Histopathological diagnosis

• Definition – repreyents the diagnosis settled by microscopic examination • For diagnosis we use specimens collected by:  Biopsy  Surgical excision  Tissues collected from autopsy

Biopsy
Could be of different types : • Microbiopsy  Needle biopsy  Curettage  Endobiopsies • Surgical biopsies

Microbiopsy
 Needle biopsy – it use needles of different types – investigation of liver, kidney, lungs, spleen, lymph nodes  Curretagge – it is used for investigation of the uterine cavity  Endobiopsies – collect bioptic specimens during an endoscopy of a cavitary organ (bronchi, stomach, bladder)

Surgical biopsies
• We can obtain tissue samples by a surgical procedure. • It could be obtained  by incision – only a part of the lesion  by excision – all the lesion is removed together with healthy tissue • Extemporaneous biopsy – is a particular form of biopsy which is performed during the operation – it is applied, especially in breast pathology

Surgical excision
• The pieses are obtained after a surgical resection • After the surgery all the extracted organs are examined macroscopically and all the pathological lesion are noted

Autopsy
• The pieses are obtained during the autopsy

Histological sections
• Fixation – the fragments are fixed in one of the following fixative solutions : formaline, Carnoy’s fluid, Bouin’s fluid

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