Common endings to official names which indicate the pharmacologic classification of a drug
Large fenestrations allow drugs to exchange freely between blood and interstitial fluid in most regions of the body.
Structure of brain capilary
Astrocyte foot processes
Brain endothelial cell
A tight junctions two adjoining cells merge, so that cells are physically joined and form a continuous wall that prevents many substances from entering the brain.
Permeability of brain capillary
Charged drug Lipid-soluble drugs Carrier-mediated transport
e- from NADPH and cytochorome P-450 reductase or NADH and cytochrome bs reductase
efrom NADPH and cytochome P-450 reductase
Free drug enters glomerular filtrate
Passive reabsorption of lipid-soluble, un-ionized Distal tubule drug which has been concentrated Collecting duct so that the intea-luminal concentration is greater than that in the perivascular space. Lonized, lipidinsoluble drug into urine
Loop of Henle
Bioavailability (F) - measure of the fraction of the dose given that reaches systemic circulation. By definition intravascular doses have F= 1.
bioequivalence For bioequivalence to exist between 2 compounds, they must have a) the same bioavailability b) the same rate of absorption
A push-button physician does not understand how a drug works and thus ignores an opportunity to individualize therapy for each patient. A curious and thoughtful physician wilI use such understanding to build a rational framework for optimal and individualized use of drugs. Appreciation of pharmacodynamics, coupled with knowledge of normal and pathological function, permits wise choices for specific situations, to say nothing of the satisfaction that comes from best practice.
3.- Amplification: The production of a measurable effect.
Drug regulation for new drugs
Clinical trial terminology
Detecting adverse drug reactions
Alphabetic classification of types of adverse drug effects.
Some important type B (bizarre) reactions