Brand name: Amoclav Generic name: Amoxicillin and Clavulanic acid Indications: infections caused by susceptible beta-lactamase

-producing organisms: lower respiratory tract infections, otitis media, sinusitis, skin and soft tissue infections, UTI, pre and post surgical procedures. Drug classification: antiinfective; beta-lactam antibiotic; amino penicillin Mechanism of action: used alone, clavulanic acid antibacterial activity is weak. In combination, it inhibits enzyme (beta-lactamase) degradation of amoxicillin and by synergism extends both spectrum of activity and bactericidal effect of amoxicillin against many strains of beta-lactamase-producing bacteria resistant to amoxicillin alone. Dosage: tab: Adult & children> 12 yr mild to moderate dental infection 375mg tid. Severe infection 625mg tid or 1g bid. 312mg/5ml suspension. Children >6yr 5ml tid, 156mg/5ml suspension. 1-6yr 5ml tid. <1yr 25mg/kg/d in divided doses every 8h in more serious infections the dosage may be increase up to 50mg/kg/d in divided dosage every 8h. vial: Adult&children >12yr 1.2g 8h. severe infection 6h daily. 3months-12yr 5/25mg/kg 8h, 0-3months 5/25mg/kg 12h. may increase to 8h. Special precaution: super infections involving pseudomonas or candida. Pregnancy and lactation.

Pregnancy risk category: B Adverse reaction: GI: diarrhea, nausea, vomiting. Skin: skin rashes and urticaria. Other: candidal vaginitis, abdominal discomfort, flatulence and headache, increases in serum ALT, AST; glomerulonephritis; agranulocytosis. Contraindication: history of penicillin associated jaundice or hepatic dysfunction. Possible cross sensitivity with other β-lactam antibiotics; infectious mononucleosis. Form: 250mg, 500mg, 875mg tablets; 125mg, 200mg, 400mg chewable tablets; 125mg/5ml, 200mg/5ml, 250mg/5ml, 400mg/5ml, 600mg/5ml oral suspension. Nursing responsibility:  Determine previous hypersensitivity reactions to penicillins, cephalosporins, and other allergens prior to therapy.  Monitor for signs and symptoms of urticarial rash (usually occurring within a few days after start of drug) suggestive of a hypersensitivity reaction. If it occurs, look for other signs of hypersensitivity (fever, wheezing, generalized itching, dyspnea), and report to physician immediately.  Lab tests: baseline C&S test prior to initiation of therapy; start drug pending results. Note: generalized, erythematous, maculopapular rash (ampicillin rash) is not due to hypersensitivity. It is usually mild, but can be severe. Report onset of rash to physician, since hypersensitivity should be ruled out.

Sign up to vote on this title
UsefulNot useful