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'[r., 8 .. l-~jil~th1J;nd'!l th~ ,,~~ri~ ~ r:f' S'ili~n1 Ctp'eL1h.~~m'~l ~is.t,ed me lnl ~~lild :~d d~:Il§h:ltet ,tl1L~ l~IG ~ ~d~m&~t~J mu.mM!i,;

M~t,'Cm];aas or H;lUJ' kiolB" ,~gm:p~isblg eM~l"~co'rd~~ T3dl'Qtgtapns~ a'U!to~~'y :m®1m~ ud smm:tk'i;, 'W;;,~ll?: ,~tfo!m$~fJ'd ®O :tDe OJ Pro'f~~(lrs: B" M~ JimrU"J~.a FfOill) M9:]1_e~ 1l. Sq_nitl ~ "arb.'t~~gl :aW1~] I., CoUirnJ ,aU fun tb_l! Co:p.e;tmth~t~tDl lJ~erot]'11' ii Ptuf.'eSstlin) J .~J. Hml~)~~ acli~tril. ,at- DfMUll1 Smg'cry; Dr.. M" D\~rlJ~~ !!i7'1I\iI :. '[n~: ~~ - ~ ~:i:"'mA~:" ~~!I!l'''' F'!~~d." C~~~!1::", ;rr;l'~ ~'f.':1 . ,eniu·s-Ni£il'!:!e.n~ ~ thn D ani ':.111:-

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A numbo of inY8tj'la~on Il'bra'ad \lit,ntry ki,udl, p~~~;ed IITIIQ'(ltl'llfiJs Nllf l;, . ·ib'i~ d~ri~riQIl! ,~-t m\y ~,pmnl; rlro~Qr' Hi .. 'W! Baad~li",1 B~r;JiDI~; D:r" M. Bonj(!~u]" Ibbaq PttJfuw r J. Ommcq Gill ~ 'NJb,dritt; Dr. J~ a~ Ulu~~ l~j IruC'Il,M ,1 tft,S; Mr,,, H t T ~ D~n ~ D. S"[Ii W'WlibiDS tun; f . r~;Pf' h~:rn· D un I!',nl~ I.~Jlkj~v~.k '" Dr. LeOn Coldi!mib~, flll~' Airtlil,'; Dr" 1]'. S,~ l\tt.K,~'y!, Nc"!.v '\,'o.rkm IJfr'O~L (1'1' L~ SJa(pvfJld t ,0.10 tOr.. M Jf,. ret .!! .Im ilth . . ~1I1 It. Iili{zgnnj cDr~ I,,, Veh:l.l Cuab1anca.

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hl!!(li,nl(lj!: m'iDill}ll'&~S, hiiiVJE be!!i[Ij knOW'll, s11U:C: ti:.i~ 'UcldJe Ages. The l'ilfi'IIH~ il'il ,dai,~~d from It.hei.r clWoo~w---1I,tic pro[pert'y or ~U!ling 3l!Ii ~,JlPi;{.t i.. e, to pr'o_r-ma1lE t.l~ ,m i'~D iOf' other 'm,iner.ols. Th~ N~,~b~' n:rl.!ii,t SehWBnJ:UUU {l'~iD~ ~ or,ctWit~d, "'rith mf: :lim l~ ;~dfJc::mpti I'i! ertciling- gW~, by :[[u::.~I:t.a ,@f ths 'V~pOl:lr9 diJD.t are I~;maa( ed 'wbm ,D'Ilnrnp~ is trl~i'd:ed with l'iiulpfiUlic fi~i(j, (S3,~)· 1m, ~'7"~ $oo~d,~ p~cd'l'lc!~ ran::' ilJqlHlOUl JC!]1I.I'li~ml cf hYMD~~m OU.Qrid~. 'G.a:y-L~~ ~t11l1 T.hi!nmil d~crjhed 'the oouQri""iIl'i c:if'ect of IIr!b.C acid. en r~~ ~ik,ill ( 1809) , TJJ,e I~~~'t :il;u:~fi__lrnIle '~;~as ,m~t isDma:ood. in ,~, 886 hf' :M)U)i~llIJn (!j,Bg,} ~

~\.m, It&lim ·du!nIist D!l:!rIll1i~~(!1 ~IJlo.ncmnl i~ l,B~3, derrncm,uiu:edr l~ffile ~~cm 1Of' Hu.:onme In a :bs.li ,d, pha[!l'l'-'~od~! fo,!.tnd. O:lJ m~dc 'l:b~ city o:f R.ome. ThR~'~el' w~t1~ Ga.r,L~aQ ~c Bl'liDI\Vm hl'tu tlg,ii:'!<t :Ilu,ad~1!: 1.1 ,~~'O, p'~m,C i'n ·I;.tth. tlac:lb~ of ~:_oth, s;.mab ~1li6· m1U1,. Tile' ,Q]i~Cill~~ry moo,e ~u;i;t.e' ~,:stiF ;;Ill]1~ ~ .~ ~aUic (If :~, .J[i~-omct~cl ~~n,troV~f" Ah01J't rtffilre '~f@_M' I 8J1,6 Gcn\l!l~ W,~cm.~ tht!i S!g;0t~ cbe~li~t. :Wililai!illR m:¥ie!U~pliO:Q .0(1], :t b,ma_dCar bm: ad ~]:lJimtW:ed rj'riJ~:t fi~J!l~e ~ wjii~pii'l(:jacl, ~n, :l1atur:e . :in. !llpdDg~ and], iSlea, .. ,w~~~Ui ie, ~~g~tniffie.. ii5ill; "in blocd ~d mii:k of ,a.mdtuilii. lILbt Frdruclu cltemistt Ni'~~!s mt:mG~ ;si:milu c.o~e~~Sl]WlS.

The ttlxh: Flw.Q~p_~Ii~, 'illf Olllrnrin~:, WJil'l:pOitillnHs w~~ ~'~l!J]tli~dl .fQW the fi19~ ti~c In, ,D:n:bJmlnr.1 ~1?-~wlm~or~ lb, h bueeau ,m, ]: i9ti 7,., ltnllt'l(ill, ,fIlbCttb.1Jit r 8g(li T=r~p,peinl(:.i Jnd .sE;ib:u1~ p~b&h~~l m@~' dC'fMfficd ,r~nm'S ci[' ~b,~~tl~~~tll~r I~n a~'i!.lk ~~IQ,~'tal p~~ni[!JJg~ ,aDd, "~'1 ~d l'a~peintt ~u~~,e_pw.d w p\rndU'~' ~bmfii~ ~~~'n'i ~I in ,9;, dO,K{' W'acldtJ ~:Jde ec:rt~~, ~tltet1!jting but DI~'~ 'v~ ~fill1 ~O\~fll! ~llnk~ti ~'bien,rfiiLiDw .. ;n rli,c peri'c.d~mm JSga '_ l:t2iQ iIillle hi~m"(-J bt ,t:be 'w~~01®1Y :of ihl~rim~ ~I~ ]j nrUim:M ~nul ~J,re,t ,aliv,e sm~d1 by ;'!!,f'mndi:c; ~ oj;', Cllifoie- :tiOiB~'~~ attlilJ. hy atE DOCas:i;~[I]il[ imlrufrn~rm:ut of 'tb:~ 8um-n'tu: wm~oo,&~in tbe~aM~~~ ~J; (:000$ =d 'm, tI:u~;n}l'Y'. Dming ~e :p-¥t t~n or fi.D,c~, ',;ears~,bfiw41"~r tIj th_~ t:a, u.t~srlM, 1lm b~ iI~iHfd..itdl. . mib :I~i!a,dMly ~C'~1f

2:aJ! r~:r !cv,Idl ,1l'£.'aSDm,. • I i I

IQ 19 f.,~ .lm:tolnccID 'dbs~~d, n cattle dJJS$ill~$ r~'~1 ·OOlmlm.aJa~~a [lYIf:od a.oout an, ]ta.Ua:m ' 'tlipUP_fli,h~l}e :r;:,U:N~'l ud. ~ ~ ~p:ni~r::.d 'WI! epil1iifJfi ,that ll$ mtiol~1Y lll1g,kc. be ~anlU!lcf;~d. lwl:h th-:- :!~il'fillJE' ~rrlu:t i_m ~~ lj,~~ite ~.~ .. ~:uets hm. rh:e fnct!l1'f. His lJ~b:onr n,t'~,net_.fld, 0,0 iIP",mlt aUlmD:o'n., It 'WU ~m, whnb a IinlllJm<' i!a tde ,CiEM 'b~ln~~ cu't enlluni~)dLy· in, the n~Gh!I:((J;ur-ll_QQd of !iI. .swiu dumini l1m. f8jct,QI"f' d~,.g the: G.r9-t W~ ~a:t ~e in:Getl.'tiy~ wm gi~cn to a i!lC!na of igv~ti g4Dicln_j; :IE l ~ A.luari..Q~ ~nml' 'b, 'Ct:'ilt,liam an.d 'CO-w(jr'lcdn~ The' ttlc: .a.R~ however. ~aQtinllm to be iI riid1~. BUL tn f9M i.m:p9rbtD,t QbKrvatforu w~ Iyublt.hed .. SI~.y.o<Jd dcscribGd ~nic lu~ itunxh::ation a.DDt: betbivDfD ·in ttl!! ~ebd,r~' of N€ltw"t,Rin:n :aluminium fact-

'I III R10k 0._1

OJ:L an'- It h.~;lm I as oll,l eo in nUFY R dOlllcstlc mnma1 dbeMI (;gdtlur) Ion ,_ '~l:l'!i",":11 in IG~nnd ~ as . pci~.sD:niII g 1:1y- ,n.uarianf conlpounds"

-.'e 'UUJ11m·l,immonds I ll-mi" an - Bunting she i\fed im 1'9 5 tho:t .~ ~

.. ,m' ~ [" .11 1"..:1 ~ _J .

nllIlJ., di.f CO'D~nifUD :l~11 rme I pJJa,;",- eU 'mo r ,ue.' ~'cnltiV' Den' _ ~lan:g s

,d~'· tal dJ - se in mmtl m'DUI~ ,lin Im~l \'ihi]cb Bb,dr and'~ " ·ay d 'eribed ~11 !'I' as aoe -n±ns' in Colorapo, hns pr.p.'V ,tl eo b f,at!u:r \ft~,cl. y ,diurlri'oo'ted wn !"~ '-' pafil11 ,e:f: I!i!e or1d~ Thlt re"G[ogy ",'IlM 1.JDkno~m_ until 19:3:~ 'I 'I~hen ··.:mithj; :Lmn't.£ tt~d InU:tE de:mo'DitFarlcd, by ie.~ o,r at:lin7i.M ~pe_·"m', 'W t

_- , ~ ;...:I , _ll .... tl;&I'Ii L:~.,..1-. in ~ . "..:I~ L_I;

tbl . dlstaSJ~ 'II .. C·; : .Ja. ," ar.~iu~.-ci, ~~li nllon:oe COD'tJeD:t m . ur.lhKJDI

wa. .~ lade mdend·,- of their' ~_, 'il ~, rein p~,'v ed that a, Clomnion dental ~tm .. t in l'··.IOi.r~'- ldiica: !,'iQl,gn: ,;)uwlm.als, a-nd mD.-nil' tim-now· w,' of 'ffill~ n, I, Mm'Ol-

D~

Simce 'dle d~ fa Ur.:M,t 1Zimmry am;e 9, r;·.CO:f"d.s,,~r, . D.um:b ; ofrc:3$Cs, 1m.i9J~ut~

,ms;Q~' in ;maIL by w;ariJous, ,Iuo:r.ide com.pO:lI D,di. Cb u:mt;; 11.)]11;': I ,01' P~g

"'{h, honCo .~'I~llillS .. ~ ;6. Cfi'! .; I, :for dll. ! ,t tim - _w 1.!}S·' by FlemnmiDI

,ller',m •.. iiiudJo· o~ in 'or.yofi~e \1{1ofk~., ID. tho Ie t dJCG2~l. ' 'tJo, ., '. '1" ROOMe mbstantiCi I_P ian,· .bB:V;- . '" ... en ris,' to.l i' .. ~, ". tij,,- dom: "D'lC lJ(S ~~c'" oloty ~ 'partie~ -l'y':m U, '. ell A. '; dlat o,f n (; ':~ic ph~.hon:t··., Jeo fa; mi;n. -. iluorin)!! iii a !OUC£ Qf e:alel,om ,Mld JlbJ~sph~B. in the :rC':~ .' of: dQmad~. ulmnw,1 8Dd. tbd I~[ I, orin!! CiDmpoultcl], far ~(In' -'a:mug pI: I . ,t p~t. c.. :~. 'ID, lVG(rb bur e

ap~. in die. L t Ow ¥,ean:' dll' :' 0": .~-~ 'm:cc' :'W~ltb aJ),d CQ-10([ "e.r.sl

dI r 'iL.::rlrl.. A [ .,_1'It 'b -

Uu. 0 ,'.lu.ui,' mtiQ_. ca~W'D - I .m.a:y lem -Cl<U!.tty~ IlDCOO.Q1='::~~

0,,-

, •. -0,1 DU~ 'af ~!1O!li1 .. Ill.

(] ~ {rC,-1t.itl1JI~I~flitl m~l,ti§i~"n ,~ JI1~firin~ iR':{tit,ic,d~fJfJ tOil' i~c ~ruiN qf ;,~ litmrQtD,f~'1 I1l~OO bDnI no ,cuUer;:;llv.e \\f'Q1rk .OlUiJ dle~Ub.Je~L·), Thits p"rolI'cd to be ~ lilI(1im~®eb~vt; tmik1 fOf I~ wc:r,~ 'lllih'D.y mdilfi d;ww Wbliltk5 [D_l in~_~ ~ l to d]e Intb.] ~(ltll ,~ecin:[~, dnoog:J'rom ree:;eu;[ '1~~'· Tb:J!iSe ~ork~ ~ ~iPread over m;W, kh.1.1w ®if s;p~lJt_~:I o~fbm difficult i!lfa!:~eu nud, m"lot tl!]oomm,Q~]" lOon ... !m,m~~~f)",. • urEh,e['nutI~~, du['ing the mn~·l.t '~rJ·rn'k IID@J, mn~clt -th~ Iilt~gtJl];c!i" a .{;oPsidB1'ti,b~c H~~mbCJ' Qr ,~ves:tigat!!Dl1;S Wlere p1llbli~ed:l gdl ,t]],e-sc: had IlS[]i W be i~~n. $ll~~ to~sid~m,Ciil1 .. Th:1s '~pooi~OD- Be,~~t"J ~ iii! w,~. ,1)(1] ~~~Wlt' of' itbG~d'~ ;C-Q"'p'~ 'ill:F 11ll~: - '~·k., f"o.f.mEI P~t I"~ A. 'PJr3L~d~WiIDr 1il:f}:miIP1,~ b~ ~ibtic!~ph.y 1@11 the: ,S,U ~jcc;t cO'.Qtcl~d,es :the ~'1\O:rk

(::ii~~1 J\m i~.t.i'a~io:r~ M,&Um.,(j/1 ltOolill i~.t(il'~i'm1.iG1~1I ;lS CMtc.ui;R :i!JI1li p'-~~hht u~dler li:iD '~fi~~~1iD,g ~~lim ~~:,. This m~rn.1Si a mrniew 'el~-a~;a(o:n ,of Un~ \\!',or.kemi, al!~ dud: llad 'L'O' 'bl!' cam~d ,@u.~ iil'_: !~:& :fa[;mrn;;y am.d m 'wl~~m!, 'L ,,-' '1 :'11 j'!JI,i!' a:m ·mOlIf,,,,_C;°I:"i ~I~""n o:'i'iIilI m ;-;"r;b.idfji'vf2li'~·'" =,tIi.. ....... dis - 1 .. "1'" . I ~.Jil

,ilII~:m,~, ,all 1i!!l'e _ ' , ."''''''''~~-!J.l!!'''' __ I!j# :J!.II' _. --'''''}:I' __ 1!;!Ii;i. Ul,I!I._ ._~u~t;g)e. aJlu,

";'i- ii'I"" _ ... ~,jt, ... _ ....... ~"'iri .... ""' • .,... . .J ,~"'11.., ""'1"..-,..,,; ,.,JIl,., n u;~'~-'Jll[ 'li;f!I;~ ...... ~_411iB'\II' 'lI".fj,'.... urAr''''",;,-

ejLU'~ l~JllIUltll.i.l"""'li!ll Iw,v.~.JI.:.L~~~lJ~, ~~IIg~~·tU.iIlJ[I,i }~!i~ ~~lr·~-i~tnL1_I.' r'Ir.-'lf'~. "!l1J1U K~~I

~U~I'9f m:t~cnn~:;n.t ~dm~~ liLlfld d ..... gia;~e ~ ~J~prn:llijmnit).r, l~" ,ru:.h~ ... ~~ 'EEf..Jcal .exiJ~I:r:1Qns Cf\[l,rt_ Ill).,

{!I~ _ ~~LC5, of ~~~'1iicmioJJ. ~¥,t<riilm::i'liJ.t I~'~ oimauJ, mtimd:e_@l ;F~T 'tmd~s' ,res-cIi:t.

'I~, ~il 0'1.,...,. ~it-.:!!~ 'lLiti ........ k ~ •• '"'",'" 'n'll ....... ned ~,- ... ~ ,,_,," ... ~: - ~ J.tjj iii'lMi'lj'i 1ii'!I6. 'IIiL~'~-iIJ....,..,,,,t 'I.~. - .. ill'

~(!!i\~~etuB~....·gO!' ~",'~..; . ~~'~ ,g,o;.Jlluu:_ 'W ;p,.ilil!.!l;!l. !!;;-'I!LJ!-~-~~~ 'Ul!i~,~!i;!lII,oIl~'Jlj,!",~!pElIiy~'" ,KillillI. 'n-"

IGdi~ ~ 1[1 ,[-.e 9~'l"t or !he illic,erral~ :rdeo,oo, I~O W '~_tt:l, Me j'O~gi'ng b~ d'The ·pr.eUtilb~frry Ji~:9,a1 ,r tlu~ :t1:tJru"ilmr~~ nlB ~il:n1;!; mo:imah, diffe_~d ];m!lJ ~,m:1i" :reJicti~ifl. - s~lfclal kiDds, ,Ql:f' :wmmi'fti.ls, W,eI'~ uSied. -BJe.1aJtm~ely ~iEL~:C: ,~b'l1l~1s WM-e ChJm5~ m o~'~r tQ be '2Ilk\l£i 1~1l d.~!DItDSEmi~C IIilt:inC CJ;1~f&ng~' by X~mr it11limihaJ[]oo. "JamllJ.!JdUa'tLOl]5 lOr G~nru~my, ~~fl~~ii ,ilnd the: ~'I)~pg ,nf t:h~ ~lfl m,a:i(ic: ,~~. ~~tb'h: [6 m.e, ~n~'f ;9J, :~'i~~t~d ~,umbl!r.i gf. anlmw.s of cu~b &d ~ I "f neaes!litJ: ,th~ m I~O _~Qa I l,.'t,m~:hoo 'lQ 'be :5lll~U:m ;m "limacl Q'u~lllIDnr.S an[W. I!h~ cl.~~p,ciil:!!'D lIn-cl it!Q]l ~!l:l oonn~~c~ Fillr' Lhb ~~M9~ tk~ ~'lJIe lof th~ - P .-rimm ~lm~~dgtlclQM jDU, ,[ ,pnrticulMi)f

"

Ii!lc appw!ed j m lbrc 't~ ,hl~' lof itb'C ,[fi.c:t th at. dlle:Y cO:Rfi-rm ,nd ~'llI~Jltc:mtm'(

warb tbel!JJ a~rdJmb~C!' ~f: p\1 blMbr:u .U' nr6 ~lan 1'0.

(4) 8:, 1'netlml 0'1' ,~ll:q tJ rQ~111:t Iqf' 1M' Ut.ahu·" :l1aJ1_~ W1d thw rJl ~U~ mMl~ ~ IIJI'dW. it no,w p",~ed JD ib~c w( D,lu~bL -rIJ'n 'idfl11. I~f tb~ "molll,

romu I D!4o-m£ int~~QdoD alia thelr mutual 'fttIUl:tiOIi~lhirp., TbJs d'"

posi1i01l ' been ,mad lb ~Y'~~m_tiCt . DC bri~ r()~~ rnkiRfR due "I-N m Clhc ,bmt.\1'1ne_tlD th u t m V be reg~tdd ~(!l1Rin Dt pr b bl". By Ihil m It wu rpc:aiJblc' Ib lh.rc:J W Itghl[ 1ft i mpmrmnl pamlt5 wn II. led with

hul'I1H ayol Ie In lui liDn~ lbt n iliuM fL. ptdbl«:m pro'Vctl to be

) In':!I (fl) and td u tap, publWlm mvI~,~ Uti Iluoflna I.. don.,

only 6ddI, ud _thou. p-~ lme. lmpottanl ~tt.

~~~' wilde' ilDlIG':I! tarnti ·af CilJl1mJsiiderabrne ~JJ:h,l ] .te~uL, iD '. ICQDI!ll~;t 01 iD:m~ iJ~~:amn p~5Jl~[lt;i:£9 rund a 'T.v>h~w of me, 1~I,mfJ·,I~yJ ~ede pmb1.~l' lum on ~ iIt~ej1n8l'ti[JlIllin~ mq~iQr~, l~ b~ml add,~~t. A !lUJ,~ma'ry c~KI~inj~, thh

SS'£don (P,art ~"

,A, 'weirk or :~i~ lih~ ~wl'e: _' roo m, ,~o,Mp.hn,Jallfll tml'knasu,. '0,[ n~~~,i.t" it irr ~jt:tnil~C I hmtdmed, by I~,be rni.I',e:mWfi'C s.p'p.~arus'· ,~ftd ". It sb~wi.·1!flj1 nyc· '~n:oC'0Jl"wm:w' Rri~irng ,h~ I~~'~ [~~,t dlm,t 11iJ p:~bh:m il~ 1llew' an.d f~r 'rooi!~~'i, IOn 'tJ!a:i! DthJ'!' h~nd~ the d;m,e~l3d ;~mi~d f~1" tlwe mit ~Y'ltemaitic ~'abrua .. iti~u ~f' IlDe q:UJBrrdJOiRJ! iaud j, Wq :D!~l2iiE:a;ry im tJile present c. ' ~f) 'ta~~ iJi 'g,D lf1m _: br:uad WlQSii~ T.IL!! 9I1!J,.C:l" ]lwo:p~, 'm llia~e 'Cl~m:kiblJ:~ed !l~mcthi[ig ~O:Wi;t'R& ~~'II_J0~~darubng aad 'bel spmt d~ec, i NCl'lttpmg :,'rla~'t kwOfW~. ~" ge" btl fa hQ'W!; j~itdig,~w.u d'D~ lJvherc fmtheir Jr~eat".oh iB d'GI:k-abl~ h:t[QriB~ m,~ ~wd'c~~OmJI, ,is, pf ~nddc~bl~ in'etat~ If,UcltnaWi; f 5~3:]i) roo'enllly'~ '( "d~tll!lil tlitGw", ;m, ~e mOdem w'Q,r_ !~n'tfte ,Ill bj'e.c 't,1 ~'t;itgmd. du~ ~~o'wbiI,I' pl\ophell1i~ W((~:'

~¥i.~ FO~m W._hncllGmUlc~I~,~i.~: slmd bel 'der:' ~r.fonchlUl(g a~ FhIlQmtnl"., we~luik t[b~(r.ltfsGh u;arwd pr;::UJ;I!:isch ft.Gu!c" wl,cblilc' .EqtebaiRe· ii~ ,eFWute.lit. ,~abhei.m.G Ulna mtJ.heN,I~e\ tID~u1itmJ£:buliIICD w'Cl'deltl :nQ'~dil' ~Ium, alld di~ ItddlltHIJ 'rgglclllI Wa\~ A_Djtwolif~n in ,erhal "',en~ N1i,~b~ mRr' m!ti Bc!oDa~

'L, "!, ~ e.Ib i,. L ~I' . " . ..iii '~]" 'l. I'" ~II ,.Jh:~ " ,_

g~l'l(m ~.eii e~lIj~ii'iIl]SelC]!e:m, , :mbm,lm,HII,g: u,p, M', :ml@(rl'~1I1i1l ,'Il:i',11 'SODyem, ul'e' '[eDge V •..

bIiiI~g d~~ lF~'IlI,qmtollwi!cbEe~ ini't ,zah'h1ru,~11,0m and~li' c[DRh:)rS~Dl'Jgisch.eo~ Eai1tmr'eD raMElilnils:clu:r WOlD Orl~F!lisdh F' ,N'g'Lu' \W~mln die' 'IJjjUDg da Ali;,;. li'IDe [ran~,~G:n~ S;i~.b:er a,t M~ 'da1l, ,hi~t • gDJ&l~~, tew uohud~Hnlr~- ~ Olu!I'I)~!l!l,glen,es lIai!;nal sicdl, dubleltet· nasI 'w~.rt mtJ, 1f'iim~Ic.b ~a mil 4:UI'" d~:tjUl.r 'b~itr~ ~et 'w "YleM:m~ j-,

,IA.,. 'D·"V'·Y~'I':; -~W" . ~F'.. ~'D"~ -'IJ ,A:y' ",~' 'Dr 7J..:~jD ;;tL ~ :11, , 'LI'., J.:-~ .L'\.,U..I...t.I:i ,,I;~J:~

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.t. LfH)2~aJ] Efteot

, [' mumnb.er ,of 6ullilriw~ ~mpCn[llDcb, ,', 'v,~ a ICOH'bdia, , eS"'Cct en tbe !m., ')m:1 fti~:liv,c: . .a 'awl 5,a~m '~IIl' be til ul:ulilcUa'~ed 'I .r:"m_otc~Cl!l~~ wWm is .!C81pabJ ~ fIif-pem:c:tm ~Ill' m 31et-p'idl~. 'COlll -queQiIlYjl IQeal ~cliOJ:l, i -, ,Ml{P.!t imnlmill~, 'ltJ h~t1m, ~:oric fo.W)d :h.yd!w,IIRh:moaiai:,c 3!d~ ~aJOll,'Cj it btiuI' sb re;j hy ,:1 '_' ~4~ f - ~tilD " Dlutio s' of l1~D'rid ' ,'p.... _Jl1. bjBuorld -"; I - 'Dd :6.uQJUi,e~".' .,:' 3Si:OW; ~e~11 ffm:B,liOJ"i,l;~ ~ &ydro,I~ed by the m.o.istlDi~ ,of 'th_ ,air- Unt[tOJ hV:dWlu~ .siiIcic ' ,id1~ ~:Hi:ghfllf' oi:u:' -~(!j :fluGri[!l!es rumr:bav~ '_ 'c@:~ i e ~:If~t.on ~~) .. , MUS me __ 'b;fiU:ies~ ,'b o~ rWll ~5ilO,' ' :SCMi'~y ,p:r:ovid: 1.11 ~ ,po_bill - , ,~fr 'Y ,~b~GllUio~ af lm:po ' I .C'-.· Polo~n, ,m _ If am:- tltWl:lgh absQf!'tiion ,hlm d:u~ m1101ll'Wi mm~n - ~

~ t eM em-~' nlth CI'~.oJic pr;,d j~ l,.,U imlo,wn :m J1HU)jJ~,c't~.J and] illl I.~ J '~m.ofY" Inpml:!UQc ,ilt. l!AJ ,= , d (:II.t m, 'lly IdilIlut d ,sDbc'-- af byiJNdJ:u.'OriG acid am not da~remmj:i~-~ , . I O'\V.ev. .. , 10 til [PJllI,t ~:teD~ ,d>~hdl' U[pP:D, ,i11.01W mD'Q}g' ItlI*i: .1fJu~liIiCe L ~ [lG~dl to. .~cl.~r,1l "~[tQsur'e c' us:: ,,[IdrI~-

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1ft du: :,' eGUI I GIl 1 h~p 8uoriEle ~ iii ',a, mar, cd ral'-ect .po:n 0011- jUB ,;md muco__ m'NJlbnmel illll the rapinlitmy I' _ - I '.:: 1m' 'liM;J d, "e1opi~_g iBID m'lammamry cl:rtn,ps., .. hcmim h· ,_"' I' to .do 'm fluori e

CHAPTER J

1 ·.~T : XI' ·.TIQ

1" 'IUf'.A .. '~I iYu\. '".'

A fUl~,ber Df :fIU(H:'ine rnmpuftld 1:1 .1 ~ fill to,Rodin efU::ct 00. the &k:rn. The ,9!ctl.VC I'IS= ,~O~ 'tm be the uqdlis!;ocirn'c d HF-'-o'la~]e, w.hi h. i· c~,p J~JI; Qr p,cTetr.a'~ni· iDta~t " pider:mJtS ! om~qUmtly~ Incal ~,lttio.li is Dot 'ClJDoo"d t'O bydrdluCftic gr]. b:'yd~~Nh;u' ··.lio~ ~. '·,dla· n]QD', It ~~n'l dnu'l: cl 'Dr an.dd .. ·

!,£J~ng lrumuan offill, ,tia,~~_: .ci:an.y 'b~I~orides OO:id lIu@siJic~f"'~ . G .~ OlD ~]j~OD. tc,maluoriaie b h:&a]~ed by ·tlle mnjs'turn 'Df di~ _'r into ,b,dtcfl1lO-

~U- ~e acid. S,l[ghdy .o'lu;bl'l: luurldes· ru!iO h5,V'~ ~. [n"05i,,~ etFect on m.

ICdI:J~ lI1u~mbmues~ The' o~dinary skin l~lls s~uc_~}' ~'rt'iW~; 'We ~o~tn.Wty tl1famy m.bsoltrti.a~ ~f.impqrt~ce;.-Pb:m-~DP~g ~aJ J;'JiSc thm~· b -'bS.OrpitfOD nm. th~e nt'UltCJU s. memb([liWi'm

The ~g-.o~ clI~D1i of h~afi'Uo.nc iilIld.:;l i wid] b."'tlOlW, in maD, I an .:

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Dliiters aDd, U_JI -.' as' eQll;m!m-'J 'j ,~-~ aile:..P iDfnl iU,ppl'll"sdon M.d~ tl'i!~' h .

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N:~:UlSCo. ~ ontiting;

mum~ pM m Ihe

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1lu~ ,bl'lpx.a:enr '~;Gnl p:1i_aen: ' 1 I,' I me p~CtDJ"iC ~n reduc d faml. In 11li,

rllporl~, O~ by ,KrauW· ~' .'17) bl o.b-uV«i ~ ,cop iil,em: 'bL - j,. of tmpern1m1 ;; In Od:l,'tf .,aaa (6g,~~ '1\~9.} there 'w~m ·rra.imry',si' ~' (lrto~ - '-rphd·tiI. UuaUy :.~ !lfDl'P~oms di!cd a:~y in tb'C ,oou--e ,aF 8" i-- d _,ys wiikout ,erWJ111l c_:t CQ!8equleD~ - ...

,- I,c;u~ i! !lClr .. e 1~g:M~deraJlI~~, ~UI_ft "MJlI ililJ dtf Ji~e: w,biGi Ma~' timom i¢a'th a€eumi mDl!t ,t~u,~d.,' '~t is. '&~m 6 m r D ,h"Wlni'i .u:t_ two halW[,s. 'il Dmt ·rare. MflfC til m ):~llunufi5~11 hO~.'jI i-s;,. VIr? oocoBldf,01t., Il~'afLuOtit M!iCl'm,dl hyck'Qfiu,oollieic arld .•• dtmmCilv IlnAG;" th~ ,hft:~.~ Gtusei i~· 1~al:V l'5tBid , .; a:hHd, ~I~/:I l'e. fS eld _in .race't wed, ,jill the ~itJunf: 1M f.i\r~ ,nDnnta

e, M:a~b:[d Anab)CQ'

~[O tna~y e ~-- the po.n .. m rtem mvesogafiolH it' ilahh: a:rc ofUttle v. e· In T hie 5, f ~av.e~ u'm.-marizGd' G p~fjldm rqarillng thc,z ~ in Vi •

:Mcfdp '1 w~ 'p - i-m 'itt Witb one ~J{€:~'prlOIl th«l 'WW acu~ iD1Iammatory

~f immJ1iD;[I pbc:nom.cna in the Ito-mach. mort 0 leu marked. Ia aoou£ halt

TAB()

Prttq '9 'II . nd'" 1lljt#m in 3" CD,Ii I Iqf . "lJ~ PdM' Plmrri1l:4 Pai.t:am-·

II i3m- tm/l. III • 1111 !-. a ,. III III III III I, III III. If' 5 '!' -oil if iii !II ~ .. ;aj ~ ,I, ~j - .. ., II ~ !!" ... !! ~. ~ ~ II II II !II ! iI III • II

PQ_i~B in r bdomen II I .... III II II .' II II II II II. III .. • II II ,., III II II II • II II II II II II P' .. '!II iI II II ~ II '1'.

ill II II" II II II II II II !II II!!I!! II. II 11 •• 111 II II II. ~ ill Ii II II II II ~ ~ .. " II. II II .... !"

n_iflJ/ •. i II !!I II III I!! III IU I!!I Io!1 I! !I' II II! !Ii !. II' Ii' ii 11'1 III • III .. 'I! II '11 .I! III II! II II II to ! • I II II Ii II II II II I. I Ii .. I ..... Il ..

P~wl~ .. ~ . ., ~ III !II fI II ! II 11 II IIi" II ., II II .. II foI I.!! .. !Ii III ... I' ! iii II oil ~ II .. I ,. ~ III. Ii [I ~ .,.

I'Mk Jlllmlll!l II! I! II !II II II 'I! ! II !' II '" dO .. II II II II II II • II II II I II II 1111 III II If;ll ~ if :1'1 r. II 'II II' iI!!II iI II III!'

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,of th~ ~a ~~a-CI=S ilIf ,'1,1 imibur ft:~UUr.l '!/tV' fo-q;nd in '(h£roaHi mt ilM~j' in U s: It ' .' fi~ ur,th in mo!lj' md ee o:phagu.s.,,, n lonly oli"'g;arnJ e ch,aDI.:OCCUn10 " n.~t ~tr irrh£s I '. ,j'!th .1 rn;. ~ l,- • ]j '. e i' u" D,CY' j Iii· lIS 0:1 am, Rsie-

rn:pirlds~

'ChM es ~ 'the m~m'!i" ~1i'i(Jfi,',ririd (}M~jlld'R~~" ,and at llim _ in tho ~wf$.j Itbt, t!!(jft p.al.ai":· ~_I to ',~ J3jf)1.~ .~, lObs. d o.~ly. '. en 'the to'!dic !wbstarl1CC j la, ,0 , luod~ ,a~id ,. f, b"ydoli rl~o iliac ~'. Tlly,- ',- ra:mer urpd",eial cOfl'U!iom of di~ mi~~OU'S Mtu'1lib>mW1llmj w'hi .. ;- ~.nu gn:Ji&~J-w'iIU ~ -J' . j'f ta n ~d or CD1~1'1.·d1 with a '~bfm 'tml ~

,

Ttl ,··Il.(JU of ItH~ ~t1:tb. conW1Zfi: may be ,addj '!btl aJlkaJimie 'm'.j !U a ru]i{:-

"tb.t[1 tOJ' - 'Jt~!£ '_ I liWl· as ·tID!. .'. ~n.~y tk:e ICO]QiIIlI.:rwn m~a . 'l:h pr.ram e -_: loJ'blO-CiD~I. h'e' m.m.s t. .fret} ~efJI·t e.h I!DS~1 in the jOS'tri'€. l1m4;OlJJ ~. 'J1d;.'Il'M Me :S~~~ .h~~a, ,a:nd 'pp@di~ ble~mp~~, . sp ciaU,' iuR I~[t p)40 I·C ·c"g10D. Tb

:oiUf or the :mu.oo[· . melD 'ra!lC' mar v~ry:p aJ'thou.P a dJfru~'e fCO" light'::r 'IOt'

w~er.J IDee :m:1th - o:~n. '.~: .P· .iaUy ~nMll! he 1· 'e:t CU.nra:M'C b},d!. on: f&.

t;QIt o~:: ·Ut, folds, ,o,rdl . M1.U%HU' IJemllran ·th fe .. f.1. ,$Dm-'timrr="gr~b Qa.no!~ .ED'Qs .. n f,nna.lti!O:EID 'F'p .w.:wall ctn.U;t 5.·, ems to ~e r,re ~rw ·.b Ith,~· Ul(,)]l1br.'ru!il ma:y cern 'to.. be tann:ed ('It} a~d. have ii !~tL' :nd'~nl 1'6' ~.I). '1':' l~t.~ h! oo,m~ . 11" lB., iaS! ofu mtane "in th.,· 'fb:n1ll [0:1' ~~~'., - d n.~·~Q,S~ ,GW wmQ.~e ctiB1u~ d - ".- cti·'a:

TAJ3r:iLE 5~

hwr'&l",u-ArI:JItiJm~m CJi4'Jig;_" ~~. ,!J.I ,tlUa til . m~ Ei1!;(1m lw.btri.tQ.non.

d.lIGdc:nwn H,I mMldcm~ ~mtC!l:r", X'YlO caR!I~ wilefe' Ute ,ill~

fe_red to ~)' rmd ~~ • t n£ludal.

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I[;Om ' nDd ft;w,iUJd o:ft fl:u:qprcd "; 'h-'-yay;e iy, lD. in T~!'bIe fi'l' a.' lill~ Ilo' ' b. -H, l'maQ'G" b-. t"W~em ~e dose aJQd ~elltb, I fiJo,S -· .. 10 ' ,c 'eta) as., dfnU ldafis 15 wDlicl', I bl· :I to ,[8' . , p. clll:1l illJaride 01' sodlum IIlw.silitw[ _:_~ Tb,c man~t qu 1 lli1ty 0_ '~~l[j.m thmoridc d13 has ch~'ed dil! 'I:h in am ,;uh,tJ:t im;di:vidupj ~

bouJt ' ',' (5,' 9;) - .' T ,w urn II u:mdlcfl" dm.~ d~ 11 .m~eh ]o,w.-; 0,.1 '[0 I I!I"

{J,I"I '2,J')~ ,'," - 'tJI, thv bagd, ~, ttOOe dosa an, ;!i'UrpriEg in tb6t up M

'I· Qf' 'odium :Duorid~ has t.e.tt mlc;( ted, ICC sadiulD ,'u' 5mc-ntc 16 t~ a., ~, W,' ,~I !€I J:chui,,4);y 5mn1J' a dos.e' 33 ~.22;B, ~ tSOdi,tIlm loof,ide I;rt;·c distinct s;rmpi(lm!! of ~isO:Dml (".tr,a~rta rab~tn" S ilnd _ omiJ1:ngl.

Tbell! ~ no l IU1.cicn1t III tcriallo ~Q, tJle us tf.) decide bJ'ibu tb£, g any dim ' ,- cr: in the: ,,' ~'ly Of s,' ilJm1. fiu oride 'and !Om u:m .8 OIi,Licarte tholJlh thtn'e'iJ ... dm-~flltQ(e in wluhi:llY ,llId IIIDRne nlcn':; , ri' ~~ .c , to lndteatc tb l dtue · DO.. ,¥ ·otluori cicl Uld,ydmfJuodiae=

29 :p\EI,t£~,~ of iii n1LlicOU fflcnlbmnC,. morr~ ~arely io~ the IQ;nn I~rr mJaJll ,. ., l"i:d o'llsio~" TJ. hi stIDl 0, ".Pfl~ r~m.i[DwtiQn IliGVleal D aeu'le se1!l.1". r: _' bili with cd[ blfiJllb",nd@fiJ h~,~.l o.tcl~tn" Md Dl::cm '-:. •

111' t.be ImldN,#n I ch· dlli~~J!lI' . re both fi'U',1!r ffn.dl ~ :p:r~filoun ted" TIl piC! t1'if-::

ils infla:~n_mu'tory' in elta act r, wH:~ sw,elli h,p' ~ D;~,d : ~ - I bl- ln

:in lh- rnuecU' m mbr, __ D. TIle d:an . 'in. tTl ' tIl,:- aL~ : d, ~d' U'IlIi'Ii1!,[

, . ft'· (Jj ;nffi!- c.ltcd~ th - large inlles~e, itS ,rUle lJll(i' ,

1'; 'e Iddmu. are au I • Jed n\,mle:r !Fr., q\llentJ, r. in 8 ,as· fi un - of

a ' tc.'xj Jl; pluitl '\~I ,j].ype'~~~:, H,d m:uy d ren ,31'U - , O:'~, ~ ,pit:he:litlm i~ tjrJ;e ,;-qlll,voJu~Lcl It but. i, 19 I' e ad ;- r ,,~' one: ere ar ~b dl:ruBl~Jg!C ~'i.t arc 1 Ul be Ea,sm,~c] ".' p _:r~tL! rnlEi'fly tlu~:rntCl'~-i~' r -b· S _ hie .'i:1illf,llll~ 0: . H~'~ :$]?IDu_ Mld 1,1UlJ_P, ~ R'l'Jm~limie, the.se ;t or c~rrooi~D"J. The ~hd'O:ml':ninal rawu M _ o~ n .Wummtc" l:miIY ~ Fbw' I~em dlQ:~e isl '~rill d! :~i:" IdO:11 in HIt'/! ~ t ' ID~ ~ and iIl'Jldu~:r 0", I-':'~ ;. Iitt ~s p[>D,'b~bL di't a S.yll~ ~m: de ~ , .. ~'bO"~ 0fh:1I! l~iLI !Of iIlWJlE.'C 'Poiu,mllllI l\1'm ~v ttJ ot~~r IJccQS nf lh~ -:I~!~lopJ~ eflln:,t i:Df 6, mill.~ 1tffi1,1lJ:I. moB _ -:nO,r/ ]wow».

: 't "l ,I . ~Dt'''' ·'miflli· ~ '~u.mii!tance that .• ,n,

- ~' I t(ll __ !III • - .. - IIr.J

,~gb,t. In, O!DI' ',L, ,brig· , cas~ (S,2S!) !1l11~' ,-

i3.1t I~~ :' I eo! f! m.m'cly hyp ,.,mla If ",: 'g8Jll'i, ~- mf~l:Q.l!S m~m:b~~ bot no '~ "': Of:.J· mng f5216.). ' n eenelusion it m ¥ be nt~ ,"OB - _, tlU!i[ o:m nim:~ 'q th - r ~cl ~. ort 11 [ro u n - I WiD ~e mrmwruingly w,c:U ,p!j( -",~d Ind dUIl;t in ,n [In) . I!I'~ '~b '_ or· "C;!1I',t h 'h e:Q pos:;U1We to ' [ld, fluonne in rJiiLC Itlr;nn3!t'& :OOD'lteQ,(!; ur ~: ~ Cll'rgamr,.

T.rl\i§l~1L;I

.JJpPIil· ,ifllQiC YDt.; lP 4niJ L,I/trll Dol ~n.Ami 1fwfHiaf, p(Ju~ninB in flm.

mUit be auum :- ,to iav tbeh.i',lhls:t d~e tQf to~ejty~ w~ ,bow ,of _ &w

L] ~~' ~ ,jCcL, j ~ ~.. t'" 1:... ! ..II -b-_.JI b

~ tD I'l e ~ to uetenmne' LUI! ~tuU mtD'JmrtollJtl, ,':n J. cas,e' JaClCfi: 'OU ~'Y'

Bam.. &gIl about .3·3 I· ~$:Qflu '.~Uci~ ~cjd e uSld 'Enerelf a ItriuD_IJa_f7 iatosicatio:n .

hC,..Ee e ...

9'\ Schwyzer (~~3) published a case. Df prdlllMed ehtoWa: luonne

DDilOltii· .. • man who f6r a I 01 time &a"d clmd JUR' quatltide.t of ~

'mp' to 9 4-10.

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b. Poh~iWlrfl' wnh C~'01illtL

In-'h,jt wi-nl,er of ,!Q~;:t--:'3~ 'l~mm1l;1J ,- M~fJJ]' :r uti Oulj;cm~!l {t9,1} ~"1ImiDcd, ,a, D\u-.,lir ,0' -', ,p:nl'i'itl'cn 'W - if'kc ~ ,','I - , "ii[lG')d . m a faotOJ;Y wll,~ ritJDltc (':," I~ ~~ , .). iI cl-mn ed aB,d, f:lDl~,un;t, JU~jlig tit ,a,Jrwlth 111'151(, go out of,S ;w,orkss,. marlf: as ~wc1[ 1M Cc.ma},- j 'iliad a" ~cwJiargdcm:ti~ OO~'!I! }£--~ti(:)n RQL p,mvio :ily Idlesc:ibGd bl!mt, :nQW ,FW~~ed II.tlll" ,~,--:.'V ,cx:mjDatiC!!iD.~ 1m D:w:l)0lB1~ ~

I m'rnlj' r~

tlu; affection had, - ,tt ' ked all th' 1boF.l'~ '0£ lb.e Drg-wUmtr hut the vm.Ubral

tdlumn and pam i! ' ,paF"' _ alar,

'On tI:le It .. , ~eB ,late th "adow or tile OOnCi ~lal bnormal denlity. The ItnmlUl'iE Wld ;d~rid ,ffinn thf.e~dln! 'nit bblrdog ,of tA~ WDaID bW~ to •

~o which thJo.1G bad Ib :::. - added - pr e '~ Ic.a~,-' Y b' - _ ,any '&~Dg '(j do With 6tUDritU:. r~ wiln srmD,ce te sb~, tile' ,m;a.IIC',f' m 'which the

pr _ - en ~ If II l~riI!t ' - dlPm~IJ]' at d; (Q ./\ ,]_ ' _ -, plitti!t W~i ,Jio'udr ~n b~ c r-

-_A .' b' ,zt ,i f \ 1b...iI..J':'" I dl ,,~'I"I d

1I0Q d ;iiD:,~e-[ v. 'ponz If -, OO~ .n ~t~ Il::a:.-, I, .ui:e ~um om Ill' : tSl'WJIC1! WaC-it m ,u

em - - - kd. h~crodl snPl,pW~ mused an odour tthicih ',as. fd ndl! d ' , dm', 5DlI!d.I osF ~~. _. genfl:uprid -:I ei(:i~ N'oB' 'of 'lite, '1:8 i-:' eord d p QW " (vm tlLow ,tb~ pr;{Jbab_ lY of t~c-p"'Ben .' _' Df'B1liO:Me~ Sehwf2Ie-rl eE'e; ,do ~ DIliII''L sc~m t~ ~Win ~'" llIDlIi],USiUai] ~,laiIiJaJdo' wi 'b .: F'd to ·the - 'tiarnt'.y.,

'au r'~s 1-;~' is, _U 'OU5, ;'\'\1' mrty"J1;Jo _ '1,';' old, man 1 n.d1. if,), : ,f~,'tml

~{u:kba~·· j' ete, W·I,~ p£cpaM'-in ',' Bodium a~o!itiiati~ ~Q:n I , 'cleol a'eu~ 'guooe ".5¥~P[m.ms ~n~ m:flil!IU]illBJtilo~ or C'QDj UInC'tiV\ aodl tb" m:!UIDOUS 1 emhf" ~ de tlle~ air F'u qr I.. TThle. ~-nf' ~ambl..fJ!.dan '. ~O'wtd m/uldpJ,~ d~ru-C~l'Gd 1;r1C'R5 ,(if 1. 'u :-wity 'j;n VaDDU, , on., Weise [D th,- ja2l,ts., OJinially fl. -- W ~-:' artk:,ulM" wd~tlll :~d It,-nbmess.au,-'f, e nclu:d_d by ii- •. - ia.rdj'~g dife: ~,ft:C leli, -g,,' , l1WbeR.tiJ:I'-D' ('1ot) .. An J~tual 'I; ougb ,SOm~'t hat ~tu;n,i~t~,' .; ~ lor I~hroni~ fiuo;rin,,' poisonl"l 'w,~ pnilbrs:hedJ m r 93~' by S~dlh.ll.:: )'lcr' (il!'~?" ThJ ',3 ,l"tmrme:n:-, w:~h 'tle"y~o.m:s, fn:riUDar:&,tWRID. a~'U~ ~~i ~nUCl . iiS co_m[l, Il,b,i'e!

D. '17'IiJ rnf,'"ILd' 0' ~VJl.:.a::.I" ' ,

•• Ii!'; , I

of ' I C' I tern J h, i '_ ~ng ~l' 'M . _, ' ' a

I'~b L ...!II,_ A ., '· . .JI '

,Uj n CSn UJ.'Q"':~U!l)FU~: ,21' ltl! - ,'(D, ,

CCI11Shl! ,'," d;uc m , 'kI!;nlfjl,ti,n;rru, ;~f:l!o 'pl\e.siLili~Ui.bJy I tIfm~ I:i~W' of 'a, dlepositi!cUl of alUW'll fluoridl .m 'th beees, B¥ mens ofexJ'rim"-,~ 6.riii :iral ~t: ,de.mol1sItnrtl!d I, at lG'.FJo~i;tc i __ .: OrlPJ: ]1 b", t trH!) '1m . tQ'mI i I IF a bt, ~\Ih -il~,1 r rbe a , ~ Qlt '''e c.hm;, ~ ie pfl,lsamiQI' W~ ObS'e-nI£d,.

to e a ,QucurMOG ~,~

e. :M'~W cd B'fulm E:~

Th. , U ,·b m tho

IJt¥tDuu:.. h ' di!- ~q - or aD,Qm ,ly .iSI 10 :fu dl 00 5maU~. f' - Lcict· d 'o~· \ 'lf1ihidl

mgiiou gd. ~1J] jl,y :t\IJ,eCll~ ,cJill,~g, w,llo ~O:ft :rown DR OD lhe ' p~ t,' but a .hi." p.:rn - ,llaJ ' of 118 m _-~ at: _,c,t;it ",uly til p'-'lml~lem:t f .Ii! '. ~ o.~ted:t Ebe d dduo. t etb ~ l'nf,' 11" In the mb,io th , ~t;. their' _:_Da -'I Th_ eh pi ,.c ciftwa~d!11 wlill mat 1n 'epl ,qLii'L~ m:p~fr,~k~ In. 'dI~ tint pt ,'_

"': nam J in POq 411' more ~dj mCly l' ',;it Jii -rmal. ,RIo ceil,' - Md b c _. ' rtwbid, wlrddall· wi1tJ] a ton Lbat recall, chalk '&r ungla~~d ,pa,-f (m6II'1 tl)~ .. ehan 'i _ltc-,dly 'ObsClt\l'ab I!:: at the eruption I&f the toQlh .. 1m tho Se.bilUd I' tl ~u nan a cia -II pjp!t. _, ~' I u _ '-e~' depc.: ~Jk:d in th ,de eoli~ ~ (st4jai). The _lour ma" w.rr itt in~I,:naity., &,om )'cUo,'w ~ 'fa, ,WJ], 'tOI b e to arc ar "I~,'..111 ~itf.,u,bu P ,tahca or. mOR ~c~ar tmllIIVI~. band. a_nd ate mi tl~ I ali - - to tb~ ta.bi_'_· ~ ces or'- '. n and ....... 1Qc:II. t· to ,y tb re exp05.cd to the Ugh l " Ig.. J).

,PLUG 'm

Tin -, ct~n, .1- :'C_ ,tb-, K' ' im 'tiJc-' ~:mr "-'l::o.r -,eth, ile-p', , "

UpDD m" lGfru,(th ~If F- - P. _nlDd m \wlic:b mq ~jMIriJ)U& fac~r h, woW'lU!d~ ,k,

I. 'ennall,~D' 'teo'- C ',-'" , ina c! rtain olr1i1" i~ tb- :p - -' od frODl ~,' ul' , :' ~ L

m, wlc age at :I!:2. Dt' 1 ,,- C SJ),ric&d or IW . I.omily ~Dab m D is, I' I J~,ull-' of. iQlw' loD~ me' ,injurious inI1l16D~j_ h,~ I 'Iled .. ,.' -'Ii< does lXl't s.eem ,be:: "l':tially ,&. _q~ JlIiI~ t, the "P,1QdJ,,_, "tell a.1~i!d '~e .tL~. 5tU~ til!" EBIUI,;l :is 'm~we bri~d i!baDJ .IIJQnna:Uy~ i ,~ndjDed to Icbi,p oJ[~ a,ntl SUm_- - do ni')l~ 'o;l \Yell~ -, :be s -_ '~ e 0:£ th ' 'enamel, m f .mow '~meguliriltid~ :P1l"-:,f I ," '" 'rieStriLd',d I;r,cas a'

- ypop1Mia, C?J~i-' ~ P81l"ri'y d:u-_ itrn real !:o,ttcJsi~~, a' !the. Dameil-!! In_' 'ot:th Alilc-a-

'b. :'"f l' 10, ) h d 'Ob.;l . ..;:I, " _" - C- -JI ............... , .... ,.,-"L ;1..,L •• ib ill .~

'''J_Ie:Ei-, ~,'Y'I ,1jU, \:~-, I', M, '~G,- ,~y. 1f:J, lue;Dt~i!:~ stare: ~if'~/~ W,iII1i!:J,I, m~ ,n-eq_U- 'C't

,. ," ~ , ~ :::;~ 'I iiI, - , .. - - -'- ;0>;1.. - -"-L _" ' A', , _. "

m '- -, I' ',' ~ - es;p ,COOJrY aMlQ,':1.la V'C'SUlf! lOlII~Elra 'ILl!>! ,'1- inD.G( 1 8;' ,'liete

I (501);, Ib- dJdiJDl .t~,y be ddayed. and tl'rull:: p. [iJ'D.an~D,t teeth, s~me~~ de~a'te ·r:~~_,-_id~bIy. &rom Ith n. nor-maw' in, size slur Ie -; Jd -pcMd.em (,.: is., r). 'The 't£'- Ii; ,are :Im]Qt .' 1')" _- -' .iJawt .I:ud 'N'r' d(,jctm ~I't an 2lbnOlm.al If· ,t~ Qftcm in;;q~l~l,", IChe~m,1 ,I:nd cohl1Dmctim- .eanse pam. Taf:~__f'Cflll'_~ns and iDfll_ m·' a ~Oli rfilrf gmprv~ Qri, IJ de¥el,tv".

(wJou~ I 1;, ,tn' tilm· o{B~ c- aDd Mi~:'Klaf .inv,a.ti.g,iui._ ,:'t w the POP~' Ill' I til 't I " . _'ElJOBIaly Wa! ,_ :ociatei1 . r tho ,drimkin ~ ~ waee.r. esp.ctiall,), !tDm arl" - ~ a - wdlJ .. Wh e the we ~ , up(Z'lY' - : - cl1 'Dlgte.d it W,M) poi!~'ble 10 -It9It the d ' ,dOpm'--l 0_ tI1~am.QRI !Ly j-, an ill ,"011. naJ'iYI~ of the :iLler

!howled nodaio8 abnDfn:nd., how, Y I'll ": Ka1 bWi ~;u:eu.pl£di .-~ wid, lb.

t " • n g. b r of w~t _ . [~5.,' ), bu c" - tal UJe ft m I ned lI:nc ear d led

ftlr-eraJ untcna,'bl~ hrypstbcsC! (JOIZ, 13(~ 18'1 65J!f)~

R ·arel. durim' It PI it I years has s~lv\e . e-

tr~ a:pm& mv. til do -ey Dfu.s ',reel the P' or 9uorid in the

Idri~' Witl1W ar .Ilarmd~eJ i\rkaDJas~ W&.r~r£ m.ctdtd ,emdnlel - endemic .. i~f ith dBs Wi, h "s il1~end;" I'. 'wThill (J. )1 i f 9,3 ~ . am.ihed a . ,~eI of dri.qJQ~g-'\w'~e.r ·stJLmplr.s &film lnlt-io'U'S puts of ", ..... 'i, and WF ablr:' to al CI iUh~t, ItO. a c~rw.i'Q

_ . 'elElt _ ~. iu,onn c n t· ,t w~ pitt2ill -I '. "til the 0 Oll en' 0 the f eth anDma~y", ~lJl drimkiD,J \J~a,~-' &' m Iv~:ar - whcr :moW d I .afDJcl.· ende m.i 'JI .ht3 ra~ .fnJm ~D 1;3;7 mg .. Hm.u,ime' p~.r liue*), In ipomDc':- (I d:ds mnd~ . ,mU'b LEIlmJtz: n.d 5milt.h (':JS) at me, same tim, 'wc:r!ll; experi'm; ru~L1 ,- ¥ti:m a co~ l tion 'M',I - ct I 'fea:un ',0 'e, ','tgji.\ :_', J'i en1bl· mo tied enamel, by ,~,n I f . ,m looncen - 'it d. drimkm . WI t~r. fram ~ a,m- . ted ,ar .. Thy aho ~hre~'1' , t.

t-liHD ~Q ·W,'· 'ifaJc tlllal1 (} , d~'1 tal ' hanges wer the sam '!ll ':110 ffi~_,_d by

. ilCOOUUlRl a:oo coUaboDto' C53S) in ~ 925, in' --: J . ~. Qr,' off.' 1,' O{O) I • diet Icqntairllng &pdium fluoricl!e~ L~Eicr . _edm nts onr~id;s dags a.:nd guinea pC (,;:p:J milfir..m d UlC ICjOlrecm~ Qf ,tlits. 0 hsenrlll, · ODJi \~hi:c.bh3:S ,~imu::.lC beea fbrtlter , ~_!_ 'D"mJ,tl j- oth er qu r ICJS. For the I ,en al dis '8JSe C~ urnng' w,': er . Am!&i1i. , .' I!!I (I I :1) ~aii aill_.1' _ ,1. UBV ~d at tJi" s "~ II,,' i.da.

W mil, now rend i)' as BD'i'tablimcd fact 'tb_gt me:tp1d '. lIlUo'~ i ~s:us:-.:

'IU.; 1"'] 'L:· 'I iilm.... .,.. ..lI", 'N'~·' 0 .. L -b ,. r ,.

uy: R· tiRJ,y J:w:lg'i' nuenae cn,R&en.~ mD uF.H1hdU-::'- WiI,tl- 1/ 'm 'UlJlI- 'UlS 10{ '-", en-

Imee in A."lzOD Smilth al1d .: ,:midJ, (1~) J;iO'~'11Gd th, '. the larinIdb: wBller do, DDil contain mare 'Um:ttn ~ WI'" ,jl;)f llu,Wl ":n:. . per litre- in, ]10 c:atid~ I~Bt 9l -. ' ftiC1C crr

Wl,t en 'cnamt 'J', tJ:u~. Bold) val:lI tics: _ ,,~ ~~i nig,. ",' t dlJS !mn.c.e.m.a:ati'

: mour balr'lhe'p~p'~ b "" sculld teeth balfb "V"~g_, t,d,,_ ,'ecmof~ll,'mwma1y. Th~ 100000Cen-' ,titm or :!~5 In~.. ", 'iii -ht'~ ;m ·,der; .. ~e' d', p' 'fiS~ OV.re~ !j. IDI:~ ft~9riDe gt'V' _ . wpd r:~t ,to~' _"'. degrees f m( ,u1~d, 1Jj' md. ~MWlOZ fS"g' I arrived at' :imi.~BT t~ll1ld vdua 'b ,anrurB[O.~ ,tb.-- '~I' 'w,~t~ &wn 15~1 WfF~nt tD~~ 1:0 ~ntil)a. I:n. l ~er. '\v'0r&s S'm1ltl and. 'Otl]!)a;hc!u:1i}\bon (7'3+J ,,- I) m e Eba:t im;prGlVed ' ·.,Ialrsi,_, tecDmquc' 11:~~ ~h.own 'tha.t ,'11~' tlwG/urld ~r(oTiI"R b I ~g.. : IWnOl r'. . lilti·~

~ii Sin.ce motrled ooa'mel ;w,as, dl. mb~d m f91D ~',cU e h.as,n~. , neopiqd in ma.nr. p.- rts· t ~;[ is abo caJl~d fflr;u1r4' fllflJ' or sb,p]y' rM/~ilg.1 m. Ii or.tD ca ' - . Ufn d~lIS IS ' m",lo.JUi'j' .i:~~ -: _ Q;tina, til : ,I1J3;QL":' d1m'~ l*,tatifM. , ~. . '. Dean (,I. ~) in , ark tea ('ISS colle~t ~d the rcpDl''t9: in dl;G U., ' . [I and mpptem ted' em ~th, qUcstiO'D.fHlbc li ~. dow 10, __ ~ ' .. _do · By thiJ nn:3.n:8lJ in addition to 'the 1'2',51 ,akeady known locallici.o in, many

Lu:~ Kiva ~ 1M ,mil (p ". m.)li

pvan .. mi'. pu inc. which ctkalty

·!~;I~"' 11,. ~,cgi!,5~d iO'thEir. ,.5 d~i"e m:-e- -, viU a 1:1 gu towm.: 'ill nral ilJD:... 'tdlllli, T:B;.EJs;" ~rizOna od 'C'o~~mdl!) b~! &e ~ 'rIll'es mo_"· m 'tea" In 4~~ rh db "asc, ~.al150 b~CD l' ~o~)~d bRl~Jcolll - ,~Jl.ruy tlI itOWD ,(!IfD~' ")

ATScti'l"irnia, I~~' 51)! BarbflltL _ s, ~.d. dtce Baha~ I\!;loodl~

:-,11 ith loe-ummce in ' ' "'~~" 'w' Jl 'y,,' Di~JIiy I " <1.-- - ,- -COlD s, .' ~ I I" ~. ,CL

" "111.., ,.;Ill • d '"' ~I ... ,_... 6 8 &' •• ~ "

:P.ieigW~ (::aiOi!~' 1r1~nIDeQJI:aU,W' ,~:ti1lJtcaiIJ ;~~ieClb:iJ,D IIllIJ 1'9:r, ~ lUl'J.!~i rmtjt;l, ttl thr'

'£B~" ~I of Rome. 1 _ I" pam and Eng] m,d, 'od robabny -, IlJiIl,Dl, the ,~ "'_ "

• ". ." ,- '!II' 4,j!. ~ tb cli' '"a ~

,~it!il' been mcopzr;;d urn Ilwwt~ a!ll'~.. lI!D nj',~ . = ,lei 'me' U :WI":" I'" .p;ii\~at;J1 m

M,' '. J 11;'0-' i~a_:' d' '. 'Dro~~, \vn" r ,ill) hnlf plio_pi orlre I...! po, ~ , , am:, .' r u a1mlm,,~,WD Wil tb,:-' ',i~A;t p.m.S!jJJ~ ~l~d_m L1)~'rtain ,a:t'ts 'of, !C,u'b Afd'~a~:as Wi", l~ III :lQ, d.:~,~ _".,Qr,e_ I and, - c 1,',,'"' 'p .Ve(rde IliaDd'S "",ll« ItDI" wlred'_', 'OIs0rtl' G,r fb-:.'~

'O~ "~rfU:eBC~S ~9~e", .I "dv,a,11: imr:onm~'ti~[I ~,~~ltaf' ([l44)' In -,~dQ the aI[~ctWlfi b~ beftJ dl~riJb-dJ trrOw ,sv eal places in "'~liro1th : :"bt" " (~;41 1 51,) s .. ~a J- pan

(5~'