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Vpt421 Veterinary Toxicology Tanuvas Lecture Notes

Vpt421 Veterinary Toxicology Tanuvas Lecture Notes

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VPT 421 TOXICOLOGY TANUVAS LECTURE NOTES
VPT 421 TOXICOLOGY TANUVAS LECTURE NOTES

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Published by: Sunil on Sep 11, 2012
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CLINICAL SYMPTOMS AND PM LESIONS

Clinical symptoms

Acute anaphylactic reactions leading to stagger, collapse, cyanosis, dyspnoea and

shock.

In selenium and vitamin E deficient cases, vomiting is noticed.

Toxicity due to orally administered iron causes emesis, bloody diarrhoea, paleness and
weakness, prostration, cyanosis and other signs of circulatory collapse.

In baby pigs pale skin, corrosion of mucosa, dark faeces, diarrhoea and tachycardia.

PM lesion

Cyanosis, congestion of major organs, swelling at the site of injection, hepatic necrosis,
icterus and pulmonary oedema.

Yellowish brown discolouration and oedema of the tissues especially near the injection

site.

40

TREATMENT

In anaphylactic reactions epinephrine, antihistaminics, oxygen and proper nursing care.

If toxicity is due to oral administration, milk of magnesia to precipitate iron will be

useful.

Egg, water, milk and emetics are found to be useful.

Desferrioxamine can be administered slowly by intravenous route at the rate of 40
mg/kg every 4 to 8 hours. . If given faster, there may be hypotension and shock.

Shock should be treated symptomatically.

Ascorbic acid administered orally with desferroxamine enhances excretion of iron. After
desferroxamine treatment, urine will be reddish brown in colour due to increased excretion
of iron (vin rose colour).

Selenium:

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