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faf.12032 (2013).
2. Agnew, D. J. et al. PLoS ONE 4, e4570 (2009).
3. Watson, R. & Pauly, D. Nature 414, 534536 (2001).


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(2012).
2. Galon, J. et al. Science 313, 19601964 (2006).
3. Mlecnik, B. et al. J. Clin. Oncol. 29, 610618 (2011).





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| 28

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.


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.
300

14
2007 2012

( .)2

116
2001 ( 2012 .)3

1. Araki, T. et al. Nature 436, 499503 (2005).


2. Bellini, G. et al. Preprint at http://arxiv.org/
abs/1303.2571 (2013).
3. The KamLAND Collaboration. Preprint at http://
arxiv.org/abs/1303.4667 (2013).


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SOURCES: ONDEJ RMEK, UNIV. MARYLAND; BARBARA RICCI; INFN


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1. Bearchell, S. J., Fraaije, B. A., Shaw, M. W. & Fitt, B. D. Proc. Natl Acad. Sci. USA
102, 54385442 (2005).
2. Friedman, H. S. & Martin, L. R. The Longevity Project: Surprising Discoveries for
Health and Long Life from the Landmark Eight-Decade Study (Hudson Street Press,
2011).
3. Edgeworth, R., Dalton, B. J. & Parnell, T. Eur. J. Phys. 5, 198200 (1984).


2013 Macmillan Publishers Limited. All rights reserved

37 | 2 0 1 3

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1. Steffen, W. et al. Ambio 40, 739761 (2011).


2. United Nations. The Millennium Development
Goals Report 2012 (UN, 2012).
3. Rockstrm, J. et al. Nature 461, 472475 (2009).
4. Biermann, F. et al. Science 335, 13061307
(2012).
5. Glaser, G. Nature 491, 35 (2012).
6. Shindell, D. et al. Science 335, 183189 (2012).
7. Sutton, M. A. et al. Our Nutrient World (Centre for
Ecology and Hydrology, 2013).
8. Carpenter, S. R. & Bennett, E. M. Environ. Res.
Lett. 6, 014009 (2011).
9. Smakhtin, V. U. & Batchelor, A. L. Hydrol. Process.
19, 12931305 (2005).
10. Huntingford, C. et al. Environ. Res. Lett. 7, 014039
(2012).


.nature.com/zowqiw :

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Incapacitating Chemical Agents: Spiez,
Switzerland, 89 September 2011 (Spiez
Laboratory, 2012); available at go.nature.com/
eysqoh.
2. Dando, M. Nature 460, 950951 (2009).
|

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1. Priem, J., Costello, K. & Dzuba, T. figshare http://
doi.org/kvx (2012).
2. Cronin, B. J. Inform. Sci. 27, 17 (2001).
3. Priem, J. & Hemminger, B. H. Front. Comput.
Neurosci. 6, 19 (2012).
4. Smith, J. W. T. Learn. Publ. 12, 7991 (1999).
5. Esposito, J. J. J. Electron. Publ. http://dx.doi.
org/10.3998/3336451.0011.203 (2008).
6. Piwowar, H. Nature 493, 159 (2013).
7. Wilhite, A. W. & Fong, E. A. Science 335, 542543
(2012).
8. Priem, J. & Hemminger, B. M. First Monday (5
July 2010).
9. Edelman, B. G. & Larkin, I. Harvard Business
School NOM Unit Working Paper No. 09-096
(2009).
10. Kuhn, T. S. The Structure of Scientific Revolutions
(Univ. Chicago Press, 1962).
The author declares competing financial interests:
see go.nature.com/szgqx9 for details.


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& 1. Tanser, F., Brnighausen, T., Grapsa, E., Zaidi, J.
Newell, M. L. Science 339, 966971 (2013).
2. Bor, J., Herbst, A. J., Newell, M. L. & Brnighausen, T.
Science 339, 961965 (2013).
3. Palella, F. J. Jr et al. N. Engl. J. Med. 338, 853860
(1998).
4. PEPFAR Blueprint: Creating an AIDS-Free Generation
(US State Dept, 2012); available at go.nature.com/
h27zl8
5. Global Report: UNAIDS Report on the Global AIDS
Epidemic 2012 (UNAIDS, 2012); available at
go.nature.com/c4lupm
6. Bunnell, R. et al. AIDS 20, 8592 (2006).
7. Donnell, D. et al. Lancet 375, 20922098 (2010).
8. Cohen, M. S. et al. N. Engl. J. Med. 365, 493505
(2011).

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Lerrer, B. & Cohen, H. Y. EMBO J. 32, 78 (2013).


Jiang, H. et al. Nature 496, 110113 (2013).
Du, J. et al. Science 334, 806809 (2011).
& Bheda, P., Wang, J. T., Escalante-Semerena, J. C.
Wolberger, C. Protein Sci. 20, 131139 (2011).
5. Zhu, A. Y. et al. ACS Chem. Biol. 7, 155159 (2012).
6. Michishita, E. et al. Nature 452, 492496 (2008).
7. Tong, L. & Denu, J. M. Biochim. Biophys. Acta 1804,
16171625 (2010).
1.
2.
3.
4.

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.
.

.



sb2896@columbia.edu :


Gates, B. C. Chem. Rev. 95, 511522 (1995).
Franz, D. et al. Phys. Rev. Lett. 110, 065503 (2013).
Billinge, S. J. L. & Levin, I. Science 316, 561565 (2007).
Juhs, P., Cherba, D. M., Duxbury, P. M.,
Punch, W. F. & Billinge, S. J. L. Nature 440, 655658
(2006).
5. Jadzinsky, P. D., Calero, G., Ackerson, C. J.,
Bushnell, D. A. & Kornberg, R. D. Science 318,
430433 (2007).
& 6. NDiaye, A. T., Bleikamp, S., Feibelman, P. J.
Michely, T. Phys. Rev. Lett. 97, 215501 (2006).
1.
2.
3.
4.


2013 Macmillan Publishers Limited. All rights reserved

.


.


.2
63








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1987
..
.1996


.
.


.

neil.dodgson@cl.cam.ac.uk :

Fattal, D. Nature 495, 348351 (2013).
Dodgson, N. A. Proc. SPIE 5291, 3646 (2004).
Land, E. H. US patent 2,099,694 (1937).
du Hauron, L. D. US patent 544,666 (1895).
Dodgson, N. A. Appl. Opt. 35, 17051710 (1996).
van Berkel, C. & Clarke, J. A. Proc. SPIE 3012,
179186 (1997).
7. Konrad, J. & Halle, M. IEEE Signal Process. Mag.
24(6), 97111 (2007).
8. Kawakita, M. et al. Proc. SPIE 8288, 82880B (2012).
9. Travis, A. R. L. Appl. Opt. 29, 43414343 (1990).
1.
2.
3.
4.
5.
6.



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kosik@lifesci.ucsb.edu :


1. Memczak, S. et al. 495, 333338 (2013).
2. Hansen, T. B. et al. Nature 495, 384388 (2013).
3. Danan, M., Schwartz, S., Edelheit, S. & Sorek, R.
Nucleic Acids Res. 40, 31313142 (2012).
& 4. Salzman, J., Gawad, C., Wang, P. L., Lacayo, N.
Brown, P. O. PLoS ONE 7, e30733 (2012).
5. Tay, Y. et al. Cell 147, 344357 (2011).
6. Franco-Zorrilla, J. M. et al. Nature Genet. 39,
10331038 (2007).
7. Poliseno, L. et al. Nature 465, 10331038
(2010).
8. Mercer, T. R. et al. Nucleic Acids Res. 39,
23932403 (2011).
9. Neveu, P. et al. Cell Stem Cell 7, 671681 (2010).
10. Zhou, H. et al. Nucleic Acids Res. 40, 58645875
(2012).
11. Tarver, J. E., Donoghue, P. C. & Peterson, K. J.
BioEssays 34, 857866 (2012).

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akrall@ucla.edu :

hchristofk@mednet.ucla.edu
1. Dang, L. et al. Nature 462, 739744 (2009).
2. Ward, P. S. et al. Cancer Cell 17, 225234 (2010).
3. Losman, J. A. et al. Science http://dx.doi.
org/10.1126/science.1231677 (2013).
4. Parsons, D. W. et al. Science 321, 18071812 (2008).
5. Mardis, E. R. et al. N. Engl. J. Med. 361, 10581066
(2009).
6. Koivunen, P. et al. Nature 483, 484488 (2012).
7. Xu, W. et al. Cancer Cell 19, 1730 (2011).
8. Lu, C. et al. Nature 483, 474478 (2012).
9. Figueroa, M. E. et al. Cancer Cell 18, 553567 (2010).
10. Turcan, S. et al. Nature 483, 479483 (2012).
11. Moran-Crusio, K. et al. Cancer Cell 20, 1124 (2011).
12. Song, L.P. et al. Oncogene 27, 519527 (2008).
13. Friedman, A. D. Oncogene 21, 33773390 (2002).
H.R.C. declares competing financial interests: see
go.nature.com/8p7lek for details.


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| 2013

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jack.connerney@nasa.gov :

1. Canup, R. M. Nature 468, 943946 (2010).
2. Salmon, J., Charnoz, S., Crida, A. & Brahic, A. Icarus
209, 771785 (2010).
3. Cuzzi, J. N. & Estrada, P. R. Icarus 132, 135 (1998).
4. Northrop, T. G. & Connerney, J. E. P. Icarus 70,
124137 (1987).
5. Ip, W.-H. J. Geophys. Res. 88, 819822 (1983).
6. Northrop, T. G. & Hill, J. R. J. Geophys. Res. 88,
61026108 (1983).
7. ODonoghue, J. et al. Nature 496, 193195 (2013).
8. Tiscareno, M. S. et al. Nature 440, 648650 (2006).
9. Cuzzi, J. N. et al. Science 327, 14701475 (2010).
10. Connerney, J. E. P., Ness, N. F. & Acua, M. H. Nature
298, 4446 (1982).
11. Burton, M. E., Dougherty, M. K. & Russell, C. T.
Geophys. Res. Lett. 37, 24105 (2010).
12. Connerney, J. E. P. Geophys. Res. Lett. 13, 773776
(1986).
13. Prang, R., Fouchet, T., Courtin, R., Connerney, J. E. P.
& McConnell, J. C. Icarus 180, 379392 (2006).
14. Connerney, J. E. P. & Waite, J. H. Nature 312,
136138 (1984).
15. Kaiser, M. L., Desch, M. D. & Connerney, J. E. P.
J. Geophys. Res. 89, 23712376 (1984).
& 16. Fischer, G., Gurnett, D. A., Zarka, P., Moore, L.
Dyudina, U. A. J. Geophys. Res. 116, A04315 (2011).
17. Moore, L. et al. Geophys. Res. Lett. 33, l22202 (2006).
18. Moore, L. et al. J. Geophys. Res. 115, A11317 (2010).




( .)1 ..

.


( .)1



.
:



.



.


.


.
.

:

.

2013 Macmillan Publishers Limited. All rights reserved




.4
.
..

65


(
)


. ..


.

.7

.
.

98
.
.



.




10


.

11


.

..





.


. .

.

churchland@cshl.edu :

1. Brunton, B. W., Botvinick, M. M. & Brody, C. D.
Science 340, 9598 (2013).
2. Shadlen, M. N. & Newsome, W. T. J. Neurosci. 18,
38703896 (1998).
3. Churchland, A. K. et al. Neuron 69, 818831
(2011).
4. Wong, K.-F., Huk, A. C., Shadlen, M. N. & Wang,
X.-J. Front. Comput. Neurosci. http://dx.doi.org/
10.3389/neuro.10.006.2007 (2007).
5. Huk, A. C. & Shadlen, M. N. J. Neurosci. 25,
1042010436 (2005).
6. Kiani, R., Hanks, T. D. & Shadlen, M. N. J. Neurosci.
28, 30173029 (2008).
7. Callaway, E. M. Trends Neurosci. 28, 196201
(2005).
8. Kimchi, E. Y. & Laubach, M. J. Neurosci. 29,
31483159 (2009).
9. Krajbich, I., Lu, D., Camerer, C. & Rangel, A. Front.
Psychol. 3, 193 (2012).
10. Adams, G. K., Watson, K. K., Pearson, J. & Platt, M. L.
Curr. Opin. Neurobiol. 22, 982989 (2012).
& 11. Raposo, D., Sheppard, J. P., Schrater, P. R.
Churchland, A. K. J. Neurosci. 32, 37263735 (2012).

| 1 . 1 (
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doi:10.1038/nature11920


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T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E

PAGE 425

The transformation of scientific publishing

A NEW PAGE
NATURE.COM/NATURE
28 March 2013 10
Vol. 495, No. 7442

EVOLUTION

THE EARLY
BIRD

Fossil eggs deviate


from dinosaur norm
PAGE 507

MILITARY HISTORY

ANALYTICAL CHEMISTRY

COLD-WAR
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T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E

UP IN THE
CLOUDS
Low cloud enhanced
2012 Greenland
heatwave PAGE 83

NATURE.COM/NATURE
4 April 2013 10
Vol. 496, No. 7443

QUANTUM PHYSICS

WEAPONS CONTROL

PLATE TECTONICS

POINT OF NO
RETURN

DOUBLE
JEOPARDY

HOW THE WEST


WAS MADE

PAGE 20

PAGE 25

How youd really die


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chemical weapons law

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western North America
PAGES 35 & 50

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doi:10.1038/nature11930

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| 76

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Mechanistic studies of an
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polymerases
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J Son et al
doi:10.1038/nature12040

T H E I N T E R N AT I O N A L W E E K LY J O U R N A L O F S C I E N C E

Eggshells and
bones from
dinosaurs
nests
PAGE 210

JURASSIC EMBRYOLOGY
NATURE.COM/NATURE
11 April 2013 10
Vol. 496, No. 7444

CLIMATE CHANGE

ITS WARM
UP NORTH

Summer temperatures
on a 600-year high
PAGE 201

HISTORY OF SCIENCE

VICTORIAN
VISIONARY

A centenary reappraisal of
Alfred Russel Wallace
PAGE 162

CARDIOVASCULAR DISEASE

THE NEXT
?STATIN

PCSK9, poster-child of
translational research
PAGE 152

11 2013

11
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motivational states
J Jennings et al
doi:10.1038/nature12041

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M Tingley et al
doi:10.1038/nature11969
|

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doi:10.1038/nature11986


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insulators
M Rechtsman et al
doi:10.1038/nature12066

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remains


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R Reisz et al
doi:10.1038/nature11978


2013 Macmillan Publishers Limited. All rights reserved

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1. Laakso, M. & Bjrk, B.-C. BMC Med. 10, 124 (2012).


2. Swan, A. The Open Access Citation Advantage:
Studies and Results to Date. (Univ. Southampton,
2010); available at go.nature.com/8xg751
3. Solomon, D. J. & Bjrk, B.-C. J. Am. Soc. Inform.
Sci. Tech. 63, 14851495 (2012).
4. Dallmeier-Tiessen, S. et al. Preprint available at
http://arxiv.org/abs/1101.5260 (2011).
5. Bjrk, B.-C. J. Am. Soc. Inform. Sci. Tech. 63,
14961504 (2012).

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pelagiphages
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Chlamydia

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accretion
action potential
active matter

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reinforcement

adaptive immunity


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adherens

Adulthood

aerosols

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()

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Multidecadal Oscillation
amyloidosis
Anatomist
Aneurysm
Ankyrin repeat

B
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)

Biomolecular

( )

archaea

Archaea

Autism spectrum
disorder
Autoinflammatory

Biophysist
Biosafety
Biosecurity
Biosustainability

Biotech

Bipotent

Atlantis Bank
ATP

Biomarkers
Biomimetics

Aphasia

bin

Atacama Large Millimeter/submillimeter


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Behavioural
Syndrome

Annelids

arrhythmogenic

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blastocyst
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Cache Rocks
Caenorhabditis
elegans
caesium-137


2013 Macmillan Publishers Limited. All rights reserved

transcriptional
silencing


)(

caffeine-free coffee
strains
Canary Rockfish
Cap and trade
cap-dependent
translation
carbon nanotubes
carbon
sequestration
Cardiomyocyte
Career arc
CELL FATE
cells proteinbuilding complex
Emryonic stem
cells

cellular recycling
cellulases
cellulosome
Cetaceans

Chaperone
Chelation
chlamydospores
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device




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circumstellar
Climatologists
Co-clinical Trial

91 | 2 0 1 3

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combustion
synthesis

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Compartmentalization

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Environmental

Response,
Compensation, and
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dynamics
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craniofacial
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crosslinks
cross-reactions

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cryo-Electron
Microscope
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data-mining
Dichlorodiphenyltrichloroethane

differential
equations



| 92

| 2013

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difluorotoluene
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emerald cockroach
wasp

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chemicals

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entorhinal cortex
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epidimeology

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epiblast
episodic tectonic
activity

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European
METAHIT

European Roma
population

Evolutionary
biology


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)

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Exoplanets

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palaeontology

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Exposomics
extremophiles
F

Fathead minows
ferrochelatase


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fluidics
fluorescent

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follower neurons
Fossil fuel offset
credits

Foxo transcription
factors

Fringe
Fungicides
G



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gender studies
Gender-bias
Gene-expression
signature
Genetic Propensity
genetic tools
Genome-wide
association
genotype
geomorphology
Germline
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gonadotropinreleasing hormone
()GnRH

G-protein-coupled
(receptor )GPCR

GTP


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Hastatic
Hazard rankingmodel

heterochromatin

Heterozygous

hind limbs

Horse mackerel
( )
humic substances

hydrofluorocarbon

hypergeometric test
I

/
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imprinted genes

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interactive
antagonisms
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intron
isotope dating


=


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/
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liquid crystals
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mammalian fossils

Marine biologist

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medial prefrontal
cortex

medium used in
cell & tissue culture
()RPMI

membrane
proximal region

mesenchyme
mesocosms

Meta-analysis


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kinase 2

Microbiome
Microbiota
Microliths
Microphysics
Microplastic
microRNA

metabolic diseases
metabolic pathways
Metabolites
metabolomics
metagenome

Mid-Atlantic Ridge
()MAR

=

( )

Mitochondria

mitochondrial
= (DNA )mtDNA
mtDNA

Mitochondrial gene
Mitochondriopathies
molecular clock
Molecular libraries
program

micro-Arcadias


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molecular motor
molecular motor
protein

molecular therapy
motor adaptation
multi-isotope
imaging mass
spectrometry

multiple olfactory
receptor neurons
N

meta-omics
metaproteomic
metatranscriptomic
methyl hexanoate
MHC

microwave
resonator

nano wires
nanomachine /
molecular machine
Nanomaterials
nanomechanical
nanoscale

93 | 2 0 1 3

Neoplasia
net sink

neurodegeneration
neurodegenerative
disorder


(
)

Neuroligin

Neuromodulatory
systems

(
)

neuron doctrine

niche
Niobium
non-Euclidean
world
non-recombining
Novel
Nucleus accumbens
O

Office of
Communications
and Education
omics technologies

oocytes
Open-Field test

optical-trapping
optofluidics


()
| 94

| 2013


( )

owl limpet )Lottia


(gigantea

Optogenetic
manipulation
Optogenetics
Ornithologist
ortholog
overexpression

oxic zone
P






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Palaeontologist

Protein-coding
single nucleotide
variants

proteorhodopsin


()

permaforest
placode
Pluripotency
Pluripotent
Polychlorinated
biphenyls

2 Polycomb repressive
complex 2

polyisocyanopeptide

polymer gels
polymorphism
polysterene bead

Polytechnic
postcranial
anatomy

premotor area
Priority Pollutant
Projection neurons

Protoplanetary

Paleobotany

Palladium
Parameterization
pelagiphages
perfluorocarbon

prolyl-tRNA
(synthetase )ProRS

protostar
Pygmy
Q


()

Quantitative Trait
(Location )QTL


()

Quarks
Quaternary periods




(


)

radiation-therapy
recalcitrance
Regenerative
medicine
replacement
therapy
residues
Retrospective tests
retrotransposon

retrovirueses
Rhodium
RNA-binding
proteins
Romani
Rougheye Rockfish


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Saccharomyces
cerevisiae

Saltpeter
Schizosaccharomyces
pombe

Scientific Advisory
(Board )SAB

Seed funding
Self-assembling
self-renewing
haematopoietic
(stem cells )HSCs

sensor
Shale gas
Shoe-leather
epidemiology

(
)

shrews
sic
sideroblastic
anaemias
silica cycling
Single Nucleotide
(Variants )SNVs
single-celled
flagellated
protozoans
solid-state
solutionism
South West Indian
Ridge
Space Colony
spatiotemporally
chaotic flows
Spectrometrist
Sperm whale

spines
spintronic

Spliceosome
Start-ups
stem induced
pluripotent
Structural Biology
Structural
genomics
subtype-selective


(
)

Supercell storm

/
()

synaptic junctions

Systematic review

Ubiquitination
UK National
Oceanography
Centre

Ultra Luminous
X-rays
Umami

UN-IPCC

United Nations
Globally
Harmonized
System of
Classification
and Labelling of
Chemicals

-

-





(
)

technophile
Telomerase
Tetratricopeptide

the Relativistic
Heavy Ion
Collider

Visioneers
visual cortex

thermophoresis

visuospatial

Vitelloginin

Time Lapse
Photography

transdifferentiation

transcriptomics

vasculature
Venture capital
firms

upregulation

transcriptional
silencing

Transduction


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Zebrafish

Transhumanism
treadmill

xenotransplantation

-2

2-heptanone
|

95 | 2 0 1 3


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| 2013

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go.nature.com/mtoodm

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..

.
. .
. .
Daily

F&SF

Science Fiction

AE
Ceaseless Skies
Beneath

.

www.kjkabza.com :
@KJKabza

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