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Cells destined to form cranial segments of the heart, the outflow tract, migrate first, and cells forming more caudal portions, right ventricle, left ventricle, and sinus venosus, respectively, migrate in sequential order
This migration forms a third layer called the intraembryonic mesoderm (in red) (panel A) which goes to the cephalic end of the embryo .
•The cells reside in the splanchnic layer of the lateral plate mesoderm. they are induced by the underlying pharyngeal endoderm to form cardiac myoblasts .
where they will form blood cells and vessels by the process of vasculogenesis.Blood islands also appear in this mesoderm. .
Other blood islands appear bilateral and close to the midline of the embryonic Shield. This islands form a pair of dorsal aortae . the islands unite and form a horseshoeshaped endothelial-lined tube surrounded by myoblasts which will form the cardiogenic region.With time.
The angioblastic cords canalize (hollow out) to form two parallel endocardial heart tubes. . At the rostral end of the embryonic body in an area called the cardiogenic region. These cords are located ventral to the pericardial coelom.FORMATION AND POSITION OF HEART TUBE Heart development: Construction of the primitive heart tube Heart development begins during week 3. mesodermal cells aggregate to form longitudinal cellular strands termed angioblastic cords.
Fusion of the endocardial tubes begins at the cranial end of the heart and proceeds caudally.Formation of the heart tube Embryonic/embryo folding brings the two endocardial tubes into the thorax where they meet along midline and fuse to form a single tube.Heart Development. Impact of Lateral Folding on Early Heart Development Angioblastic cords Endocardial tubes .
Causes of Embryonic Folding: (MUST TO KNOW) The rapid growth of the neural tube is thought to cause the embryo to fold and bring the developing primitive heart caudal to the brain plate .
cloacal membrane and connecting stalk ventrally.OTHER IMPACTS OF EMBROYNIC FOLDING Brings the cardiac region and allantois ventrally. Encloses the embryo in amniotic cavity. Brings the buccopharyngeal membrane. • Narrows the connection between yolk sac and midgut of the gastrointestinal tract to a channel. the yolk stalk or vitelline duct .
The two endocardial heart tube fuse in cephalo-caudal direction. . the dorsal mesocardium disappears creating the transverse pericardial sinus. The tube is attached to the dorsal side of the pericardial cavity by dorsal mesocardium.) With further development . w/c connects both sides of the pericardial cavity.
Folding of the embryo .
Endocardium: forming internal endothelial lining of the heart. Myocardium: forming the muscular walls. This outer layer is responsible for formation of the coronary arteries including their endothelial lining and smooth muscles .A mesothelial cells from the regions of the sinus vensus migrate over the heart to form epicardium thus the heart tube consist of three layers. Epicardium: covering the outside of the tube.
FUSED ENDOCARDIAL HEART TUBE .
Formation of endocardial heart tube .
Heart Development-Circulation Ant. the body via the common cardinal veins 2. Aortic arches Sinus venosus Truncus arteriosus Ventricle Blood enters the caudal end of the tube. the sinus venosus (which receives blood from 1. Aortic arches Cranial capillaries Vitelline v. Bulbis cordis Atrium Umbilical a. Cardinal v. Cardinal v. the yolk sac via the vitelline veins). the placenta via the umbilical veins 3. Umbilical v. Dorsal aorta Post. Vitelline a. .
From the atrium. Dorsal aorta Post. blood enters the primitive ventricle. . Cardinal v. Vitelline a. Umbilical v. Cardinal v. Aortic arches Cranial capillaries Vitelline v. Bulbis cordis Atrium Umbilical a. blood flows cranially into the primitive atrium. Aortic arches Sinus venosus Truncus arteriosus Ventricle From the sinus venosus.Heart Development-Circulation Ant.
Cardinal v. Bulbis cordis Atrium Umbilical a. Aortic arches Cranial capillaries Vitelline v. blood enters the primitive ventricle. Vitelline a. Aortic arches Sinus venosus Truncus arteriosus Ventricle From the sinus venosus. blood flows cranially into the primitive atrium. Dorsal aorta Post. From the atrium.Heart Development-Circulation Ant. . Cardinal v. Umbilical v.
Vitelline a. blood is pumped to the bulbis cordis which drains into truncus arteriosus. v.Heart Development Ant. The truncus is continuous cranially with the expanded aortic sac from which the aortic arches arise. . Dorsal aorta Post. Aortic arches Sinus venosus Truncus arteriosus Ventricle From the ventricle. Bulbis cordis Atrium Umbilical a. Cardinal v. Umbilical Umbilical v. Cardinal v. Aortic arches Cranial capillaries Vitelline v.
Bulbis cordis Atrium Umbilical a. Umbilical v. Vitelline a. . Aortic arches Cranial capillaries Vitelline v. the placenta and the yolk sac. Cardinal v. Cardinal v.Heart Development Ant. Aortic arches Sinus venosus Truncus arteriosus Ventricle Blood flows from the aortic arches into the dorsal aortae in order to reach the embryonic body. Dorsal aorta Post.
FORMATION OF THE CARDIAC LOOP AT 22 DAYS the Heart begins to beat .
The heart tube continues to elongate And bend on day 23 .
• This bending which may be due to cell shape changes . It is complete by day 28 . creates the cardiac loop.
Atrioventricular canal connects the common atrium and the early embryonic ventricle.The atrioventricular junction remains narrow and forms the atrioventricular canal. The proximal portion of the bulbus form the primitive right ventricle The primitive ventricle becomes trabecculated & forms the primitive left ventricle .
• •It is called the primary interventricular foramen . externally indicated by the bulboventricular sulcus.remains narrow.• The junction between the ventricle and the bulbus cordis.
Distal part known as truncus arterioses forms the roots and proximal portions of the aorta and the pulmonary artery . III. Middle part known as cornus cordis forms out flow track of both ventricles. II. Proximal part which forms the trabeculated part of the right ventricle. • The bulbus cordis has three parts: I.Cont….
The primitive ventricle becomes trabeculated and form the primitive left ventricle .The atrial portion of bulbus remain temporarily smooth walled. The proximal portion of the bulbus form the primitive right ventricle.
Formation of cardiac looping .
in which the heart lies on the right side of the thorax instead of the left. • The spleen reflects the differences: • •those with left-sided bilaterality have polysplenia. those with rightsided bilaterality have asplenia or hypoplastic spleen. . • •Genes regulating sidedness are expressed during gastrulation. is caused because the heart loops to the left instead of the right.Abnormalities of Cardiac Looping • Dextrocardia. • Dextrocardia may coincide with situs inversus. • •Patients with laterality sequences also have increased incidences of other malformations. especially heart defects. a complete reversal of asymmetry in all organs.
.5 that specifies the cardiogenic field and. plays a role in septation and in development of the conduction system. • This combination is responsible for inducing expression of NKX2.5.Molecular Regulation of Cardiac Development • Signals from anterior (cranial) endoderm induce a heartforming region in overlying splanchnic mesoderm by turning on the transcription factor NKX2. • The signals require secretion of bone morphogenetic proteins (BMPs) 2 and 4 and inhibitors (crescent) of WNT genes in the endoderm and lateral plate mesoderm. later.
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