Caitlin Cleary Biochemistry Spring ‘12

such as cholesterol  Causes chest pain. heart attack. and stroke  Can lead to coronary artery disease .What is it?  A type of arteriosclerosis characterized by changes in the endothelial lining and the formation of a plaque  Occurs in people whose blood contains elevated levels of plasma lipids.

How does it occur? .

Inflammation  Promotes initiation and development of atherosclerosis. and therefore contributes to fast forming acute blood clots  Inflammation can be triggered by:  Infection  Obesity  Hypertension .

some degree of atherosclerosis has developed in 80 to 90% of people in the united states  Nearly 50% of the US population has elevated LDL cholesterol .Who is at risk?  Everyone!  By the time young adults reach their 30s.

Prevention  Start monitoring for risk factors in adolescents  Fasting Lipid Profile  Evaluate for hypertension  Screen for diabetes  Screen for metabolic syndrome  Therapeutic Lifestyle Changes  Diet  Physical activity  Cessation of smoking .

Current Treatments  Dietary supplements and herbal preparations are questionable  LDL Cholesterol-Lowering Therapies  Statins  Ezetimibe  Eicosapentaenoic acid from Fish Oil  Niacin .

Future Treatment?  Oral Anit-CD3 Antibody Treatment Study  Treated mice with 5 microgram dosage of anti-CD3 antibody for 5 days    50% reduction in lesion formation 38% reduction in accumulation of macrophages 30% decrease in T-cell infiltration .

Masakazu. CA: Brooks/Cole... Ridker. Paul M. 38-50. Oral Anti-CD3 Antibody Treatment Reduces Regulatory T Cells and Inhibits the Development of Atherosclerosis in Mice. (2009). Lewis.. (2012). Belmont. 105. Masafumi. Prevention and Treatment of Atherosclerosis: A Practitioner’s Guide for 2008.Works Cited Campbell. Tomoya. Attilio. & Farrell. Shawn O. Biochemistry.. Shinohara. Peter.. Yamashita. Takeda. 120. (2002). Sandra J. Naoto. Hideto. 122(1A). Journal of the American Heart Association. The American Journal of Medicine. Inflammation and Atherosclerosis.. (2009). . Libby. 1996-2005. et al. 1135-1143. & Maseri. Mary K.. Tawa. Sasaki. Nakajima. Kenji.. Journal of the American Heart Association..

Sign up to vote on this title
UsefulNot useful