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BIOS 20250 2011 White Exam I key

BIOS 20250 2011 White Exam I key

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BIOS 20250 2011

Exam I-white KEY

NAME _____________________________

1. Wolverine urine disease is a rare dominant sex-limited disorder that results in the urine being maize and blue color (this really disgusting phenotype is particularly prevalent in individuals living in Michigan). Mary Smith, and her parents, and her mother’s parents are all unaffected. However, her great grandfather (the father of her mother’s mother) is Bo Schembechler, who has the disease. Mary is married to Brady Hoke, whose father and brother both have the disease. (16 pts) a. What is the probability that Mary and Brady’s first child will have Wolverine urine? Probability Mary is a heterozygote = 1/2 x 1/2 x 1/2 = 1/8 Rr Brady is unaffected and must be homozygous recessive (rr) = 1 Probability of having an affected child = 1/8 x 1/2 x 1/2 = 1/32 = 3.125% (only males are affected)

b. What is the probability that their first child will have normal urine? 1 – 1/32 = 31/32 = 96.88%

c. What is the probability that their second child will have normal urine, if their first is affected? 1 – (1/2 x 1/2) = 1 – 1/4 = 3/4 = 75%

d. If Mary’s sister has a son born with this terrible disease, what is the probability that Mary and Brady’s first child will be affected? (Ignore parts a, b, and c when answering this question) 1/2 x 1/2 x 1/2 = 1/8 = 12.5%

determine the most accurate mode of inheritance (assume all three pedigrees are represent very rare diseases). For each pedigree. (12 pts) X-linked dominant autosomal recessive autosomal dominant X-linked recessive sex-limited dominant Y-linked . Shown below are 6 pedigrees.2.

chromatids. (17 pts) Meiosis I Meiosis II Mitosis Chromosome no. a.3. or meiosis II (metaphase II). Diagram the chromosomes in each cell and draw a dashed line to represent the location/orientation of the cell division. state the number of chromosomes.5 picograms of DNA in the haploid cell). Chromatid no. You are studying a haploid organism that contains a metacentric chromosome and a telocentric chromosome (a total of 0. b. picograms DNA Meiosis I 4 8 2.0 Mitosis 2 4 1.0 Meiosis II 2 4 1. and picograms of DNA that are present in the diagrammed cell. Each of the circles below represents the cell as the chromosome(s) arrange in the center of the cell during mitosis (metaphase).0 . Under each cell. meiosis I (metaphase I).

125% b. What is the probability of having a son that has the dominant A and B phenotypes? (3/4 x 3/4) x 1/2 = 9/32 = 28. the gender of the individual.91% h.[(3/4 x 3/4 x 1/2 x 1 x 1 x 3/4) + (3/4 x 3/4 x 1/2 x 1 x 0 x 3/4)] = 1. What is the probability of having a child that is phenotypically like either parent? (3/4 x 3/4 x 1/2 x 1 x 1 x 3/4) + (3/4 x 3/4 x 1/2 x 1 x 0 x 3/4) = 27/128 = 21. Gender is determined differently for humans and fruit flies.625% 5. (12 pts) GENOTYPE XX XY X0 XXY XXX XXYY FLY GENDER female male male female metafemale (lethal) female HUMAN GENDER female male female male female male .[27/128 + 0] = 101/128 = 78. state as accurately as possible. What is the probability of having a child that is not heterozygous for the B gene? 1 . b. You cross two individuals of the following genotypes: Aa Bb Cc Dd EE Ff x Aa Bb cc DD ee Ff.4. What is the probability of having a child that is genotypically like either parent? (1/2 x 1/2 x 1/2 x 1/2 x 0) + (1/2 x 1/2 x 1/2 x 1/2 x 0) = 0 f. assume that the individual has 2 complete sets of autosomes. C.(1/2) = 1/2 = 50% c. In all cases.09% d. What is the probability of having a child that has the recessive b and f phenotypes? (1/4 x 1/4) = 1/16 = 6.25% e. What is the probability of having either a son with the recessive a. What is the probability of having a child that has all 6 dominant phenotypes? (3/4 x 3/4 x 1/2 x 1 x 1 x 3/4) = 27/128 = 21. All six genes exhibit independent assortment. What is the probability of having a child that is phenotypically unlike either parent? 1. (16 pts) a.09% g. and c phenotypes or a daughter with the dominant B. and F phenotypes? (1/4 x 1/4 x 1/2 x 1/2) + (3/4 x 1/2 x 3/4 x 1/2) = 1/64 + 9/64 = 10/64 = 5/32 = 15. For each of the following genotypes.

The maternal grandfather was blind and had normal hips and the paternal grandmother was blind. The second daughter has hip dysplasia (XhXh). we can treat the cross as two separate crosses.75% b. The fact that one of the pups had normal hips. the mother must be heterozygous for hip dydplasia (XHXh).25% c. a female pup that is blind and has hip dysplasia? c. the probability of genotype bb XhXh = 1/4 x 1/4 = 1/16 = 6. a pup that is a carrier for both traits? d. In dogs.6. an X-linked recessive trait is characterized by hip dysplasia and an autosomal recessive trait that results in a retinal degenerative phenotype (blindness). the cross can be designated as Bb XHXh x Bb XhY. For blindness: Bb x Bb  1/4 bb For hip dysplasia: XHXh x XhY  1/4 XhXh Therefore. What is the probability that the next pup will be: a.5% d. Two dogs. the probability of genotype Bb XHXh = 1/2 x 1/4 = 1/8 = 12. Therefore. a. For blindness: Bb x Bb  1/4 bb For a male with normal hips: XHXh x XhY  1/4 XHY Therefore. both parents must be carriers for the disease (Bb). a male pup with hip dysplasia and normal vision? b. a male pup that is blind and has normal hips (15 pts) Because one of the female pups is blind (bb). Therefore. both with normal vision. then use the product rule to determine the combined probabilities. Because the two traits assort independently. the probability of genotype XhY B. have two female pups: one is blind and the other has hip dysplasia. a pup with normal vision (and either normal hips or hip dysplasia)? e.25% . For male with hip dysplasia: XHXh x XhY  1/4 XhY = 1/4 = 25% For normal vision: Bb x Bb  3/4 B— = 3/4 Therefore.= 1/4 x 3/4 = 3/16 = 18. For normal vision: Bb x Bb  3/4 B— = 3/4 = 75% e. the father must have the recessive trait (XhY). The breeder decides to breed the dogs one more time. and the mother must have at least one Xh allele. Only a daughter can be a carrier for both traits For blindness: Bb x Bb  1/2 Bb For hip dysplasia: XHXh x XhY  1/4 XHXh Therefore. the probability of genotype bb XHY = (1/4 x 1/4) = 1/16 = 6.

48% d. (12 pts) a. where they had been in the Peace Corps for 20 years. these earplugs could be plugged into a portable radio.56% . Dick and Jane panic. who had white earplugs growing out of his ears. Diagram the pedigree. because Jane is expecting her second child (the first was normal). Jane and Dick are expecting a child and are very afraid that the child may suffer from this disease because it is present in both of their families. At a recent family reunion. what is the probability that their second child will be normal? d. Jane’s great-great-grandmother (her mother’s mother’s mother’s mother) suffered from it. Dick’s uncle (his father’s brother) and Jane’s aunt (her mother’s sister) both returned from Africa. the earplugs can be plugged into an iPod. (You do not have to redraw the pedigree.) a.7. Ipoditis is a rare autosomal recessive disease where little white earplugs grow out of your ears. Many years ago. Calculate the probability that Dick and Jane’s second child will suffer from Ipoditis. If their first child is normal. while nowadays. (1/2)(1/2)(1/2) x (2/3)(1/2)(1/2) x 1/4 = 1/192 = 0. b.52% c. What is the probability that Jane and Dick’s child will suffer from Ipoditis? c. married and had a son. b. (1/2)(1/2) x (1/2)(1/2) x 1/4 = 1/64 = 1/64 = 1. During that time they met. as did Dick’s great uncle (his father’s father’s brother). 1 – 1/192 = 191/192 = 99.

What is the probability that the expecting mother is a carrier? Probability that grandmother is heterozygote = 2/3 x 1/2 = 1/3 Probability that grandmother is homozygous dominant = 2/3 Probability that grandfather is heterozygote = 1/2 x 1/2 = 1/4 Probability that grandfather is homozygous dominant = 3/4 Aa x Aa Aa x AA AA x Aa (1/3 x 1/4 x 2/3) + (1/3 x 3/4 x 1/2) + (2/3 x 1/4 x 1/2) = 1/18 + 1/8 + 1/12 = 26. What is the probability that the expecting father is a carrier? 2/3 = 66.8. Using the following pedigree: (11 pts) a.7% d. What is the most likely mode of inheritance? Autosomal recessive b.4% x 66. What is the probability that their first child will be affected? 26.7% x 25% = 4.4% .4% c.

For each cross. smooth bushy. rough bushy. rough x bushy. rough narrow. smooth x narrow. determine which is dominant and which is recessive. rough x bushy. rough narrow.9. rough Cross 3: bushy. rough Cross 4: bushy.smooth or rough and growth type – bushy or narrow). smooth x narrow. smooth x narrow. smooth BbRr x BbRr bbRr x BbRr Bbrr x bbRR Bbrr x bbRr bbrr x bbrr OFFSPRING PHENOTYPES bushy. Your little brother idolizes Gregor Mendel and started inbreeding petunias 10 years ago. smooth x narrow. rough bushy. rough 29 114 155 99 0 . smooth x narrow. he set up the following five crosses of his petunia plants. smooth 32 99 12 38 0 99 0 112 150 100 0 40 0 104 175 narrow. For each of the two traits (leaf shape. smooth bushy is dominant to narrow rough is dominant to smooth Cross 1: bushy. smooth x narrow. ALSO determine the genotypes of both parents. rough narrow. (12 pts) CROSS bushy. rough Cross 5: narrow. rough x bushy. rough Cross 2: narrow. As a science fair project to study genetic traits. rough x bushy.

Diagram as accurately as possible. )f X.!$. There is a recessive mutation on the X chromosome that results in color-blindness. Xa . i. whatisthephenomenonthatproducesthischildcalled? Me io{t.-t O Meiosis leading to the generation of Bob's sperm Pohrbody O Porarbody spermatid Metaphaseror n -/O spermatid T* @ I b. v\ /^. What is the colorblind daughter's mother. Bob and Mary have a daughter who is color blind.**.v's egg Metaphase I Meiosis I of (H. Make sure you label the wild-type and color-blind alleles on all the chromosomes (* for the dominant allele and "c" for the color-blind allele). the meiotic events leading to Mary and Bob's gametes that produce this exceptional child.r)f. Nobody on Bob's side of the family is color blind. Mary's father is the only color-blind individual on her side of the family. (19 pts) Meiosis leading to the generation of Mar. .e X1X')f her c. nottJ' yctnc{'o' genotype (what sex chromosomes does she possess and what are Y Y) and underline the chromosomes she inherited from the alleles for colorblindness.

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