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Quiz Gastrointestinal Part 1 of 2

Quiz Gastrointestinal Part 1 of 2

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Quiz Gastrointestinal Part 1 of 2
Quiz Gastrointestinal Part 1 of 2

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Published by: MedShare on Apr 15, 2009
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1) The azo compounds sulfasalazine, balsalazide, and olsalazine are designed to deliver
5-ASA to a specific portion of the GI tract after cleavage of the azo structure by resident
bacteria. High concentrations of the active drug are meant to be made available at what
portion of the GI tract?
a) Esophagus and stomach
b) Stomach and duodenum
c) Duodenum and jejunum
d) Jejunum and ileum
e) Ileum and colon
2) Which of the following drugs would be most effective at delivering 5-ASA in a patient
with or ulcerative colitis (or Crohn disease) of the small intestine?
a) Mesalamine (Asacol)
b) Mesalamine (Pentasa)
c) Mesalamine (Rowasa)
d) Mesalamine (Canasa)
e) Mesalamine products are not useful at the small intestine
3) Slow acetylators (e.g. Middle Eastern) have more frequent and severe adverse effects
than fast acetylators (e.g. Asian) when taking which drug?
a) Sulfasalazine (Azulfidine)
b) Balsalazide (Coazal)
c) Olsalazine (Dipentum)
d) Mesalamine (Asacol)
e) Mesalamine (Pentasa)
4) Prednisone and prednisolone are glucocorticoids used to reduce inflammatory
processes in IBD. How are they most commonly administered?
a) IV or IM
b) Sublingual spray or tablet
c) Oral tablet
d) Transdermal patch
e) Enema or suppository
5) A patient with ulcerative colitis is prescribed a purine analog (azathioprine, 6-
mercaptopurine). What is the clinical effect?
a) Blocks inflammatory cell adhesion molecules
b) Inhibits dihydrofolate reductase
c) Acts as an immunosuppressant
d) Binds to soluble TNF-alpha trimers with high affinity
e) Binds to proteins in the ulcer base to protect further damage
6) Which of the following is true when combining allopurinol with purine analogs?
a) Allopurinol metabolism is reduce, allopurinol dosing is cut in half
b) Allopurinol metabolism is reduce, purine analog dosing is cut in half
c) Purine analog metabolism is reduce, allopurinol dosing is cut in half
d) Purine analog metabolism is reduce, purine analog dosing is cut in half
7) What is the mechanism of action for methotrexate (Trexall), a drug used to maintain
remission in Crohn disease?
a) Blocks inflammatory cell adhesion molecules

Gastrointestinal – Part 1

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b) Inhibits dihydrofolate reductase
c) Acts as an immunosuppressant
d) Binds to soluble TNF-alpha trimers with high affinity
e) Binds to proteins in the ulcer base to protect further damage
8) Infliximab (Remicade) is used in patients with Crohn disease remission or fistulating
Crohn disease who are dependent on glucocorticoids or have not responded to
methotrexate. What is its mechanism of action?
a) Blocks inflammatory cell adhesion molecules
b) Inhibits dihydrofolate reductase
c) Acts as an immunosuppressant
d) Binds to soluble TNF-alpha trimers with high affinity
e) Binds to proteins in the ulcer base to protect further damage
9) What infection seen in patients taking infliximab is the most important clinically?
a) Sepsis
b) Listeriosis
c) Pneumonia
d) Pneumocystosis
e) Latent TB reactivation
10) What screening test must be done for patients before beginning infliximab?
a) HIV blood test
b) Chest x-ray
c) PPD test
d) Blood glucose
e) CBC, T4 count
11) Which of the following symptoms is most associated with delayed infliximab
infusion reaction, where circulating antibodies are present?
a) Fever
b) Pruritis
c) Urticaria
d) Chills
e) Facial edema

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