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Cells destined to form cranial segments of the heart, the outflow tract, migrate first, and cells forming more caudal portions, right ventricle, left ventricle, and sinus venosus, respectively, migrate in sequential order
This migration forms a third layer called the intraembryonic mesoderm (in red) (panel A) which goes to the cephalic end of the embryo .
they are induced by the underlying pharyngeal endoderm to form cardiac myoblasts .•The cells reside in the splanchnic layer of the lateral plate mesoderm.
.Blood islands also appear in this mesoderm. where they will form blood cells and vessels by the process of vasculogenesis.
With time. the islands unite and form a horseshoeshaped endothelial-lined tube surrounded by myoblasts which will form the cardiogenic region. Other blood islands appear bilateral and close to the midline of the embryonic Shield. This islands form a pair of dorsal aortae .
The angioblastic cords canalize (hollow out) to form two parallel endocardial heart tubes. .FORMATION AND POSITION OF HEART TUBE Heart development: Construction of the primitive heart tube Heart development begins during week 3. mesodermal cells aggregate to form longitudinal cellular strands termed angioblastic cords. These cords are located ventral to the pericardial coelom. At the rostral end of the embryonic body in an area called the cardiogenic region.
Heart Development. Fusion of the endocardial tubes begins at the cranial end of the heart and proceeds caudally.Formation of the heart tube Embryonic/embryo folding brings the two endocardial tubes into the thorax where they meet along midline and fuse to form a single tube. Impact of Lateral Folding on Early Heart Development Angioblastic cords Endocardial tubes .
Causes of Embryonic Folding: (MUST TO KNOW) The rapid growth of the neural tube is thought to cause the embryo to fold and bring the developing primitive heart caudal to the brain plate .
the yolk stalk or vitelline duct . cloacal membrane and connecting stalk ventrally.OTHER IMPACTS OF EMBROYNIC FOLDING Brings the cardiac region and allantois ventrally. Brings the buccopharyngeal membrane. Encloses the embryo in amniotic cavity. • Narrows the connection between yolk sac and midgut of the gastrointestinal tract to a channel.
. the dorsal mesocardium disappears creating the transverse pericardial sinus. w/c connects both sides of the pericardial cavity.) With further development . The tube is attached to the dorsal side of the pericardial cavity by dorsal mesocardium.The two endocardial heart tube fuse in cephalo-caudal direction.
Folding of the embryo .
Epicardium: covering the outside of the tube. Endocardium: forming internal endothelial lining of the heart. This outer layer is responsible for formation of the coronary arteries including their endothelial lining and smooth muscles . Myocardium: forming the muscular walls.A mesothelial cells from the regions of the sinus vensus migrate over the heart to form epicardium thus the heart tube consist of three layers.
FUSED ENDOCARDIAL HEART TUBE .
Formation of endocardial heart tube .
the body via the common cardinal veins 2. the placenta via the umbilical veins 3. the sinus venosus (which receives blood from 1. the yolk sac via the vitelline veins).Heart Development-Circulation Ant. Aortic arches Cranial capillaries Vitelline v. . Cardinal v. Aortic arches Sinus venosus Truncus arteriosus Ventricle Blood enters the caudal end of the tube. Dorsal aorta Post. Umbilical v. Bulbis cordis Atrium Umbilical a. Vitelline a. Cardinal v.
blood flows cranially into the primitive atrium. Dorsal aorta Post. Bulbis cordis Atrium Umbilical a.Heart Development-Circulation Ant. Umbilical v. Aortic arches Sinus venosus Truncus arteriosus Ventricle From the sinus venosus. From the atrium. blood enters the primitive ventricle. Aortic arches Cranial capillaries Vitelline v. Cardinal v. . Vitelline a. Cardinal v.
Cardinal v. blood enters the primitive ventricle. From the atrium. Dorsal aorta Post. Umbilical v. Aortic arches Sinus venosus Truncus arteriosus Ventricle From the sinus venosus. Aortic arches Cranial capillaries Vitelline v. . Vitelline a. Bulbis cordis Atrium Umbilical a. blood flows cranially into the primitive atrium.Heart Development-Circulation Ant. Cardinal v.
Aortic arches Sinus venosus Truncus arteriosus Ventricle From the ventricle. Vitelline a. Aortic arches Cranial capillaries Vitelline v. v. Cardinal v. Cardinal v. The truncus is continuous cranially with the expanded aortic sac from which the aortic arches arise. Dorsal aorta Post. Bulbis cordis Atrium Umbilical a.Heart Development Ant. Umbilical Umbilical v. blood is pumped to the bulbis cordis which drains into truncus arteriosus. .
Bulbis cordis Atrium Umbilical a. Umbilical v. . Cardinal v. Vitelline a. Dorsal aorta Post. the placenta and the yolk sac. Cardinal v. Aortic arches Cranial capillaries Vitelline v. Aortic arches Sinus venosus Truncus arteriosus Ventricle Blood flows from the aortic arches into the dorsal aortae in order to reach the embryonic body.Heart Development Ant.
FORMATION OF THE CARDIAC LOOP AT 22 DAYS the Heart begins to beat .
The heart tube continues to elongate And bend on day 23 .
• This bending which may be due to cell shape changes . It is complete by day 28 . creates the cardiac loop.
The proximal portion of the bulbus form the primitive right ventricle The primitive ventricle becomes trabecculated & forms the primitive left ventricle .The atrioventricular junction remains narrow and forms the atrioventricular canal. Atrioventricular canal connects the common atrium and the early embryonic ventricle.
externally indicated by the bulboventricular sulcus. • •It is called the primary interventricular foramen .• The junction between the ventricle and the bulbus cordis.remains narrow.
II. Distal part known as truncus arterioses forms the roots and proximal portions of the aorta and the pulmonary artery . Middle part known as cornus cordis forms out flow track of both ventricles. • The bulbus cordis has three parts: I. III. Proximal part which forms the trabeculated part of the right ventricle.Cont….
The atrial portion of bulbus remain temporarily smooth walled. The primitive ventricle becomes trabeculated and form the primitive left ventricle . The proximal portion of the bulbus form the primitive right ventricle.
Formation of cardiac looping .
especially heart defects. • •Genes regulating sidedness are expressed during gastrulation. a complete reversal of asymmetry in all organs. in which the heart lies on the right side of the thorax instead of the left. is caused because the heart loops to the left instead of the right. • The spleen reflects the differences: • •those with left-sided bilaterality have polysplenia. • Dextrocardia may coincide with situs inversus. . • •Patients with laterality sequences also have increased incidences of other malformations. those with rightsided bilaterality have asplenia or hypoplastic spleen.Abnormalities of Cardiac Looping • Dextrocardia.
• The signals require secretion of bone morphogenetic proteins (BMPs) 2 and 4 and inhibitors (crescent) of WNT genes in the endoderm and lateral plate mesoderm.5.5 that specifies the cardiogenic field and. later.Molecular Regulation of Cardiac Development • Signals from anterior (cranial) endoderm induce a heartforming region in overlying splanchnic mesoderm by turning on the transcription factor NKX2. . plays a role in septation and in development of the conduction system. • This combination is responsible for inducing expression of NKX2.
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