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Exam I-white KEY

NAME _____________________________

1. Wolverine urine disease is a rare dominant sex-limited disorder that results in the urine being maize and blue color (this really disgusting phenotype is particularly prevalent in individuals living in Michigan). Mary Smith, and her parents, and her mother’s parents are all unaffected. However, her great grandfather (the father of her mother’s mother) is Bo Schembechler, who has the disease. Mary is married to Brady Hoke, whose father and brother both have the disease. (16 pts) a. What is the probability that Mary and Brady’s first child will have Wolverine urine? Probability Mary is a heterozygote = 1/2 x 1/2 x 1/2 = 1/8 Rr Brady is unaffected and must be homozygous recessive (rr) = 1 Probability of having an affected child = 1/8 x 1/2 x 1/2 = 1/32 = 3.125% (only males are affected)

b. What is the probability that their first child will have normal urine? 1 – 1/32 = 31/32 = 96.88%

c. What is the probability that their second child will have normal urine, if their first is affected? 1 – (1/2 x 1/2) = 1 – 1/4 = 3/4 = 75%

d. If Mary’s sister has a son born with this terrible disease, what is the probability that Mary and Brady’s first child will be affected? (Ignore parts a, b, and c when answering this question) 1/2 x 1/2 x 1/2 = 1/8 = 12.5%

2. Shown below are 6 pedigrees. For each pedigree. determine the most accurate mode of inheritance (assume all three pedigrees are represent very rare diseases). (12 pts) X-linked dominant autosomal recessive autosomal dominant X-linked recessive sex-limited dominant Y-linked .

chromatids. picograms DNA Meiosis I 4 8 2. Diagram the chromosomes in each cell and draw a dashed line to represent the location/orientation of the cell division. a. You are studying a haploid organism that contains a metacentric chromosome and a telocentric chromosome (a total of 0.0 Meiosis II 2 4 1. state the number of chromosomes.3. b. (17 pts) Meiosis I Meiosis II Mitosis Chromosome no.5 picograms of DNA in the haploid cell). meiosis I (metaphase I). or meiosis II (metaphase II).0 . Chromatid no.0 Mitosis 2 4 1. Each of the circles below represents the cell as the chromosome(s) arrange in the center of the cell during mitosis (metaphase). and picograms of DNA that are present in the diagrammed cell. Under each cell.

What is the probability of having a child that is genotypically like either parent? (1/2 x 1/2 x 1/2 x 1/2 x 0) + (1/2 x 1/2 x 1/2 x 1/2 x 0) = 0 f. You cross two individuals of the following genotypes: Aa Bb Cc Dd EE Ff x Aa Bb cc DD ee Ff. For each of the following genotypes.[(3/4 x 3/4 x 1/2 x 1 x 1 x 3/4) + (3/4 x 3/4 x 1/2 x 1 x 0 x 3/4)] = 1. What is the probability of having a child that is not heterozygous for the B gene? 1 .[27/128 + 0] = 101/128 = 78. (12 pts) GENOTYPE XX XY X0 XXY XXX XXYY FLY GENDER female male male female metafemale (lethal) female HUMAN GENDER female male female male female male .625% 5. and F phenotypes? (1/4 x 1/4 x 1/2 x 1/2) + (3/4 x 1/2 x 3/4 x 1/2) = 1/64 + 9/64 = 10/64 = 5/32 = 15. In all cases.4. assume that the individual has 2 complete sets of autosomes. b. Gender is determined differently for humans and fruit flies. the gender of the individual. C. state as accurately as possible. What is the probability of having either a son with the recessive a. and c phenotypes or a daughter with the dominant B. What is the probability of having a child that is phenotypically unlike either parent? 1. All six genes exhibit independent assortment. What is the probability of having a child that has the recessive b and f phenotypes? (1/4 x 1/4) = 1/16 = 6.(1/2) = 1/2 = 50% c.125% b. (16 pts) a.25% e. What is the probability of having a son that has the dominant A and B phenotypes? (3/4 x 3/4) x 1/2 = 9/32 = 28.09% g.91% h. What is the probability of having a child that has all 6 dominant phenotypes? (3/4 x 3/4 x 1/2 x 1 x 1 x 3/4) = 27/128 = 21. What is the probability of having a child that is phenotypically like either parent? (3/4 x 3/4 x 1/2 x 1 x 1 x 3/4) + (3/4 x 3/4 x 1/2 x 1 x 0 x 3/4) = 27/128 = 21.09% d.

the father must have the recessive trait (XhY). a female pup that is blind and has hip dysplasia? c. The maternal grandfather was blind and had normal hips and the paternal grandmother was blind. Two dogs. the probability of genotype Bb XHXh = 1/2 x 1/4 = 1/8 = 12.5% d. the mother must be heterozygous for hip dydplasia (XHXh). In dogs. For blindness: Bb x Bb 1/4 bb For a male with normal hips: XHXh x XhY 1/4 XHY Therefore. Therefore. then use the product rule to determine the combined probabilities. a male pup that is blind and has normal hips (15 pts) Because one of the female pups is blind (bb).25% . a pup that is a carrier for both traits? d. have two female pups: one is blind and the other has hip dysplasia. both with normal vision. For male with hip dysplasia: XHXh x XhY 1/4 XhY = 1/4 = 25% For normal vision: Bb x Bb 3/4 B— = 3/4 Therefore. For normal vision: Bb x Bb 3/4 B— = 3/4 = 75% e. Therefore. Because the two traits assort independently. the probability of genotype bb XhXh = 1/4 x 1/4 = 1/16 = 6.25% c. The second daughter has hip dysplasia (XhXh).= 1/4 x 3/4 = 3/16 = 18. an X-linked recessive trait is characterized by hip dysplasia and an autosomal recessive trait that results in a retinal degenerative phenotype (blindness). a pup with normal vision (and either normal hips or hip dysplasia)? e. we can treat the cross as two separate crosses.75% b. Only a daughter can be a carrier for both traits For blindness: Bb x Bb 1/2 Bb For hip dysplasia: XHXh x XhY 1/4 XHXh Therefore. the probability of genotype bb XHY = (1/4 x 1/4) = 1/16 = 6. and the mother must have at least one Xh allele. the cross can be designated as Bb XHXh x Bb XhY. both parents must be carriers for the disease (Bb). the probability of genotype XhY B. a male pup with hip dysplasia and normal vision? b. What is the probability that the next pup will be: a. The breeder decides to breed the dogs one more time.6. The fact that one of the pups had normal hips. For blindness: Bb x Bb 1/4 bb For hip dysplasia: XHXh x XhY 1/4 XhXh Therefore. a.

these earplugs could be plugged into a portable radio. while nowadays. as did Dick’s great uncle (his father’s father’s brother).7. the earplugs can be plugged into an iPod. Ipoditis is a rare autosomal recessive disease where little white earplugs grow out of your ears. (1/2)(1/2) x (1/2)(1/2) x 1/4 = 1/64 = 1/64 = 1. where they had been in the Peace Corps for 20 years.) a. Calculate the probability that Dick and Jane’s second child will suffer from Ipoditis. (12 pts) a. What is the probability that Jane and Dick’s child will suffer from Ipoditis? c. Jane’s great-great-grandmother (her mother’s mother’s mother’s mother) suffered from it. At a recent family reunion.56% . who had white earplugs growing out of his ears. Jane and Dick are expecting a child and are very afraid that the child may suffer from this disease because it is present in both of their families.52% c. (1/2)(1/2)(1/2) x (2/3)(1/2)(1/2) x 1/4 = 1/192 = 0. Dick’s uncle (his father’s brother) and Jane’s aunt (her mother’s sister) both returned from Africa. 1 – 1/192 = 191/192 = 99. Many years ago. b. what is the probability that their second child will be normal? d. If their first child is normal. Diagram the pedigree. (You do not have to redraw the pedigree. During that time they met. because Jane is expecting her second child (the first was normal). b. married and had a son.48% d. Dick and Jane panic.

4% c.7% x 25% = 4. What is the probability that the expecting mother is a carrier? Probability that grandmother is heterozygote = 2/3 x 1/2 = 1/3 Probability that grandmother is homozygous dominant = 2/3 Probability that grandfather is heterozygote = 1/2 x 1/2 = 1/4 Probability that grandfather is homozygous dominant = 3/4 Aa x Aa Aa x AA AA x Aa (1/3 x 1/4 x 2/3) + (1/3 x 3/4 x 1/2) + (2/3 x 1/4 x 1/2) = 1/18 + 1/8 + 1/12 = 26.8. Using the following pedigree: (11 pts) a.7% d.4% x 66. What is the probability that the expecting father is a carrier? 2/3 = 66.4% . What is the probability that their first child will be affected? 26. What is the most likely mode of inheritance? Autosomal recessive b.

9. rough Cross 4: bushy. rough x bushy. Your little brother idolizes Gregor Mendel and started inbreeding petunias 10 years ago. (12 pts) CROSS bushy. rough narrow. smooth x narrow. smooth bushy. smooth x narrow. smooth x narrow. determine which is dominant and which is recessive. rough bushy. rough narrow. rough narrow. rough x bushy. rough x bushy. smooth BbRr x BbRr bbRr x BbRr Bbrr x bbRR Bbrr x bbRr bbrr x bbrr OFFSPRING PHENOTYPES bushy. smooth x narrow.smooth or rough and growth type – bushy or narrow). smooth x narrow. he set up the following five crosses of his petunia plants. smooth bushy is dominant to narrow rough is dominant to smooth Cross 1: bushy. smooth x narrow. rough 29 114 155 99 0 . rough Cross 3: bushy. rough bushy. rough x bushy. ALSO determine the genotypes of both parents. rough Cross 5: narrow. rough Cross 2: narrow. smooth 32 99 12 38 0 99 0 112 150 100 0 40 0 104 175 narrow. For each of the two traits (leaf shape. As a science fair project to study genetic traits. For each cross.

Mary's father is the only color-blind individual on her side of the family. What is the colorblind daughter's mother. nottJ' yctnc{'o' genotype (what sex chromosomes does she possess and what are Y Y) and underline the chromosomes she inherited from the alleles for colorblindness. the meiotic events leading to Mary and Bob's gametes that produce this exceptional child. There is a recessive mutation on the X chromosome that results in color-blindness. Nobody on Bob's side of the family is color blind.**. whatisthephenomenonthatproducesthischildcalled? Me io{t.r)f. )f X. v\ /^. Xa .-t O Meiosis leading to the generation of Bob's sperm Pohrbody O Porarbody spermatid Metaphaseror n -/O spermatid T* @ I b.e X1X')f her c. i.v's egg Metaphase I Meiosis I of (H.!$. Bob and Mary have a daughter who is color blind. (19 pts) Meiosis leading to the generation of Mar. . Diagram as accurately as possible. Make sure you label the wild-type and color-blind alleles on all the chromosomes (* for the dominant allele and "c" for the color-blind allele).

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