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7. Glycolysis and TCA Cycle - Compartmentation

7. Glycolysis and TCA Cycle - Compartmentation

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Published by Dr. SHIVA AITHAL

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Categories:Types, Research, Science
Published by: Dr. SHIVA AITHAL on Aug 16, 2009
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03/17/2012

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GLYCOLYSIS & TCA CYCLECOMPARTMENTATION

H H OH H HOCH2 ---C---C---C---C--CHO OH OH H OH

GLUCOSE

H H OH P-OCH2 ---C---C---C---CO--CH2OP OH OH H Fructose-1,6-bis-P P-OCH2 COCH OH 2

H H OH H P-OCH2---C---C---C---C--CHO OH OH H OH Glucose-6-P H H OH P-OCH2---C---C---C---CO--CH2OH OH OH H Fructose-6- P

ATP ADP

ATP ADP 2NAD+ 2Pi 2ADP

(Di-OH-acetone- P) P-OCH2 CH(OH)CHO

Glycerone-3-P
G L Y C O L Y S I S

3-P-Glyceraldehyde 1,3-bis-P-Glycerate

P-OCH2CH(OH)COO- P

2 NADH+2H 2 ATP

+

P -OCH2 CH(OH)COO

_

_ P-OCH2CH(O- P)COO CH2 =C(O-P) COO _

3-P-Glycerate

2-P-Glycerate

P-enolpyruvate
_

2ADP

2H2O 2ATP

CH3COCOO

PYRUVATE
2HSCoA 2NAD+ 2H2O
CH2COOC(OH)COOCH COO2

PYRUVATE DEHYDROGENASE

PYRUVATE ACETYL-CoA
-OOCCOCH COO2 CH3CO.SCoA

2CO2 2NADH+2H+ 2HSCoA

Oxaloacetate

Citrate + 2NAD+ 2NADH+2H 2H2O 2NAD+ 2CO2 2NADH+2H+ 2UQH2 2CO2 2NADH+2H+ 2HSCoA 2GTP

T C A C Y C L E

-OOCCH(OH)CH COO2

Malate

CH(OH)COOCHCOO- Isocitrate CH COO2

-OOCCH=CHCOO-

Fumarate

-OOCCOCH CH COO2 2

2-Oxoglutarate 2UQ 2NAD+

-OOCCH CH COO2 2

Succinate

-OOCCH CH CO.SCoA 2 2

Succinyl-CoA

2Pi 2GDP

Anaerobic Oxidation of Glucose
C6H12O6 +10NAD+ +2UQ +2ADP +2Pi +2GDP + 2Pi + 4H2O 6CO2 +10NADH+10H++2UQH2+2ATP+2GTP

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