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NF-kB Hematopoesis Innate immune B and T cells Secondary limphoid organ Pattern recognition Receptor Toll-like receptor TLR

signaling to NF-kb Cytoplasmic PRRs that activate NF-kB

NF-kB Bacterial recognation Viral recognation

Recognation of other pathogen

Immediate antimicrobial responses Inflammation

Initiation of adaptive responses

NF-kB Ag R signaling to NF-kB T cell responses mediated by NF-kB B cell responses mediated by NF-kB

Lymphoid cell survival