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Vpt421 Veterinary Toxicology Tanuvas Lecture Notes

Vpt421 Veterinary Toxicology Tanuvas Lecture Notes

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VPT 421 TOXICOLOGY TANUVAS LECTURE NOTES
VPT 421 TOXICOLOGY TANUVAS LECTURE NOTES

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Published by: Sunil on Sep 11, 2012
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Arsenic affects those tissues which are rich in oxidative enzymes especially in the
alimentary tract, kidney, liver, lungs and epidermis.

It is a potent capillary poison. Although all beds are affected, the spalnchnic areas are

more sensitive.

Loss of capillary integrity and dilatation allows transudation of plasma fluid into the
intestinal mucosa and lumen which results in sharply reduced blood volume, hypotension,
shock and circulatory collapse.

Toxic arsenic nephrosis is common in small animals and man.

Glomerular capillaries dilate, swell and varying degree of degeneration occur. This
results in oliguria and urine contains red blood cells and casts.

Following percutaneous absorption, capillaries dilate and arsenic causes blistering and

oedema.

Skin becomes dry, papery and may crack, bleed and develop secondary infection.
•Tolerance to arsenite: Habitual use of small quantities of arsenic is said to render the body
tolerant much larger doses.

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