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ABSTRACT Sponge is a superior sea animal due to its capability in producing and utilizing active biomolecules, particularly secondary

metabolite compounds as defensive mechanism for its survival. This fact indicates the possibility of using sponge biomolecules as biopesticidal for plants and as pharmaceutical material for human. The sponge Petrosia alfiani is a species endemic in Spermonde islands water of South Sulawesi, Indonesia, and can not be found in the rest of the world. A pilot study on this species indicated the presence of many useful biomolecules that can be obtained, and the possibility of discovering new molecules is high. Therefore, further in-depth study on Petrosia alfiani is needed by isolating its secondary metabolites and characterizing its chemical and bioactivity against microbes and cancerous cells. Fractionation method was performed continually, starting from extraction with non-polar solvent followed by semipolar solvent and then more polar solvents. The structural elucidation of the target biomolecules was done by spectroscopy. Synthesis against the isolated biomolecules as lead compound was done by using retrosynthesis approach and disconnection method. This study will be conducted continually for two years, the first year is the isolation and characterization of chemical and bioactivity of the molecules contained in Petrosia alfiani, the second year is synthesis, duplicating the lead molecule found in Petrosia alfiani. This study will pave the way to the availability of new pharmaceutical material from oceanic natural material. In addition, the result of this study will enrich the subject of oceanic material chemistry.