MECHANISM OF INDICATION CONTRAINDICATION ACTION Acetazolamide is an  Hypersensitivity to enzyme inhibitor that acts  Glaucoma carbonic anhydrase particularly on carbonic

(lowers inhibitor GENERIC NAME: anhydrase. Carbonic intraocular  Hypersensitivity to Acetazolamide anhydrase is the enzyme pressure in the sulfonamides that converts carbon treatment of  Depressed levels BRAND NAME: dioxide and water to glaucoma) of serum Diamox carbonic acid (H2CO3).  Epilepsy potassium and Carbonic anhydrase  Congestive sodium inhibitors, such as heart failure  Marked kidney and CLASSIFICATION: Acetazolamide inhibits  Drug-induced liver disease carbonic anhydrase in the edema  Suprarenal grand Carbonic Anhydrase tissues and fluid thus, Altitude sickness failure Inhibitor decreasing carbonic acid (mountain sickness  Hyperchloremic in the body. disease In the eye, the inhibitory  Concurrent use of DOSAGE: 500 mg/ action of Acetazolamide ophthalmic carbonic tab decreases the secretion of anhydrase inhibitors aqueous humor that (brinzolamide, lowers the intraocular dorzolamide) pressure which is  Adrenal gland failure ROUTE: Oral desirable in glaucoma. In (Addison’s disease) the central nervous  Sickle cell anemia system (CNS), restrained  Chronic nonFREQUENCY: TID carbonic anhydrase congestive glaucoma retards the abnormal and Use cautiously in paroxysmal excessive  Chronic respiratory discharge from the disease neurons of CNS.  Diabetes Mellitus In the kidneys, carbonic  Second or third acid is excreted due to the trimester of inhibited carbonic pregnancy




Depression 1. 1. Monitor individuals  Tiredness taking acetazolamide  Body malaise with primidone and  Drowsiness and confusion carbamazepine. Aceta  Transient zolamide may increase nearsightedness the blood levels of  Anorexia carbamazepine and  Metallic taste quinidine and may  Nausea and vomiting decrease the blood  Crystalluria levels of primidone.  Renal calculi 2. Instruct the patient to  Rashes avoid taking aspirin  Hyperglycemia with Acetazolamide.  Hyperchloremic acidosis Increase in side effects  Hypokalemia such as drowsiness,  Aplastic anemia confusion, lethargy,  Hemolytic anemia hyperventilation and  Leucopenia ringing in the ears  Weight loss when acetazolamide is  Paresthesias taken with aspirin.  Tingling feeling of the 3. Monitor electrolyte extremities levels.  Polyuria  Polydipsia  Blushing  Headache  Irritability  Photosensitivity (rare) Occasional adverse reactions:  Urticaria  Melena

anhydrase function. The result is renal loss of bicarbonate which carries out sodium, potassium and water. Alkalinization of urine and diuresis then takes place.

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Lactation History of kidney stones

Hematuria  Glycosuria  Hepatic insufficiency  Flaccid paralysis During long-term therapy, an acidotic state may occasionally appear. This can managed or corrected by the administration of bicarbonate.

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