You are on page 1of 1

Bone healing

Fracture Rupture of blood vessels produce clot formation

Produces Hematoma that fills the fracture Gap and surrounds the bone Injury

Releases by Degranulated platelets and Inflammatory cells: PDGF (platelet derived growth fractor) TGF-B (transforming Growth factor Beta) FGF-( Fibroblast growth factor) IL- Interleukin

The clotted provides fibrin mesh that will Seal of the fracture site Create framework for influx of inflammatory cell In growth of fibroblast (that forms collagen) New capillary blood vessel (angiogenesis)

Activates Osteoprogenitor cells from: *Peristeum *Medullary Cavity *Soft Tissue

Stimulates osteoclastic (bone crushing) and osteoblastic bone forming) activity

Fractured ends are being remodeled Simultaneously. It deposits subperiosteal trabeculae of woven bone that are oriented perpendicular to the cortical axis and within the medullary cavity. End of 1st week

Soft Tissue Callus or Pro Callus are formed These are cartilage that has no structural rigidity to weight bearing

Forms a network of bone that connects to the reactive trabeculae deposited elsewhere in medullary cavity and beneath the peristeum

Undergoes Endochondral ossification (Growth Palate)

Fractured ends bridged by a bony callus (controlled wt. bearing can be tolerated)