CONNECTIVE REPAIR

LP 7

Healing:
The healing of lesions from inflammatory focus is characterized by 2 types of processes:  regeneration  connective repair REGENERATION : Represents the morphologic and functional recovery of the injured tissue with the same type of tissue (in injured tissues that kept the capacity of
dividing).

After the capacity of cellular divission we can distinguish three types of cellular lesions:
• • •

Labile cells (capacity of regeneration or continue multiplication) - epidermis Stable cells (the capacity of de regeneration is limited) - liver Permanent cells (they don’t have the capacity of divission) - miocardium

CONNECTIVE REPAIR
 Represents the morphological and functional recovery of the injuried tissue by

fibrous tissue.

( in large tissue destructions: inflammation, necrosis)

The characteristic element of connective repair is:

Granulation tissue (connective-vascular tissue).
It could be:
 YOUNG  MATURE  FIBROUS

Examples of connective repair
Connective organization
• Replacement of inflammatory exudate by granulation tissue • Connective organization of a thrombus • Connective organization of miocardial infarction

Connective encapsulation
Is specific to the large lessions that could not be repaired by connective organization At the periphery of these large areas (abscess, hematoma) there is a connective-vascular tissue that by maturation forms a connective capsule that limits the affected area by the rest of the tissue

Young granulation tissue (Vascular granulation tissue)
Microscopically:

 New cappilaries

(with prominent endotelium);
 Inflamatory cells

(neutrophils, macrophages, lymfocytes) and eritrocytes.
Rare fibroblasts; Eosinophilic transudate.

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MATURE GRANULATION TISSUE
(fibro-vascular granulation tissue) Connective organization of myocardial infarction

Microscopically
 A decreased number of

new capillaries;

 A decreased number

of inflammatory cells (lymphocytes, macrophages).

Numerous fibroblasts.

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MATURE GRANULATION TISSUE (fibro-vascular granulation tissue)

Connective Organization of a thrombus

Oclusive thrombus replased by a granulation tissue

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FIBROUS TISSUE (Fibrous granulation tissue)

Wall of liver chronic abscess Microscopically
 Rare vessels

 Numerous fibrocytes;  Collagen fibers.

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