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COMPACT BEAD ARRAY SENSOR SYSTEM (CBASS®)
Advantages/Features Sensitivity: > 1000 times more sensitive than current commercial immunoassay systems (fg/ml for 6 protein toxins); <10 copies/ml for genomic DNA (without PCR) Speed: Sample-to-answer in as little as 10 minutes Assay types: Immunoassays (bacteria, viruses, proteins); nucleic acid hybridization assays Sample matrices tested: growth media, milk, juice, serum, plasma, blood, saliva, urine Multiplexing: Current prototype extendable to 64 distinct targets (scalable technology) Portable: battery-powered, automated prototype (<10 kg) with USB interface Applications Healthcare, including laboratory and point-of-care diagnostics Veterinary diagnostics Food safety Environmental testing National security For more information contact: Rita Manak, Ph.D. Head, Technology Transfer Office 202 767-3083 rita.manak@nrl.navy.mil Identification Number: SEN29 Available for License: US Patent Nos. 5,981,297; 7,736,889; 7,867,915; and US Patent Pub. Nos. 2008-0044312 and 2010-0144057. Other related applications have been filed.

The Naval Research Laboratory has developed a rapid, yet extremely simple, biosensor system for detecting a wide range of biomolecules at attomolar concentrations (10-18 moles/liter or about 30 analyte, or target, molecules/drop of liquid). The compact Bead Array Sensor System (cBASS®) captures, labels, discriminates, and detects target species using magnetic microbeads, fluidic force discrimination  (FFD), and a Bead ARray Counter (BARC®) sensor microchip. A multiplexed FFD assay can be performed in as little as 10 minutes using only two reagent mixtures and three assay steps. Assays are adaptable for extraction, pre-concentration, and identification of a wide range of analytes in complex sample matrices for a variety of applications.
References "Design and Performance of GMR Sensors for the Detection of Magnetic Microbeads in Biosensors," Sensors and Actuators A 107(2003) 209. "Rapid, Femtomolar Bioassays in Complex Matrices Combining Microfluidics and Magnetoelectronics," Biosensors and Bioelectronics 23 (2007) 191.

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