Worftshop n.9 - Mrlig.

anl ePith€lial lumors

r CrniDonatoNc€llmorpholog/
. Egnplesofcarcinonas:
. Squanocell arcrrcinont
. Mrcroscopt :
> Veg€t tivc
zUlc..ativ€
r Mic.os.opy:
; Difierenti, tcd - kerati n ized
> Modo.lte dilt€renlitted
i diffrrentiit.d
Poo.ly
o B*o.ellulrrcarcinom,
. Mdoscopy: ulcus rcdcns
. \4icd\copr: nodular ba:alc€ll c,r,innmt
. Macrosco0y:
I C.vitaryorylns
o vcgetrtive
o UlcetuliYe
. lnfiltmrivc
> P,rHchlnatoN orgrns
o Nodtrltr
. rnfiftr,iil.
(diffusc)
. Microscopy:
t Coloni. difiercrtirtcd tubular c!n'nofrd
. PnthaaJsofslrcding:
. Mi.roscopy:
; Lynph nodes merashscs
' Macms.opt:
viscenl n€t.silsis: lun& lir€r
'
cdinonas aE mllisnnnl runos nlal orieinale in epilheliun l hcl ft 01
th€e rlFs: epidernoid cminon4 md adcnocarcinona. Recening
dilGFnrktion, crcinonas could be (srding): difcrcnliatd. Dodente
difcrcnrirted. poor dilleicnriared md urdilTmtiatcd (daplasic).

Squrmocelltrlrr ca.cin.nr
'llcorisnr ofthh rumor is in cpidcmn. cpidemoid ndcosa or epidenoid
nebpldia ol colunnr or tmnsitional ePitheliufr .
M&rosc.pically. ir could be of lro rnes: vcsetet or ulccmlcd
h the vesctdl lnm thc tumor has r cadinows-likc appeardnce. *irh
bioad base of dtuchfrent dd d
iE€sular suf&e. l! inliltnlcs rhc udcdynrr
hyeB Md an becone ulceraled
 liculccratedvdmrisalossofsubslaroe{ilhincsuldbordcsdddccp
and large basci lhe tumor inliltrlcs thc piofound laycs
Mictuscopically. drc tunxrdeives lilm +idcnnis. deslroys the bascflcnl
ncmb8ne. ,nli hding lhc conneclire 1issu. ol thc dcnnis
'lhc ru.Dr h compsed lion hldds of polygonal arypical cclls
Fsc'.bling $nh epidcrmG *hich !rc sepran.d b! a nduccd c
I. casc of $ell dillercnriatcd cpidcmoid corcinomr the lunonl sLands are
ocnacd bt co.ccnlric keratin layen (lhc nrnroral cells are lilled \itb kcrarir)
Ino$n as kemliir pearLs or cohcods alobcs
Itu modcnle difiiftnli.red .arcinona is composed by arlpi.rl cclluld
Glands with reduced kcrxrinhalion.
lhe poorl] dillatonrialcd carcirronu is rom sed by poLyloral alypica!
.clh widoul kcnrinislion.
Ihc epidemoid c.(inoma car netaslasiTf, b] llhphatic wat in lymph

Itaso.ellulrr cnrcinonr
h^ilL d ro" IJpar'--"\f,
Mxcmscopically: isr ulcentcd lcsion c[araclerizcd by a trobtrnd loss of
sub$ancc $irh pmnri'rnr b.ilds (ulcN rodcns) rc[cscnrcd bv rrnoml I ssue.
Mifoscopicalll. the runou is composcd b tunrcfl1 isla.ds ol cclh dral
rcscmbLc lhc bxsal lar"cr of enidennis lhc tutFr dcsrovs th. hastnrdr
m.rnbmDe and rn lilldcs nr underlynrg dcm,\ 'lht lunomlnlards afe scPrrated
by a rcduccd stona. lhc cellular distosirion inside oI lhcsc l5Llnds is
.h.mcleistic: rh. cclk Iilm lhe Friphcry tuc lomin! p.lisldes a.d tlre.ental
.clls de dlandcnr dGloscd The tm.ur dociil melNlx$/c aud r\

Adcnocarcinomas
An malignant epnhclid ru.rou6 arising iron glhdular cpi$elium of
carirary oryaos or pd.nchymarou\ c\.cnnc or cndocriDe oramsll
Nlacmsc.picallt. the lumours hrrc dillcom n&roscoprcrL amefM..s

Cossy. lhe tunlorf oieimriry ln calitry orgtuE couLd he ol lhreE

ltpes: !cg.rariv.. rlccr i!€- md intltariv..
- The legerant carcinoma is a polypoid tumour Looking like a .arlitlorver.
{irh a brcad basc of.lrachme.r and an nrcgtrlar surlace lhar oojds in
lhc inlcstinal Iunenand inilrEles theRall
Thc ulc€raled carcinona h a profound los\.1 $$su.ce r th brcld ba\c.
linritcd bt tDorallis\ue TlP base h irlegular- covcr.'d byncc.otrc lr\sue
- lhe inliluaivc carcinoma invadcs $c wall Ni(h thickcning ol it and
reducrion of llE lunren (srcnosis).
Grcssl), rhc lutrouB oriai.aling in rhcpftenchymauus oretuN nE oi l$o
lyFsi nodular lnd dilluse.
 lhc Dodular l{trd G. nodular rtrmour ol grclldincNions dd ldcaular
and invasive horders presenting nccioric .nd hem.fthacic ares
lhc dillusc lnms iMllrale liltle bt linle lhe ncarb! lhsues
Micmscopicllll. thcE ate rhrcc l]'pes .l difeEnliartun: {.lL
Lt,llcrc.riated. n.dcraE dilllrcnrirtd and poorly dilfcEnliared runros
. Well difler€nti,l€d tubula. dcnocnrcinom, oftolon lhetunourhas oigin in
glandular cpilheliunr. fomine lunonl Clands rhar pcnetrtc duscul.ns mu'osac
qilh i.vasion oJ lll.oloic l!ye* lhc tunror is conposcd b] rubular slrucluros
limited b! m a(ypical ePnhcLnrm silh ! dullilaverdistosiilon rnrt wilh a rcduced

Mod.rate difie.entilted rdonocarcinon, of colon. Ls a tunrour comP'scd 0-v

(unoral
rubuld srnrctures limited by an arrpical epitheliDn.nd she.ls of alvpical

I'oorll difiercnh,r.d ad€noc,rcinomt of coloh lhe lumour is coDrpos€d bv

aryFic.lcclls dranaed i. shccls
u;dili.rcnrirl€d aden..rrcinon, or cobn (anrllasic adeno.arcinoma) Thc
llLmour is comDs.d b) attlicalcelLs xranaed iir shccli. cortls. $nho$ lbminA

Thc tur.plasix mcans lack ofdilfeEntiatlor' thc.hdacreri{ics oflhe xnaplaslic cclh

presenl pleonorohGnr (un.!o. in sh4c) and m'/.c!rosrs

'l henuclcd .bnomdilies !c: hypcrconasia. alteration ol nNlcuslo cltopL.snr

rario. lri.non In shape lflcomornhisn) and si^ (rr'7.cr.!ors). n.erc or
duhiple nuclcolr. mroscs.

i ."".tt.. t.""', 1 1'lir'c \'r

'"d" 1 RrorJ
.',.,".. rr., \ 'r''i'b . 1lcrr '.n' \1\ o r' dtr-
'".i..
lea{lins to visceralnerdascs es ciallJ_ in hngorliv'r

LrnDh node neta($h of dd€nocarcinonra

r"i""ti..rnl*rrr. ,1" inrolvcd lvmth nodes rc cnlargcd $irh loosing nomal
nrulLutu br rcnlr g $ith rum'ra InJ+'
\a r. ...,11. '' lr I un dr e l. " l?r< 't 'l-r "li l:ni' i'' 'd F "
.o" .: . .' "'r' .el d rrl l
"rr,,"
iLnrcn"es rhar s wlv.'e ate savin! lhal nrimaf tunor sa'
r idenocdcnrom'

M0.roscoDicrllv. the inlolvcJ orsa.s. such r\ livcr nd lLug prcscnt nunrple

;"J,1* oidifral.nl st.. $ilh.esular b.rJ.s. surtounded br nomalpa'$ch!m0