DRUG NAME paracetamol DOSAGE: 250mg/tab

MECHANISM OF ACTION Produces analgesia by unknown mechanism, but it is centrally acting in the CNS by increasing the pain threshold by inhibiting cyclooxygenase. Reduces fever by direct action on hypothalamus heatregulating center with consequent peripheral vasodilation, sweating, and dissipation of heat.

INDICATION Fever reduction. Temporary relief of mild to moderate pain. Generally as substitute for aspirin when the latter is not tolerated or is contraindicated.

ADVERSE REACTION (≥1%)Body as a Whole: Negligible with recommended dosage; rash. (≥1%)Acute poisoning: Anorexia, nausea, vomiting, dizziness, lethargy, diaphoresis, chills, epigastric or abdominal pain, diarrhea.

CONTRAINDICATION Hypersensitivity to acetaminophen or phenacetin; use with alcohol.

ROUTE & FREQUENCY: PO 1 tab for T 37.8˚C

NURSING CONSIDERATION >Monitor for S&S of: Hepatotoxicity, even with moderate acetaminophen doses, especially in individuals with poor nutrition or who have ingested alcohol (3 or more alcoholic drinks daily) over prolonged periods; poisoning, usually from accidental ingestion or suicide attempts.