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CBC Basic Interpretation

CBC
is one of the most common laboratory tests in medicine.

Typically, it includes the following:


White blood cell count (WBC or leukocyte count) WBC differential count Red blood cell count (RBC or erythrocyte count) Hematocrit (Hct) Hemoglobin (Hb) Mean corpuscular volume (MCV) Mean corpuscular hemoglobin (MCH) Mean corpuscular hemoglobin concentration (MCHC) Red cell distribution width (RDW) Platelet count Mean Platelet Volume (MPV)

objective

The CBC interpretation are useful in the diagnosis of various types of anemias.

It can reflect acute or chronic infection, allergies, and problems with clotting.

MICROCYTIC <80 fl

NORMOCYTIC 80-100 fl

MACROCYTIC >100 fl

MICROCYTIC ANEMIA
The Differential diagnoses for Microcytic anemia are: Most commonly Iron deficiency anemia (IDA) Anemia of chronic disease (ACD) Thalassemia Others are : Sideroblastic anemia Pb poisoning Cu poisoning Zinc ingestion

MACROCYTIC ANEMIA
Causes of Macrocytosis:
Vit.B12 and folate deficiency Macrocytosis secondary to reticulocytosis Drug induced Constitutional Hypoplastic anemia Myelodysplastic syndrome Liver disease Hypothyroidism Hemolysis

NORMOCYTIC ANEMIA CAUSES OF NORMOCYTIC ANEMIA: Dimorphic anemia Anemia of chronic illness Hemolysis Bleeding Anemia of renal insufficiency A

Leucocytosis: Causes of Neutrophilic leucocytosis Pyogenic infections Drug induced e.g. steroids In case of brisk bleeding Systemic onset JRA Periodic fever syndrome Stress Myeloid leukaemia Growth factor use like G CSF. Myeloproliferative disorders

Lymphocytosis: Viral infections Infectious mononucleosis CMV infection Lymphoproliferative disorder Whooping cough Koch Addisons disease.

Monocytosis: (AMC >400) Enteric fever Koch Recovery from neutropenia Viral infections Primary hemopoietic disorders like JMML