1736 69 imMEDIAte Advan Bro 6pp 13/2/07 12:14 Page 4

Process
Development

It’s all about speed

Customized formulations
for process development

www.safcbiosciences.com Member of the Sigma-Aldrich Group

1736 69 imMEDIAte Advan Bro 6pp 13/2/07 12:14 Page 5

Gain the imMEDIAte ADVANTAGE™

• Quick-turnaround
• Customized non-cGMP formulations in small volumes
• Designed for industrial-focused process development customers

We offer the media formulations you want, when you want them,
to develop and scale-up your commercial cell culture processes.

Responsive to your timelines Flexible

• Orders manufactured within 10
business days or less
• Multiple manufacturing locations
throughout the United States and
Europe ensure global responsiveness
Global imMEDIAte ADVANTAGE™ lead times
14
Move more quickly through the drug
development pipeline
• Small volume custom liquid and
powder reagents
• Ideal for use in media and feed
selection and optimization
• Assists with engineering runs,
technical transfer, toxicology runs,
developing small-scale models and
the scale-up process

Seamless scale-up
Days from order to complete manufacture

12

10 • More than 95% of all components

are used in cGMP manufacturing,
8
have been QA released and meet
6 stringent Raw Material Specifications
4 • Batch records for manufacturing
2 processes and finished products
utilize the same business processing
0
Jul-Sep Oct-Dec Jan-Mar Apr-Jun Jul-Sep Oct-Dec Jan-Mar Apr-Jun
system as cGMP manufacturing
2004 2004 2005 2005 2005 2005 2006 2006
• Certificates of Compliance are
available upon request
Projects scaled-up from imMEDIAte
ADVANTAGE™ to cGMP production

25

Standard Testing
20

pH
Number of projects

15

Osmolality
10

Physical Appearance
5

Abbreviated Sterility
0 (for liquid formulations)
Jul Oct Jan Apr Jul Oct Jan Apr Jul Oct Jan Apr
-Sep -Dec -Mar -Jun -Sep -Dec -Mar -Jun -Sep -Dec -Mar -Jun
2003 2003 2004 2004 2004 2004 2005 2005 2005 2005 2006 2006
Solubility (for dry powder formulations)
1736 69 imMEDIAte Advan Bro 6pp 13/2/07 12:13 Page 2

Responsive Expertise
SAFC Biosciences is the world’s leading supplier
of cell culture reagents to producers of marketed biological
products. We are committed to supplying high-quality
critical raw materials and specialized cell culture products
and services to the global health care industry.

By providing the broadest range of highly customized

products and services possible to cell culture-based
manufacturing companies we demonstrate our commitment
to being responsive experts.

SAFC Biosciences’ cycle of support

Nutrient
Customer consumption &
project formation
timeline met (Testing Services)

Small scale
Custom product
custom manufacture:
stability testing
imMEDIAte
(Testing Services)
ADVANTAGE™

Scale-up
support to GMP:
imMEDIAte
ADVANTAGE™
1736 69 imMEDIAte Advan Bro 6pp 13/2/07 12:14 Page 6

Concentrates, feeds and

supplements
• SAFC Biosciences has extensive
experience manufacturing
concentrates, feeds and
supplements to match your complex
manufacturing systems
• Feasibility is formulation-dependent
and is verified prior to manufacture
• We routinely provide customers
with vitamin, trace element, amino
acid and hydrolysate feeds
• Customization of your concentrates,
feeds and supplements is available

Testing services
This specialized service consists of
Personalized service
a battery of tests for nutrient analysis
• imMEDIAte ADVANTAGE™ offers you designed to provide valuable
direct access to dedicated staff with information for cell and media
extensive expertise, experience and optimization studies. Testing to support
knowledge in formulation chemistry stability studies is also available.
to support the completion of your We offer:
milestones
Item No. Tests to Support
• SAFC Biosciences provides a single
Nutrient Analysis
point of contact that follows the
processing of your order from 88103 Amino Acid Analysis (HPLC)
receipt to your doorstep, allowing 88102 Cholesterol
you to focus on your projects 88202 Glucose
88101 Lipids/Fatty Acids
88100 Vitamin Analysis (HPLC)

Item No. Tests to Support Stability

88210 Appearance
88208 Bioburden
88204 Endotoxin (LAL)
88212 Growth Promotion (MTT)
88224 Moisture
88206 Osmolality
88213 Osmolality (without sodium bicarbonate)
88207 pH
88214 pH (without sodium bicarbonate)
1736 69 imMEDIAte Advan Bro 6pp 13/2/07 12:14 Page 7

Placing your order

Format Lot Size Packaging Options Fill Capacity Options

To take advantage of
SAFC Biosciences’ Liquid media 1 L to 50 L Plastic bottles 50 mL to 2000 mL
responsive expertise in
Liquid media 1 L to 200 L Plastic bottles 500 mL to 2000 mL
helping you meet your
process development Liquid media 5 L to 200 L Media bags 5 L to 20 L
milestones or request (10 L stock bag &
20 L stock bag)
pricing, contact your
Business Development Dry powder 500 g to 5 kg Plastic containers By volume up to 100 L
Manager or Customer media (dependent on g/L
weight of product)
Service.
Dry powder 500 g to 5 kg Plastic containers By weight up to 5 kg
media

Please have the following information available when requesting imMEDIAte ADVANTAGE™ services

Item No. (if previously ordered from SAFC Biosciences) Name

Item Description Position

Company Name
Liquid Dry Powder

Lot Size Address

Preferred Package Size

Formulation

Tel:

Fax:

E-mail:
1736 69 imMEDIAte Advan Bro 6pp 13/2/07 12:14 Page 3

Contact us

United States

SAFC Biosciences, Inc.

13804 W. 107th Street
Lenexa, Kansas 66215
USA

Tel: +1 913-469-5580
Toll Free – USA: 1 800-255-6032
Fax: +1 913-469-5584
E-mail: info-na@sial.com

Europe

SAFC Biosciences Ltd.

Smeaton Road, West Portway
Andover, Hampshire SP10 3LF
UNITED KINGDOM

Tel: +44 (0)1264-333311

Fax: +44 (0)1264-332412
E-mail: info-eu@sial.com

Asia Pacific

SAFC Biosciences Pty. Ltd.

18-20 Export Drive
Brooklyn, Victoria 3025
AUSTRALIA

Tel: +61 (0)3-9362-4500

Toll Free – AUS: 1 800-200-404
Fax: +61 (0)3-9315-1656
E-mail: info-ap@sial.com

imMEDIAte ADVANTAGE™ is a
trademark of SAFC Biosciences, Inc.
© 2006 SAFC Biosciences, Inc.

Issued December 2006 G052

www.safcbiosciences.com Member of the Sigma-Aldrich Group