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Endpoint in Clinical Trial Endpoint is an outcome they are trying to measure with a clinical trial.

In a clinical research , a clinical endpoint generally refers to occurrence of a disease, symptom, sign or laboratory abnormality that constitutes one of the target outcomes of the trial. For example, a clinical trial investigating the ability of a medication to prevent heart attack might use chest pain as a clinical endpoint. Any patient enrolled in the trial who develops chest pain over the course of the trial, then, would be counted as having reached that clinical endpoint. The results would reflect the fraction of patients who reached the endpoint of having developed chest pain, compared with the overall number of people enrolled. When an experiment involves a control group, the proportion of individuals who reach the clinical endpoint after an introduction to IP is compared with the proportion of individuals in the control group who reached the same clinical endpoint, reflecting the ability of the IP introduction to prevent the endpoint in question. In cancer research, common endpoints include discovery of local recurrence of cancer, discovery of regional metastasis, discovery of distant metastasis, onset of symptoms, hospitalization, increase or decrease in pain medication requirement, requirement of chemotherapy, requirement of surgery, requirement of radiotherapy, death from any cause or death from disease. The results of a clinical trial generally indicate the number of people enrolled who reached the pre-determined clinical endpoint during the study interval compared with the overall number of people who were enrolled. A clinical trial will usually define a primary endpoint as a measure that will be considered success of the therapy being trialed. Additional objectives and endpoints are secondary. The primary endpoint should be the most meaningful result in a clinical trial. An example of a primary endpoint in cancer clinical trials is survival. Other results that contribute to the interpretation of the clinical trial are then considered secondary endpoints.