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1918: Spanish Flu

1957: Asian Flu


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1920

1940

1968: Hong Kong Flu


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1960

1980

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- B/Wisconsin/1/2010

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. 6-8

1. Centers for Disease Control and Prevention. MMWR. Prevention of Pneumococcal Disease. ACIP Recommendations 1997;46:RR8. 2. Austrian R et al. Ann Intern Med.
1964;60:759-776. 3. Fine MJ et al. JAMA. 1996;274:134-141. 4. Feikin DR et al. Am J Pub Health. 2000;90:223-229. 5. Restrepo MI et al. Chest. 2008;133:610-617.
6. ECDC report. Antimicrobial resistance surveillance in Europe 2010. 7. Liares J et al. Clin Microbiol Infect. 2010;16:402-410. 8 Kyaw MH et al. N Engl J Med.
2006;354:1455-1463.

:
1

(WHO 2002)

2.000.000

1.500.000

All Ages
Children <5 yrs

1.000.000

500.000
Polio,
diphtheria,
yellow fever

0
Pneumococcal
disease

Measles

Rotavirus

Hib

Pertussis

Tetanus

World Health Organization. Global immunization data; January 2008.


http://www.who.int/immunization/newsroo /Global_Immunization_Data.pdf. Accessed April 26, 2009.

Other

Meningococcus

(, 2009)

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1. Centers for Disease Control and Prevention. 2010. Active Bacterial Core Surveillance Report, Emerging Infections Program Network,
Streptococcus pneumoniae, 2009.

65

65


( 100.000)


( 100.000)

40

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1,2


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*
**
1. WHO. Acute Respiratory Infections (Update September 2009). 2. Centers for Disease Control and Prevention. Epidemiology and Prevention of Vaccine Preventable
Diseases. The Pink Book. 11th Edition. May 2009.

,

1a

Calgary, Alberta Canada . 1998-2007


100
90
80
70
60
Meningitis
Pneumonia
Bacteraemia only

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40
30
20
10
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6-23
months months

2-4
years

5-15
years

16-64
years

65-84
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85
years

Total

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1. Kellner JD, CID, 2009

SE1005,23-5-11

CO00655

1
, 21/11/2011

http://static.diavgeia.gov.gr/doc/45-2

http://static.diavgeia.gov.gr/doc/45-2

23-
PNEUMO 23, PNEUMOVAX

23
1,2,3,4,5,6B,7F,8,9N,9V,10A,11A,12F,14,15B,17F,18C,19A,19F,20,22F,23F,33
25 g .

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: 91.7%.
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0.5 mL Pneumo 23
(0.5 mL) Pneumovax

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SPMD, SmPc PNEUMOVAX, 2010

CO00655

PPV23
5 1a,b,c, 2b
PPV23 120 ( 60 f
, 71 : 65-88 ).
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GMTs 95%CI (OPK) * 65
23F.
2.


IgG

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1. Musher DM et al, J Infect Dis,2010; 2. Manoff S et al, J Infect Dis, 2010

1000 50 years


PPV23 1a,2g
(, )

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< 48
,
.

( Arthus)
388C

:
3

1.Hammitt LL, Vaccine, 2011 ; 2. Musher DM, J Infect Dis, 2010; 3. CDC, in Pink Book, 2008; 4. WHO, position paper,2008; 5. Jackson LA, Jama,1999;
6. SmPC Pneumovax II, 2009, 7. SmPC Pneumo 23,2010.

CO00655

Prevenar 13 13
S.pneumoniae

Prevenar 13

50-76% ( )
50+ 1
1. Prevenar 13 Summary of Product Characteristics, Dec 2011


, 24/10/2011



Streptococcus pneumoniae, > 50
.

( ):

,

Streptococcus pneumoniae ,
6 17

http://www.ema.europa.eu/docs/en_GB/document_library/EPAR__Summary_for_the_public/human/001104/WC500057248.pdf


, 09/07/2013


Streptococcus pneumoniae, 18 .


( ):

,

Streptococcus pneumoniae ,
6 17

http://ec.europa.eu/health/documents/community-register/2013/20130709126228/anx_126228_el.pdf

;1

(ps) () 1
1. Pollard AJ et al. Nat Rev Immunol. 2009;9:213-220.

;1,2

B
T

T-

T-

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1,2

1. de Roux A et al. Clin Infect Dis. 2008;46(7):1015-23. 2. Pollard AJ et al. Nat Rev Immunol. 2009;9:213-220.

50

1 *


PPV

PPV


Prevenar 13 .

* Prevenar 13 .1

, 23 , Prevenar 13 1

1. Prevenar 13 Summary of Product Characteristics, Dec 2011

European Respiratory Society and the European Lung Foundation. Lung Health in Europe: Facts & Figures: a better understanding of
lung disease and respiratory care in Europe. 2003:1-60. http://www.european lungfoundation.org/uploads/Document/
WEB_CHEMIN_13411_122285371.pdf. Accessed February 18, 2010.


10


.

10

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37.163

156.006

133.281

119.334.821,7
397.129.180,7
313.663.094,3
830.127.096,7

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0,83 . 10 83 .
. * +
Athanasakis et. al 2013

( )


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,

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: 7,1% (Minas et al 2010)

, ,

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/)

=

+

(Athanasakis et al 2010)
: 981,72
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59,5%
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660.000
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173,5

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(costeffective) *Bloom 2005]

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