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Anaphylaxis Exposure to a protein or Hapten protein Dendritic Cells Antigen complex Present antigen to T 1st exposure Cells The

Proteins are being Processed by: Macrophage MCH protein binds peptide Dendritic Cells Fragments of antigen (Presenting cells) protein. Presented Externally To the cell surface Bound to MCH-2 T2H (type 2 helper T cells) cells recognize The antigen MCH-2 Complex T Cells produced Lymphokines Interleukin- 4 Provide Signals

MCH-1: Present Antigens to cytotoxic cells MCH-2 present antigens to T helper cells

Plasma Cells produce And release IgE antibody into the Bloodstream Variable Region Specificity of antibody Antigen induced the immune response Constant Region High affinity to IgE receptors in mast cells and basophil

these signals will promote Proliferation and differentiation of antibody-producing plasma cells 2ND exposure

IgE bind to specific receptors Mast Cells and Basophils

Sensitized to Allergen

Cross Linking Happen

Activation of phospholipase Cytokine Gene Activation

Change in the membrane of mast Cells and Basophils

Primary Mediators Secondary Mediators *Histamine *Arachidonic Acid -Vasodilation -leukotrienes -Inc. vascular permeability -Prostaglandin -bronchial constriction *Proteases *Chemotactic Factors

Causes them to rupture and undergo Degranulation

Release of Primary and secondary mediators Smooth muscle spasm Edema Leukocyte infiltration Mucus secretion

Cysteiyl Leukotrienesspasm of smooth muscle