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Human Papilloma Virus (HPV)(PSPD)

Human Papilloma Virus (HPV)(PSPD)

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Published by Sari Fitrianingsih
HPV
HPV

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Published by: Sari Fitrianingsih on May 02, 2013
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01/11/2014

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Human Papilloma Virus (HPV

)

Eka Yudha Rahman

DNA untai ganda terdifferensiasi sel inang • Replikasi : tergantung pd stadium • Karakteristik : -Potensial onkogenik (+) -Tropik pd sel epitel kulit dan mukosa Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011 .Morfologi dan sifat HPV • Virion : struktur ikosahedraldiameter 55 nm • Genom : bulat.

10.12.17.31.52 Neoplasia mukosa genital.15. condyloma anogenital Veruca plana. verrucae genital.33.40 Epidermoplasia verruciformis 20 Basilioma 13.17.Tipe Virus & akibat infeksinya pd manusia TIPEVIRUS 1 2 3.8 6.25. veruca plantaris Veruca vulgaris.&20 dpt jadi ganas Dpt jadi ganas Mu ngkin jadi ganas Cenderung jadi ganas Dpt jadi ganas Cenderung jadi ganas Ca in situ Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011 .39. epidermoplasia verruciformis Veruca vulgaris et plantaris Epidermoplasia verruciformis Condiloma accuminata.14. metaplasi-displasi servik 9.36. laring. Pyk Bowen 34 Pyk Bowen 30.28 4 5. papiloma laring.18.35.11 PENYAKIT KETERANGAN Jinak Jinak Jarang jadi ganas Jinak 30% konversi menjadi ganas Umumnya Jinak Myrmecia tapak tangan. 40 Neoplasia Laring 37 Keratoacanthoma 12.19.32 Penyakit Heck 16. esofagus.

Gamb klinis Epidermodysplasia verruciformis Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011 .

16 and 18 proteins made in yeast . 11. vulvar and penile terkait dengan tipe 16 &18 (70% kanker penile ) Effective Vaccine (quadrivalent recombinant HPV 6.Papilloma Viruses • 51 tipe teridentifikasi .paling umum tipe 6 & 11 papiloma laring pada anak  infeksi didpt selama perjalanan dlm jalan lahir ibu dgn genital warts • Papiloma laring  infeksi laten  lesi baru • Kanker cervical.Gardasil) Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011 .

Clinical Warts • • Cauliflower-like lesions Dpt menyebabkan itching/burning • Kadang tanpa symptom Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011 .

Sub-clinical Warts • • • Flat Virtually invisible Dpt menyebabkan itching/burning • • Dpt tanpa symptom Identifikasi dgn vinegar & pembesaran 4-10X Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011 .

Transmisi • • • Skin to skin contact Condoms offer little protection Don't treat partners unless symptomatic Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011 .

Ca Cervix Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011 .

Diagnosis Laboratorium  Deteksi virion dari lesi  Deteksi antigen virion pada jaringan lesi (imunofluoresensi & imunoperoksidase)  Isolasi dan Identifikasi virus  Pemeriksaan Histo-sitopatologi  Deteksi Gen virus Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011 .

Treatment  Ekstirpasi/eksisi lesi  Interferon intra lesi  Kauterisasi dgn laser atau cryosurgery  Pemberian podofilin dan bleomisin  Pemberian Bichloracetic Acid (BCA or TCA) Kuliah PSPD (EKA YUDHA RAHMAN) 2/21/2011 .

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