Generic Name: Cefazolin Brand Name: Ancef Dosage: 250 mg CLASSIFICATIONS Therapeutic: Anti-infectives Pharmacologic: First generation

cephalosphorins ACTIONS • Bind to bacterial cell wall membrane, causing cell death. • Active against many gram-positive cocci including: Streptococcus pneumoniae, Group A beta-hemolytic streptococci; Penicillinas-producing staphylococci. INDICATION •Treatment of: Skin & skin structure infections; pneumonia; urinary tract infections; bone & joint infections CONTRA INDICATIONS Contraindicated in: •Hypersensitivity to cephalosphorins. Serious hypersensitivity to penicillin. Use Cautiously in: • Renal impair- ment • History of GI disease, especially colitis • Geriatric patients (consider age-related decrease in body mass, renal/hepatic/ cardiac function, concurrent medications and chronic disease states) • Pregnancy or Lactation SIDE EFFECTS/ ADVERSE EFFECTS • CNS: Seizures (high doses) • GI: Pseudomembranous colitis, diarrhea, nausea, vomiting, cramps • GU: Interstitial nephritis • DERM: Rashes, urticaria

laryngeal edema.• HEMAT: Blood dyscrasias. pruritis. appearance of surgical site. WBC) at beginning and during therapy. redness. and resuscitation equipment close by in case of anaphylactic reaction. Keep epinephrine. mucus. Discontinue drug and notify physician or other health care professional immediately if these problems occur. • Before initiating therapy. swelling). wheezing). or pus. loose or foul-smelling stools) and allergy. • Instruct patient to notify health care professional if fever and diarrhea develop. • Obtain specimens for culture and sensitivity before initiating therapy. Persons with a negative history of penicillin sensitivity may still have an allergic response. • Instruct patient to report signs of superinfection (furry overgrowth on the tongue. especially if diarrhea contains blood. urine. • Monitor site for thrombophlebitis (pain. . vaginal itching or discharge. Advise not to treat diarrhea without consulting healthcare professional. obtain a history to determine previous use of and reactions to penicillins or cephalosphorins. an antihistamine. • Observe patient for signs and symptoms of anaphylaxis (rash. hemolytic anemia • LOCAL: Pain at IM site. phlebitis at IV site • MISC: Allergic reactions including Anaphylaxis and Serum sickness. Change sites every 48-72 hr to prevent phlebitis. superinfection NURSING CONSIDERATIONS • Assess patient for infection (vital signs.

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