Brand name: Vessel due F Generic name: Sulodexide Indication: Vascular pathologies w/ thrombotic risk, transient ischemic attacks

& cerebrovascular disease, peripheral vascular insufficiency, diabetic retinopathy, MI, retinal vasal thrombosis. Mechanism of action: Inhibits coagulation by attacking several sites of the coagulation system. Its effect is dependent on the presence of antithrombin III, an alpha 2globulin whose activity is augmented by heparin. The heparin- antithrombin complex inactivates factors IXa, Xa, XIa and XIIa, and prevents thrombin formation. Furthermore, the complex reverses the effect of already formed thrombin. In high concentrations, heparin also inhibits thrombocyte aggregation. Drug Classification: Anticoagulant, antithrombotics & fibrinolytics Dosage: Acute cases 1 amp 10-20 days once daily followed by 1-2 cap bid 30 mins before meals for 60-90 days. Chronic cases1-2 cap bid 30 mins before meals for 60-90 days. Special Precaution: Periodically monitor parameters. Pregnancy. Pregnancy Risk Category: (not yet applicable); Heparin: C

Adverse Reaction: Cap GI disorders: nausea, vomiting, epigastralgia. Amp Pain, burn, hematoma at the site of injection. Contraindication: Hypersensitivity to sulodexide, heparin & heparin- like products. Diathesis & hemorrhagic diseases. Form: Capsule- 250 LSU; Ampule- 300 LSUx2 mL Nursing Responsibilities:  Assess patients for signs of bleeding and hemorrhage (bleeding gums; nosebleed; unusual bruising; black, tarry stools; hematuria; fall in hematocrit or blood pressure; guaiac- positive stools). Notify physician if these occur.  Monitor patient for hypersensitivity reactions (chills, fever, urticaria). Report signs to physician  Subcutaneous: observe injection sites for hematomas, ecchymosis, or inflammation.  Monitor platelet count every 2-3 days throughout therapy. May cause mild thrombocytopenia, which appears on the 4th day and resolves despite continued heparin therapy.

Sign up to vote on this title
UsefulNot useful