PATHOPHYSIOLOGIC DIAGRAM - SIADH

Drugs
•Antidepressants •Chemotherapy agents •Past Antidiabetic Agents

Pulmonary Tumors

Intrathoracic Conditions
[Positive-Pressure Breathing]

Disease and Injury to CNS
•Brain Tumors •Hydrocephalus •Head Injury •Meningitis •Encephalitis

Produce and Release ADH Independent of Normal Hypothalamic Control

Enhanced action of ADH on Renal Tubules

Increased HypothalamicPosterior Pituitary Gland Release

Activation of: •Baroreceptors •Cariopulmonary receptors •Osmoreceptors

Impaired HypothalamicPosterior Pituitary Structures

Excess ADH Secretion

Increased Water Reabsorption through Renal Tubule
Edema

Dilutional Hyponatremia

Increased Plasma Volume

Increased Intracellular Water Volume

Decreased Aldosterone Secretion Decreased Sodium Reabsorption

Increased Glomerular Filtration Rate Increased Sodium Filtration

Swollen Cells

Natriuresis with Oliguria Muscle Cramps And Weakness

Hyponatremia Stupor/coma

Orthostatic Hypotension

Water intoxication