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Blas to Mycosis

Blas to Mycosis

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Published by: karenkaren09 on Oct 16, 2013
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Blastomycosis (also known as "North American blastomycosis," "Blastomycetic dermatitis," and "Gilchrist's disease"[2]) is a fungal infection caused by the

organism Blastomyces dermatitidis. Endemic to portions of North America, blastomycosis causes clinical symptoms similar tohistoplasmosis.[3] Contents [hide]
           

1 Cause 2 Pathogenesis 3 Signs and symptoms 4 Diagnosis 5 Treatment 6 Prognosis 7 Epidemiology 8 History 9 Additional images 10 See also 11 References 12 External links

Cause[edit] B. dermatitidis is asexual form of Ajellomyces dermatitidis. (These can be differentiated on basis of presence or absence of "A Antigen", B. dermatitidis being positive for it.) It is a dimorphic fungus. Pathogenesis[edit]

Blastomyces dermatitidis from a lesion in dog.

usually asymptomatic. a fast. these are resistant to phagocytosis and express glycoprotein BAD-1. 40% immunocompromised individuals have CNS involvement and present as brain abscess. epidural abscess or meningitis. although infection can be asymptomatic. with fever. Some of these escape phagocytosis and transform into yeast phase rapidly. headache. myalgia (muscle pain). a productive cough. night sweats. Signs and symptoms[edit] Blastomycosis can present in one of the following ways:    a flu-like illness with fever. chills. tachypnea. with symptoms of low-grade fever. and brain. arthralgia (joint pain). In lung tissue.Inhaled conidia of B. bone. and diffuse pulmonary infiltrates. and a nonproductive cough which resolves within days. which is a virulence factor as well as an epitope. an acute illness resembling bacterial pneumonia. The incubation period is 30 to 100 days. skin lesions. progressive. they multiply and may disseminate through blood and lymphatics to other organs. and weight loss. prostatitis may be asymptomatic or may cause pain on urinating. Having thick walls. genitourinary tract. with symptoms of high fever. laryngeal involvement causes hoarseness. bone lytic lesions can cause bone or joint pain. can be verrucous (wart-like) or ulcerated with small pustules at the margins.       . chills. dermatitidis are phagocytosed by neutrophils and macrophages in alveoli. and pleuritic chest pain. a productive cough. shortness of breath. and severe disease that manifests as ARDS. including the skin. a chronic illness that mimics tuberculosis or lung cancer. hypoxemia.

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