Brand name: Calcibloc OD Generic name: Nifedipine Indication : Treatment of high blood pressure Drug Classification: Therapeutic category

: Calcium channel blockers Mechanism of Action: Inhibits Calcium ion from entering the “slow channels or select voltage-sensitive areas of vascular smooth muscle and myocardium during depolarization, producing a relaxation of coronary vascular smooth muscle and coronary vasodilation; increases myocardial oxygen delivery in patients with vasospatic angina. Dosage: Adults and Elderly: Initial: 10 mg 3 times/day as capsules or 30 mg once daily as sustained release. Usual dose: 10-30 mg 3 times/day as capsules. Maximum: 120-180 mg/day Special Precaution: Used with caution and titrate dosages in for patients with impaired renal or hepatic function. Use caution when treating patients with congestive heart failure, sick-sinus syndrome, severe left ventricular dysfunction, hypertrophic cardiomyopathy, hypotension, second or third degree A-V block, concomitant therapy with beta-blockers or digoxin, edema or increased intracranial pressure with cranial tumors. Do not abruptly withdraw( may cause chestpain). Elderly may experience hypotension and constipation more readily.

Pregnancy risk category C Adverse Effects: an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives), unusually fast or slow heartbeats, severe dizziness or fainting, psychosis, yellowing of the skin or eyes (jaundice); or swelling of the legs or ankles. Other, less serious side effects may be more likely to occur. Continue to take nifedipine and talk to your doctor if you experience headache, fatigue, or tiredness, flushing, insomnia, vivid or abnormal dreams, nausea or constipation, increased urination. Contraindication: hypersensitivity to nifedipine or any other calcium channel blocker and adenosine. Form: Capsule, liquid filled Tablet extended release Tablet, sustained release Nursing Responsibilities: Monitor BP, heart rate, and I and O ratio closely when starting or adjusting dosage. Monitor BP closely when used in conjunction with other antihypertensives. Use orthostatic precautions for inpatients; advise outpatients about orthostatic precautions. Monitor serum glucose closely in diabetic patients. Monitor for gingival hyperplasia. Pregnancy Risk Factor C- benefits of use should outweigh possible risks.

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