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• Arginine vasopressin (AVP), also known as
vasopressin, argipressin or antidiuretic hormone (ADH), is a hormone found in most mammals, including humans. Vasopressin is a peptide hormone. It is derived from a preprohormone precursor that is synthesized in the hypothalamus and stored in vesicles at the posterior pituitary. Most of it is stored in the posterior pituitary to be released into the blood stream; however, some of it is also released directly into the brain Antidiuretic hormone (ADH): A relatively small (peptide) molecule that is released by the pituitary gland at the base of the brain after being made nearby (in the hypothalamus). ADH has an antidiuretic action that prevents the production of dilute urine (and so is antidiuretic).
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Laboratory findings in diagnosis of SIADH includeHyponatremia <130 mEq/L, and POsm <270 mOsm/kg. Other findings includeUrine sodium concentration >20 mEqlL (inappropriate natriuresis) Maintained hypervolemia Suppression of renin-angiotensin system No equal concentration of atrial natriuretic peptide Low blood urea nitrogen (BUN) Low creatinine Low uric acid Low albumin