzymes, membrane proteins, or other essential

structural proteins.

Metals may complex with one another or with the same protein molecule resulting in

altered toxicity.

Organic and inorganic forms of metals may result in marked variation in expression of

toxicity.

Organomercurials result in clinical signs and lesions commonly affecting the central
nervous system while inorganic mercury results in acute gastroenteritis and renal damage.

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