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Titanium Tetrachloride

Titanium Tetrachloride

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Published by: rajneesh482 on Aug 13, 2013
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Standard Operating Procedure

Read the EH&S Standard Operating Procedures Fact Sheet before filling out this form. Print out the completed form and keep a readily accessible hard copy in the lab (also keeping an electronic copy is highly recommended).

Date: SOP Title: November 4, 2010 Titanium Tetrachloride (TiCl4) Richmond Sarpong 841A Latimer (510) 643-2485

Principal Investigator: Room and Building: Lab Phone Number:

Section 1 – Process

Section 2 – Hazardous Chemicals
Titanium tetrachloride is extremely moisture sensitive and reacts violently with air and/or water. Upon reaction with water TiCl4 will also liberate highly toxic gases (HCl gas).

Section 3 – Potential Hazards
TiCl4 is reacts violently upon exposure to water, and as such can be purchased as solutions in an organic solvent. They must be handled under an inert atmosphere to minimize exposure to both air and moisture. Inhalation of gases released upon contact with moisture will cause destruction of the tissue of the mucous membranes and may be fatal. Contact with the skin will cause severe burns and contact with the eyes will cause damage. TiCl4 may also be harmful if absorbed through the skin.

Section 4 – Approvals Required
Use of titanium tetrachloride reagents requires training and the approval of the appropriate lab member.

Section 5 – Designated Area
Titanium tetrachloride should only be used in the fume hood. Additionally, it should be stored under inert atmosphere.

usually slowly to control heat evolution.File. Once the desired amount of titanium tetrachloride has been drawn into the syringe. This should seal the bottle and keep air and/or moisture from entering. the septum of which can be pierced by clean. to remove most air from the needle and syringe. This process is repeated several times. Once the addition of reagent is complete. There are two options for the handling of titanium tetrachloride. For smaller amounts of reagent. the second is to transfer using a cannula. Clean the needle immediately after use to prevent clogging. dry needle fitted to a Schlenk line which is supplying an inert gas.0001. as applying force to dispense the reagent can cause them to separate and expose the reagent to moisture. then the needle is removed and the gas inside is expelled to the atmosphere. dry reagent needle (<16 gauge) with the appropriate size syringe is used to pierce the septum and inert gas is drawn in to the syringe. Upon charging a dry flask with dry reagents/solvents and reaching the desired temperature. then water. Section 7 – Personal Protective Equipment A laboratory coat. The first option is the use of a syringe and needle. After the excess reagent has been expelled. The needle is then removed from the reagent bottle and quickly pierced into the septum of the reaction flask. and the plunger is pulled out slightly to draw a blanket of inert gas into the needle. If either of these comes apart the reagent will come out and will most likely lead to injury and damage. Proper syringe/needle transfer is as follows: All glassware and solvents should be dried prior to the treatment with any titanium tetrachloride. Be careful to hold the needle and syringe together. Do not use any titanium tetrachloride while working alone.com/ etc/medialib/docs/Aldrich/Bulletin/ altechbullal134. At this point. the titanium tetrachloride is dispensed. The inert gas flow is adjusted by monitoring of the oil bubbler on the Schlenk line. the tip of the needle is pulled above the level of reagent. while a cannula transfer is safer and more practical for amounts >15 mL. gloves and safety glasses should be worn at all times when handling titanium tetrachloride. piercing the same hole in the septum. This line is used to keep the reagent under a blanket of inert gas during the entire process. The excess reactive reagent can be expelled into a beaker of sand. Flame-dried glassware which has been cooled under an inert atmosphere just before use is ideal. Replace the cap and wrap the outside with parafilm to further ensure safe storage.Par.pdf for a detailed procedure on proper Schlenk technique.Section 6 – Special Handling Procedures and Storage Requirements Clear all areas where the reagent will be opened prior to use.tmp/al_techbull_al134. Upon purging the needle appropriately. See http://www. . the needle can be rinsed with hexanes multiple times. the needle can be removed from the reaction flask. A clean. the titanium tetrachloride can be added. Titanium tetrachloride is often stored under refrigeration and must be warmed to room temperature prior to use. the tip is submerged below the level of reagent and the required amount is drawn up into the syringe. simultaneously place a piece of tape over the hole formed by the needle while removing it from the bottle. Be careful to hold the end of the plunger as well as the joint where the needle and syringe meet. Titanium tetrachloride is contained in a Sure-Seal bottle.sigmaaldrich . the preferred technique is to use a syringe and needle. To close the reagent bottle.

soak up with inert absorbent materials and dispose of as hazardous waste. Keep in suitable closed containers for disposal. In the case of a spill. Section 10 – Waste Disposal Fully quench all reagent before disposal. Do not let the product enter drains and avoid the inhalation of vapors. Section 12 – Process Steps Process Steps Safety Measures .Section 8 – Engineering/Ventilation Controls Work inside the hood. Section 11 . In case of contact with the eyes. rinse eyes at the eye-wash station for at least 15 minutes and continue to rinse during transport to the hospital. Control the exotherm by the slow addition of reactive. Remove all contaminated clothing and get underneath the running water quickly. For the quench of excess titanium tetrachloride. slowly add to a pre-cooled flask of isopropanol at 0 °C in an ice bath in a dry flask. Keep the hood sash as low as possible to prevent spills/splashes outside the hood. The large amount of water should remove hydrochloric acid and reduce burning. Section 9 – Spill and Accident Procedures In case of contact with your person wipe of excess liquid (to reduce extreme burning upon exposure to water) and get to the nearest safety shower immediately. wipe all excess liquid then wash all contaminated skin with copious amounts of water.Decontamination Remove all contaminated clothing.

Training Documentation Name (Printed) Signature Date .

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