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  • Dengue

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    Igor Vlatković
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    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
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    17 views4 pages

    Dengue

    Uploaded by

    Igor Vlatković

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 4

    Humoralni imunosni odgovor

    Sekundarne infekcije su znatno tee ADE Strukturni E protein

    snani epitopi

    Stanini imunosni odgovor

    bitan u teim oblicima bolesti

    DHF i DSS

    snaan citokinski, a slab citotoksini odgovor krina-reaktivnost kod sva 4 serotipa

    Virusne determinante bolesti

    DENV2 i DENV3 tei oblici dok su DENV1 i DENV4 uzrokovali slabiji fenotip bolesti

    4-5 subtipova

    Epidemija u Tajlandu DENV2 Azijski

    Antibody-dependent enhancement

    Nije bitan samo afinitet, nego i dostupnost epitopa


    U teim sluajevima je izraen citokinski T odgovor (slika bolesti) Mutacije mogu dovesti do epidemija

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