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1. remarkable ability to dissolve large, non-volatile molecules e.g.

g., supercritical CO2 can dissolve n-alkanes containing over 30 carbon atoms related to their high densities dissolved analytes are easily recovered equilibrate with atmosphere at relatively low temperatures e.g., analyte in supercritical CO2 can be recovered by reducing the pressure and allowing the CO2 to evaporate no need for organic solvents environmentally friendly inexpensive, innocuous and non-toxic higher diffusion coefficients and lower viscosities relative to liquid faster and higher resolution separations

2. low to moderate molecular weight, thermally labile molecules. It can also be used for the
separation of chiral compounds

3. b) supercritical-fluid chromatography is inherently faster than liquid chromatography because of the lower viscosity and higher diffusion rates in the mobile phase. Packed columns for SFC can be much longer than those for HPLC, providing well over 100,000 plates. Because of the low viscosity of supercritical media, columns can be much longer than those used in liquid chromatography, and column lengths of 10 to 20 m and inside diameters of 50 or 100 m are common.

4. Because the carbon dioxide is the stauonary phase which is nonpolar csupercritical fluids. carbon dioxide properties is that its unableto elute very polar or ionic compounds.

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