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Kedar Karki1 Senior Veterinary Officer, Purnima Manandhar2 Senior Veterinary Officer, Central Veterinary Laboratory Tripureshwor, Kathmandu, Nepal, Mr.Om Prasad Neupane3 M.Sc zoology Final year St.Tribhuwan University Kathmandu Nepal. Abstract: An outbreaks of a syndrome of unknown etiology associated with the feeding of moldy dry forage and green fodder to goats in Dhakeri village of Banke District . Goats suddenly became ill with symptoms of knuckling of the fetlocks of the pelvic limbs, with no apparent ataxia or flexor weakness. Weight bearing was possible while the digits were extended, but with knuckling, weight was supported on the dorsal surface of the foot .The more severely affected goats were paraplegic and recumbent. anorexia, apathy, diarrhea and ruminal stasis,flaccid posterior paralysis,hindlegs stretched forward both side of abdomin,paralysis of all four legs, head bented to sides, aimlessly head and rear shaking .On clinical examination based on history these goats were provisionally diagnosed as Dhakeri-Bange as being called locally and Endemic Mycotic polyneuropathy syndrome as seen first time in Nepal due to moldy forage/fodder poisoning in natural pasture were treated with Antidegnala liquor(sr). On mycological and microbiological examination of tissue samples from post-mortem of dead goat and forage/fodder samples from pasture and goats feeding stalls on respective medium revealed the growth of fungal pathogens like Aspergillus and Penicillium spp with E.coli.These results provide circumstantial evidence that feeding of moldy forages and green fodder leaves infected by Penicillium and Aspergillus spp may cause outbreaks of a systemic Mycosis in these goats.
All goats present in farmers house and stalls and pasture on clinical examination were found having symptoms like Anorexia. with no apparent ataxia or flexor weakness. M. W. Dysmetria.r) Background: Fungus. coagulative necrosis of the mucosa in the rumen. Teige . ChauhanR S1. diffuse. 2: Post-Mortem Examination of dead goats. Aspergillus Spp. W.F. G. but with knuckling. Skaar .Liver with shrunken appearance pale to yellowish discoloration with bile filled distended bladder pin point hemorrhage in kidney. 2 . White 2008.2008. reticulum and omasum and congestion and hemorrhages in the abomasum. MahendranMahesh. and C. Collett MG. Ihler . The goats included in this study had knuckling of the fetlocks of the pelvic limbs. The syndrome was consistent with sciatic or peroneal nerve disease.mycoticpolyneuropathy. Jr. van der Westhuizen GC. Dullness. Material and Method: 1: Clinical examination of goats in herds. . During the autumn season in Month of October-November of year 2008 about 300 goats raised by farmers of different village development comities in Banke districts of Nepal started showing paralytic symptoms like Kumri and were treated with the preparation of Diethylcarbamazin but disease situation did not subsided. weight was supported on the dorsal surface of the foot similar to reported by Dr.Antidegnala liquor(s. various stage of polyneuropathic condition. S. M. TelangAG1.*. Whitlow and W.Moldy forage. and ruminal stasis. Medd. Maurice E.The more severely affected goats were paraplegic and recumbent.and reported by DhamaK. Schneider DJ. van der Westhuizen GC. R. but with knuckling. Marasas WF. Collett MG. On Post-Mortem examination of all 16 goats revealed the lesions which included mild focal erosions to severe.2008. SinghKP1. with no apparent ataxia or flexor weakness. weight was supported on the dorsal surface of the foot . Goat. Weight bearing was possible while the digits were extended. 1985. Pickering. A field and clinical laboratory investigation was initiated to find out the cause of disease and to provide the appropriate curative and preventive measure. Murray and D. Ataxia. Diarrhea. Hagler. : L. greenfodder.Dhakeri-Bange. Hanche-Olsen . The paraplegic goats also have had a component of femoral nerve involvement. small intestine with excessive mucus similar to lesions experimentally induced by Schneider DJ.Banke. knuckling of the fetlocks of the pelvic limbs. 1985. I. Penicillium. Marasas WF. I. J. Weight bearing was possible while the digits were extended. Generalized weakness.
pdf 2008 Sabreen. diarrhea and ruminal stasis and Clinical pathological findings included mild focal erosions to severe.Those goats received the treatment as earliest time recovered promptly the delayed treated goats too recovered but took bit longer time the treatment response was similar to earlier findings of Karki et.2008. Hanche-Olsen . J. www. On mycological and microbiological examination of tissue samples from post-mortem of dead goat on respective medium revealed the growth of fungal pathogens like Aspergillus and Penicillium spp with E.al. reticulum and omasum and congestion and hemorrhages in the abomasum.com/index/q7g038v8x3m10026. Hussein S. Pickering.Liver with shrunken appearance pale to yellowish discoloration with bile filled distended bladder pin point hemorrhage in kidney.These results provide circumstantial evidence that feeding of moldy maize grain and green fodder leaves infected by Penicillium and Aspergillus spp and timely use of Antidegnala liquor has controlled the further mortality in sick goats and when remaining animals in herd there was no further appearance of syndrome indicative of the above 3 . Ihler . I. Brasel 2001. S. I. Result and Discussion: As during warm humid climate of tropics and subtropics favors growth of mold and fungus in feed grains and fodder especially after heavy monsoon rain feeding of exclusively such grain to livestock and poultry seems to cause the detrimental effect in the health these animals. G. Medd. W.F.* 2001.springerlink. M.r) 2 ml s/c followed by 1 ml daily for next four days. and Zaky. M. Murray and D.Where as all nasal and rectal swabs from sick and dead animals tested for PPR with penside test turn out to be negative.SinghalLokesh1. R.Similarly rest of animals in herds were also provided with same drugs at the dose rate of 1 ml orally for four days. Teige . and Jeffrey M. As in this investigation clinical signs of anorexia. M. coagulative necrosis of the mucosa in the rumen.coli similar to the findings of Karki et. 4:Treatment of clinically affected goats and Rest herd: All goats that were showing clinical symptoms were treated with Antidegnala liquor(s.2008 C. Hussein. 3: Microbial/Mycobial samples. TomarSimmi2 2007. apathy. and C.al 2008. S. small intestine with excessive mucus. Culture examination of Post-Mortem Tissue On mycological and microbiological examination of tissue samples from post-mortem of dead goat and forage and fodder from natural pasture on respective medium revealed the growth of fungal pathogens like Aspergillus and Penicillium spp with E.coli. diffuse. Z. Skaar . Wendell Horne 2008.
Indian Veterinary Research Institute.www. INDIA. Izatnagar-243122 (UP). 1985 Jun. I. INDIA.polyneuropathic syndrome was caused by a systemic Mycosis in these goats need to be looked into.com/ijor. Volume : 9. Marasas WF.ces. Port Blair. Jr.au/?act=view_file&file_id=AP03059. Onderstepoort J Vet Res.csiro. A&N Islands. van der Westhuizen GC..pdf:-Retrived on 13 october 2008 6: L.gov/pubmed/4047622 -:Retrived on 13 october 2008 2. Pickering :Review of the epidemiology and economic importance of Pyrenophora semeniperda. SinghKP1.edu/disaster/drought/Mycotoxin-Review. ChauhanR S1. Medd. Whitlow and W.. References: 1: Schneider DJ. Murray and D.jsp?cfile=htm/bc/212202. indianjournals. INDIA. www. . M. Central Agricultural Research Institute(CARI).aspx?target=ijor:jii&volume=9&issue=1and2&arti cle=001&type=pdf –:-Retrived on 13 october 2008 4: outbreaks called "moldy corn toxicosis. An experimental mycotoxicosis in sheep and goats caused by Drechslera campanulata. M.52(2):93-100. SinghalLokesh1. 2Division of Animal Sciences.nih. MahendranMahesh. Indian Veterinary Research Institute.R. www. Issue : 1 and 2.nlm. Prevention and treatment www. TomarSimmi2 Aflatoxins-hazard to livestock and poultry production: A review Journal of Immunology & Immunopathology Year : 2007. Australasian Plant Pathology 32(4) 539 – 550.pdf:-Retrived on 13 october 2008 3: DhamaK. Mold and Mycotoxin Issues in Dairy Cattle: Effects. W. W.tamu. sheep. MYCOTOXINS IN FEED AND FOOD-PRODUCING CROPS Associate Department Head and Extension Program Leader for Plant Pathology and Microbiology andCommittiChairmanpublications.. Division of Pathology." "poultry hemorrhagic syndrome.*. TelangAG1.ncsu.edu/publications/Corn/B-1279 Mycotoxins. a fungal pathogen of green oats.ncbi. Adult cattle. Wendell Horne.com/mvm/index. Izatnagar-243122 (UP). 1CADRAD. Collett MG.htm :-Retrived on 13 october 2008 5: C. Hagler.merckvetmanual.publish.. G. and goats are relatively resistant to the acute form of the .pdf:-Retrived on 4 .
NV 89557.* Incidence of Aflatoxigenic Moulds and Aflatoxins in Cheeses. www.uk/secure/veteri nary/chap1mammalian. AFLATOXICOSIS IN SHEEP AND GOATS : A Diagnostic Support System for Veterinary Medicine Cause Page: 2008 Cornell University College of Veterinary Medicine.. Available online 19 September 2001. Hagler. Reno. wild deer. Brasel.org. Department of Animal Science and W...edu.. Z.pdf:-Retrived on 13 october 2008 11: Sabreen.com/index/q7g038v8x3m10026. Hussein.. (ICMSF. & Toxicology Dept.. M. Whitlow. White: AFLATOXIN TOXICITY. 6-8 February 2001 Dept. Maurice E.An Additional Stress Factor for Dairy Cattle Department of Poultry Science North Carolina State University. :-Retrived on 13 october 2008 9:Aspergillus/aspergillosiswebsite. Raleigh NC www.24k -:-Retrived on 13 october 2008 10: Meat and meat products: Other animals carrying E.pdf :-Retrived on 13 october 2008 8: Dr.cals. and *Forensic Med. Food Hygiene Dept. W. Toxicity. Mail Stop 202. Fac. Rhizopus.aun. www. M. S. and impact of mycotoxins on humans and animals School of Veterinary Medicine. Jr. metabolism. USA Received 16 April 2001. and Aspergillus spp. Assiut.ncsu. Med.PDF:Retrived on 13 october 2008 12: Hussein S.www.. Mycotoxin Contamination of Feedstuffs .eg/env_enc/ee2002/1-50_n_. 1980b). BULLETIN : Its Cong of Food Hygiene & Human Health. pigs. goats.edu/an_sci/extension/dairy/mycoto~1. of Vet. Vet. by Penicillium. of FoodHygiene.htm . and Zaky. 5 .Med.aspergillus.springerlink.13 october 2008 7: L. . and Jeffrey M. coli O157 include sheep. University of Nevada-Reno. Fac.. M. Assiut Univ. accepted 10 July 2001...
4 April 2oo8 14:Polyneuropathy Associated with Forage Sources in Norwegian Horses:Journal of Veterinary Internal Medicine. Oslo. Page 178-184 S. Norway 15:A Laboratory outbreak investigation of Post-Monsoon Endemic Moist Eczematous Syndrome in cattle in Jhapa District of Nepal. J. Teige 2 .N. Kathmandu.Tripureshwor. Oslo. Oslo. and C. 2 Department of Basic Sciences and Aquatic Medicine. in mules at Udayapur District. Tek Bahadur Air Senior Vet. 1 no. Gobinda Rokaya. Ihler 1 1 Department of Companion Animal Clinical Sciences.Mr Purna Maharajan Vet Technician of Central Veterinary Laboratory for doing the microbiology and post-mortem works and office assistant Mr.Mr.Veterinary Technicians working in Dhakeri.Poornima Manandhar and Pragya Koirala.Jaya Bahadur Karki.Dipendra Oli.Central Veterinary Laboratory.com/retrieve/pii/S0300483X01004711.Kohalpur area for providing help during sample collection and treatment.Ramlal Rokaya. Skaar 3 . Equine Section.linkinghub. Mr. :-Retrived on 13 october 2008 13: Kedar Karki and Purnima Manandhar: Clinical-Epidemiological Investigation of Mouldy Corn Poisoning due to Penicillium spp. Norway and 3 Department of Food and Feed Hygiene.Thanks are also deu to the all farmers for their co-opreation during this investigation process without which this report shouldnot have come in this shapeThanks are due to Mr. Page No. 233-236 Kedar Karki. National Veterinary Institute.elsevier. Nepal: Veterinary World pp 107-110 vol. Bal Bahadur Kunwar Mr. Hanche-Olsen 1 .F. Norwegian School of Veterinary Science. Technician and Mr. Issue 1. Nepal Acknowledgment: We would like to thank Mr.Panday and Miss Srijana Acharya of Kantipur Publication Regional Office Nepalganj for providining early indication of problem. Thanks are due to Mr.J. VOLUME 1 NO. Norway. Technician of Microbioly Unit. 6 . 8 (August-2008).Mr. I. 2008. Chandra Bahadur Rana for his tireless effort in handling the carcass during post-mortem work .Bhimsen Adhikari Vet.Volume 22.
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