Blue Brain

Do neurons dream of electric sheep?
By: Michael R. Rink

Main Points  Objectives of the Project  Data Collection  Model  Expected Consequences  Future Work .

Genetic (another 5-10 years)  Cellular – 100. 2007  Detailed Cellular scale (10.000  Point Source -100 million (mouse brain) .000 neurons) Full Neocortex  Modular  Atomic (days/ms). 2005 – November 26.Objectives   Phase 1: 1cm^3 NCC  June 6.

Full Mammal Brain 2 years  Emergent behavior   Learning/ self-wiring  Interact with environment  Japanese built robot rat  Whole new models to connect sensory cortex to hardware .

000 fold  Multi-core & Multi-threading are really useful  .000 fold  ASICS 1.Full Human Brain Need speed increase of ~10million fold  Algorithm improvements 100-1.000-10.

Patch Clamp Robot .On Going Data Collection    Decades of research on 2 year old rat somatosensory cortex Hundreds of new data points a day 50% success rate Fig A.

3. 4 and 5 .Blue Column 1 The microcircuits (from left to right) for layers 2.

Blue Column 2    A single thick tufted layer 5 pyramidal neuron located within the column. a small pyramidal neuron in layer 5 and the large thick tufted pyramidal neuron in layer 5. with neurons located in layers 2 to 5. . c | One pyramidal neuron in layer 2. d | An image of the NCC.

Blue Column Construction Model the 3d neuron  Repair defects from in vitro preparation   Patch clamping damages the cell  Insert 12+ ion channels in each component compartment based on HH models & studies  October 2005 Petilla Classification Convention .

   Each neuron is unique within statistically determined bounds – procedurally generated Stored in database after creation Each layer procedurally generated from database then shifted/rotated to avoid collisions  Generating the column takes longer than running it  Simulation runs at 1/100th real time .

  Individual synapses functionalized and plasticized with learning algorithms Map Neuron to Processor 1:1 – 10:1  Axons mapped onto inter-processor communications .

Expected Consequences  Each NCC will be unique  Hopefully. NCC output will approach convergence  NCCs will begin to appear similar (lack of molecular detail to tie in genetic elements)  Connected Neurons fire together  Predicted by Hebbian learning  Emergent behavior .

   Blue = rest Yellow = group 1 Red = group 2 .

  Global Excitatory state Notice the blue. inhibited neurons .

Future Work Experimental Aid  How complex of a problem can an NCC solve  Emergence of Conciousness   Director Markram .

Any Questions? .

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