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By- Chintan Chavda firstname.lastname@example.org
1. What is colostrum?
Colostrum is the pre-milk liquid that mothers produce at birth. Commonly referred to as "baby's first milk" and “biologic soup,” colostrum is the leftover mixture of materials present in the mammary gland and ducts at delivery. It slowly becomes mixed with newly secreted milk, yet it differs from mature milk in composition and is not as plentiful. Breasts produce colostrum beginning during pregnancy and continuing through the early days of breastfeeding. This special milk is yellow to orange in color and thick and sticky. It is low in fat, and high in carbohydrates, protein, and antibodies to help keep your baby healthy. Colostrum is extremely easy to digest, and is therefore the perfect first food for your baby. It is low in volume (measurable in teaspoons rather than ounces), but high in concentrated nutrition for the newborn. It is full of immune-enhancing antibodies, other important immune factors, and essential growth factors to ensure health and vitality for adults and children.
Colostrum versus Whole milk
(Ref- Feeding and Nutrition, Publ. by Cooperative Extension, Institute of Agricultural and Natural Resources, University of Nebraska-Lincoln, Issued May 1990)
Specification Total solids (%) Total Protein (%) Casein (%) Immunoglobulins (%) Fat (%) Lactose (%) Minerals (%)
Colostrum (1st milking) 23 14 4.8 6 6.7 2.7 1
Whole milk (11th milking) 13 4 2.5 0.09 4 4.9 0.74
2. What makes Bovine colostrum so beneficial?
There are over 90 known components in colostrum. The primary components, divided into two classes, are immune factors and growth factors. Colostrum also contains a precise balance of vitamins, minerals and amino acids. All of these factors work together in perfect synergy to restore and maintain health.
Colostrum's Immune Factors :
Immune Factors in colostrum have been shown to help the body fight off harmful invaders such as viruses, bacteria, yeast and fungus. Each factor plays a specific role in our bodys defense
cartilage. salmonella. streptococcus. (Serotonin & dopamine) Assist in regeneration and improve normal growth of aged or injured muscle. including viruses and bacteria IgM . They are required for growth and development. staphylococcus.Antibodies IgG . H pylori. growth and development. candida. Colostrums’ Growth Factors : Growth Factors help build and restore bone. muscle. medical studies show that PRP in colostrum also supports an under active immune system. These factors have also been shown to help increase lean muscle. and assist in wound healing. controls antibody response IgD . They act as coenzymes. prevents hemolytic disease in infants IgE . In addition to immunoglobulins. Amino acids are divided into essential (not produced by the body) and nonessential (can be produced by the body).Highly antiviral and antibacterial. and cryptosporidia. connective tissue. bone.Destroys bacteria. Colostrums’ growth factors may: Affect the brain's mood regulating chemicals to brighten our moods. nerve tissue. Support healing skin when applied topically Repair our body\'s precious RNA and DNA. Other Beneficial Components : Vitamins and Minerals are nutrients that are essential for normal metabolism. enabling chemical process to take place throughout the body.Antiviral.against these attackers. supporting alertness and better concentration.Found in mucous membranes. Immune Factors . colostrum contains over 20 antibodies to specific pathogens including E coli. Help burn fat for fuel instead of muscle tissue in times of fasting (diet).Neutralizes toxins and other invaders. and build & retain lean muscle (non-diet). In addition. rotavirus.Immunoglobulins: . Growth factors have also been shown to help slow the signs of aging.Involved in regulating allergic response IgA . Assist the internal regulation of blood glucose levels and "brain chemicals". Known Components of Bovine Colostrum 1. prevents infection Secretory IgA (SigA) . Amino Acids are the building blocks of proteins. Vitamins and minerals are indispensable for the maintenance of health. helps protect against infection . skin and cartilage. skin collagen and nerve tissue. PRP also helps balance an overactive immune system present in autoimmune diseases. help the body burn fat for fuel.
Stimulates the production of IgA Lactoferrin .Complex carbohydrates.Glycoprotein that protects against the bacteria that causes stomach ulcers Alpha 2-AP glycoprotein Alpha 1.Powerful antioxidant. anti-aging.Helps repair tissue.a (TGF. responsible for regulation and intensity of immune response.Stimulates growth of connective tissue.Function as hormonal transporters Orosomucoids . plays a role in wound healing and helps with cell division and neuron survival and regeneration Gonadotropin-Releasing Hormone (GnRH) .Helps protect and maintain the skin Fibroblast Growth Factor (FGF) . may regulate blood-sugar and cholesterol levels Insulin-like Growth Factor II (IGF-II) . Shown to produce cell destruction in certain human cancers. help prevent lung inflammations and ear infection Non Specific Inhibitors (NSI\'s) . Tumor Necrosis Factor (TNF).Precursor to albumin Albumin .Similar to Growth Hormone Insulin .Factors that inhibit a wide range of respiratory illness 2. supports growth of the lining of the gut.b (TGF .Affects how the body uses fat and protein Growth Hormone (GH) .Resists infection B Lactoglobulin . bone and cartilage Transforming Growth Factor . decreases signs of aging Transforming Growth Factor .Responsible for proper metabolism of blood sugar .a) . increase T-cell activity. and Lymphokines) Antiviral. helps repair DNA and RNA.Raises brain serotonin levels. Growth Factors Epithelial Growth Factor (EGF) . antibacterial.(Including Interleukins. Interferon Y. stimulate production of immunoglobulins Proline-Rich Polypeptide (PRP) . anti-inflammatory Lactoferrin-Fe .Help protect body from bacterial infection.Shown to cause lung cancer cells to create selective suicide (apoptopsis) Cytokines . antiviral.Binds and transports iron Glycoproteins: .Enhances wound healing and tissue repair Insulin-like Growth Factor I (IGF-I) .Alpha-1 protein in plasma Prealbumin . anti-tumor (stimulates death of some tumors).Proteins that activate the complement of the immune system Kappa Casein .antitrypsin .Iron chelator Transferrin .macroglobulin .Stimulates release of follicle-stimulating hormone. IgA Specific Helper . Platelet-Derived Growth Factor (PDGF) .Antibody.(Including Protease and Trypsin Inhibitors) Protect components from destruction by stomach acids Lactalbumin .Regulates growth. protein Complement 3 & 4 (C3 & C4) .Regulates the activity of the immune system Lysozymes .Assists in formation and healing of connective tissue. topical antibiotic Gamma Globulin .Contains essential amino acids Oligosaccharides .Inhibitor of trypsin Alpha 2.b) .Increases lean muscle mass. gonadotropic substances and treats endometriosis Prolactin . improves mood under stress Multimeric a-Lactalbumin .
Cell replication and tissue growth Pantothenic Acid .Stimulates GH.Involved in growth and tissue repair Methionine . carbohydrates and protein Riboflavin (Vitamin B2) . immune support Magnesium .Cell membrane integrity. helps regulate blood sugar Leucine . promotes wound healing and muscle growth Cystine . used in treatment of acne 4. energy.Carbohydrates that link to lipids and proteins Glycogen .Antioxidant.Aids in calcium absorption. energy Folic Acid . utilization of amino acids Vitamin B12 . supports wound healing and immune function Vitamin A (from carotene) . body fat reduction Iron .Strengthens bones and teeth Potassium .Produces serotonin.Metabolism of carbohydrates. precursor for serotonin 6.Antioxidant Glycoconjugates .Lowers blood pressure. healthy bones.Energy production. healthy eyes Beta-carotene .An antioxidant involved in collagen synthesis Glutanic Acid .Converts into glucose when needed by tissues Retinoic Acid . implicated in neurological conditions . immune system support Thiamin (Vitamin B1) . immune function. increases \"feel good\" chemicals in brain Valine .Antioxidant.Assists neurotransmitter function.Synthesis of DNA and RNA.Normal development of red blood cells Vitamin E .An important building block of proteins 3.Assists in muscle development & repair. assists with psychiatric disorders Phosphorus .Stimulates niacin production.Maintains strong.Stimulates antibody production Phenylalanine .Oxygen transport and storage.Helps transport potassium to the brain. activates enzymes Chromium . tissue repair. Vitamins and Other Nutrients Vitamin B6 . Sulfur . plays important role in nerve function Zinc .Muscle relaxation. wound healing and hormone production Histidine . helps regulate antibody and enzyme production Threonine .Involved in muscle repair. activates Vitamin A 5. helps prevent arterial fat buildup Lysine . maintains cell integrity Vitamin C . Essential Amino Acids Isoleucine . collagen synthesis. aids growth and repair of muscle tissue Tryptophan .Resistance to infections.Regulates energy. Minerals Calcium .Glucose metabolism disorders. Nonessential Amino Acids Arginine .Metabolism of fats.Antioxidant.Metabolite of Vitamin A. maintains fluid balance in cells Sodium .
Alanine . In those first few days it is extremely important to breastfeed newborn at least 8-12 times each 24 hours and more often is even better.Helps decrease muscle wasting. How Does Colostrum Work? Colostrum is highly beneficial in the unique manner in which it provides the body with its numerous immune and growth factors. Bifidobacterium. Colostrum provides not only perfect nutrition tailored to the needs of the newborn.Components of many cell membranes including leukocytes Enzymes .Enzyme involved in conversion of hypoxanthine to xanthine Lactobacillus Acidophilus.Glycoproteins that aid the recycling of iron Lactoperoxidase .microglobulin .Iron-binding protein Haptoglobulin . The concentration of immune factors is much higher in colostrum than in mature milk. 4. Frequent breastfeeding also helps prevent engorgement. The remainder are absorbed and distributed to assist in our internal defense processes. It is this combination of action that makes colostrum as unique and effective as an oral supplement.Regulate mood. involved in energy metabolism Serine . breasts will begin producing mature milk around the third or fourth day after birth.Involved in glucose metabolism Tyrosine . noted moisturizer 7. In order to remain healthy.Involved in fat metabolism and muscle growth.An antioxidant Orotic Acid . Bovine Colostrum for New Born When baby is breastfed early and often.Helps synthesis of DNA. Ig and antibodies. Additional Factors Found in Colostrum Beta 2. Most infectious disease-causing organisms enter the body through the mucous membranes of the intestinal tract. as well as environmental toxins. may improve memory.Precursor to certain nucleotides Peroxidase . but also large amounts of living cells which will defend the baby against many harmful agents. RNA. David Tyrell in England. This allows baby to get all the benefits of the colostrum and also stimulates production of a plentiful supply of mature milk. . 3.Transfers oxygen to tissues. Milk will then increase in volume and will generally begin to appear thinner and whiter (more opaque) in color.Induce chemical changes in the body Haemopexin . revealed that a high percentage of the antibodies and immunoglobulins present in colostrum are believed not to be absorbed but remain in the intestinal tract where they attack disease causing organisms before they can penetrate the body and cause disease. published in 1981. Clinical research by Dr.Help restore a supportive bacterial environment in the body. contaminants and allergens where they attack us. Lactobacillus Bifidus . such as bacteria and viruses. helps prevent free radical damage Xanthine Oxidase Enzyme . appetite suppressant Glycine . it is critical that we are able to combat disease-causing organisms. aids in glycogen storage Proline .Aids in wound healing and collagen synthesis Aspartic Acid .
natural. It contains large quantities of an antibody called secretory immunoglobulin A (IgA) which is a new substance to the newborn. but milk volume greatly increases. effective and biologically transferable for human use. Before the baby was born.plus help create new levels of vitality and well being. as long as your baby receives milk. It would be hard to imagine any nutritional substance more natural or beneficial. “Colostrum is so safe. The disease-fighting properties of human milk do not disappear with the colostrum. . A newborn's intestines are very permeable. Colostrum actually works as a natural and 100% safe vaccine. During this transition. it has been prepared by nature as the first food for infants. taken by humans to treat and heal dozens of conditions. 5. natural. Baby received the benefits of another antibody. And this superfood creates no problems for those with lactose intolerance. The colostrum gradually changes to mature milk during the first two weeks after birth. side effects or allergies reported through thousands of years of human use of bovine colostrum. Colostrum seals the holes by "painting" the gastrointestinal tract with a barrier which mostly prevents foreign substances from penetrating and possibly sensitizing a baby to foods the mother has eaten. Baby will receive immunological protection against many different viruses and bacteria. called IgG. Also. According to Dr. through your placenta. And bovine colostrum is safe for consumption by humans. but IgA protects the baby in the places most likely to come under attack from germs. Bovine colostrum is not a drug: It is a safe. Robert Preston with the International Institute of Nutritional Research. Colostrum has an especially important role to play in the baby's gastrointestinal tract. namely the mucous membranes in the throat. Is Bovine Colostrum Safe and Effective in Human? Research has shown that bovine colostrum is easily assimilate by humans and is up to 40 times richer in immune factors than human colostrum. the research shows that only cows’ colostrum contains special glycoproteins and protease inhibitors which are extremely effective at protecting the destruction of colostrum’s active components by adult human digestive enzymes and stomach acids. Yes. only colostrum from dairy cows has been shown to be safe. protective white cells which can destroy disease-causing bacteria and viruses. non-allergenic food. the concentrations of the antibodies in milk decrease. and intestines. Colostrum also contains high concentrations of leukocytes. In fact.” There have been no contra-indications. IgG worked through the baby's circulatory system. lungs.
which is then passed on in their colostrum. render the colostrum less effective. the molecular structure of the immune and growth factors in bovine colostrum is very similar to those found in humans. which can be avoided by lowering the dose. However. as with all health supplements. 2003. Bovine colostrum contains substances that are effective against many of the different microorganisms that are now resistant to the antibiotics on the market Bovine colostrum is not species specific. 6. Bovine Colostrum Studies on Athletic Performance The Journal of Sports Medicine. reports an investigation of whether concentrated bovine colostrum affected the incidence or duration of self-reported symptoms of upper respiratory tract infections in adult males. Based on self-reports in a double blind. These substances contaminate the colostrum and milk of cows. and growth hormones as are most other dairy cows. Colostrum used naturally contains low levels of lactose and during processing these are reduced further 7. or fungicide. reports that bovine colostrums helped male distance cyclists retain more energy following a bout of intensive training. These cyclists who used bovine colostrums performed at a higher level with fewer signs of fatigue during tests taken after their five days of intensive training. placebo controlled study. August. it is always advisable to consult with your doctor in the first instance. 2006. cows are universal donors of colostrum. steroids. Does bovine colostrum have any side effects? Colostrum is a high-protein. as a result lactoseintolerant individuals generally experience no problems and some even report that colostrum helps with their condition. In particular. herbicide. which allows them to develop natural immunity. in addition to posing potential health risks to those who ingest the milk or colostrum. That means it can be consumed safely by every mammal. When cows feed on naturally raised pasture. Health benefits/Application of Bovine colostrum a. unadulterated product (colostrum) cows should be pasture-fed on grass that has not been treated with pesticide. The European Journal of Nutrition. preliminary evidence was found that concentrated bovine colostrum protein may enhance resistance to the development of symptoms of upper respiratory tract infection. September. If you can drink milk without any problem then you can probably take colostrum. including humans. To insure a pure. If this reaction continues however then it is best to discontinue the colostrum treatment. . they are exposed to a great variety of naturally occurring disease causing organisms. Some individuals may experience a mild gastrointestinal distress or a bloated feeling. In a sense. low fat and reduced lactose dairy product. They should not be subjected to courses of antibiotics.
5. Indomethacin alone caused a 3-fold increase in gut permeability. 2003 reports a study examining the effects of bovine colostrum on peak vertical jump power. While the concentration of the growth factors present has been incompletely defined. controlled protocol. 2001 edition of Clinical Science reports that the use of non-steroidal antiinflammatory drugs (NSAIDs) cause gastrointestinal injury. if any. July. resistance exercise one-repetition maxima. Both groups also received mesalazine initially or as an increased dosage. and EGF 6 µg/L. parallel design study concluded that bovine colostrum supplementation during training significantly increased peak anaerobic power. Researchers concluded that bovine colostrum may provide a novel approach to the prevention of NSAID induced gastrointestinal damage in humans. Researchers concluded that bovine colostrums enema shows potential as a novel therapy for left-side d colitis with an additional benefits over using me sala zine alone. After the 4 weeks. alactic anaerobic work capacity. TGF-β 25 µg/L. double-blind. but had no effect on alactic anaerobic work capacity. TGF-β. the first on the healthy volunteers. which reduces gastrointestinal injury in rats and mice. double-blind. November. IGF I and II. Bovine Colostrums and Distal Colitis The Ailmentary Pharmacology and Therapeutics. c. Two studies were performed. The preliminary results obtained suggest benefits for persons acutely exposed to NSAIDs. Fourteen patients with a mean age of 45 and mild to moderately severe distal colitis were given colostrum enema or placebo for 4 weeks. Bovine colostrum is a cheap. In the first group. the colostrum group showed a mean reduction in symptoms of -2. reports a study designed to examine the efficacy of colostrum enemas in the treatment of distal colitis during a randomized. dietary supplementation might have on non-steroidal anti-inflammatory drug (NSAID)-induced GI inflammation and permeability. Researchers hypothesized that colostrum could reduce the rise in gut permeability caused by NSAIDs in volunteers and patients taking NSAIDs for clinical reasons. Bovine colostrum is rich sources of various growth factors. however. The Journal of Sports Science. while the placebo group showed a mean response of +0. placebo. and epidermal growth factor (EGF) have been identified in Bovine colostrum. Bovine Colostrums and Drug-Induced Intestinal Permeability The June. . Since these growth factors are capable of stimulating growth and repair processes within the gastrointestinal tract (GI). and plasma insulin-like growth factor (IGF-1) concentrations. peak cycle power. In the second group. two studies have been conducted to determine what effect. no increased gut permeability was seen when colostrum was co-administered with NSAID indomethacin. b. readily available source of growth factors. permeability was not influenced by co-administration of test solutions. BC did not appear to provide any GI benefits among persons chronically utilizing NSAIDs.9. This randomized. and the second on the NSAIDs patients. controlled. 2002. Bovine colostrum utilized in the two trials contained approximately 43 g/L protein content (primarily consisting of Ig) and the following growth factor profile (values are approximations): IGF-I and II 2 mg/L.
such as rotavirus. and its etiology. Currently no explanation exists for these disparate observations. Bovine Colostrum and Gastrointestinal health Review of irritable bowel syndrome. consistent with previous observations. the Bovine colostrum preparation was tested against the placebo to determine whether either an effect on intestinal permeability had. d. While short-term doses of NSAIDs appear to consistently increase intestinal permeability. piroxicam. After completing this arm of the trial. have reported low intestinal permeability with long-term NSAID use. Baseline permeability assessments were lower in these persons than in volunteers in the previous trial (who were not taking NSAIDs chronically). A milk whey solution with similar protein content but lacking growth factors was used as a placebo. Only bovine colostrum has proven clinical efficacy in eradicating intestinal pathogens. In an initial study conducted in rats. a two-week washout period was followed by a second arm of the trial in which participants receiving the active intervention were switched to the placebo. and may help control the infections seen in chronic disorders such as irritable bowel . supplementation with Bovine colostrum resulted in a dosedependent reduction in the amount of GI damage caused by indomethacin. short-term treatment with NSAIDs has previously been shown to increase intestinal permeability. Permeability increased approximately threefold in response to indomethacin in the participants taking the whey placebo while no significant increase in intestinal permeability was observed when the Bovine colostrum preparation was coadministered with indomethacin. The five days of supplementation did not have an effect on baseline intestinal permeability values in persons not taking NSAIDs. including ulcerative colitis and Crohn's disease. including infective agents such as Shigella and Campylobacter. Consistent with results of the first study. while Sigthorsson et al reported an approximate two-fold increase. A milk solution used as a placebo was not effective. BC appear to hold promise as a dietary addition in persons beginning NSAIDs. Indomethacin was introduced on days 3-7. seven males. voltarol. a study on the effects of Bovine colostrum on NSAID-induced intestinal permeability in humans was conducted. while those receiving the placebo received active treatment. No significant effect of either the active or placebo treatment was observed. or naproxen) for at least one year were randomized to receive either 125 mL Bovine colostrum or placebo three times daily for seven days with a two-week washout period between study arms. conflicting reports on the impact of chronic long-term use of NSAIDs on intestinal permeability exist. Struthers et al. Infections of the gut are difficult to treat because no antimicrobial therapy is available that is effective against Clostridia spores. it is possible that long-term use of NSAIDs results in an adaptation response by the small intestine. supplemented their diets with 125 mL Bovine colostrum or whey placebo three times daily for seven days. In the second study. However. following an initial baseline permeability assessment. Irrespective of the explanation. As a result of the positive outcome. but not for persons chronically taking NSAIDs while being free of adverse GI effects. In the first study. 15 persons taking NSAIDs (ibuprofen. Prior to commencing the studies. at least in certain individuals.
Kim JW. The role of colostral antibodies in prevention of microbial infections. Gut 44(2):212-217 (1999). The proteins found in colostrum can promote the growth of beneficial bacteria such as Lactobacilli and Bifidobacteria in the gut. colostrum stimulated intestinal cell growth and reestablished a healthy epithelial layer following injury. difficile resists digestion in the GI tract and retains its toxin-A binding abiliity and neutralizing activity is retained. Colostrum and milk-derived peptide growth factors for the treatment of gastrointestinal disorders. LaMont JT. Marnila P. Ref.Lilius EM. Center for Digestive Diseases (2001) Factors in colostrum which promote the development of the GI tract in newborn infants also help protect against such diseases as Crohn’s disease. Cho YK. Warren E. villous loss. Tunnel vision in the bowel. Laine DC. Asia Pacific Journal of Clinical Nutrition 14(1):103-107 (2005). Supplementation with bovine colostrum reduced the increase in intestinal permeability. NSAIDs given to animals have much the same effect as they do in humans. In an in vivo experimental study. Nutritional and physiologic significance of human milk proteins. Ref. colitis. Jeon WK. Johnson WS.Carver JD. Protective effects of bovine colostrum on non-steroidal anti-inflammatory drug induced intestinal damage in rats. namely. Ref. Adenekan RO. Shin MS. Bostwick EF. In an in vitro experimental study.Playford RJ. Park DI. . Macdonald CE. Imperial College. Gut 44(5):653-658 (1999). the loss of proteins. Calnan DP. and loss of enteric protein and albumin. London (2003). increased enteric bacteria levels. Colostrum or peptides derived from it are useful for the treatment of a wide variety of gastrointestinal conditions.Lonnerdal B. increased intestinal permeability. Surace R. American Journal of Clinical Nutrition 72(1):5-14 (2000).Warny M. American Journal of Clinical Nutrition 77(6):1537S-1543S (2003). Colostrum may be used alone or in combination with other anti-inflammatory and/or immune substances. Preparations from immune milk and colostrum have proven effective in the prevention of various gastroenteric infections without the risk of transferring disease from mother to infant. Lebel F. The growth factors in colostrum help heal intestinal erosions and ulcerations. Fatimi A. Yun JW. Current Opinion in Infectious Diseases14(3):295-300 (2001). Ref. Kim BI. Non-steroidal Anti-inflammatory Drugs are effective against arthritis but cause gastrointestinal injury. A bovine colostrum IgG concentrate specific against C. Kelly CP. Pothoulakis C. Sung IK. colostrum powder was also shown to reduce gastric injury. It also contains anti-inflammatory factors and is nutrient rich. Ref. and villous damage. Johnson W. and chemotherapy-induced mucositis. MacDonald CE. Sohn CI. Ref. NSAID-induced gut injury. Bovine colostrum is a health food supplement which prevents NSAID induced gut damage. Trophic factors for the gastrointestinal tract.Playford RJ. Marchbank T. Kim EJ. including inflammatory bowel disease. Floyd DN. Goodlad RA. necrotizing enterocolitis and diarrhea. Clinical Perinatology 23(2):265-285 (1996). Park HS. Yeom JS. Ref.Borody TJ.Gastrointestinal Inflammation and Repair Group. Bovine immunoglobulin concentrate-clostridium difficile retains C difficile toxin neutralising activity after passage through the human stomach and small intestine.syndrome due to the number of biologically active components in colostrum. Ref. the enteric bacteria overgrowth. Barness LA. Taking colostrum prior to NSAIDs reduced gastric injury by up to 60%. Ref. Mammalian colostrum offers passive protection against a variety of microbial pathogens.
Nucleosides. Bovine Colostrum and Respiratory Health In dealing with something as elusive as the common cold or as invasive as influenza. the best offense is a good defense. 6.Schlimme E. begins to shrink after puberty and almost disappears by the time we are 50-60 years old. occurrence.Kelly GS. Lactoferrin: a multifunctional immune regulatory protein. mechanism of action and applications. Kussendrager KD. Treatment of diarrhea in hum an immunodeficiency virus infected patients with immunoglobulins from bovine colostrum . They act as regulators in the body. Immunol Today 1995. Nucleosides and nucleotides: natural bioactive substances in milk and colostrum. Bovine colostrum has higher amounts of immunoglobulins. Some of these cells. It is also rich in oligosaccharides. HS. 9(1-3):1-5. Martin D. 4. Coupling a nutritious diet with a program of exercise and routine supplementation with high quality bovine colostrum is the best possible defense. 2000 Apr. Meisel H. gastrointestinal disturbances. nucleotides and nucleobases are all present in colostrum and milk. colostrum contains specific hormones that regulate the functions of the thymus and other substances that help to keep the immune system under control and poised to respond to possible infections before they become established Ref1. Brit J Nutr 2000. a glandular structure in the upper chest that is considered the seat of the immune system. They play an important role in the maturation of the newborn’s intestine. In addition. Ref. I yer S. This occurs primarily because the thymus. 8. British Journal of Nutrition 84(Suppl 1):S59-S68 (2000). Mol. 6(4): 332-41. our immune system loses its ability to regulate itself and to respond to a challenge efficiently. Polyamines. 7. Transfer factor . Helper/Suppressor T-lymphocytes. Ref. . including spermidine. Activities and characteristics of transfer factors.lymphocytes. T-lymphocytes (T-cells) are generated from stem cells in the bone marrow and mature in the thymus. van Hooijdonk AC. Alternative Medical Review 8(4):378-394 (2003). e. Nucleotides and nucleosides contribute to iron absorption in the gut and influence saturation and elongation rates in fatty acid synthesis. and immuneregulating factors. Ribonucleosides modulate cell proliferation and apoptosis (cell death). As we age. 9(1-3): 13-16. Treatment with bovine hyperimmune colostrum of cryptosporidial diarrhea in AIDS patients. Biotherapy 1996. AIDS 1990. 4(6):581-4. Nord J. 13:93-110. CH. Brock J. Clin Investig 1992. cytokines and nucleosides than mature milk. British Journal of Nutrition 84(Suppl 1):S55-8 (2000).current status and future prospects. 2. Lawrence. et al. growth factors. Nucleotides affect immune responses in infants. Transfer factors: identification of conserved sequences in transfer factor molecules. They are present in all mammalian milk and colostrum. Biotherap y 1996. antimicrobials. regulate the immune system by controlling the strength and quality of every immune response. Lactoperoxidase: physico-chemical properties. generate cell-mediated responses and directly destroy abnormal cells that have specific sites on their surface that are recognized by the Killer T. 70(7):588-94. CH. Ann Rev Nutrition 1995. called Killer T-lymphocytes. Kirkpatrick. Med. diarrhea (particularly in people with immune deficiency). a second type of cell. spermine and putrescine. and infectious diseases. 16(9):417-19. 3. W. Bovine colostrums: a review of clinical uses. Rum p JA. are highly regulated polycations involved in cell growth and differentiation. athletic performance.Löser C. Kirkpatrick. It has been shown that the thymus can be restored to normal function by the growth factors in colostrum. et al. Polyamines in human and animal milk. 5.. Lactoferrin: molecular structure and biological function. Borkowsk y. Ref. Lonnerdal B. 84(Suppl 1):S19-25. Research indicates that colostrum can have a beneficial effect on improving body composition.
It is also well documented that IGF-1 and the associated Superfamily of proteins found in colostrum operate in concert with growth hormone in the regeneration and repair of damaged cells. a/k/a thymulin. resulting in increased utilization of available glucose. In addition. among others. Biochem J 1991. Thom as F.60. biochem ical properties and technological characteristics of lactoferrin. Boscherini B. primarily because the thymus begins to shrink after puberty and essentially disappears by the time we are 50-60 years old. 376: S63-6. All of the these diseases represent an immune system that is out of control and could be restored and regulated through routine dietary supplementation with a high quality first milking colostrum. Brit J Nutr 2000. Chiarelli F. nitrogen retention and muscle protein synthesis following treatm ent of diabetic rats with IGF-1. Gopal PK. f. Rosenfeld RG.9. are complex clinical conditions with variable outcomes. Spagnoli A. Clin Endocrinol 1999. Oligosaccharides and glycoconjugates in bovine milk and colostrum . 276(3): 547-54. structure. 84(Suppl 1):S69-74. Gill HS. as we age. 12. Steijns JM. Brit J Nutr 2000. colostrum contains a) specific hormones. Bovine Colostrum and Metabolic Diseases Both Types I and II diabetes have an associated genetic component through which individuals appear to be predisposed. where sufficient insulin is available. it has been shown experimentally that restoration of reduced IGF-1 levels results in an enhancement of glucose utilization with a corresponding diminution of glucose levels in the blood and urine. g. Bovine Colostrum and Autoimmune Diseases Diseases such as systemic lupus erythematosus (SLE) and rheumatoid arthritis. Evaluation of the com ponents of insulin-like growth factor (IGF) and IGF binding protein (IGFBP) system in adolescents with t ype 1 diabetes and persistent m icroalbum inuria: relationship with increased excretion of IGFBP . Anabolic and tissue repair functions of recom binant insulinlike growth factors. that has been shown to keep the immune system under control. such dietary supplementation could also help such individuals overcome the associated lethargy normally experienced with such diseases. therefore.61 Scientific studies have shown that the thymus can be restored to normal function by IGF-1 the levels of which diminish in the circulation with age. since IGF-1 is responsible for directing the conversion of glucose to glycogen and glycogen is a primary metabolic energy resource. 51(5): 587-96. In addition. Ref10. Daily supplementation of the diet of the diabetic patient with high quality first milking bovine colostrum will provide a functional source for the restoration of diminished levels of IGF-1.59. Occurrence. This becomes extremely important for the Type I diabetic to assure effective and controlled utilization of available glucose once is/her insulin levels are restored. and b) proline-rich peptide (PRP). 13. Increased weight gain. the alpha and beta chains of thymosin.3 18 kD N-term inal fragm ent. Skotiner V. Ref- . 84(Suppl 1):S11-7. In the Type II diabetic. Diabetics also have low levels of IGF-1 in their circulation. van Hooijdonk AC. our immune system loses its ability to regulate itself efficiently. that are known to regulate the functions of the thymus. As indicated above (see Respiratory Diseases). 11. desirable for individuals afflicted with autoimmune diseases in order to assure that sufficient levels of IGF-1 and growth hormone are continuously available in the circulation. Vorwerk P.75 Routine dietary supplementation with high quality bovine colostrum is. Acta Pediat Scand 1990.
et al. et al. Also the low level bovine colostrum supplement increased levels of IGF-F to a greater degree than the whey protein group. a low level bovine colostrum supplement. AIDS 1990. h. and saliva immunoglobulin concentrations during a strength and speed training period. In this study the main goal was to determine the effect of bovine colostrum on serum amino acid concentrations as well as strength measurements. 2000 Apr. In other words high levels of bovine colostrum produced the greatest increases in IGF-I. Treatment of diarrhea in hum an immunodeficiency virus infected patients with immunoglobulins from bovine colostrum. 17. Nord J. 6(4): 332-41. The results from this study clearly showed that bovine colostrum produced significant increases in essential amino acid concentrations within the muscles compared to no increases in the placebo group. Biotherapy 1996. The three conditions were identical in regards to the sprint and strength training with the only notable difference amongst them being the type of drink/supplement consumed during the training period. Med. There were two conditions in which 12 active male subjects underwent both treatments but with 1 month between each protocol. 16. Rum p JA. Treatment with bovine hyperimmune colostrum of cryptosporidial diarrhea in AIDS patients. Activities and characteristics of transfer factors. HS. In a study by Antonio et al. if bovine colostrum can have such positive influence on IFG-I the authors reasonably speculated that this supplement may have a tremendous effect on athletes due to the anabolic and muscle building effects of IGF-I.current status and future prospects. 4(6):581-4. Kirkpatrick. From this study the scientists recommend that 8 weeks or more of 20 grams of bovine colostrum will enhance lean muscle hypertrophy which will further lead to increases in strength and power. 9(1-3):1-5. and a high level bovine supplement containing 5 times the amount of colostrum as the low level group. Clin Investig 1992. All of them underwent 3 different conditions each lasting a period of 8 days but with a 13 day period between conditions to eliminate factors from the previous condition. Borkowsk y. CH. However there were no differences in strength in either group. W . 3. This should be especially important and significant for athletes or anyone interested in advanced human performance and hypertrophy. There were two groups: a placebo/whey protein group and a bovine colostrum group. 15. The results from this study showed a positive correlation between IGF-I and levels of bovine colostrum. Transfer factor . Bovine Colostrum References 1. Measurements were taken before and after each treatment to determine changes in amino acid concentrations and levels of strength. CH. he and his team examined the effect of 8 weeks of bovine colostrum supplementation on body composition and exercise performance in active men and women. 9(1-3): 13-16.14. 70(7):588-94. Lawrence. In a study by Mero et al their purpose was to examine the effects of bovine colostrum supplementation on serum insulin-like growth factors (IGF-I). These conditions included a whey protein supplement. In this study 9 male subjects were all either advanced sprinters or jumpers. Mol. 2. Kirkpatrick. Biotherap y 1996. Transfer factors: identification of conserved sequences in transfer factor m olecules. 18. One of the more recent studies regarding bovine colostrum supplementation was again conducted by Mero and his team of nutritional scientists. The bovine colostrum group experienced a greater significant increase in lean body mass than the whey protein group. Finally. The authors . The two conditions involved subjects ingesting either a 20 gram bovine colostrum supplement or a 20 gram placebo/maltodextrin supplement.. amino acids.
but had no effect on alactic anaerobic work capacity. including players from the Dutch national team. However. 4. 1RM. peak cycle power. . Seventeen female and 18 male elite field hockey players. In other words.theorized that the lack of increases in strength. few have dealt solely with athletic subjects on the playing field especially at the higher level. or plasma IGF-I when compared to the control/whey protein group. specifically in the bovine colostrum condition may be due to the 2 week duration of the study which is relatively short to induce significant gains in strength. He examined the effect of 8 weeks of supplementation with bovine colostrum on body composition and exercise performance (5 x 10-m sprint. bovine colostrum supplementation during training significantly increased peak anaerobic power and vertical jump. and plasma insulin-like growth factor (IGF-I) concentrations. In a study by Buckley et al (62) they examined the effects of bovine colostrum on peak vertical jump power. In this study there were 42 competitive cyclists who were randomly divided into three groups and required to consume either 20g a day of bovine colostrum + 40g whey protein concentrate. vertical jump. 5. The sprint test improved significantly in the colostrum group versus the placebo/whey group while there was also a slight increase in the vertical jump performance test for the bovine colostrum group. Coombes et al decided to clarify this issue by conducting his own study in which bovine colostrum was tested on endurance cyclists. Peak vertical jump and peak anaerobic cycle power both significantly improved in the bovine colostrum group when compared to the whey group. Therefore it was concluded by the authors of this study that bovine colostrum supplementation may cause significant improvements in anaerobic power output and explosive capabilities in elite athletes. shuttle-run test. and suicide test) in elite field hockey players. alactic anaerobic work capacity. resistance exercise one-repetition maximum (1-RM). Simply put. However. the cyclists improved their two hour time trials by reducing their time by 2-3 minutes over the placebo group. 60g of bovine colostrum. Their times were on the average of 30 seconds faster than the 60 grams bovine colostrum group. This was an 8 week study composed of 51 males subjects divided into two groups: a placebo/whey protein group and a bovine colostrum group. Hofman et al did just this. received either 60g of colostrum or whey protein daily. or 60g of whey protein/placebo group. Although many studies have examined human subjects in a laboratory setting. Thus it can be surmised that bovine colostrum combined with high quality whey protein elicits the greatest gains in human performance. Thus the authors noted that bovine colostrum supplementation worked equally as well as traditional whey protein powder for certain factors and was superior in eliciting changes in other factors such as anaerobic power. Although most studies have found bovine colostrum to be of great aid to power and strength athletes little has been found or studied in regards to long term endurance performance. 6. there was no significant change in body composition or endurance between the two groups. Of interesting note is that the group which combined 20 grams of bovine colostrum with whey protein experienced superior outcomes over the group that consumed 60 gram of only bovine colostrum. It appears that either of the bovine colostrum protocols elicited significant gains over the placebo/whey protein group. alactic anaerobic work capacity and resistance exercise one-repetition max changed equally in both groups.
2001 Mar. 2000.9±2. Gopal PK. Kelly. Baechle. and maintenance of time trial heart rate (2. 84: S69-S74. Buckley JD. a 2. Br J Nutr. Amino Acids. It appears that strength and muscle mass increases are the most evident results of bovine colostrum supplementation. 5. High intensity training was not performed until seven weeks into the endurance program as a means to further improve the cyclist's time trials. Antonio J. Oligosaccharides and glycoconjugates in bovine milk and colostrum. Abbott MJ. However. 4. 17(3): 243-7. Van Gammeren D. J Sports Sci. Alen M. 7. 3. as soon as the five day period of high intensity training was added there was a significant change between the two groups. However. professional athletes may find it highly advantageous to their performance. IgG. Rasi S. Effect of bovine colostrum on anaerobic exercise performance and plasma insulin-like growth factor I. Effects of bovine colostrum supplementation on serum IGF-I. The benefits of the bovine colostrum group although complex and highly scientific were: a 1. Of similar interest to endurance athletes is a study by Shing et al in which he investigated the influence of low dose bovine colostrum supplementation on exercise performance in cyclists over a 10 week period that also included 5 days of high intensity training. 28(3): 327-35. Brinkworth GD. Summary and Recommendation Although there are a relatively few number of research studies performed on bovine colostrum all of them show empirical evidence of aiding athletic performance. G. 1144-1151. hormone. Nykanen T. and enhanced ventilatory system and cardiopulmonary processes by helping individuals work more efficiently. In addition. these numbers illustrate how the athletes were able to improve endurance time trials by slightly altering their physiological makeup with proper supplementation of bovine colostrum and training. i. Protein metabolism and strength performance after bovine colostrum supplementation. No. reduced endurance times. 378-394. and Takala T. Nutrition. Sanders MS. 2000. National Strength and Conditioning Association. Aalto J. Alternative Medicine Review. 2005 May...6±4. Therefore collegiate athletes should avoid using this product. 2. Ref1. 21(7): 577-88. The results before high intensity training during the first seven weeks showed no change. T. Keinanen O. 2003 Jul. Leppaluoto J. Lahti K.2% improvement from baseline in time trail performances. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. 2003: Volume 8. and saliva IgA during training. Some of the other noted benefits associated with bovine colostrum supplementation include: increased IGF-1 levels. Knuutinen J.7%). Bovine Colostrum: A Review of Clinical Uses. Mero A.5±3. Gill HS. It also appears that bovine colostrum enhanced the ventilatory system and cardiopulmonary processes by helping them work more efficiently.0% overall increase in time trial intensity (%VO2max). It should be noted that bovine colostrum's powerful effect on increasing IGF-1 levels is so prominent that the NCAA has banned its supplementation for its athletes. Simply put.3±6. There were two groups: a bovine colostrum group which consumed 10 grams a day or a placebo/whey protein group. Journal of Applied Physiology: EXERCISE AND MUSCLE.83. R. Earle. increased hormone levels. 4. Riski J. increased peak anaerobic power and vertical jump. Miikkulainen H. Mero A.6%). Number 4. Pakkanen R. 6. Essentials of Strength Training and Conditioning. Vol.7. . October 1997. bovine colostrum supplementation prevented a decrease in ventilatory threshold following the high intensity period of training (4.
His doctor was planning surgery to remove his colon. This lining is so powerful that it can last a person’s whole life if he or she doesn’t take antibiotics.http://holisticgastroenterology.8. The key to taking these is in knowing which ones to take for the individual & their unique needs.” Ref. What Doctors say about Colostrum? 1. I recommended that he start taking double doses of colostrum. Oftentimes people take probiotics for issues like chronic diarrhea treatment or colitis cures and then is disappointed that this supplementation doesn’t work. The fact is that colostrum helps to repair a wide variety of gastrointestinal issues. He was literally dying.com/probiotics-and-colostrum 2. the sufferer needs to remember how essential it is to take the correct colostrum-with the correct probiotic. Probiotics and colostrum truly go hand in hand. instead of quickly just leaving your body. you will need to take colostrum and probiotics to get this necessary ingredient into your system. From that point on he has gained 32 pounds of weight. This process enables the probiotics to remain permanently in your gut. There are a lot more that will be using this colostrum.” . this developed the mucosal lining in your body. The fact is that probiotics are useless without colostrum. When people are fed soy formulas. they are put at a major disadvantage as far as their health is concerned.” Why spend your money on probiotics if they will just be immediately leaving your system? The reason why colostrum is so essential is that it allows the probiotics to stick to the inner surface of the GI tissue. His parents were most delighted to see the change. It can get complicated. One young 12 year old boy in California was suffering from a severe case of mucosa colitis and losing weight. When that is the case. Taking the wrong ones can at best do nothing & at worst. Just one example is if the person taking either one of these is lactose intolerant. this will kill off the friendly bacteria regardless of whether you have taken it with colostrum or not. When you were first breastfed. If you are looking to relieve issues like colitis or chronic diarrhea. Please share these healing testimonies with others who need healing. and within 7 days he began to have normal bowel movements. Different antibiotics require different probiotics to replace the specific strains that were killed off. Of course. Albert Snow “Many people take Probiotics without realizing that it is essential to also take colostrum along with it. if you were never breastfed. This article will explain why it is so essential to take the two together.make you sick. In this case. This truly is a wonderful product for those who are fighting to regain health and wholeness. His father called me and asked what could be done naturally. you will need to repeat the cycle over again from the start and begin a new course of probiotics with colostrum. “Probiotics and Colostrum” by Dr. Of course. “We are so excited about the results we are having from the colostrum. After 5 days. They will just go “in one door and out the other. if you take antibiotics at any point during your life. Here are four wonderful healing results we have to share with you. don’t skimp on taking the two together. the bleeding from the rectum ceased. Also there is often times the need to take different ones at different stages of the treatment.
many older people have fragile immune systems due to a multiplicity of factors. including stress. MD. but when I added the bovine colostrum she was pain free in three days.” By. diabetes. and bovine colostrum dispensed for the treatment of rheumatoid and osteoarthritis has provided them with amazingly good results. One small-boned elderly gentleman who was terribly overweight did suffer in total agony from rheumatoid arthritis. MD 6. cancer. helps lose weight. diseases. heart disease.Alejandro Nitsch. . many post-war mothers didn’t breast-feed their babies.. However. She now takes it religiously. “I have a number of patients who are arthritic. low cost when compared to other current experimental biologic response modulators. “[Colostrum's] oral administration. about a bottle of 120 capsules per week.. Colostrum may well be one of the most important immune system nutrients to come along in the last 50 years.” By. and now many of these grown-up babies are dealing with prevalent and difficult-to-treat immune-compromised conditions. and provides many vitamins. enzymes. toxin-laden food and polluted air. He could hardly walk. Part of this problem is due to the breakdown of the environment and the nutrient-deficient food we eat. “Scientists have long known about the increased resistance of breast-fed babies to certain infections. Furthermore. 3. Colostrum plays a therapeutic role in AIDS. Minnesota. and slows down and even reverses aging. autoimmune diseases. ND. and parasitic infections. Her left knee exhibited a lot of inflammation as the result of having been damaged in a prior automobile accident. and he soon reached the point where he could walk without pain even though he did not lose the weight.By. ND. Guatemala 5. For those who can afford it. colds. Colostrum has antioxidant and anti-inflammatory properties. They have more energy. and two-thirds of my cancer patients are taking colostrum. accelerates healing of all body tissue. illness.Daniel G. “Bovine colostrum rebuilds the immune system. McCann Wellness Center Cottage Grove. as clinicians. I used bovine colostrum for the arthritic treatment of my 56 year-old mother. To us. my staff and I do a lot of work with cancer. bacterial. bacteria.something humanity has always longed for. and I stretch my resources to help them by dispensing colostrum to them at little or no cost.Michael McCann. and it keeps down some of their infections as a complication of the illness. PhD 4. since more and more illnesses and disease conditions are linked to a suppressed or compromised immune system.. allergies. herpes. the most valuable aspect of this new therapeutic alternative is its almost miraculous effect on pain relief. and much more. increase bone and lean muscle mass.. In Mexico. and fungi. particularly to intestinal disorders. because of changing cultural values. and the absence of side effects are remarkable. minerals. gingivitis. DC. Clark. I put him on colostrum. I typically have them take five or more 480 milligram capsules a day – that’s over 2000 mg.. viral. the flu. I had tried a number of different therapies such as shark cartilage and MSM without success. destroys viruses. viruses. About half of my patients are poverty-stricken. Colostrum really does seem to make a beneficial difference for my cancer patients. burn fat. and amino acids” By.James Wilson..
org/home-page/colostrum-is-safe-and-effective-what-one-of-the-worlds-leading-physicians-has-to-say. Since the patient did not take treatment with anything else. 8.icnr.com/probiotics-and-colostrum http://www.org/all-about-colostrum/is-colostrum-safe.thefinchleyclinic. Mexico Ref. 4.Stephen Hynes. http://www.” By. this patient returned for laboratory testing and discovered that his hepatitis viral load had plummeted to 100.html http://www. this is convincing proof to me that bovine colostrum works synergistically in a combined nutritional protocol.htm .net/Nutrition/Supplements/BovineColostrum.co/colostrum_question. I’ve gone on to successfully treat many more cases of hepatitis C.com/od/breastfeedingbasics/g/colostrum. 6. 7.html For More Information on Colostrum.llli. Hynes runs a clinic in Ciudad Acuna.com/shop/what-colostrum-a-519. I put together a protocol for him of bovine colostrum.exrx. 3. ND.colostrum.I am giving colostrum to hepatitis C patients. calcium orotate.about. reduced glutathione and protease enzymes.html http://www.com/shop2012/index.http://www. 5.html http://holisticgastroenterology.html http://www. Within two months.htm http://www.colostrummax. 2.icnr.org/faq/colostrum. One of these people living in Northern California who found it impossible to come to Mexico consulted me by telephone. His situation was really serious because he had a hepatitis C viral load of 8 million.php?route=information/information&information_id=10 http://breastfeeding. Dr. Refer1.
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