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MULTIDISCIPLINARY TREATMENT OF GASTROINTESTINAL STROMAL TUMORS

Andy Maleachi

GIST
A unique tumor Recognized only in the last decade

GIST

Requirement to successfully treat patients with GIST :


Pathologic

and Radiographic

Evaluation Surgical Treatment Oncologic care

GIST
Distinct disease based on KIT (CD 117) expression PDGFR mutations in 5% of GIST that lack KIT expression

GIST

There is much interest in GIST pathology and treatment, because the KIT proto-oncogene and the PDGFR mutations can be inhibited by Imatinib Mesylate (Targeted therapy), although the location of mutation will also predict their responses